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Academic Comparison Of Athletes And Non-Athletes In A Rural High School, Holt E Zaugg

Faculty Publications

This study compares academic performance, behavior, and commitment of basketball and volleyball athletes and non-athletes in a rural Canadian high school. It compares mid-term and final grades in each school discipline; visits to an administrator for disciplinary visits; and demerit points for improper behavior; and estimates the mean weekly time commitment for athletes in each sport.

Identifying Swelling-Activated Channels From Ion Selectivity Patterns, Dan R. Halm

Neuroscience, Cell Biology & Physiology Faculty Publications

No abstract provided.

Influence Of The Ccr2-V64i Polymorphism On Human Immunodeficiency Virus Type 1 Coreceptor Activity And On Chemokine Receptor Function Of Ccr2b, Ccr3, Ccr5, And Cxcr4, Benhur Lee, Benjamin J. Doranz, Shalini Rana, Yanji Yi, Mario Mellado, Jose M. R. Frade, Carlos Martinez-A., Stephen J. O'Brien, Michael Dean, Ronald G. Collman, Robert W. Doms

Biology Faculty Articles

The chemokine receptors CCR5 and CXCR4 are used by human immunodeficiency virus type 1 (HIV-1) in conjunction with CD4 to infect cells. In addition, some virus strains can use alternative chemokine receptors, including CCR2b and CCR3, for infection. A polymorphism in CCR2 (CCR2-V64I) is associated with a 2- to 4-year delay in the progression to AIDS. To investigate the mechanism of this protective effect, we studied the expression of CCR2b and CCR2b-V64I, their chemokine and HIV-1 coreceptor activities, and their effects on the expression and receptor activities of the major HIV-1 coreceptors. CCR2b and CCR2b-V64I were expressed at …

Regulation Of Connexin43 By Phosphorylation In Heart Development, John C. Duncan

Loma Linda University Electronic Theses, Dissertations & Projects

Serine/threonine protein kinases have been shown to reversibly regulate cell-cell communication through gap junctions formed by connexin 43 (Cx43) (Godwin et al.7 1993). The Cx43 protein expression levels are unclear and what role phosphorylation plays in the regulation of signal transduction through these gap junctions during heart formation. Reportedly, mutations which replace potentially phosphorylatable serines within the Cx43 protein are associated with heart malformations (Britz-Cunningham et al.. 1995), highlighting the importance of determining the levels of Cx43 and the activities of PKA and PKC during heart development.

Western analysis performed on hearts from developmentally significant time points revealed principally high …

Localization Of Sodium, Potassium-Adenosine Triphosphatase In The Cerebral Cortex Of Developing Rats, Maki Ujiie

Loma Linda University Electronic Theses, Dissertations & Projects

Active transport via Na⁺, K⁺-ATPase plays an important role in establishing and maintaining proper ionic gradient across all mammalian cell membranes. A strict regulation of Na⁺, and K⁺ ion levels is especially important in excitable cells such as neurons and myocytes. Inhibition of the enzyme is associated with several pathological conditions and has serious detrimental effects on cerebral cortical cells. Yet the enzyme appears to be limited in amount and distribution in newborn rats. In this study, Na_⁺, K⁺- ATPase expression and distribution in early postnatal rats were studied …

The Relationship Of The Incisive Canal To Maxillary Median Diastema, Jeffery S. Corbett

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to assess the relationship between the incisive canal and maxillary median diastema, and to identify an imaging method capable of documenting the geometry and dimensions of the incisive canal. The sample consisted of 59 dry skulls, 26 of which had a maxillary median diastema ranging in size from 0.1 mm to 2.8 mm (mean 1.0 mm, SD = 0.7 mm). Each skull had all of the permanent maxillary teeth present from first molar to first molar and lacked any apparent non-orthodontic condition that could have caused the diastema. Diastema width and canal diameter were …

Alternative Splicing Of The Latency-Related Transcript Of Bovine Herpesvirus 1 Yields Rnas Containing Unique Open Reading Frames, Laxminarayana R. Devireddy, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

The latency-related transcript (LRT) of bovine herpesvirus 1 (BHV-1) is the only abundant viral RNA detected during latency. A previous study (A. Hossain, L. M. Schang, and C. Jones, J. Virol. 69:5345–5352, 1995) concluded that splicing of polyadenylated [poly(A) ⁺] and splicing of nonpolyadenylated [poly(A) ^-] LRT are different. In this study, splice junction sites of LRT were identified. In trigeminal ganglia of acutely infected calves (1, 7, or 15 days postinfection [p.i.]) or in latently infected calves (60 days p.i.), alternative splicing of poly(A) ⁺ LRT occurred. Productive viral gene expression in trigeminal ganglia is readily detected …

