Digital Commons Network^™

Synergistic Effects Of Traumatic Head Injury And Apolipoprotein 4 In Patients With Alzheimer’S Disease, R. Mayeux, R. Ottman, Gladys E. Maestre, C. Ngai, M.-X. Tang, H. Ginsberg, M. Chun, B. Tycko, M. Shelanski

School of Medicine Publications

The apolipoprotein 4 allele increases the risk of Alzheimer’s disease (AD), but cerebral deposition of B-amyloid with age, a genetic mutation, or head injury may contribute to the pathogenesis of this disease. We examined the risks of AD associated with traumatic head injury and apolipoprotein 4 in 236 community-dwelling elderly persons. A 10-fold increase in the risk of AD was associated with both apolipoprotein 4a nd a history of traumatic head injury, compared with a two-fold increase in risk with apolipoprotein 4 alone. Head injury in the absence of an apolipoprotein 4 allele did not increase risk. These data imply …

What's Happening: December 28, 1994, Maine Medical Center

What's Happening

No abstract provided.

Louisiana State University Medical Center - 1994 - Fall Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 1994 Fall Commencement of LSU Health Sciences Center - New Orleans held December 15, 1994.

What's Happening: December 14, 1994, Maine Medical Center

What's Happening

No abstract provided.

Daughter Cells Of Saccharomyces Cerevisiae From Old Mothers Display A Reduced Life Span, Nicanor Austriaco, Brian K. Kennedy, Leonard Guarente

Biology Faculty Publications

The yeast Saccharomyces cerevisiae typically divides asymmetrically to give a large mother cell and a smaller daughter cell. As mother cells become old, they enlarge and produce daughter cells that are larger than daughters derived from young mother cells. We found that occasional daughter cells were indistinguishable in size from their mothers, giving rise to a symmetric division. The frequency of symmetric divisions became greater as mother cells aged and reached a maximum occurrence of 30% in mothers undergoing their last cell division. Symmetric divisions occurred similarly in rad9 and ste12 mutants. Strikingly, daughters from old mothers, whether they arose …

Update - December 1994, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Minding Our Language: Metaphors and Biomedical Ethics

Dentalgram - Vol. 08, No. 12, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• SD applications
• New display
• IDP students
• Faculty activities
• Holiday tips
• Holiday pet protection
• Spirit of the season
• Eating tips
• Volunteers thanked

Destructive Hostility: The Jeffrey Dahmer Case: A Psychiatric And Forensic Study Of A Serial Killer, Jeffrey Jentzen, George Palermo, L. Thomas Johnson, Khang-Cheng Ho, K. Alan Stormo, John Teggatz

School of Dentistry Faculty Research and Publications

We were involved as forensic experts in the case of the serial killer Jeffrey Dahmer. We discuss the scene and victim autopsy findings, with a brief consideration of the basic emotion of hostility. These findings support the thesis that at the basis of this serial killer's behavior were primary unconscious feelings of hate that he had channeled into a sadistic programmed destruction of 17 young men. The interview of the serial killer, the photographic scene documentation, and the autopsy findings stress the ambivalent homosexuality of the killer, his sexual sadism, his obsessive fetishism, and his possible cannibalism and necrophilia.

Illness Behavior In Meniere's Disease Patients, Dianne Riesenmy

Theses

In order to determine whether or not vertiginous and nonvertiginous Meniere's disease patients differ in regard to certain emotional and psychosocial attitudes, ideas, affects, and attributions related to illness behavior, 30 Meniere's disease patients (16 vertiginous; 14 nonvertiginous) completed the Illness Behavior Questionnaire (IBO) either at a Meniere's support group meeting or through the mail. Comparison of sample mean scores revealed that the vertiginous group showed greater hypochondriasis and affective disturbance than did the nonvertiginous group. The nonvertiginous group demonstrated greater denial of life stressors not related to illness and greater psychological (rather than somatic) perception. The same group showed …

Transcriptional Regulation Of Insulin-Like Growth Factor : Binding Protein-4 By Protein Kinase A And Protein Kinase C Signal Transduction Pathways In Human Bone Cells, Kuk-Wha Lee

