Digital Commons Network^™

The Chironian Vol. 108 Spring 1991, New York Medical College

The Chironian

No abstract provided.

Selection Of Genetic Variants Of Simian Immunodeficiency Virus In Persistently Infected Rhesus Monkeys, Dawn P. Wooley, Ronald C. Desrosiers

Neuroscience, Cell Biology & Physiology Faculty Publications

Genetic and antigenic variation may be one means by which lentiviruses that cause AIDS avoid elimination by host immune responses. Genetic variation in the envelope gene (env) was studied by comparing the nucleotide sequences of 27 clones obtained from two rhesus monkeys infected with molecularly cloned simian immunodeficiency virus. All 27 clones differed from each other and differed from the input clone in the gp120 (SU) portion of the envelope gene. Nucleotide substitutions were shown to accumulate with time at an average rate of 8.5 per 1,000 per year in SU. Surprisingly, the majority of nucleotide substitutions (81%) resulted in …

Nurse Leaders: The Relationship Between Return To School And Sex Role Traits, Family Demographics And Household Responsibilities, Mary Lynn Anderson

Dissertations

The purposes of this study were: (a) to describe differences , if any, in sex-role traits, age and number of children, proportionate income, and responsibility for household tasks and childcare between female registered nurses who return to college and those who do not; and (b) to extend the research regarding the adult learner's return to college in the specific area of baccalaureate degree completion by registered nurses. Chi square and analysis of variance of survey data, and interviews were used in determining differences between the student and nonstudent groups.

Four hypotheses were tested. The only hypothesis which was supported was …

The Academic Coordinator Of Clinical Education In Physical Therapist Educational Programs, Norene Clouten

Dissertations

In physical therapist educational programs the faculty member responsible for the clinical education portion of the curriculum is the Academic Coordinator of Clinical Education (ACCE). The factors that attract individuals to the career of ACCE and that influence them either to leave or remain in the position are of interest and concern to those planning for the future of the profession. The purpose of this study is to gather information about the career of the ACCE. The study was designed to determine the: (a) Personal characteristics and occupational status of ACCEs, (b) preparations made for the career of ACCE, (c) …

Identification And Ranking Of Stressors Specific To The Acute Head Care Nurse, Joan A. Breen

Community & Environmental Health Theses & Dissertations

No abstract provided.

Effects Of Ultrasonic Scaling And Hand Scaling On Root Typography, Kim Lee Herremans

Dental Hygiene Theses & Dissertations

The purpose of this study was to determine the effects of scaling and root planing with the modified P-10 Cavitron^R tip and curet instruments on root surface topography. Sample specimens included 20 periodontally involved extracted human teeth. Specimens were carved into a three split root design, each sample specimen acting as its own control. Control and experimental surfaces were randomly assigned to each specimen. Scaling techniques were applied on the assigned experimental surfaces for 2 minutes and 14 seconds. A scanning electron microscope was used to examine and micrograph root surface topography of experimental surfaces. Photomicrographs were evaluated using …

Promoting Careers In Dental Hygiene: The Dental Hygienist's Role, Taline Dadian

Dental Hygiene Theses & Dissertations

The purpose of this study was to investigate whether practicing dental hygienists promote their profession as a desirable career. A self-designed, 48 item questionnaiire, Dental Hygienists' Participation in Career Recruitment, was mailed to a random sample of 600 dental hygienists residing in the Commonwealth of Virginia. Data were obtained from 393 dental hygienists for a 65.5 percent response rate. Responses from each item were analyzed by frequency distributions, percentages and chi-square test for independence at a 0.05 level of confidence. The factors determined to influence dental hygienists' decisions towards promoting careers in dental hygiene included the perceived image of the …

Problems And Coping Styles Of Antepartal Patients Being Treated For Risk Of Preterm Labor, Janet Wiehrs Rogers

Ellmer School of Nursing Theses & Dissertations

The purpose of this study was to identify the range of problems and coping strategies as perceived by antepartal patients experiencing medical treatment to decrease risk of preterm labor. In this qualitative, interpretive study problems and coping strategies were identified through semi-structured interviews with a convenience sample of seven antepartal patients. Using content analysis of interview data, identified problems were categorized, and for each problem, coping strategies were identified and grouped using the categories of the Jalowiec Coping Scale. Major categories of problems were: bedrest, role change, finances, uncomfortable emotions, and reactions of families and friends. Supportant, palliative, and confrontive …