Spinal Cord Compression: Histologic Spectrum Of Lesions, I. N. Soomro, N.Kayani N.Kayani, Shahid Pervez, A. S. Hussainy, R. Ahmed, S. Muzaffar, S. A. Aziz, S. H. Hasan

Department of Pathology and Laboratory Medicine

Histologic diagnosis ultimately determines the prognosis and treatment of lesions causing spinal cord compression. Modem imaging techniques have revolutionized the procedure of localizing lesions pre¬senting with signs and symptoms of spinal cord compression. As a result, these lesions are more accessible for fine needle aspiration and biopsy. A quick diagnosis is possible if cytologic preparation is made. Similarly, intraoperative frozen section facility not only provides rapid diagnosis, but also offers oppor tunity of appropriate management decision there and then. Histology in many cases needs help of special stains and immunocytochemistry. This study looks at the histologic spectrum of these lesions, …

Louisiana State University Medical Center - 1998 - Summer Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 1998 Summer Commencement of LSU Health Sciences Center - New Orleans held August 08, 1998.

Characterization Of Metal-Regulated Genes In Pseudomonas Fluorescens, Melanie Pearson

Honors Theses

One side effect of today's industrialized world is increased levels of heavy metals in the environment. Many of these metals are necessary for biological function as trace elements, but at higher concentrations are toxic. Other metals, such as cadmium, are not beneficial at any level, and have only deleterious effects on living organisms. Cadmium is primarily thought to interfere with normal biological function of proteins. Human exposure to cadmium appears to primarily damage the kidneys, but may also affect the liver, lungs, immune system, and central nervous system. Bacteria, however, have developed several methods for handling toxic heavy metals: cation …

Identification Of Putative Cytoskeletal Protein Homologues In The Protozoan Host Hartmannella Vermiformis As Substrates For Induced Tyrosine Phosphatase Activity Upon Attachment To The Legionnaires' Disease Bacterium, Legionella Pneumophila, Chandrasekar Venkataraman, Lian-Yang Gao, Subbarao Bondada, Yousef Abu Kwaik

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The Legionnaires' disease bacterium, Legionella pneumophila, is a facultative intracellular pathogen that invades and replicates within two evolutionarily distant hosts, free living protozoa and mammalian cells. Invasion and intracellular replication within protozoa are thought to be major factors in the transmission of Legionnaires' disease. We have recently reported the identification of a galactose/N-acetyl-d-galactosamine (Gal/GalNAc) lectin in the protozoan host Hartmannella vermiformis as a receptor for attachment and invasion by L. pneumophila (Venkataraman, C., B.J. Haack, S. Bondada, and Y.A. Kwaik. 1997. J. Exp. Med. 186:537–547). In this report, we extended our studies to the …

The Effects Of Personalized Dietary Education On Glycosylated Hemoglobin Levels In Adult Diabetic Patients, Lacey Gentry

MSN Research Projects

Diabetes mellitus is a complex and multifactorial disease process with numerous debilitating outcomes if improperly managed. This chronic illness requires continuing medical care and education to prevent acute exacerbations and to reduce the risk of long-term complications. The primary manifestation, hyperglycemia, can be the result of various elements. One major cause of hyperglycemia is inappropriate dietary intake which results in detrimental short- and long­ term effects. A glycosylated hemoglobin measurement can be utilized as a marker in monitoring long-term glycémie control. This quasi-experimental study examined the effect of personalized dietary education on glycosylated hemoglobin levels in adult diabetic patients. The …

Design Of An Epidemiologic Study Of Drinking Water Arsenic Exposure And Skin And Bladder Cancer Risk In A U.S. Population, Margaret R. Karagas, Tor D. Tosteson, Joel Blum, J Steven Morris, John A. Baron, Bjoern Klaue

Dartmouth Scholarship

Ingestion of arsenic-contaminated drinking water is associated with an increased risk of several cancers, including skin and bladder malignancies; but it is not yet clear whether such adverse effects are present at levels to which the U.S. population is exposed. In New Hampshire, detectable levels of arsenic have been reported in drinking water supplies throughout the state. Therefore, we have begun a population-based epidemiologic case-control study in which residents of New Hampshire diagnosed with primary squamous cell (n = 900) and basal cell (n = 1200) skin cancers are being selected from a special statewide skin cancer incidence survey; patients …

Molecular Basis For Effects Of Carcinogenic Heavy Metals On Inducible Gene Expression, Joshua W. Hamilton, Ronald C. Kaltreider, Olga V. Bajenova, Michael A. Ihnat, Jennifer Mccaffrey, Bruce W. Turpie, Erin E. Rowell, Jannet Oh, Michael J. Nemeth, Carrie A. Pesce, Jean P. Lariviere

