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Principles And Particularity: The Role Of Cases In Bioethics, John D. Arras

Indiana Law Journal

Symposium: Emerging Paradigms in Bioethics

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1994), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1994 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• ABC’s of Medical Education
• New Curriculum: Making Students Better Doctors
• First OMM Fellowship Recipients Named
• Herbert Lotman: Chairman of the Board
• PCOM Profile: Alexander E. Rodi, DO
• PCOM Annual Report 1994: Building for the Future
• Academic Update
• The PCOM Mission
• Master Facilities Plan
• PCOM Financial Review
• Officers of the College
• PCOM Board of Trustees
• PCOM Alumni Recognized at ACOS Convention
• PCOM Celebrates National Primary Care Day
• PCOM Golf Classic
• PCOM Appoints Senior Vice President
• Evening of Art Raises Funds for PCOM Health …

Vital Signs, Fall 1994, Boonshoft School Of Medicine

Vital Signs

A twenty page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Who Are The Parents Biotechnological Children?, Larry I. Palmer

Faculty Publications

We do not underestimate the difficulties of legislating on this subject. In addition to the inevitable confrontation with the ethical and moral issues involved, there is the question of the wisdom and effectiveness of regulating a matter so private, yet of such public interest. Legislative consideration of surrogacy may also provide the opportunity to begin to focus on the overall implications of the new reproductive biotechnology- in vitro fertilization, preservation of sperms and eggs, embryo implantation and the like. The problem is how to enjoy the benefits of the technology-especially for infertile couples-while minimizing the risk of abuse. The problem …

Characterization Of An Antiviral Agent Based On Nonionic Surfactants And It's Effects On Human Dermal Fibroblasts, Ji Young Li

Biological Sciences Theses & Dissertations

The AIDS ·pandemic has directed various research endeavors towards finding an appropriate method for eliminating all potentially infectious material within bone allografts before implantation into a recipient. To that effect, Panavirocide was conceived by Medicine and Applied Science·s, Inc. This compound, in which three nonionic surfactants serve as the active agents, has been shown to inactivate HIV-1 particles within blood and blood products. Because Panavirocide has never been used with allografts, the purpose of the present research was to characterize the nonionic surfactants for the putative alteration of the formulation by determining the critical micelle concentration values and to determine …

Jefferson Alumni Bulletin – Volume Xliii, Number 3, Fall 1994

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIII, Number 3, Fall 1994 Diary of an SCI, page 5 Colleagues honor Cotler with portrait, page 7 Neurosensory institute is established, department of neurosurgery expands, page 7 Teaching molecular medicine, preparing for practice in the 21st Century, page 8 On campus, page 11 Jefferson Research, page 12 Giving to Jefferson, page 14 Obituaries, page 16 Class notes, page 18

Symptoms Six Weeks After Covid-19 Are Reduced Among Us Health Care Personnel Receiving Additional Vaccine Doses During The Omicron Period, December 2021-April 2022., Nicholas M. Mohr, Ian D. Plumb, Eliezer Santos León, Malea Pinckney, Karisa K. Harland, Anusha Krishnadasan, Karin F. Hoth, Fernand Rwamwejo, John P. Haran, Melissa Briggs-Hagen, Eric Kontowicz, David A. Talan

Jefferson Hospital Staff Papers and Presentations

BACKGROUND: The objective of this study was to test the hypothesis that subsequent doses of the coronavirus disease 2019 (COVID-19) vaccine are associated with lower incidence of COVID-19-like symptoms at 6 weeks after infection.