Identification Of Health Promotion Behaviors, Perceived Health Status And Perceived Health Education Needs Of Older Women, Susan Carol Fellinger Reynolds

Ellmer School of Nursing Theses & Dissertations

The health-promoting behaviors, perceived health status, and perceived health education needs of older women were identified in this non-experimental, descriptive, correlational study. Fifty women over 60 years of age, living in three housing complexes for the elderly, disabled and handicapped in two southeastern United States cities were asked to complete The Health-Promoting Lifestyle Profile, The Perceived Health Status Questionnaire, The Health Education Needs Questionnaire, and Demographic Data Sheet. It was concluded that the women engaged in a high level of health-promoting behaviors. The participants rated their health as good and rated their health as good compared to that of other …

Norfolk Resource Mothers Program Evaluation, Margaret Moore Konefal

Theses and Dissertations in Urban Services - Urban Management

This study uses the post-test only design to assess the preliminary effects of a community-based policy initiative, the Norfolk State University Resource Mothers Program (RMP), on the gestational ages, birth weights, and survival rates of infants born to participating adolescent mothers.

The RMP uses experienced mothers or paraprofessionals similar in race and socio-economic status to the participating teenagers. These persons are trained to assist pregnant adolescents and teen parents with nonmedical dimensions of pregnancy and child care. They recruit teens into the RMP, encouraging them to get early prenatal care. Resource Mothers provide teen mothers and their families with practical …

Development And Characterization Of Monoclonal Antisperm Antibodies: Potential For Contraception, Dilrowshan H. Haque

Theses and Dissertations in Biomedical Sciences

There is an expressed need to develop a greater variety of safe contraceptive methods which would find acceptance worldwide, particularly in developing countries. Immunization against spermatozoa might be such a method as judged by the accumulated evidence from studies on human females and in a number of female animal species.

Two extraction techniques were used for sperm membrane antigen isolation. The first technique involved NP-40 detergent for antigen extraction from human motile sperm and the second technique employed homogenized human testis for antigen extraction. Using these immunogens, sperm membrane-specific monoclonal antibodies (MAbs) were developed. When these antisperm MAbs were subjected …

What's Happening: March 27, 1991, Maine Medical Center

What's Happening

No abstract provided.

Mis-Taken On Lacan: The Manqué Business Of Psychoanalysis, Bennet Schaber

Syracuse Scholar (1979-1991)

No abstract provided.

Amalgam Fillings: Do Dental Patients Have A Right To Informed Consent, Michael A. Royal

RISK: Health, Safety & Environment (1990-2002)

Recent animal studies have shown significant mercury absorption from dental fillings and resulted in unfavorable media attention. Yet, an FDA advisory committee has found no evidence of Risk to dental patients, and many dentists believe that patients are being unnecessarily alarmed. The paper reviews the history of amalgam fillings through the recent animal studies and concludes that the Risk, whatever it may prove to be, is sufficiently high to warrant permitting patients to choose between amalgam and alternative dental filling materials.

Nutrition Support Of Hiv+ Patients, Johanna T. Dwyer

Henry Ford Hospital Medical Journal

Case management strategies for the nutritional support of patients infected with the human immunodeficiency virus (HIV) are evolving as the disease becomes less rapidly fatal and more chronic. Nutritional status changes in advanced HIV infection are similar in many respects to protein-calorie malnutrition. Current clinical effort and research focuses on the beneficial effects of preserving lean body mass and keeping asymptomatic patients in good nutritional status by preventing micronutrient deficiencies and by treating preexisting nutritional problems rather than attempting to intervene late in the disease's course, after secondary malnutrition has already developed. Nutrition support and intervention trials only late in …

Human Growth Hormone Treatment: Henry Ford Hospital Experience 1964-1990, David C. Leach

Henry Ford Hospital Medical Journal

Treatment with human growth hormone (GH) at Henry Ford Hospital began in 1964 and has included 145 patients. A total of 68 patients were treated with extracted hormone and 77 with recombinant GH. The appearance of Creutzfeldt-Jakob disease, now five cases worldwide, in patients treated with extracted hormone abruptly stopped its use in the United States. The development of recombinant GH in 1985 has resulted in greater availability of treatment. Diagnostic criteria are now more liberal and certain patients without GH deficiency, i.e., those with the Turner syndrome, are now being successfully treated with GH. GH is expensive and its …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

The Calendar - March 1991, Nova University

The Calendar

No abstract provided.