Loma Linda University Electronic Theses, Dissertations & Projects

The Insulin-like Growth Factor (IGF) system is an important local regulator of osteoblast proliferation, the primary determinant of bone formation. Six IGF Binding Proteins (IGFBPs) either inhibit or enhance IGF actions. Previous studies have shown that IGFBP-4 is an important negative regulator of osteoblast cell proliferation and that agents such as PTH which increase intracellular cAMP significantly increase expression of IGFBP-4 at the protein and mRNA levels. The underlying molecular mechanism which accounted for IGFBP-4 expression had not been determined and was the focus of my dissertation. Agents which increase intracellular cAMP rapidly increased IGFBP-4 mRNA levels. Nuclear run-off experiments …

The Pollution Effects Of Pleasure/Work Boat Sewage Discharges On Fecal Contamination Levels Of Waters In And Around Marinas And Other Places Where Boats Are Moored On The Eastern Shore Of Virginia, George H. Bangs

Community & Environmental Health Theses & Dissertations

Contamination of seafood harvested from and recreational areas of the Chesapeake Bay, its tributaries and the Atlantic coast inshore waters may cause health problems for people consuming the seafood or coming in contact with the waters by swimming, water skiing, or other water sports. These health problems include, but not limited to, dysentery, typhoid and hepatitis (Natchez, 1990). This is a preliminary study into the level of fecal pollution generated by sewage discharges from boats in marinas and other places where boats are moored on the Eastern Shore of Virginia. Sites selected for the study included; (I) marinas and other …

Cytokines And Ovulation In The Mouse Ovary, Jong G. Kim

Electronic Theses and Dissertations

Ovulation has been hypothesized as an inflammatory process. Interleukin(IL)-1$\alpha$, IL-1$\beta$ and tumor necrosis factor(TNF)-$\alpha$ are potent cytokines produced from macrophages and various other cell types, and are pivotal components of inflammation. Although previous studies have investigated cytokine activities in the reproductive system, there is little information on their precise localization and activities during the periovulatory period. To investigate the role of cytokines in ovulation, experiments were designed to determine the immunohistochemical localization and time specific production of cytokines IL-1 and TNF-$\alpha$ using a mouse model at 36h, 12h, 6h, 2h before ovulation, and at 6h and 18h after ovulation in …

Microcirculation: Electrophysiological Basis For The Response Of Endothelial Cells To Inflammatory Mediators-Bradykinin, Kai Miao

Electronic Theses and Dissertations

Using conventional microelectrodes, I studied the electrical basis for determining the resting V$\sb{\rm m}$ in intact EC's from hamsters. The resting V$\sb{\rm m}$ were found to be $-$40 mV for aortic EC's and $-$43 mV for vena caval EC's. The contributions of ions to the resting V$\sb{\rm m}$ of aortic EC's were compared in terms of the transference number (t$\sb{\rm ion}$). To develop a technique for in situ monitoring changes in V$\sb{\rm m}$ of postcapillary venular EC's in the hamster mesentery, a voltage-sensitive fluorescent probe, bisoxonol, was used to load the cells and the fluorescence signals were analyzed under an …

What's Happening: November 30, 1994, Maine Medical Center

What's Happening

No abstract provided.

What's Happening: November 16, 1994, Maine Medical Center

What's Happening

No abstract provided.

Progressive Cross-Linking Of Fibrin Gamma Chains Increases Resistance To Fibrinolysis, Kevin R. Siebenlist, Michael W. Mosesson

Biomedical Sciences Faculty Research and Publications

In the presence of plasma transglutaminase (factor XIIIa) fibrin first undergoes intermolecular covalent cross-linking between its gamma chains to create gamma dimers followed by slower cross-linking among its alpha chains to form alpha polymers. Progressive cross-linking of gamma chain dimers occurs at the slowest rate, resulting in gamma trimers and gamma tetramers (“gamma multimers”). Most studies indicate that cross-linked fibrin clots become resistant to fibrinolysis, but the basis for this event is not clear. In this study, we explored the role of gamma chain multimerization compared with alpha polymerization as causal factors in time-dependent development of resistance to fibrinolysis. Fibrin …

A New Wave Dialectic1 The Reinvention Of Human Embryology, C. Ward Kischer

The Linacre Quarterly

No abstract provided.