METHODS: This study was a case-control analysis of health care personnel in an ongoing multicenter COVID-19 vaccine effectiveness study. We enrolled participants at the time of COVID-19-like symptoms between December 19, 2021, and April 27, 2022, which corresponded to the early Omicron-predominant period after original monovalent severe acute respiratory syndrome coronavirus 2 additional vaccination doses became available. Our outcome was self-reported symptoms completed 6 weeks after …

Regulation Of Collagenase Gene Expression By Il-1 Beta Requires Transcriptional And Post-Transcriptional Mechanisms, Matthew P. Vincenti, Charles I. Coon, Oneil Lee, Constance E. Brinckerhoff

Dartmouth Scholarship

Interleukin-1 beta is believed to contribute to the pathophysiology of rheumatoid arthritis by activating collagenase gene expression. We have used a cell culture model of rabbit synovial fibroblasts to examine the molecular mechanisms of IL-1 beta-mediated collagenase gene expression. Stimulation of rabbit synovial fibroblasts with 10 ng/ml recombinant human IL-1 beta resulted in a 20-fold increase in collagenase mRNA by 12 h. Transient transfection studies using collagenase promoter-CAT constructs demonstrated that proximal sequences responded poorly to IL-1 beta, possibly due to insufficient activation of AP-1 by this cytokine. More distal sequences were required for IL-1 beta responsiveness, with a 4700 …

What's Happening: September 21, 1994, Maine Medical Center

What's Happening

No abstract provided.

What's Happening: September 7, 1994, Maine Medical Center

What's Happening

No abstract provided.

Review Of: The Genetic Frontier: Ethics, Law, And Policy (Mark S. Frankel & Albert Teich Eds., American Association For The Advancement Of Science 1994), Suzanne A. Sprunger

RISK: Health, Safety & Environment (1990-2002)

Review of: The Genetic Frontier: Ethics, Law, and Policy (Mark S. Frankel & Albert Teich eds., American Association for the Advancement of Science 1994). Acknowledgments, appendix, contributors, figures, index, introduction, notes, references, tables. LC 93-37230, ISBN 0-87168-526-4. [260 pp. Paper $22.95. 1333 H St., NW, Washington DC 20005.]

Dentalgram - Vol. 08, No. 09, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• Board results
• Challenge grant
• Faculty authors
• Biomaterials dinner
• SD volunteers
• Family Retreat
• Honored students
• Potluck vespers
• Faculty activities
• Library acquisitions
• Copy costs
• Rwanda update
• Staff at seminar
• Tips from Graphics
• Parking Lot Sale
• Farewell luncheon
• Calendar

Effects Of Natural Sequence Variation On Recognition By Monoclonal Antibodies Neutralize Simian Immunodeficiency Virus Infectivity, Weon Sang Choi, Catherine Collignon, Clotilde Thiriart, Dawn P. Wooley, E. J. Scott, Karen A. Kent, Ronald C. Desrosiers

Neuroscience, Cell Biology & Physiology Faculty Publications

The determinants of immune recognition by five monoclonal antibodies (KK5, KK9, KK17, Senv7.1, and Senv101.1) that neutralize simian immunodeficiency virus infectivity were analyzed. These five neutralizing monoclonal antibodies were generated to native SIVmac251 envelope glycoprotein expressed by a vaccinia virus recombinant vector. All five recognize conformational or discontinuous epitopes and require native antigen for optimal recognition. These monoclonal antibodies also recognize SIVmac239 gp120, but they do not recognize gp120 of two natural variants of SIVmac239, 1-12 and 8-22, which evolved during the course of persistent infection in vivo (D.P.W. Burns and R.C. Desrosiers, J. Virol. 65:1843-1854, 1991). Recombinant viruses which …

Update - September 1994, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Ritualized Genital Mutilation the Procedure
-- A Cultural Perspective
-- Female Genital Mutilation: A Question of Fundamental Human Rights
-- Ethics When Cultures Clash
-- Ethics Consultation (Review)

A Retrospective Quantitative Assessment Of Trichloroethylene Exposure Of Workers At Aircraft Maintenance Facilities At Hill Air Force Base Through The Use Of Modeling, Anthony O. Copeland

