Digital Commons Network^™

Nsu Going Back May Be The Best Way Of Getting Ahead Courses, Seminars, Workshops, Conferences Spring 1998, Nova Southeastern University

Abraham S. Fischler College of Education and School of Criminal Justice College Archive

No abstract provided.

Vital Signs, Spring 1998, Boonshoft School Of Medicine

Vital Signs

A twenty four page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Dentalgram - Vol. 12, No. 04, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• AADS/AADR meetings
• Christian dentists
• Foundation gives grant
• Student news
• Department news
• State Board investigators trained at LLUSD

The Chironian Vol. 115 Spring 1998, New York Medical College

The Chironian

No abstract provided.

Oncolog, Volume 43, Number 04, April 1998, Sunita Patterson, Sunni Hosemann, Alison Ruffin, Mitchell Morris Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Molecular research leads to clinical trials for bladder cancer
• Patients to test exercise theory in quality-of-life study
• Practice guidelines and collaborative paths point the way
• Protocols: Bladder Cancer Clinical Trials Interventions Span Surgery, Chemotherapy, Radiotherapy, and Genetic Manipulation
• DiaLog: The New Math of Today’s Health Care, by Mitchell Morris, MD, Vice President for Information and Health Care Systems

Digest Of The Philadelphia College Of Osteopathic Medicine (Spring 1998), Philadelphia College Of Osteopathic Medicine

Digest

The Spring 1998 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates
• Our Centennial
• Planting the Seeds for Better Physician Communication
• Library Steps into 21st Century
• Convention Highlights
• Uncle Manny Leaves a Legacy
• Mission Milestones
• Profiles
• Lights, Camera, Action
• Class Notes
• Just Published
• In Memoriam
• Coming Events

The Changing World Of Genetics And Abortion: Why The Women's Movement Should Advocate For Limitations On The Right To Choose In The Area Of Genetic Technology, Renee C. Esfandiary

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Nsu Going Back May Be The Best Way Of Getting Ahead Courses, Seminars, Workshops, Conferences Spring 1998, Nova Southeastern University

Abraham S. Fischler College of Education and School of Criminal Justice College Archive

No abstract provided.

The Relationship Between Leadership/Followership In Staff Nurses And Employment Setting, Elaine S. Vandoren

Dissertations

This study tested the hypothesis that staff nurses in hospitals used different leadership and followership behaviors than staff nurses in home care settings. Leadership behaviors were measured using the Multifactor Leadership Questionnaire (Bass, 1995); followership was measured using Kelley’s Followership Style Questionnaire (1992). Three hospital and home care agencies belonging to a private nonprofit corporation in the Midwest provided data. A total of 136 surveys were used in data analysis; 57% of distributed surveys were returned.

Differences between the hospital and home care staff nurses were not found. Self-perception, difficulty in applying clinical behaviors to the MLQ, unknown aspects of …

Antigen-Specific Cd8+ T Cells Protect Against Lethal Toxoplasmosis In Mice Infected With Neospora Caninum, Lloyd H. Kasper, Imtiaz A. Khan

Dartmouth Scholarship

Neospora caninum is a coccidial protozoan parasite that appears morphologically indistinguishable from Toxoplasma gondii and that infects a large range of mammals. Both inbred and outbred strains of mice exhibit a high degree of resistance to infection with N. caninum. Three inbred strains of mice (A/J, BALB/c, and C57BL/6) that were infected intraperitoneally with N. caninum were protected against a lethal challenge from T. gondii. Vaccine-induced protection was Neospora dose dependent. A rise in the CD8+ T-cell population in mice that had been vaccinated with N. caninum and challenged with T. gondii was observed. Adoptive transfer of CD8+ T-cell splenocytes …

Mla's Professional Development Program: How We Took Control Of Our Future, Fred W. Roper

Faculty Publications

No abstract provided.

Mathematical Models Of Tumors And Their Remote Metastases, Carryn Bellomo

Mathematics & Statistics Theses & Dissertations

Clinical observations and indications in the literature have led us to investigate several models of tumors. For example, it has been shown that a tumor has the ability to send out anti-growth factors, or inhibitors, to keep its remote metastases from growing. Thus, we model the depleting effect of such a growth inhibitor after the removal of the primary tumor (thus removing the source) as a function of time t and distance from the original tumor r.