Dentalgram - Vol. 08, No. 11, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• New associate dean
• Diversity note
• DH scholarships
• Junior DH officers
• Student winner
• Faculty activities
• Library journal
• Azusa Pac U concert
• Honored employee
• Picnic update
• Family Retreat

Bridging Conflicting Ideologies: The Origins Of American And British Occupational Therapy., Ruth L. Schemm

Department of Occupational Therapy Faculty Papers

Occupational therapy practice has bridged two contradictory value systems for more than 100 years. This article describes the origins of practice ideas in both the United States and Britain and demonstrates that founding members of the occupational therapy profession all shared a core of humanistic beliefs while embracing the emerging paradigm of scientific medicine. The result has been an intellectual tension between the biological and the psychosocial aspects of practice. For more than 75 years, occupational therapists struggled to balance the art and science of patient care; recent debates on modalities, practice domains, and research priorities indicate that the unifying …

A Study Of Euplotes Crassus Telomere Proteins And Related Genes, John Scott Perez

Department of Chemistry: Dissertations, Theses, and Student Research

A novel PCR technique used to amplify Euplotes crassus macronuclear chromosomes was developed to provide scientific proof that an Euplotes crassus 1.0 kb gene is not genetically related to an Oxytricha nova 1.8 kb β-telomere protein gene. Theories and experimental procedures associated with the development of this PCR technique were the product of research that will have a profound impact on future studies of telomere protein genes and telomeric DNA in a multitude of eukaryotic cells. The hypothesis that a β-telomere protein does not exist in Euplotes crassus was supported by the result of this study.

Expression of the recombinant …

The Biological Speciation And Toxicokinetics Of Aluminum, Emily Devoto, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

This review discusses recent literature on the chemical and physiological factors that influence the absorption, distribution, and excretion of aluminum in mammals, with particular regard to gastrointestinal absorption and speciation in plasma. Humans encounter aluminum, a ubiquitous yet highly insoluble element in most forms, in foods, drinking water, and pharmaceuticals. Exposure also occurs by inhalation of dust and aerosols, particularly in occupational settings. Absorption from the gut depends largely on pH and the presence of complexing ligands, particularly carboxylic acids, with which the metal can form absorbable neutral aluminum species. Uremic animals and humans experience higher than normal body burdens …

What's Happening: October 19, 1994, Maine Medical Center

What's Happening

No abstract provided.

What's Happening: October 5, 1994, Maine Medical Center

What's Happening

No abstract provided.

The Life-Long Learning Imperative... Ends And Means, David A. Nash

Oral Health Science Faculty Publications

No abstract provided.

The Chironian Vol. 111 Fall 1994, New York Medical College

The Chironian

No abstract provided.

Dentalgram - Vol. 08, No. 10, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• Goodacre gala
• Farewell luncheon
• Student research
• Freshman orientation
• Harassment seminar
• New IDP students
• Faculty activities
• New library hours
• High school tour
• Back pain tips
• In memoriam
• Parking lot sale
• Fall Classic Picnic

Santa Clara Magazine, Volume 36 Number 4, Fall 1994, Santa Clara University

Santa Clara Magazine

6 - THE MIND THIEF November is national Alzheimer's Disease Month, drawing attention to an illness that robs patients of their memories, their competence, sometimes their very personalities. By Maureen McInaney '85

12 - CREDIBILITY MAKES A DIFFERENCE A look at a key element of leadership: building trust. By James M. Kouzes and Barry Z. Posner

18 - PUTTING THE PIECES TOGETHER SCU's $125 million Challenge Campaign is transforming the University.

24 - NO PROBLEMO A racked-up knee, a forfeited football scholarship, an extra 50 pounds-no problemo. A work of short fiction. By Jan Maulhardt '90

28 - THE NUCLEAR …

Introduction: Emerging Paradigms In Bioethics Symposium, Roger B. Dworkin

Indiana Law Journal

Symposium: Emerging Paradigms in Bioethics

Posthumous Reproduction, John A. Robertson

Indiana Law Journal

Symposium: Emerging Paradigms in Bioethics

Principals And Other Emerging Paradigms In Bioethics, Tom L. Beauchamp

Indiana Law Journal

Symposium:Emerging Paradigms in Bioethics