Theses and Dissertations

Monte Carlo simulation and source-receptor modeling are used to estimate the TCE exposures encountered by select workers at aircraft maintenance facilities at Hill Air Force Base between 1955 and 1979. An epidemiological study of this group, a retrospective cohort study of 14,457 workers who were employed at the base for a minimum of one year between 1952 and 1956, was headed by Dr. R. Spirtas of the National Cancer Institute to evaluate mortality associated with occupational exposure. One of the major conclusions of the study was that TCE 'probably does not pose a strong carcinogenic risk for man.' In the …

A Comparative Pharmacokinetic Study Of The Role Of Gender And Developmental Differences In Occupational And Environmental Exposure To Benzene, Elizabeth A. Brown

Theses and Dissertations

The purpose of this study is two-fold. First, it shows that physiological differences between men and women result in gender-specific exposures with respect to benzene. Second, it assesses the potential for a lactating woman's occupational and personal benzene exposure to impact a nursing infant's exposure, highlighting the possibility of subjecting an infant to the effects of industrial chemicals via breast feeding. This study employs physiologically based pharmacokinetic (PBPK) modeling to investigate the influence of physiological parameters and to evaluate the ability of inhaled benzene to transfer from mother to infant through breastmilk. The models are run through scenarios that simulate …

A Comparative Study Of Activities Of Daily Living Levels Of Catholic Nuns In A Motherhouse Nursing Home And Mainstream Women In A Community Nursing Home, Betty Ann Ray Duke

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Education and Behavioral Sciences at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Arts by Betty Ann Ray Duke on August 31, 1994

Epidermal Growth Factor Coordinately Regulates The Expression Of Prostaglandin G/H Synthase And Cytosolic Phospholipase A2 Genes In Embryonic Mouse Cells., Kenneth P. Chepenik, Arturo Diaz, Sergio A. Jimenez

Department of Medicine Faculty Papers

Confluent, primary cultures of mouse embryo palate mesenchyme (MEPM) cells are refractory to activation of phospholipase A2 (PLA2) by the calcium ionophore A23187. However, treatment of these cultures with epidermal growth factor (EGF) permits the cells to activate PLA2 in response to A23187. We have developed this finding by exploring molecular mechanisms by which growth factors modulate mobilization and metabolism of arachidonic acid. We found chronic treatment (> 6 h) of confluent MEPM cells with EGF (a) increases their ability to metabolize exogenous arachidonic acid to prostaglandin E2 (PGE2) and (b) stimulated constitutive expression of activities of PLA2 and cyclooxygenase …

Molecular Cloning And Expression Of A Unique Receptor-Like Protein-Tyrosine-Phosphatase In The Leucocyte-Common-Antigen-Related Phosphatase Family, Wei-Ren Zhang, Naotake Hashimoto, Faiyaz Ahmad, Wendi Ding, Barry J. Goldstein

Department of Medicine Faculty Papers

Protein-tyrosine-phosphatases (PTPases) have been implicated in the regulation of certain tyrosine kinase growth factor receptors in that they dephosphorylate the activated (autophosphorylated) form of the receptors. In order to identify PTPases that potentially act on receptor targets in liver, we used the human leucocyte common antigen-related PTPase (LAR) cDNA [Streuli, Krueger, Hall, Schlossman and Saito (1988) J. Exp. Med. 168, 1523-1530] and isolated two closely related transmembrane PTPase homologues from a rat hepatic cDNA library. Both PTPases had large extracellular domains that contained three immunoglobulin-like repeats and eight type-III fibronectin repeats. Both enzymes had tandem homologous PTPase domains following a …

Louisiana State University Medical Center - 1994 - Summer Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 1994 Summer Commencement of LSU Health Sciences Center - New Orleans held August 13, 1994.

