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The Risk Factors Of Cerebral Palsy In Very Low Birth Weight Prematurity, Jen-Wen Hung, Min-Yuan Yu, Hsueh-Wen Chang, Fang-Chih Hung, Chau-Peng Leong, Chung-Bin Huang, May-Kuen Wong

Rehabilitation Practice and Science

nfants with a birth weight less than 1500gm (very low birth weight, VLBW) are more likely to have disabling cerebral palsy(CP). The aim of this study was to identify prenatal, perinatal, postnatal risk factors for CP in VLBW infants and to determine the usefulness of cranial ultrasonographic (us) findings in predicting CP.The study group comprised 159 VLBW infants born at Chang Gung Memorial Hospital in Kaohsiung in the period from 1989 to 1996. CP was diagnosed via clinical evaluation in twenty-five (15.7%) of these Children. Univariate analysis identified antepartum hemorrhage, pre-eclampsia, birth weight, gestational age, the type of delivery, Apgar …

The Effect Of Jogging On Anterior Knee Laxity After Anterior Cruciate Ligament Reconstruction, Fawzi F. Bouzubar

Rehabilitation Sciences Theses & Dissertations

Jogging is commonly performed in the latter stages of the rehabilitation program (2½-3 months) following ACL reconstruction. However, its cyclic loading effect on the ACL graft, 4-6 months after surgery has not been examined. Therefore, the purpose of this study was to examine changes in anterior knee laxity before and after 15 minutes of jogging on the treadmill. Subjects (N=l 1) were 8 males and 3 females (X age= 30.27 ± 4.76 years; heights= 175.7 ± 10.7 cm; weights= 81.1 ± 15.9 kg) with unilateral ACL reconstruction (central 1/3 patellar tendon graft, postoperation range = 4-6 months). Measurements were made …

Enhancing The Effectiveness Of Social Skills Interventions With Adolescents, David J. Hansen, Douglas W. Nangle, Kathryn A. Meyer

Department of Psychology: Faculty Publications

Competent social interactions are clearly necessary for adjustment and successful functioning in society. The many developmental events and changing social expectations that occur during adolescence can make it particularly challenging for youth to establish and maintain competent social interactions. Research on social skills training with adolescents began in the mid-tolate 1970’s and it has improved much over the years. The research has gradually moved beyond a focus on basic skill assessment and acquisition in clinical settings toward techniques designed to assess and promote generalization and maintenance of an effective interpersonal repertoire in real world settings and situations. This article discusses …

Increased Glutathione Metabolic Defense Capabilities In Cultured Alzheimer's Diseased Lymphoblast Cell Lines, Collin M. Shaw

Dissertations and Theses

The hypothesis to be tested states that the pathology of Alzheimer's disease (AD) involves elevated levels of oxidative stress, resulting in elevated levels of cellular oxidative defense mechanisms. If the premise is true, than AD pathologically afflicted cells should have a higher demand for glutathione (GSH) as an innate oxidative defense mechanism hence; greater GSH concentrations, increased GSH resynthesis capabilities, and increased levels of cystathionine gamma-lyase (CNase). Alzheimer diseased and age matched control lymphoblast cells, obtained from OHSU's Oregon Brain Aging Study, were cultured, and GSH biochemistry was subsequently evaluated. GSH was depleted by exposing cells to the GSH depleting …

Cytochalasins Useful In Providing Protection Against Nerve Cell Injury Associated With Neurodegenerative Disorders, Mark P. Mattson

Sanders-Brown Center on Aging Faculty Patents

The present invention relates to novel therapeutic uses of certain compounds to protect nerve cells from injury and death. The compounds include cytochalasin D and related analogs, and cytochalasin E and related analogs.

Staphylococcal Enterotoxin B Primes Cytokine Secretion And Lytic Activity In Response To Native Bacterial Antigens, K. M. Mason, T. D. Dryden, Nancy J. Bigley, P. S. Fink

Neuroscience, Cell Biology & Physiology Faculty Publications

Superantigens stimulate T-lymphocyte proliferation and cytokine production, but the effects of superantigen exposure on cell function within a complex, highly regulated immune response remain to be determined. In this study, we demonstrate that superantigen exposure significantly alters the murine host response to bacterial antigens in an in vitro coculture system. Two days after exposure to the superantigen staphylococcal enterotoxin B, splenocytes cultured with Streptococcus mutans produced significantly greater amounts of gamma interferon (IFN-gamma) and interleukin-12 than did sham-injected controls. The majority of IFN-gamma production appeared to be CD8(+) T-cell derived since depletion of this cell type dramatically reduced the levels …

Length Of Pregnancy And Birthweight Between Black And White Women, Christine Herdt