It has also been shown clinically that oxygen and glucose are nutrients critical to the survival and growth of tumors. Thus, we model …

Reaction-Diffusion Models Of Cancer Dispersion, Kim Yvette Ward

Mathematics & Statistics Theses & Dissertations

The phenomenological modeling of the spatial distribution and temporal evolution of one-dimensional models of cancer dispersion are studied. The models discussed pertain primarily to the transition of a tumor from an initial neoplasm to the dormant avascular state, i.e. just prior to the vascular state, whenever that may occur. Initiating the study is the mathematical analysis of a reaction-diffusion model describing the interaction between cancer cells, normal cells and growth inhibitor. The model leads to several predictions, some of which are supported by experimental data and clinical observations $\lbrack25\rbrack$. We will examine the effects of additional terms on these characteristics. …

A Needs Assessment For A Distance Education Baccalaureate Degree Completion Program For Associate Degree Level Dental Hygienist, Joan Gugino Ellison

Dental Hygiene Theses & Dissertations

The purpose of this descriptive research was to determine the need for a distance education program for geographically dispersed dental hygienists to complete a baccalaureate degree program in dental hygiene. The sample consisted of randomly selected licensed dental hygienists in the Commonwealth of Virginia. A self-designed instrument, titled The Distance Education for a Dental Hygiene Degree Completion Program Questionnaire, was mailed to the study participants after establishing validity and reliability. The questionnaire asked participants to provide information concerning personal demographics, educational background, and interest in completing a dental hygiene baccalaureate degree via distance education. Frequencies, percentages, crosstabulations, chi-square test …

Developmental And Hormonal Regulation Of The Expression Of Cytosolic Phospholipase A2 Protein Levels In Baboon Placenta, Kathleen Elizabeth Dunstan

Chemistry & Biochemistry Theses & Dissertations

Cytosolic phospholipase A₂ ( cPLA₂) specifically catalyzes the release of arachidonate from membrane phospholipids, thus initiating synthesis of prostaglandins, thromboxanes, and other eicosanoids. The human and nonhuman primate placenta actively synthesize high levels of eicosanoids which play both an autocrine and paracrine role in placental function. Previous studies in Dr. Miriam D. Rosenthal's laboratory have shown that cPLA₂ mRNA levels are developmentally regulated. The present study was designed to determine whether placental cPLA₂ protein levels increased during gestation. Since the marked increases in estrogen levels during normal pregnancy have been shown to enhance morphological and …

The Role Of Glycoconjugates In Mediating Human Fertilization And Induction Of Fetomaternal Tolerance, Manish S. Patankar

Theses and Dissertations in Biomedical Sciences

Using the hemizona assay (HZA), a in vitro sperm-egg binding assay, we show that specific glycoconjugates known to inhibit immune cell interactions mediated by the selectins, potently block human sperm-egg binding. The selectin ligand sialyl Lewis^x inhibits sperm binding in the HZA by 60% at a concentration of 1 mg/ml. Our data indicates that glycodelin-A, a endometrial glycoprotein known to block sperm-egg binding in the HZA at low concentrations expresses unusual fucosylated lacdiNAc type glycans. The fucosylated lacdiNAc type sugars have been previously shown to be 15-20 fold more potent ligands of E-selectin. Glycodelin-S a seminal plasma glycoform of …

Pressure-Induced Intracellular Signaling In Isolated Arteries, Victor A. Miriel

Theses and Dissertations in Biomedical Sciences

The ability of cells to respond to mechanical stimuli has been studied through a variety of techniques in numerous cell types. The cells of the vascular wall have adapted to specific mechanical stresses through the activation of intracellular signaling pathways which result in cell-specific responses such as hypertrophy, hyperplasia, proliferation, and migration. Vascular smooth muscle of the arteries have been shown to be sensitive to mechanical stimuli such as stretch, and pressure.

