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Identification Of Persistent Defects In Insulin Receptor Structure And Function In Capillary Endothelial Cells From Diabetic Rats, Ching Fai Kwok, Barry J. Goldstein, Dirk Muller-Wieland, Tian-Shing Lee, C. Ronald Kahn, George L. King

Department of Medicine Faculty Papers

Insulin actions and receptors were studied in capillary endothelial cells cultured from diabetic BB rats and their nondiabetic colony mates. The endothelial cells from diabetic rats of 2 mo duration had persistent biological and biochemical defects in culture. Compared with normal rats, endothelial cells from diabetic rats grew 44% more slowly. Binding studies of insulin and insulin-like growth factor I (IGF-I) showed that cells from diabetic rats had 50% decrease of insulin receptor binding (nondiabetic: 4.6 +/- 0.7; diabetic: 2.6 +/- 0.4% per milligram protein, P < 0.01), which was caused by a 50% decrease in the number of binding sites per milligram protein, whereas IGF-I binding was not changed. Insulin stimulation of 2-deoxy-glucose uptake and alpha-aminoisobutyric acid uptake were also severely impaired with a 80-90% decrease in maximal stimulation, in parallel with a 62% decrease in insulin-stimulated autophosphorylation (P < 0.05). ¹²⁵I-insulin cross-linking revealed an 140-kD alpha subunit of the insulin receptor similar to …

Dentofacial Development In Children With Chronic Nasal Respiratory Obstruction -- A Cephalometric Study, Tai-Yang Hsi

Master's Theses

No abstract provided.

Oncolog, Volume 34, Number 04, October-December 1989, Gabriel N. Hortobagyi Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• For Cancer Patients, Home May Be Their Hospital
• Neoadiuvant Chemotherapy for Patients with Stage III Breast Cancer
• Newer Methods of Delivery To Enhance GI Cancer Treatment

Oncolog, Volume 34, Number 03, July-September 1989, Stephen L. Huber Ms, Nicky Dozier Pharmd, Naguib A. Samaan Md, Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Understanding Dose Intensity is Essential for Optimizing Chemotherapeutic Regimens
• Dysplastic Nevus Syndrome Identifies Patients at High Risk for Melanoma
• Multiple Endocrine Neoplasia Syndromes

Oncolog, Volume 34, Number 02, April-June 1989, Vicki Huff Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Bone Marrow Transplantation Supports Patients through High-Dose Chemotherapy
• Genetic Linkage Analysis of Familial Wilms' Tumor
• Osteosarcoma: Expandable Prostheses and Allografts Reduce the Need for Amputation

Oncolog, Volume 34, Number 01, January-March 1989, Mark S. Roh Md, Lillian M. Fuller Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Treatment Options for Colorectal Liver Metastases
• Improved Treatments for Non-Hodgkin's Lymphoma
• Early Discharge for Mastectomy Patients Does Not Increase Morbidity

Synapsis: Philadelphia Campus (1989), Philadelphia College Of Osteopathic Medicine

All Yearbooks

This yearbook inculdes Rugby, Soccer, Basketball, Yearbook Staff, Bridge Club, Swimming, Political Science Club, Poli Sci Club, Gene Banker Society, Student National Medical Association, SNMA, Student Council, Class Officers, Note Service, Geriatrics Society, Phi Sigma Gamma, PSG, (ΦΣΓ), Lambda Omicron Gamma, LOG, (ΛΟΓ), Women's Auxiliary, Christian Medical Society, Group Leaders, Croquet, Running.

In Vivo Formation Of Hybrid Toxins Comprising Shiga Toxin And The Shiga-Like Toxins And Role Of The B Subunit In Localization And Cytotoxic Activity, Debra L. Weinstein, Matthew P. Jackson, Liyanage P. Perera, Randall K. Holmes, Alison D. O'Brien

Uniformed Services University of the Health Sciences

Shiga toxin, Shiga-like toxin I (SLT-I) and Shiga-like toxin II (SLT-H) are cell-associated cytotoxins that kill both Vero cells and HeLa cells, whereas Shiga-like toxin II variant (SLT-llv) is an extracellular cytotoxin that is more cytotoxic for Vero cells than for HeLa cells. The basis for these differences in cytotoxin localization and host cell specificity were examined in this study. The A and B subunit genes of Shiga toxin and the SLTs were recombined by two methods so that hybrid toxins would be formed in vivo. Complementation of heterologous subunits was accomplished by cloning the individual A and B subunit …

J Am Coll Dent 1989 56 3

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

Outlook Magazine, Spring 1989

Outlook Magazine

No abstract provided.

