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Optimization Of Cryopreservation Protocols For Cardiovascular Tissue, Jianfei Hu

Theses and Dissertations in Biomedical Sciences

The purpose of this research was to determine the effects of cryopreservation on the physical, biochemical and cellular aspects of heart valve tissue. The present study demonstrated that radiolabeled proline accumulation provides a quantitative estimate of total cellular metabolic viability. Radiolabeled inulin was demonstrated to be a useful marker for extracellular tissue space. Assessment of metabolic viability of the cellular population of leaflet tissue as a function of procurement and processing revealed that proline accumulation declined with increasing warm and cold ischemic times. Amphotericin B and streptomycin were toxic to the cells. Cefoxitin, lincomycin, polymyxin B, vancomycin and penicillin had …

Mechanisms Of Interference With Simian Virus 40 (Sv40) Dna Replication By Trans-Dominant Mutants Of Sv40 Large T Antigen, Christine M. Bentivoglio, Jiyue Zhu, Charles Cole

Dartmouth Scholarship

Mutations at multiple sites within the simian virus 40 (SV40) early region yield large T antigens which interfere trans dominantly with the replicative activities of wild-type T antigen. A series of experiments were conducted to study possible mechanisms of interference with SV40 DNA replication caused by these mutant T antigens. First, the levels of wild-type T antigen expression in cells cotransfected with wild-type and mutant SV40 DNAs were examined; approximately equal levels of wild-type T antigen were seen, regardless of whether the cotransfected mutant was trans dominant or not. Second, double mutants that contained the mutation of inA2827, a strong …

Homeless Children Having Children, Yvonne M. Vissing

New England Journal of Public Policy

Homeless teenagers who have babies pose a significant population of concern for those in health and human services. This article explores demographic, structural, and economic changes for homeless young and single-parent families. It proposes that their homelessness is due to these barriers and the problems that result. Case studies illustrate the process of troubled teens becoming homeless women with babies. Policy recommendations for assisting these youngsters are offered.

The Manufacture Of Dependency: Shelterization Revisited, Kostas Gounis

New England Journal of Public Policy

Emergency shelters have been the most comprehensive and enduring response to homelessness in the United States, with New York City leading the way since the early 1980s. Shelters have emerged as a hybrid between a degraded type of "public housing" and a new form of "institutionalization." The persistence of shelter dependency, or "shelterization," is an intractable problem that frustrates policymakers and service providers. Popular among certain circles of professional pathologists is the view that shelterization is a form of "adaptation" to the violent, anomic, and generally antisocial environment of the shelter. This explanation of shelter dependency is theoretically flawed and …

The Pendulum Swings: How Changes In Federal And State Policy Have Affected The Status Of Homeless People With Mental Illness In Ohio, Kim Bryant

New England Journal of Public Policy

Public policy in the problem areas of homelessness and mental illness has been reactive, rather than proactive, for the past thirty to forty years. As a result of this approach, federal and state policies have swung, like a pendulum, from one extreme to the other, taking the homeless mentally ill population on a most difficult ride. Public policies concerning these issues must become proactive, even if it means a complete overhauling of federal and state social service systems. Only with proactive policies will mentally ill individuals, and all people, have the housing, food, and health care they need, and the …

Ms211: Texas Hadassah Medical Research Foundation (Thmrf) Board Announcing Foundation's Goals, Armin Weinberg

Works on Radiation Effects: 1990-2020

This looks like draft Press Release piece of the announced the affiliation with The Methodist Hospital Health Care Network. Talks about initial plans to organize a conference, list of additional member of the effort, including a Tx Congressman Martin Frost as honorary member, and a report from an Israeli scientist from Hadassah Zeev Weshler on the issue facing them with immigrants to Israel from the contaminated areas. See more at Armin Weinberg, PhD Papers and its finding aid.

The Imperative To Restore Nature: Some Philosophical Questions, Lisa Newton

Center for the Study of Ethics in Society Papers

The purpose of WMU's Center for the Study of Ethics is to encourage and support research, teaching, and service to the university and community in areas of applied and professional ethics. These areas include, but are not restricted to: business, education, engineering, government, health and human services, law, media, medicine, science, and technology.