Master's Projects

The pregnancies of Black women are complicated by adverse outcomes, such as prematurity and low birthweight, at twice the rate of complications in pregnancies of White women (Taylor, Katz, & Moos, 1995). Early access to and adequate utilization of prenatal care services are essential for successful pregnancy and birth outcomes (Rowley, 1994). The purpose of this study was to determine if there was a difference in length of pregnancy and birthweight between Black and White women at risk for preterm birth in a Preterm Delivery Prevention Program. A chart review of 79 clients enrolled in the Preterm Delivery Prevention Program …

The Meeting Of Pain And Depression: Comorbidity In Women, Marta Meana

Psychology Faculty Research

The higher prevalence of depression in women is coupled with a higher prevalence of pain complaints. Growing evidence suggests that the comorbidity of these conditions is also proportionately higher in women than men. This paper critically reviews the empirical findings relating to gender differences in comorbid pain and depression as well as findings in support of hypothesized etiologic factors that could explain why women may be more susceptible than men to comorbidity. The empirical evidence for biogenic, psychogenic, and sociogenic explanatory models is presented, and an integration of these models is proposed as a guideline to both research and clinical …

Chimeric Isoprenoid Synthases And Uses Thereof, Joseph Chappell, Kyoungwhan Back

Pharmaceutical Sciences Faculty Patents

Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous isoprenoid synthase. Also disclosed is a chimeric isoprenoid synthase polypeptide including an assymetrically positioned homologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring …

Bird Use Of Riparian Vegetation Along The Truckee River, Califonia And Nevada, Suellen Lynn, Michael L. Morrison, Amy J. Kuenzi, Jennifer C. C. Neale, Benjamin N. Sacks, Robin Hamlin, Linnea S. Hall

Great Basin Naturalist

The Truckee River in California and Nevada is subject to diverse water regimes and a corresponding variety of flow rates. Original riparian vegetation has been altered by these variable flow rates and by a variety of human uses resulting in loss of native riparian vegetation from its historic extent. We conducted bird surveys along the Truckee River during spring 1993 to (1) determine relationships between birds and the present vegetation; (2) determine the importance of different vegetation types to sensitive bird species that have declined recently in the western United States due to competition from exotic plant species, cowbird ( …

Thiazolidinediones Inhibit Lipoprotein Lipase Activity In Adipocytes, Subramanian Ranganathan, Philip A. Kern

Clinical and Translational Science Faculty Publications

The thiazolidinediones troglitazone and BRL 49653 improve insulin sensitivity in humans and animals with insulin resistance. Adipose tissue lipoprotein lipase is an insulin-sensitive enzyme. We examined the effects of thiazolidinediones on lipoprotein lipase expression in adipocytes. When added to 3T3-F442A, 3T3-L1, and rat adipocytes in culture, troglitazone and BRL 49653 inhibited lipoprotein lipase activity. This inhibition was observed at concentrations as low as 0.1 μM and within 2 h after addition of the drug. Lipoprotein lipase activity was inhibited in differentiated adipocytes as well as the differentiating cells. Despite this decrease in enzyme activity, these drugs increased mRNA levels in …

Assessing The Accuracy Of A New Diagnostic Test When A Gold Standard Does Not Exist, Todd A. Alonzo, Margaret S. Pepe

UW Biostatistics Working Paper Series

Often the accuracy of a new diagnostic test must be assessed when a perfect gold standard does not exist. Use of an imperfect test biases the accuracy estimates of the new test. This paper reviews existing approaches to this problem including discrepant resolution and latent class analysis. Deficiencies with these approaches are identified. A new approach is proposed that combines the results of several imperfect reference tests to define a better reference standard. We call this the composite reference standard (CRS). Using the CRS, accuracy can be assessed using multistage sampling designs. Maximum likelihood estimates of accuracy and expressions for …

Dentalgram - Vol. 12, No. 10, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• New students profiled
• Student orientation
• Students honored for National Board results
• Departmental news
• Reminders
• Photo gallery
• LLU dentists visit Siberia

Assessment Of Side Effects Induced By Injection Of Different Adjuvant/Antigen Combinations In Rabbits And Mice, P.P.A.M. Leenaars, M. A. Koedam, P. W. Wester, V. Baumans, E. Claassen, C. F.M. Hendriksen