The Reduction Of Stress As Perceived By The Alzheimer Patient Caregivers Through The Use Of Support Groups, Linda Blewer Swindle

Theses

This thesis explores how support groups can reduce perceived stress among caregivers of individuals with Alzheimer’s disease. Linda Blewer Swindle, a registered nurse, provides a comprehensive look at both the emotional and practical challenges faced by those providing care, particularly as the disease progresses through its stages. The work begins with a clinical overview of Alzheimer’s, differentiating it from normal aging and emphasizing the disease’s slow, irreversible, and deeply disruptive nature.

Swindle then examines the concept of stress, highlighting both physiological and psychological dimensions, and describes Rational Emotive Therapy (RET) as a tool to help caregivers reframe negative thought patterns. …

Aging Society: Conflict And Struggle Toward The Establishment Of The Meaningful Life For All Generations, Yasukatsu Kudo

Theses

Winter of our life-- A smell of leaves is fallen. The chill finds its way in the dry wind. Leaves little room for a coy disguise. Reflection of our life, Underneath the crammed seams, Is vivid and no-lies. Only a blind man, sitting on the corner, Busy smoothing his gray beard, Can recall his dreams . A song of geese is beaten on the ground. When the ice engraves our wrinkles, Our memories are flatten And worn out.

Statistically, the past few decades showed the rising living standards of the elderly. Social Security benefits have increased almost 50 percent in …

J Am Coll Dent 1989 56 2

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

The Role Of The Insulin Receptor Tyrosine Kinase In Two Models Of Insulin Resistance, Nancy Barchus Block

MUSC Theses and Dissertations

Activation of the insulin receptor tyrosine kinase in vitro and in vivo was studied in two rat models of insulin resistance: hypercortisolemia and streptozotocin-induced diabetes. In control rats, intravenous insulin administration resulted in dose-dependent in vivo activation of the skeletal muscle insulin receptor kinase. Chronic cortisone treatment did not affect the kinase activity of receptors solubilized from muscle after activation with insulin in vivo or in vitro. In contrast, diabetes depressed skeletal muscle insulin receptor kinase activation in vivo by ~50%. Diabetes impaired the in vitro insulin stimulation of receptor kinase activity from skeletal muscle and liver towards the substrate …

Celebrating Mother And Child On The Fortieth Day: The Sfax Tunisia Postpartum Program, Francine Coeytaux, Beverly Winikoff

Poverty, Gender, and Youth

This edition of Quality/Calidad/Qualité gives information about a postnatal family planning program in the Sfax Center of the Tunisia Maternity and Newborns Hospital. This program, developed jointly by the national family planning program and the Maternity staff, has had extraordinary success in getting more mothers to return after six weeks for their postnatal visit. During the visit, the period between births is discussed; and family planning services are offered as an important means for achieving both the recovery and good health of the mother, as well as the physical and mental development of the infant. The report describes a few …

Outlook Magazine, Summer 1989

Outlook Magazine

No abstract provided.

J Am Coll Dent 1989 56 1

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

Domains Of Nursing Practice: Application Of Benner's Model., Rebecca Jean Patterson

All ETDs from UAB

No abstract provided.

Facilitating The Nursing Process For The Nursing Diagnosis "Alteration In Thought Processes", Meridell Veen

Masters Theses

The purpose of this study was to determine if nurses who were given a tool to facilitate assessment of thought processes would collect more assessment data, diagnose "alteration in thought processes" more frequently, and include a care plan for this diagnosis more often. A quasi-experimental pre-treatment/post-treatment design was used. An inservice program about the Level of Cognitive Function Scale (LOCF) was the treatment.; Of the 40 randomly selected subjects from the 199 adult critical care nurses at a metropolitan hospital, 20 completed the study with pre-treatment and post-treatment data. Data were collected by scoring patient assessment/care plans pre-treatment and 4 …

Virginia Dental Journal (Vol. 66, No. 4, 1989)

Virginia Dental Journal

No abstract provided.