Cushing's Disease: Dilemmas Of Diagnosis And Management, M. Saeed-Uz-Zafar, Raymond C. Mellinger, Max Wisgerhof

Henry Ford Hospital Medical Journal

Determining the cause of Cushing's disease and correcting the abnormality presents a continuing challenge to the clinician despite remarkable advances in diagnostic and therapeutic techniques. We present seven cases to illustrate 1) the classic disorder cured by pituitary adenomectomy: 2) persistence of the disease after adenomectomy: 3) Cushing's disease manifesting in the puerperium and remitting with dopamine agonist therapy: 4) a patient whose disease relapsed at least five times during 20 years of treatment by adrenalectomy, pituitary radiation, mitotane, and pituitary adenomectomy; 5) the Nelson syndrome; 6) the ectopic adrenocorticotropic hormone (ACTH) syndrome in a patient with dexamethasone suppressible urinary …

Contemporary Approach To Thyroid Disease Emphasizing Use Of High-Sensitivity Thyrotropin Assays, Carolyn S. Feldkamp, Malachi J. Mckenna

Henry Ford Hospital Medical Journal

Capabilities of new high-sensitivity immunoradiometric assays for thyroid-stimulating hormone (TSH-IRMA) to distinguish among hypothyroid, euthyroid, and hyperthyroid subjects and patient groups with low TSH for nonthyroidal causes suggested an algorithmic approach (directed TSH) to the evaluation of patients with suspected thyroid disease. Utilizing the algorithm, a TSH-IRMA result outside normal limits (0.5 to 5.0 mUlL) generates follow-up tests on the same sample. The interpretation of thyroid function tests (TSH-IRMA, thyroxine, resin uptake, free thyroxine index) and associated studies in the context of different clinical settings is reviewed. The approach is a cost-effective and efficient utilization of laboratory services.

Acquired Cisplatin Resistance In Human Ovarian Cancer Cells Is Associated With Enhanced Repair Of Cisplatin-Dna Lesions And Reduced Drug Accumulation., Ricardo J. Parker, Alan Eastman, Frieda Bostick-Bruton, Eddie Reed

Dartmouth Scholarship

Studies were undertaken to investigate acquired resistance to cisplatin in human ovarian cancer cells. The cell lines A2780 and A2780/CP70 were studied to assess their respective characteristics of drug accumulation and efflux, cytosolic inactivation of drug, and DNA repair. All experiments were performed using 1-h drug exposures. The A2780/CP70 cell line was 13-fold more resistant to cisplatin than A2780 cells. When studied at their respective IC50 doses, drug accumulation rates were similar for the two cell lines. However, the resistant cell line was twofold more efficient at effluxing drug, which was associated with reduced total drug accumulation for equivalent micromolar …

Molecular Mechanism Of The Stimulation Of Alkaline Phosphatase Activity In Human Bone Cells By 1,25(Oh)2 D3, Eru Kyeyune-Nyombi

Loma Linda University Electronic Theses, Dissertations & Projects

To facilitate this study an in vitro human model system was established that exhibited many aspects of normal osteoblasts. The human osteosarcoma cell line (TE85 cells) expressed a skeletal alkaline phosphatase activity (an accepted bone cell differentiation marker) which was stimulated by 1,25(OH)₂D₃ (a potent differentiating agent), under serum-free conditions in a dose-dependent, time-dependent, and cell density-dependent manner. Cytochemical analysis of the stimulation of ALP activity by 1,25(OH)₂D₃ showed that 1,25(OH)₂D₃ increased the number of TE85 cells that expressed detectable ALP activity, suggesting that 1,25(OH)₂D₃ promoted the process …

Factors Related To Self-Care Agency And Self-Care Practices Of Obese Adolescents, Kathy Shadle James Dnsc, Msn, Rn

Dissertations

Identification of factors that influence obese adolescents' health behaviors is necessary if obese adolescents are to benefit from therapeutic interventions. The purpose of this descriptive-correlational study was to identify the relationships between selected basic conditioning factors (BCFs)--perceived health status (PHS), perceived self-efficacy (PSE), family satisfaction (FS), and life events (LE)--and the self-care agency (SCA) and self-care practices (SCP) among obese adolescents. The relative predictive strength of each BCF in relation to the outcome variables was also explored. Orem's self-care theory provided the conceptual framework for this study. The convenience sample of 100 obese adolescents included campers from two southern California …

Cells That Express All Five Proteins Of Vesicular Stomatitis Virus From Cloned Cdnas Support Replication, Assembly, And Budding Of Defective Interfering Particles, Asit K. Pattnaik, Gail W. Wertz