Biomedicine and Animal Models in Research Collection

We evaluated the side effects induced by injection of Freund's adjuvant (FA)and alternative adjuvants combined with different antigens. Rabbits and mice were injected subcutaneously, intramuscularly (rabbits) and intraperitoneally (mice)with different adjuvants (FA, Specol, RIBI,TiterMax, Montanide ISA50)in combination with several types of antigens (synthetic peptides, autoantigen, glycolipid, protein, mycoplasma or viruses). The effects of treatment on the animals' well-being were assessed by clinical and behavioural changes (POTand LABORASassays) and gross and histopathological changes. In rabbits, treatment did not appear to induce acute or prolonged pain and distress. Mice showed behavioural changes immediately after (predominantly secondary) immunization. Injection of several adjuvant/antigen mixtures …

Animal Organs In Humans: Uncalculated Risks And Unanswered Questions, Gillian R. Langley, Joyce D'Silva

Biomedicine and Animal Models in Research Collection

This report, produced jointly by the British Union for the Abolition of Vivisection and Compassion in World Farming, fills a number of significant gaps in the current debate about xenotransplantation.

In this report we also summarise the ethical and welfare issues concerning experiments on animals for xenotransplant research and their possible use as source animals for organs. Both these aspects are responsible for much pain and distress caused to many animals. We prefer the term “source animals” to “donor animals”, because animals do not choose to donate their organs for xenotransplantation.

Chironian Fall/Winter 1998, New York Medical College

The Chironian

No abstract provided.

Transient Expression Of A Translation Initiation Factor Is Conservatively Associated With Embryonic Gene Activation In Murine And Bovine Embryos., P A De Sousa, A J Watson, R M Schultz

Obstetrics & Gynaecology Publications

In the present study the abundance of mRNAs for eukaryotic translation initiation factors eIF-1A (formerly known as eIF-4C), -2alpha, -4A, -4E, and -5 was examined in in vivo-derived mouse embryos throughout preimplantation development using a semiquantitative reverse transcription-polymerase chain reaction assay. Although the mRNA profile for each gene is unique, only mRNA for eIF-1A transiently increases during embryonic gene activation (EGA) at the 2-cell stage, and this was confirmed by an independent hybridization-based assay. In in vitro-developed bovine embryos, mRNA for eIF-1A was transiently detected at the 8-cell stage, when the major activation of the genome occurs in this species. …

Nurses Alumni Association Bulletin, Fall 1998, Betty Piersol, Elizabeth K. Prisnock, Marian E. Smith, Margaret Summers

Nursing Alumni Bulletins

1998-1999 Meeting Date Calendar

1999 Annual Luncheon & Meeting Notice

Fall Social

Officers and Committee Chairs

Bulletin Publication Committee

The President's Message

Treasurer's Report

News About Our Graduates

Highlight Of 1998

Operation Smile

Scholarship Funds At Work

Romania Trip

Double Honors

Doris Bowman

Memorial Service For Janet Hindson "A time for everything"

On the Lighter Side

Twenty Ways to Kill an Organization

Happy Birthday

Fiftieth Anniversary

Resume Alumni Association Meetings

Alumni Office News

Committee Reports

• Bulletin
• By-Laws
• Relief Fund
• Social
• Scholarship
• Development
• Nominating

Luncheon Photos

In Memoriam, Names of Deceased Graduates

Class News

Certification Reimbursement Application

Relief Fund Application

Scholarship …

Influence Of Physical Setting On Seagrass Landscapes Near Beaufort, North Carolina, Usa, Mark S. Fonseca, Susan S. Bell

Integrative Biology Faculty and Staff Publications

Field surveys were conducted in Core and Back Sounds, North Carolina, USA, to relate the physical setting of seagrass beds, as measured by a wave exposure index (REI), tidal current speed and water depth, to various measures of the sedimentary environment, spatial heterogeneity of seagrass distribution and measures of seagrass abundance. Seagrass beds in this area form patterns ranging from continuous to semi-continuous to widely dispersed, discrete patches across a gradient of increasing hydrodynamic activity. Tidal current speeds, exposure to waves and relative water depths revealed strong correlative evidence that physical processes influenced landscape-scale (50 x 50 m range with …

Benzodiazepine Self-Poisoning In Pakistan: Implications For Prevention And Harm Reduction, M M. Khan, Hashim Reza

Department of Psychiatry

The pattern of all index admissions for benzodiazepine self-poisoning to a university hospital in Karachi, Pakistan are described. Of the 329 medication self-poisoning cases, 84% were benzodiazepine overdoses. Diazepam was the preferred drug in 69% of these cases, with majority ingesting between 20-30 tablets of 5 mg each, 44% bought the benzodiazepine over the counter (OTC) for the purpose of overdose. The preference for benzodiazepines over analgesics (as freely available) may be related to the motives underlying parasuicide acts and their popularity as 'sleeping pills' in Pakistan. Educating the 'chemist' and limiting the number of tablets dispensed at a time …