Anion Permeation In An Apical Membrane Chloride Channel Of A Secretory Epithelial Cell, Dan R. Halm, Raymond A. Frizzell

Neuroscience, Cell Biology & Physiology Faculty Publications

Single channel currents though apical membrane Cl channels of the secretory epithelial cell line T84 were measured to determine the anionic selectivity and concentration dependence of permeation. The current-voltage relation was rectified with single channel conductance increasing at positive potentials. At 0 mV the single channel conductance was 41 ± 2 pS. Permeability, determined from reversal potentials, was optimal for anions with diameters between 0.4 and 0.5 nm. Anions of larger diameter had low permeability, consistent with a minimum pore diameter of 0.55 nm. Permeability for anions of similar size was largest for those ions with a more symmetrical charge …

An Update On The Role Of Ploidy In Prostate Carcinoma, Jill M. Peters-Gee

Henry Ford Hospital Medical Journal

One of the characteristic features of prostate carcinoma is its marked variation in biologic behavior. DNA quantitation has been studied in prostate carcinoma using a variety of techniques. Evaluation of tumor ploidy suggests that this may be the best predictor of the biologic behavior of prostate cancer in individual patients. This comprehensive review addresses the current studies, stage by stage, to clarify the clinical significance of these findings.

Primary Papillary Serous Carcinoma Of The Peritoneum: A Case Of Complete Remission Of Bulky Peritoneal Disease After Chemotherapy, Walid A. Saleh, Cosmas J. M. Van De Ven, Wooshin Kim

Henry Ford Hospital Medical Journal

Peritoneal papillary serous carcinoma is a rare tumor that involves the surface of the pelvic and/or abdominal peritoneum. Long-term survival among patients with this tumor has been rare. Most patients with this cancer have been treated with debulking surgery and postoperative chemotherapy. A case of incompletely resected peritoneal papillary serous carcinoma with a complete response to cisplatin-based chemotherapy is reported. Subsequent laparotomy revealed no residual tumor. This case suggests that primary chemotherapy may be successful in treating unresectable primary papillary serous tumors of the peritoneum.

The Current Role Of Prostatic Acid Phosphatase And Prostate-Specific Antigen In The Management Of Prostate Cancer, Sugandh D. Shetty, Joseph C. Cerny

Henry Ford Hospital Medical Journal

No abstract provided.

Adenocarcinoma Of The Prostate: Overview Ii, Joseph C. Cerny

Henry Ford Hospital Medical Journal

No abstract provided.

The Epidemiology Of Prostate Cancer In Black Men, David A. Burks, Ray H. Littleton

Henry Ford Hospital Medical Journal

Data on the epidemiology of prostate cancer from the 1930s to the present document a dramatic racial difference in incidence, survival, and mortality rates in American men. American black men have the highest incidence and mortality rates of prostate cancer in the world. Survival data have been related to access to medical care, genetic and environmental factors, and cultural differences, including diet and social habits. Most reports present conflicting data with no clear positive correlations, and conclusions are often speculative. Better controlled, prospective studies of epidemiologic variables and a comprehensive genetic evaluation of black families with prostate cancer are needed …

Maximal Androgen Ablation: A Review, Brian J. Miles, Joseph Babiarz

Henry Ford Hospital Medical Journal

Primary management of advanced (stage D) adenocarcinoma of the prostate is androgen ablation. Since this principle was discovered in the early 1940s, therapeutic alternatives and "progress" have centered around different ways to obtain castrate levels of androgens. The role of adrenal androgens in supporting prostate or prostatic cancer growth has been debated for decades and until recently was believed to be minimal. In the 1980s the concept of maximum androgen suppression, involving both the testes and adrenal glands, was reintroduced with some investigators claiming exceptional results. We review studies that have examined this concept, with emphasis on the largest trial …

Presentation And Evaluation Of Patients With Epidermoid Head And Neck Cancers, Michael S. Benninger

Henry Ford Hospital Medical Journal

Epidermoid cancer of the head and neck occurs most frequently in individuals with predisposing factors for neoplastic development. Primarily these include exposure to smoking and alcohol, although other predisposing factors may he present. Site-speciflc symptoms along with a history of predisposing environmental exposure can direct physicians to suspect head and neck cancer. Endoscopy and ancillary testing are performed for tumor staging and subsequent treatment planning.