This study attempts to add to the current knowledge of mechanotransduction by utilizing the isolated artery preparation. This preparation allows for the study of vascular smooth muscle signal …

Enhancement Of Atp Levels And Glucose Metabolism During An Infection By Chlamydia: Nmr Studies Of Living Cells, David M. Ojcius, H. Degani, Joel Mispelter, Alice Dautry-Varsat

All Dugoni School of Dentistry Faculty Articles

The Chlamydia species are obligate intracellular bacteria that proliferate only within the infected cell. Since the extracellular bacteria are metabolically inert and there are no cell-free systems for characterizingChlamydia metabolism, we studied metabolic changes related to ATP synthesis and glycolysis in HeLa cells infected withChlamydia psittaci during the course of the 2-day infection cycle using noninvasive 31P and 13C NMR methods. We find that the infection stimulates ATP synthesis in the infected cell, with a peak of ATP levels occurring midway through the infection cycle, when most of the metabolically active bacteria are proliferating. The infection also stimulates synthesis of …

Biological Warfare As Psychological Warfare, Ibpp Editor

International Bulletin of Political Psychology

This article describes the psychological benefits of an offensive biological warfare program

Jefferson Alumni Bulletin – Volume Xlvii, Number 2, March 1998

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 2, March 1998

Department Restructurings Respond to the Evolution in Scientific Disciplines, Page 4

The Rb2/p130 Gene and Endometrial Cancer, Page 7

Gene Therapy Trial for Glioblastoma, Page 8

Ovarian Cancer Vaccine is Promising in First Tests, Page 9

Transgenic Mouse for Study of Photoaging, Page 10

Uric Acid Reduces MS Symptoms in Mice, Page 11

Albert Einstein Healthcare Network Will Join Jefferson Health System by July, Page 12

Proposed Amendments to Alumni Association Bylaws, Page 14

Joseph Seltzer, ’71, the Next Alumni President, Page 15

Wallace Miller ’56 Receives RSNA Gold Medal, …

Development Of A Blocking Enzyme-Linked Immunosorbent Assay For Detection Of Serum Antibodies To O157 Antigen Of Escherichia Coli., W Laegreid, M Hoffman, J Keen, R Elder, J Kwang

Manuscripts, Articles, Book Chapters and Other Papers

The O157 antigen of Escherichia coli shares structural elements with lipopolysaccharide (LPS) antigens of other bacterial species, notably Brucella abortus and Yersinia enterocolitica 09, a fact that confounds the interpretation of assays for anti-O157 antibodies. To address this problem, a blocking enzyme-linked immunosorbent assay (bELISA) was designed with E. coli O157:H7 LPS as the antigen and a monoclonal antibody specific for E. coli O157, designated 13B3, as the competing antibody. The bELISA had equivalent sensitivity to, and significantly higher specificity than, the indirect ELISA (iELISA), detecting anti-O157 antibodies in sera from cattle experimentally inoculated with O157:H7. Only 13% of sera …

Subcellular Localization Of Mineralocorticoid Receptors In Living Cells: Effects Of Receptor Agonists And Antagonists, Géza Fejes-Tóth, David Pearce, Anikó Náray-Fejes-Tóth

Dartmouth Scholarship

Results on the subcellular localization of the mineralocorticoid receptor (MR) have been controversial. To determine the subcellular distribution and trafficking of the MR in living cells after binding of agonists and antagonists, we expressed a MR-green fluorescent protein (GFP) chimera in mammalian cells lacking endogenous MR. The GFP-tagged MR (GFP-MR) remained transcriptionally active, as determined in cotransfection experiments with the MR-responsive reporter, TAT3-LUC. The subcellular localization of GFP-MR was monitored by fluorescence time-lapse microscopy. In the absence of hormone, MR was present both in the cytoplasm and nucleus. Aldosterone induced a rapid nuclear accumulation of the MR. Aldosterone-bound GFP-MR was …

Accuracy Of The Ovulon Fertility Monitor To Predict And Detect Ovulation, Richard J. Fehring, William D. Schlaff

College of Nursing Faculty Research and Publications

The purpose of this pilot study was to correlate the three biologic markers of the Ovulon fertility monitor (a long-term predictive peak about 6 days before ovulation, a short-term predictive peak about 1 day before ovulation, and a nadir at the time of ovulation) with the peak in cervical mucus and the luteinizing hormone (LH) surge in the urine. Ten volunteer subjects (mean age 30.2 years) monitored their cervical-vaginal mucus, the surge of LH in the urine with a home assay test, and their vaginal electrical readings (with Ovulon monitors) on a daily basis for one to four menstrual cycles. …