Perceptions Of Nurse Practitioners In Primary Care Toward Rationing Of Health Care, Donna Baucum

MSN Research Projects

The United States has the highest cost of health care in the world. In an effort to control this continually escalating expense, the concept of rationing of health care has been offered as a solution. Health care providers, such as nurse practitioners, will be confronted with making decisions related to the allocation of health care. Thus, the purpose of this descriptive study was to explore the perceptions that nurse practitioners have regarding rationing of health care. Henderson's Model of Nursing served as the theoretical framework. The research question that guided this study was what are the perceptions of nurse practitioners …

The Effect Of Cardiac Rehabilitation On Quality Of Life, Anxiety, And Self-Care In Coronary Artery Disease Patients, Susan Susskind Wilkinson

Theses & Dissertations

This study was designed to explore the effect of cardiac rehabilitation program participation on anxiety, quality of life, and self-care among coronary artery disease patients.

Major lifestyle changes are required after a person experiences an acute coronary event. Rehabilitation programs for coronary artery disease patients are designed to assist the patient with these lifestyle changes by altering the survivor's self-care patterns and improve long-term physical and psychological outcomes. By coordinating education, counseling, and exercise programs, the nurse can help individuals move toward a maximal physiological, psychological, social and vocational recovery. This study was designed to explore the effect of cardiac …

Dentalgram - Vol. 08, No. 08, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• New dean
• Careers in Dentistry
• New PA system
• New residents
• Chaplains' plans
• Potluck vespers
• Library acquisitions
• An unbearable trip
• Safety tips
• Blood drive
• Fall picnic
• Ham radio club
• Memorial tree
• Classic car for sale
• Parking lot sale
• "Talk" workshop
• Special Section

Comparison Of Micrscan Identification And Susceptibility Testing Methods For Streptococcus Dysgalactiae To Conventional Biochemical Reactions And Kirby-Bauer Susceptibility Testing Methods, Anthony Hatcher

Masters Theses & Specialist Projects

A total of 100 isolates of Streptococcus dysgalact iae from bovine mastitis infections was used to evaluate and compare the biochemical reactions of the gram positive Combo Type 6 panel on the MicroScan autoSCANR system to a conventional procedure for identification of streptococci. Of the 100 isolates, 83.3% was identified as "Very Rare Biotype" by the MicroScan and classified as S. dysgalactiae by conventional methods. Of the remaining 16.7%, MicroScan identified 3.3% as Streptococcus morbillorum, 3.3% as Aerococcus viridians, 3.3% as Streptococcus constellatum/milleri, 1.7% as Streptococcus agalactiae, 1.7% as Streptococcus mitis, 1.7% as Streptococcus sanguis, and 1.7% as Streptococcus intermidis/rni …

The Role Of Cd8+T Cells In The Immune Response To Trypanosoma Cruzi In Mice Held At Elevated Environmental Temperature, Zhijan Ming

Masters Theses & Specialist Projects

When maintained at 36°C, T. cruzi infected C3H mice survive an infection that is lethal to mice maintained at room temperature. To study the role of CD8+ T cells in this phenomenon, anti-CD8 monoclonal antibody (MAb) was used to deplete CD8+ T cells in vivo. An IgG2a-producing rat hybridoma (designated 53-6.72) was adapted to serum free medium, and anti-CD8 MAb was purified from culture supernatant by ammonium sulfate precipitation. Mice were injected intraperitoneally with 200(ig of MAb for three consecutive days. On the fifth day, the result of the in vivo depletion of CD8+ T cells was determined by an …

The Role Of Cd4+T Cells In The Immune Response To Trypanosoma Cruzi In Mice Held At Elevated Environmental Temperature, Qi Guo

Masters Theses & Specialist Projects

The immune response of mice infected with Trypanosoma cruzi (the causative agent of Chagas' disease) has been extensively studied, and it has been demonstrated that changes in environmental temperature can influence the resistance of infected mice to the parasite. In particular, several investigators have demonstrated an increased resistance to T. cruzi infection when infected mice are maintained at 36°C. This increased resistance is reflected in decreased parasitemias and increased longevity. In addition, this enhanced resistance has been shown to be an immunological phenomenon. CD4+ T cells play a very important role in immune responses to parasitic infections through the secretion …