Dartmouth Scholarship

Certain forms of the heavy metals arsenic and chromium are considered human carcinogens, although they are believed to act through very different mechanisms. Chromium(VI) is believed to act as a classic and mutagenic agent, and DNA/chromatin appears to be the principal target for its effects. In contrast, arsenic(III) is considered nongenotoxic, but is able to target specific cellular proteins, principally through sulfhydryl interactions. We had previously shown that various genotoxic chemical carcinogens, including chromium (VI), preferentially altered expression of several inducible genes but had little or no effect on constitutive gene expression. We were therefore interested in whether these carcinogenic …

In Vitro Assessment Of The Toxicity Of Cocaine And Its Metabolites In The Human Umbilical Artery, Tessa L. Long

Electronic Theses and Dissertations

An in vitro model was used to assess the effect of cocaine and its metabolites on the umbilical artery. Objectives were to pharmacologically confirm the presence of adrenergic innervation using tyramine, evaluate the ability of cocaine, benzoylecgonine, norcocaine and cocaethylene to potentiate vasoconstriction by serotonin and norepinephrine, examine the ability of ketanserin to block the enhanced vasoconstriction produced by cocaine, and determine displacement of 3 H-ketanserin by serotonin, norepinephrine, tyramine and mianserin. The vasoconstrictive effect of tyramine (100 μM) was enhanced in the presence of cocaine by 257%. Vasoconstrictive effects of serotonin and norepinephrine were significantly enhanced by cocaine by …

Expression Of Toxoplasma Gondii-Specific Heat Shock Protein 70 During In Vivo Conversion Of Bradyzoites To Tachyzoites, Neide M. Silva, Ricardo T. Gazzinelli, Deise A. O. Silva, Eloisa A. V. Ferro, Lloyd H. Kasper, Jose R. Mineo

Dartmouth Scholarship

Stage conversion between bradyzoites and tachyzoites was investigated in C57BL/6 mice chronically infected with the ME-49 strain of Toxoplasma gondii. In order to promote bradyzoite-tachyzoite conversion, mice were treated in vivo with neutralizing doses of anti-gamma interferon (IFN-gamma) or anti-tumor necrosis factor alpha (TNF-alpha) antibodies. Expression of parasite-specific antigens SAG-1, SAG-2, and heat shock protein 70 (Hsp-70) was visualized in the central nervous system by immunocytochemistry and measured by photometric assay. The immunosuppressive effect of anti-IFN-gamma or anti-TNF-alpha treatment was immediate, leading to parasite stage conversion as indicated by the increased expression of tachyzoite-specific antigens (SAG-1 and SAG-2) and by …

Perceived Health Competency And Health Value, Acculturation And Obesity In A Mexican American Population, Roberto Eliud Maldonado

Theses and Dissertations - UTB/UTPA

Mexican Americans have a higher incidence of obesity than non-Hispanic whites, yet this population seems to be less concerned with maintaining an ideal body weight than non-Hispanic whites. This puts the Mexican Americans population at higher risk for illnesses associated with increased body fat and obesity. One important factor found to influence health maintenance behavior is perceived self-efficacy, or the degree to which the individual feels capable of effectively managing his or her behavioral outcome. This study examines the moderating effect of health competency and health value on body weight in individuals undergoing acculturation.

Although no significant correlations were found …

Outcomes Of An Educational Program On The Knowledge Level Of Shaken Baby Syndrome Among Adolescent Babysitters, Mickey White Parks

MSN Research Projects

Shaken baby syndrome is a form of child abuse that exhibits no external sign of injury. A recent study by Starling, Holden, and Jenny (1995) indicated that approximately 3 0% of the perpetrators were nonparental child caregivers. The purpose of this study was to determine if there were differences in the knowledge level of shaken baby syndrome among adolescent babysitters before and after an educational intervention. The nursing theory. Modeling and Role-Modeling, was used to guide this study. Data were collected from a convenience and network sample consisting of 21 adolescents aged 12 to 17 years who reside in suburban …

Screening For Domestic Violence By Nurse Practitioners In The Primary Care Setting, Patricia A. Plant

MSN Research Projects

Domestic violence produces major health care problems for women. The prevalence and serious nature of this problem mandates recognition and intervention. Research has demonstrated that health care providers either overlook or fail to recognize or address potential domestic violence issues and situations during health care encounters. This descriptive study was designed to examine the screening practices of nurse practitioners for domestic violence certified and practicing in Louisiana. The theoretical framework for the research was based on the Health Promotion Model (Pender, 1987), which focuses on the integration of health-promoting behavior into lifestyles. The research question for this study was as …

The Effects Of Two Teaching Methodologies On Knowledge Of Insulin Administration Practices In An Older Adult Group, Clara D.J. Pieh

MSN Research Projects

Approximately 11 million people are affected with acute and chronic complications of diabetes. An estimated $20 billion is spent annually on the diagnosis and management of diabetes. Client adherence to self-care practice is essential to the control of diabetes. The self-care practice of injecting insulin is imperative for the management of both patients with type 1 and type 2 diabetes. Teaching modalities which effectively increase patient knowledge about insulin administration need to be developed and implemented. Therefore, the purpose of this study was to determine whether individualized instructions or audiovisual instructions increased the knowledge of insulin administration practices in older …

The Relationships Among Health Promoting Behaviors, Perceptions Of Health, And Quality Of Life In Elders With Atrial Fibrillation, Eric W. Smith

MSN Research Projects

The purpose of this study was to define health-promoting behaviors, perception of health, and quality of life in elders with atrial fibrillation to develop a basis for development of guidelines for nurse practitioners in practice.