The Greatest Memory Teacher Ever: Review Of Memory’S Ghost: The Nature Of Memory And The Strange Tale Of Mr. M., By Philip J. Hilts, Brian H. Bornstein

Department of Psychology: Faculty Publications

Although psychologists and neurologists have been familiar with the case of H.M. for years, this small volume makes his story—and what it can teach us about the functioning of memory—accessible to a much wider audience. Hilts has done a good job of piecing together H.M.’s early life, in the absence of any living relatives and all but a few written records. He recreates the life of a very normal youth in the 1930s and 1940s; normal, that is, until H.M.’s first epileptic seizure. In 1954, after several other treatments for the epilepsy had failed, H.M. (at age 27) had a …

Dentalgram - Vol. 12, No. 02, Loma Linda University School Of Dentistry

Dentalgram

In this issue

• Alumni-Student Convention
• Frenectomies abound
• On-site authorization
• Weingart Foundation grant
• Connected concert
• Department news
• Employee of the Quarter
• Fall '97 Dean's List

Mechanism Of Triazolo-Benzodiazepine And Benzodiazepine Action In Anxiety And Depression: Behavioral Studies With Concomitant In Vivo Ca1 Hippocampal Norepinephrine And Serotonin Release Detection In The Behaving Animal, Patricia A. Broderick, Omotola Hope, Pierrot Jeannot

Publications and Research

1. Real time, in vivo microvoltammetric studies were performed, using miniature carbon-based sensors, to concurrently detect norepinephrine (NE) release and serotonin (5-HT) release, in 2 separate electrochemical signals, within CA₁ region of hippocampus in the freely moving and behaving, male, Sprague Dawley laboratory rat.

2. Concurrently, four parameters of open-field Behavior I.E. Ambulations, Rearing, Fine Movements and Central Ambulatory behavior (a measure of anxiety reduction behavior), were assayed by infrared photobeam detection.

3. Time course studies showed that the mechanism of action of the triazolobenzodiazepine (TBZD), adinazolam, (Deracyn®) is dramatically different from that of the classical benzodiazepine (BZD), diazepam …

Vasodilators Activate Erythrocyte K-Cl Cotransport, Norma C. Adragna, H. Ahmed, Peter K. Lauf

Pharmacology and Toxicology Faculty Publications

No abstract provided.

Investigation Of The Roles Of Toxin-Coregulated Pili And Mannose-Sensitive Hemagglutinin Pili In The Pathogenesis Of Vibrio Cholerae O139 Infection, Carol O. Tacket, Ronald K. Taylor, Genevieve Losonsky, Yu Lim

Dartmouth Scholarship

In this study, adult volunteers were fed tcpA and mshA deletion mutants of V. cholerae O139 strain CVD 112 to determine the role of toxin-coregulated pili (TCP) and mannose-sensitive hemagglutinin (MSHA) in intestinal colonization. Eight of 10 volunteers who received CVD 112 or CVD 112 ΔmshA shed the vaccine strains in their stools; the geometric mean peak excretion for both groups was 1.4 × 10⁵ CFU/g of stool. In contrast, only one of nine recipients of CVD 112 ΔtcpA shed vibrios in his stool (P < 0.01); during the first 24 h after inoculation, 3 × 10² CFU/g was recovered from this volunteer. All recipients of CVD …

Dna Methylation And Carcinogenesis In Digestive, Javed Yakoob, Fan Xue-Gong, Hu Guo-Ling, Zhang Zheng

Section of Gastroenterology

No abstract provided.

Proactive Technique For Workplace Chemical Exposure, James A. Duru

Theses

The rapid increase in the number and quantities of chemicals released into the environment has been accompanied by a lack of adequate pre-released testing for advance health outcomes. Chemicals which serve as feed stock to millions of industries all around the world to produce and process food, cosmetics, equipment, and energy to propel industries, automobiles, home heating and electricity have serious adverse health consequences. They are hazardous. These substances can explode, ignite, react and corrode. Adapting the definition of the international program on chemical safety, a "hazard" is a source of danger. This thesis proposes some proactive prevention techniques useful …