School of Veterinary and Biomedical Sciences: Faculty Publications

An alternative approach to structurefunction analysis of vesicular stomatitis virus (VSV) gene products and their interactions with one another during each phase of the viral life cycle is described. We showed previously by using the vaccinia viruslT7 RNA polymerase expression system that when cells expressing the nucleocapsid protein (N), the phosphoprotein (NS), and the large polymerase protein (L) of VSV were superinfected with defective interfering (DI) particles, rapid and efflicient replication and amplification of DI particle RNA occurred. Here, we demonstrate that all five VSV proteins can be expressed simultaneously when cells are cotransfected with plasmids containing the matrix protein …

Interleukin-1 Or Phorbol Induction Of The Stromelysin Promoter Requires An Element That Cooperates With Ap-1., Karen Sirum-Connolly, Constance E. Brinckerhoff

Dartmouth Scholarship

Interieukin-1, a mediator of inflammation, or tumor promoting phorbol esters induce transcription of stromelysin, a metalloproteinase that degrades extracellular matrix molecules and that is overexpressed in diseases such as rheumatoid arthritis. Sequences required for induction of transcription of the human stromelysin promoter are contained on a 46 base pair fragment. This fragment contains a sequence with a high degree of similarity to the binding site for the transcription factor activator protein-1 (AP-1) and indeed, the AP-1 sequence of this fragment is necessary but not sufficient for the maximal response to phorbol 12-myristate 13-acetate (phorbol) or interleukin-1. Maximal induction requires functional …

Caduceus 1991, Stritch School Of Medicine

Stritch School of Medicine Yearbooks

No abstract provided.

Southeastern University Of The Health Sciences Catalog 1991-1993, Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Santa Clara Magazine, Volume 33 Number 2, Winter 1991, Santa Clara University

Santa Clara Magazine

10 - GROWING UP ADOPTED Santa Clarans who have adopted children or are adopted discuss their experiences with interracial adoption and talk about the identity crisis years most adoptees face. By Susan Frey

16 - WHAT YOUR DOCTOR DOESN'T KNOW CAN KILL YOU A small but growing number of doctors around the world are turning to biological medicine to treat their patients with cancer and other serious diseases. By Michael Sheehan '77

20 - SCU's FATHER GOOSE When John Drahrnann shepherds undergraduates through the academic maze, he often counsels their parents as well. By Thomas F. Black and Maureen Mclnaney …

Pharmacokinetics Of Ceftibuten-Cis And Its Trans Metabolite In Healthy Volunteers And In Patients With Chronic Renal Insufficiency, Judy Shepard Kelloway, Walid M. Awni, Chin C. Lin, Josephine Lim, Melton B. Affrime, William F. Keane, Gary R. Matzke, Charles E. Halstenson

Pharmacotherapy and Outcomes Science Publications

The impact of renal insufficiency on the dispositions of 300 mg of orally administered ceftibuten-cis, a new broad-spectrum oral cephalosporin, and its primary metabolite ceftibuten-trans was characterized in 30 adult subjects. Subjects were divided into five groups of six subjects each on the basis of their 24-h ambulatory creatinine clearances (CL_CR). The apparent total body clearance (CL_P/F; where F is absolute bioavailability) and renal clearance of ceftibuten-cis were significantly lower in subjects with end-stage renal disease (on maintenance hemodialysis; group V) and in those with severe (CL_CR, 5 …

Interaction Between Tetraethylammonium And Amino Acid Residues In The Pore Of Cloned Voltage-Dependent Potassium Channels, Michael Kavanaugh, Michael D. Varnum, Peregrine B. Osborne, Macdonald J. Christie, Andreas E. Busch, John P. Adelman, R. Alan North

Biomedical and Pharmaceutical Sciences Faculty Publications

Extracellular tetraethylammonium (TEA) inhibits currents in Xenopus oocytes that have been injected with mRNAs encoding voltage-dependent potassium channels. Concentration-response curves were used to measure the affinity of TEA; this differed up to 700-fold among channels RBK1 (KD 0.3 mM), RGK5 (KD 11 mM), and RBK2 (KD greater than 200 mM). Studies in which chimeric channels were expressed localized TEA binding to the putative extracellular loop between trans-membrane domains S5 and S6. Site-directed mutagenesis of residues in this region identified the residue Tyr379 of RBK1 as a crucial determinant of TEA sensitivity; substitution of Tyr in the equivalent positions of RBK2 …