Nurse Practitioners’ Developmental Screening And Referral Practices For Children With Developmental Delays, Terri Chisolm Smith

MSN Research Projects

Children with developmental delays benefit from participation in early intervention programs. Yet many children are not screened for developmental delays, and many children with developmental delays are not referred to early intervention programs. Families depend on their primary health care providers for the detection of developmental delays and information about services available for their children with developmental delays. The primary care nurse practitioner is in an ideal position to screen for delays, provide necessary referrals for services, and assist the families in maximizing their self- care potentials. Orem's self-care deficit theory of nursing served as the theoretical framework for the …

Medicare Coverage And Technology Diffusion: Past, Present, And Future, Robin J. Strongin

National Health Policy Forum

This issue brief provides an overview of the Medicare coverage process. Coverage involves deciding whether or not to pay for a particular service or product. This brief examines Medicare's coverage determination process, which includes technology assessment, payment determination, and the demand for evidence. Options for improving the coverage determination process are reviewed.

Nornicotine Enantiomers For Use As A Treatment For Dopamine Related Conditions And Disease States, Peter A. Crooks, Linda Phyliss Dwoskin, Michael Thomas Bardo

Pharmaceutical Sciences Faculty Patents

Optically active nornicotine compounds as a treatment for dopamine-related conditions and disease states. Such disease states include the treatment of myasthenia gravis, Parkinson's disease, Alzheimer's disease, schizophrenia, eating disorders, ulcers, drug addiction and as a substitute for psycho-stimulant self-administration.

Cannabinoid Receptor Agonist Efficacy For Stimulating [35S]Gtpγs Binding To Rat Cerebellar Membranes Correlates With Agonist-Induced Decreases In Gdp Affinity, C. S. Breivogel, D. E. Selley, S. R. Childers

Pharmaceutical Sciences

No abstract provided.

Dentalgram - Vol. 12, No. 07, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• MS degree for dentistry grand students
• Photo gallery
• Kasischke named assistant dean
• Department news
• Inter-American Dental Conference
• Student news

Summer 1998, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Summer 1998

Jefferson Alumni Bulletin – Volume Xlvii, Number 3, July 1998

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 3, July 1998

Drug Development and Clinical Trials, Page 4

Thomas Jefferson university Hospital is Ranked One of the Top 100 in the Country, Page 8

The W.W. Smith Charitable Trust Gives $1.5 Million, Page 9

First GI Text from an Endoscopic Perspective, Page 9

Brucker Lecture on Refocusing of Managed Care, Page 10

Gene Therapy for Canavan’s Disease, Page 11

Decorin May Be a Natural Cancer Fighter in Cells, Page 13

Clue to How a Protein Works to Suppress Tumors, Page 13

Francis Elected to ACP Board of Regents, Page 23

Gap Analysis Of The Vegetation Of The Intermountain Semi-Desert Ecoregion, David M. Stoms, Frank W. Davis, Kenneth L. Driese, Kelly M. Cassidy, Michael P. Murray

Great Basin Naturalist

A conservation gap analysis was conducted for the Intermountain Semi-Desert ecoregion to assess the representation of land-cover types within areas managed primarily for biodiversity objectives. Mapped distributions of plant communities were summarized by land-management status categories. The total amount of land permanently protected in the ecoregion is

Winter Macroinvertebrate Communities In Two Montane Wyoming Streams, Christopher M. Pennuto, Frank Denoyelles Jr., Mark A. Conrad, Frank A. Vertucci, Sharon L. Dewey

Great Basin Naturalist

Macroinvertebrate communities were examined on 4 winter dates over a 4-yr period in 2 high-altitude Rocky Mountain streams to document overwintering assemblages potentially experiencing spring acid pulses. Taxa richness values were comparable to other published lists for alpine and montane stream systems despite the fact that most literature reflected summer collections. Mean benthic density ranged from 1406 to 19,734 organisms/m², and drift rates ranged from 0 to 1740 organisms/100 m³. Benthic collections showed higher taxa richness than drift collections while the Ephemeroptera and Plecoptera occurred in greater proportions in drift than in benthos. The Nemouridae (Plecoptera), …