Menno-Knight, March 1992, Mennonite College Of Nursing

Menno-Knight

Student newsletter of the Mennonite School/College of Nursing.

Suicide In Micronesia And Samoa: A Critique Of Explanations, Donald H. Rubinstein

Pacific Studies

No abstract provided.

The Periodontal Intraosseous Defect Following Root Conditioning With Citric Acid And Wound Closure Including A Ptfe Membrane : An Experimental Study, Betty Glaser Kersten

Loma Linda University Electronic Theses, Dissertations & Projects

Treatment of the intrabony or intraosseous periodontal defect has rendered much attention over the last few decades. Numerous approaches have been advocated; however, overall comparisons between treatments do not exist. This review summarizes and discusses outcomes of therapeutic modalities in the intrabony periodontal lesion from controlled clinical studies. The modalities reviewed include scaling and root planning, gingival flap surgery, gingival flap surgery including wound closure with interdental denudation, root-biomodification, placement of autologous, allogenic, or xenogeneic bone grafts, placement of alloplastic grafts, and placement of tissue guiding barrier membranes. In addition histologic observations of healing in the intrabony periodontal lesion are …

Adenosine Regulates A Chloride Channel Via Protein Kinase C And A G Protein In A Rabbit Cortical Collecting Duct Cell Line., Erik M. Schwiebert, Katherine H. Karlson, Peter A. Friedman, Paul Dietl, William S. Spielman, Bruce Stanton

Dartmouth Scholarship

We examined the regulation by adenosine of a 305-pS chloride (Cl-) channel in the apical membrane of a continuous cell line derived from rabbit cortical collecting duct (RCCT-28A) using the patch clamp technique. Stimulation of A1 adenosine receptors by N6-cyclohexyladenosine (CHA) activated the channel in cell-attached patches. Phorbol 12,13-didecanoate and 1-oleoyl 2-acetylglycerol, activators of protein kinase C (PKC), mimicked the effect of CHA, whereas the PKC inhibitor H7 blocked the action of CHA. Stimulation of A1 adenosine receptors also increased the production of diacylglycerol, an activator of PKC. Exogenous PKC added to the cytoplasmic face of inside-out patches also stimulated …

The Expression And Regulation Of The Hsdk Genes Of Escherichia Coli K-12, Ainu Parkash

Loma Linda University Electronic Theses, Dissertations & Projects

The DNA restriction and modification (R-M) genes in bacteria play a defensive role in the organism, offering protection to the host from invaders such as bacteriophages. The expression of these genes in E. coli K-12 had not previously been studied due to the complexity of the EcoK R-M enzymes. The use of lacZ gene fusion techniques allowed studies of the expression of the hsdK genes for the first time. Operon fusions of Mu(/ac) to the hsdK genes show that the two hsdK promoters, p _res and p _mod, are weak (50 Miller units) and that …

Selective Associations: A Methodological Critique, Rick A. Bevins

Department of Psychology: Faculty Publications

A crossover design must be used and a crossover data pattern must result if selective associations are to be inferred. In addition, three other methodological criteria must be met. (1) Only the nature of the reinforcer should be varied, (2) nonassociative explanations must be ruled out, and (3) the differences in behavior controlled by the conditioned stimuli (CSs) must be caused by a learning difference and not a performance difference. Experimental evidence typically cited as demonstrating the existence of selective associations was reviewed here and found to fall short of meeting the criteria stated herein. I conclude that interpretations invoking …

Update - February 1992, Loma Linda University Center For Christian Bioethics

Update

In this issue:

[ Faith, Medicine, and Religious Liberty - Part 1, Jehovah's Witnesses ]
-- Blood Transfusions: A Patient's Right to Refuse
-- Jehovah's Witnesses and Blood Transfusion
-- Blood Transfusions: A Patient's Right to Refuse
-- A Patient's Right to Refuse Blood Transfusions: The Legal Rights of Privacy, Autonomy, and Free Exercise of Religion