A Mimbres Burial With Associated Colon Remains From The Nan Ranch Ruin, New Mexico, Harry J. Shafer, Marrianne Marek, Karl J. Reinhard

Karl Reinhard Publications

The skeletal remains of an adult male associated with desiccated tissue and a coprolite were recovered from an apen-air midden deposit at the NAN Ranch Ruin (LA15049)) a large Mimbres site in Grant County) New Mexico. The find dates to about A.C. 1000-1100. Identifiable macroscopic elements in the caprolite consist offi nely fragmented corn and tiny seed fragments of an unknown plant. High amounts of willow (Salix) and mustard (Brassicaceae) pollen may indicate the ingestion of medicinal plants to combat a deteriorating health condition. The individual was approximately 35 -40 years old at the time of death and suffered from …

Bioarcheological Synthesis For "From The Gulf To The Rio Grande: Human Adaptation In Central, South, And Lower Pecos Texas", Karl Reinhard, Ben W. Olive, D. Gentry Steele

Karl Reinhard Publications

One of the main problems encountered in the review of the bioarcheology of Region 3 has been the limited number of sites where human skeletal material has been adequately recovered and analyzed. In the preceding chapter it was documented that less than 30% of the burials recovered from recorded sites have been reported in published literature. It was further estimated that of the 323 sites with burials, no more than 80 sites have published detailed bioarcheological reports on the burials recovered. Only 50 of these 80 reports provide individual descriptions of each burial which facilitate subsequent analyses and evaluation.

Four …

Showering In Labor: An Effective Pain Management Alternative, Kathleen A. Austin

Masters Theses

Health care professionals continue to be concerned about the relief of pain and anxiety associated with childbirth. There are recent anecdotal reports in the literature which describe showering as an effective nonpharmaceutical alternative for labor pain management. The effectiveness of showering can most likely be explained physiologically by the "gate control" theory of pain.; The purpose of this descriptive-correlational study was to examine the labor patient's perception of the effectiveness of showering as a comfort measure and the relationship between showering in labor and outcome variables such as analgesia use, anesthesia use, and childbirth satisfaction. After approval by appropriate human …

The Perception Of Loneliness By Adolescents Who Are Mildly Mentally Retarded., Beverly Desmond Hansen

All ETDs from UAB

No abstract provided.

The Relationship Between Selected Variables And The Self-Esteem In Adolescent Females., Portia Lanette Foster

All ETDs from UAB

No abstract provided.

Self-Esteem In Children With Attention Deficit Hyperactivity Disorder., Anne Horlock Shealy

All ETDs from UAB

No abstract provided.

Effects Of Methylxanthines On Newborn Rat Respiration, Craig Gatto

Masters Theses

Methylxanthines (MX), such as theophylline, are commonly used in the treatment of recurrent apnea due to their stimulant effects on the respiratory center. Structure-activity studies have demonstrated that substitution of alkyl groups on the 3-position of the xanthine nucleus results in increased bronchodilator potency, while substitution on the 1-position is important for adenosine antagonism and CNS stimulation. Three different alkylxanthines were studied to determine the structural requirements for respiratory stimulation. Respiratory rates and volumes were determined in 4- to 7-day-old rats using a volume displacement body plethysmograph. Measurements were made before and at 5 minute intervals after subcutaneous (s.c.) injection …

Jefferson Alumni Bulletin – Volume Xxxviii, Number 2, Winter 1989

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XXXVIII, Number 2, Winter 1989

Minerva Medica, Page 2

Jefferson’s program on health policy, Page 12

First woman alumni president, Page 16

Class notes, Page 21

Effect Of Intravenous Gammaglobulin On Circulating And Platelet-Bound Antibody In Immune Thrombocytopenia, G Garbano, Mansoor Saleh, P G. Mori, A F. Lobuglio, D Shaw

Haematology and Oncology, East Africa

Ten patients with idiopathic thrombocytopenic purpura (ITP) were studied before and following a rise in circulating platelets subsequent to infusions of intravenous gammaglobulin (400 mg/kg/day x 5 days). We quantitated the amount of circulating IgG capable of binding to normal donor platelets in vitro using an 125I-monoclonal anti-human IgG assay, as well as the amount of IgG associated with the patients' platelets before and following therapy. We found no evidence for a decrease in platelet-specific IgG antibodies in these patients undergoing an acute response to therapy. These data suggest that the short-term efficacy of intravenous gammaglobulin is due to effects …

The Relationship Between Coxsackievirus B Infection And Insulin-Dependent Diabetes Mellitus., Lynne Elaine Wagenknecht

All ETDs from UAB

No abstract provided.