Stab Wounds To Rat Brains : Demyelination, Remyelination And The Cellular Response, Particularly Of Oligodendrocytes, Xie Dangci

Loma Linda University Electronic Theses, Dissertations & Projects

The present body of knowledge concerning the results of central nervous system injury is incomplete and controversial. The role of oligodendrocytes, the cells involved in phagocytosis, the stages of demyelination, and the evidence for remyelination are of interest. Following stab wounds to rat brain cortex, corpus callosum and hippocampus, the animals were examined at 4,7,11,18,23,29,45,60 and 70 days postoperation (dpo). To help in the identification of cells immunocytochemical markers for astrocytes and immature oligodendrocytes were used. These were labels for glial fibrillary acidic protein (GFAP) and myelin/oligodendrocyte specific protein (MOSP) respectively. Light and electron microscopy were correlated using conventionally prepared …

Effects Of Furosemide And Oleic Acid On Thyroxine Binding To Isolated Pairs Of Thyroxine Binding Serum Proteins, Deborah Hustead

Loma Linda University Electronic Theses, Dissertations & Projects

Dosage dependent binding inhibition and redistribution of thyroxine (T₄) between three pairs of thyroxine binding serum proteins, TBG-TTR, TBG-albumin and TTR-albumin, by furosemide (0.0 to 1.0 mol/L) and oleic acid (0.0 to 0.10 mol/L) were studied using equilibrium dialysis with purified binding proteins at concentrations 1/200 of levels in normal human sera, separated across the dialysis membrane and competing for T₄.

Furosemide (1.0 mol/L) reduced TBG bound T₄ in both the TBG-TTR system and TBG-albumin system (>90% decrease) and inhibited T₄ binding to TTR in the TTR-albumin system (68% decrease) and to albumin …

Short And Long Term Effects Of Proton Microbeam Irradiation : In The Lateral Geniculate Nucleus Of Felis Domesticus, Chad Sherwood Reder

Loma Linda University Electronic Theses, Dissertations & Projects

Little is known of the effects of proton irradiation on neural tissue. A 1.0 mm microbeam was used on the cat lateral geniculate nucleus (LGN) to quantify the short term (< 3 months) and long term (< 9 months) effects of radiation damage. The LGN is a large structure with well defined afferent, efferent, and receptive field properties.

Electrophysiological and histological techniques were used to examine the effects of the microbeam at 60, 40, and 16 Gy, administered as a single bolus. Recordings of light evoked responses in the LGN were obtained using microelectrodes in nine animals within 12 weeks of irradiation, and 6 animals within 36 weeks of irradiation. Receptive fields were mapped onto a tangent screen using standard receptive field techniques. Histological measures included afferent …

A Thyroid Hormone-Regulated Gene In Xenopus Laevis Encodes A Type Iii Iodothyronine 5-Deiodinase., Donald L. St Germain, Robert Schwartzman, Walburga Croteau, Akira Kanamori, Zhou Wang, Donald D. Brown, Valerie Galton

Dartmouth Scholarship

The type III iodothyronine 5-deiodinase metabolizes thyroxine and 3,5,3'-triiodothyronine to inactive metabolites by catalyzing the removal of iodine from the inner ring. The enzyme is expressed in a tissue-specific pattern during particular stages of development in amphibia, birds, and mammals. Recently, a PCR-based subtractive hybridization technique has been used to isolate cDNAs prepared from Xenopus laevis tadpole tail mRNA that represent genes upregulated by thyroid hormone during metamorphosis. Sequence analysis of one of these cDNAs (XL-15) revealed regions of homology to the mRNA encoding the rat type I (outer ring) 5'-deiodinase, including a conserved UGA codon that encodes selenocysteine in …