-- [ Second National Conference on Health Care for the Elderly Co-sponsored by the Center for Christian Bioethics and Multidisciplinary Geriatric Council - March 1 & 2 ]

Cross-Cultural Association Between Dietary Animal Protein And Hip Fracture: An Hypothesis, Benjamin Jac Abelow

Yale Medicine Thesis Digital Library

Age-adjusted female hip fracture incidence has been noted to be higher in industrialized countries than non-industrialized countries. A possible explanation which has received little attention is that elevated metabolic acid production associated with a high animal protein diet might lead to chronic bone buffering and bone dissolution. In an attempt to examine this hypothesis, cross-cultural variations in animal protein consumption and hip fracture incidence were studied. When female fracture rates derived from 34 published studies in 16 countries were regressed against estimates of dietary animal protein, a strong, positive association was found. This association could not plausibly be explained by …

Characterization Of Pregnancy Induced Changes In Glucose Metabolism, Stacey Ann Berg

Yale Medicine Thesis Digital Library

Many reports indicate that pregnancy is a diabetogenic state in which there is both insulin resistance and an exaggerated maternal glucose and insulin response to food ingestion. However, the magnitude of these aberrations and their temporal relationship have not been adequately characterized. This study utilizes the hyperglycemic clamp technique to investigate the insulin secretory response and tissue sensitivity to insulin under hyperglycemic conditions in normal and gestational diabetic pregnancies. Our results indicate that third trimester normal pregnancy is characterized by an increased first phase (108.81+/-13.03 uU/ml) and second phase (228.57+/-43.40 microunits/ml) insulin secretory response as compared to non-pregnant controls (72.93+/-15.76, …

Winter 1991-1992, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Winter 1991-1992

Caduceus 1992, Stritch School Of Medicine

Stritch School of Medicine Yearbooks

No abstract provided.

A Student Assistance Programs Model, David Edward Eby

All Graduate Projects

The purpose of this study was to develop a manual detailing the components of Student Assistance Programs in the Olympia School District. The manual would be useful to a school district or a high school intent on establishing Student Assistance Programs. The development of the manual was beneficial to the Olympia School District due to fact that Student Assistance Programs were established at the two high schools, Capital High School and Olympia High School in 1991. A vice-principal and a key staff member from Capital High School attended workshops and conducted research on what type of program would address the …

Articulations 1992, Som School Of Osteopathic Medicine, Umdnj University Of Medicine And Dentistry Of Nj

Yearbooks

University of Medicine and Dentistry of New Jersey (UMDNJ) School of Osteopathic Medicine yearbook for the class of 1992. 104 pages.

Contents: Osteopathic Oath p.1, UMDNJ-SOM Campus p. 2, University Affiliated Medical Centers p. 7, Dean's Message p. 8, Administration & Faculty p. 9, A Look Back p. 17, Who We Are p.33, Graduation p. 85, Directory p. 95.

Nothing Recedes Like Success - Risk Analysis And The Organizational Amplification Of Risks, William R. Freudenburg

RISK: Health, Safety & Environment (1990-2002)

Professor Freudenburg believes that there is room for improvement in Risk analysis, particularly in drawing on systematic studies of human behavior in the calculation of real, empirical probabilities of failure. The need is argued to be especially acute where technological Risks are associated with low expected probabilities of failure and are managed by human organizations for extended periods of time. This permits complacency to set in.

Summary Of Workshop To Review An Omb Report On Regulatory Risk Assessment And Management, John S. Evans, John D. Graham, George M. Gray, Adrienne Hollis

RISK: Health, Safety & Environment (1990-2002)

Summary of the results of an invitational workshop conducted to peer review the 1990 OMB report, CURRENT REGULATORY ISSUES IN Risk ASSESSMENT AND Risk MANAGENMENTIN REGULATORY PROGRAM OF THE UNITED STATES GOVERNMENT, APRIL 1, 1990 - MARCH 31, 1991.