Oncolog, Volume 43, Number 10, October 1998, Beth W. Allen, Beth Notzon, Alison Ruffin, Fran Zandstra Rn, Bsn, Mba, Ocn

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Endometrial cancer: prompt responses yield high survival rates
• Celebrating the end of a destructive relationship: one smoker's story
• Gene therapy for brain tumors moves from laboratory to clinic
• Protocols: Trials Offer Treatment Options for Patients with Endometrial Cancer
• Protocols: Brain Tumor Trials Encompass Radiation, Drug, Biological, and Gene Therapies
• House Call: Using Antioxidants: Read the Road Signs and Yield to Caution
• DiaLog: Protecting Hard-Won Surgical Cure: Surveillance for Recurrent Endometrial Cancer, by Fran Zandstra, RN, BSN, MBA, OCN, Center Administrative Director, Gynecology Oncology Center

Stachybotrys: Is Nevada At Risk?, Terrylynn C. Foley

UNLV Theses, Dissertations, Professional Papers, and Capstones

Stachybotrys chartarum (atra) is a toxigenic fungus that is known to adversely impact the health of animals. Until recently, there have only been a few documented clinical reports linking Stachybotrys chartarum to human health effects. Scientists are increasingly convinced that Stachybotrys and its metabolites are responsible for several adverse health effects experienced by people all over the world, although conclusive proof has yet to be established. All the physical requirements needed for indoor Stachybotrys sporulation and growth is provided through water leaks (plumbing, roof or ceiling), flood events, nutrient sources (cellulose and nitrogen), pH, and temperature(23° - 28°C). Stachybotrys has …

Center For Professional Ethics, Volume 1, Issue 1, 1998, Case Western Reserve University

Center for Professional Ethics

Table of Contents:

• Tom Anderson Appointed as Ethics Fellow
• Director's Corner: Off base / On Base, by Robert P. Lawry
• Physician-Assisted Suicide: Morally Permissible?
• In Memorium: Marliln Samuels, 1996 Fellow
• News and Notes

A Cross-Sectional Study Examining Lifestyle And Rheumatoid Arthritis, Leslie Nazaroff

Loma Linda University Electronic Theses, Dissertations & Projects

Objective. Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the synovial joints. RA affects 0.5-2% of the population. Though it is predominantly a progressive disease, adjunct therapy may slow the destructive pathway or alleviate affiliated symptoms. This study examined the effects of lifestyle (diet and exercise) and self-efficacy on symptoms of RA as measured by disease activity and health satisfaction.

Methods. Seventy-five RA patients (77% female) from the Loma Linda University Faculty Medical Offices, Rheumatology Department completed self-assessment surveys on their lifestyle practices and RA affliction. Disease symptoms and activity were assessed with the Arthritis Impact Measurement …

A Protein Encoded By The Latency-Related Gene Of Bovine Herpesvirus 1 Is Expressed In Trigeminal Ganglionic Neurons Of Latently Infected Cattle And Interacts With Cyclin-Dependent Kinase 2 During Productive Infection, Yunquan Jiang, Ashfaque Hossain, Mariah Teresa Winkler, Todd Holt, Alan R. Doster, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

Despite productive viral gene expression in the peripheral nervous system during acute infection, the bovine herpesvirus 1 (BHV-1) infection cycle is blocked in sensory ganglionic neurons and consequently latency is established. The only abundant viral transcript expressed during latency is the latency-related (LR) RNA. LR gene products inhibit S-phase entry, and binding of the LR protein (LRP) to cyclin A was hypothesized to block cell cycle progression. This study demonstrates LRP is a nuclear protein which is expressed in neurons of latently infected cattle. Affinity chromatography indicated that LRP interacts with cyclin-dependent kinase 2 (cdk2)-cyclin complexes or cdc2-cyclin complexes in …

Jefferson Alumni Bulletin – Volume Xlvii, Number 4, October 1998

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 4, October 1998

Flanagan, Gallo, and Nadel are Honored with the Alumni Achievement Awards, Page 6

Clinic Presentations Treat a Range of Fields, Page 8

Alumni are Invited to Compete for the Gratz Prize, Page 13

Annual Giving Tops Two Million Dollars, Page 26

Depression In Mexican American Adolescence And Its Relations To Ethnic Identity And Self Esteem, Deborah Cohen Woloski

Theses and Dissertations - UTB/UTPA

This study investigated incidence of depressive symptomatology, clinical depression, and suicidal ideation in a high school sample of 1751 Mexican-American adolescents. The relations of depression, as measured by the Diagnostic Scale for Depression-26 (DSD26), self-esteem, as measured by the abbreviated Rosenberg's Self-esteem Scale and ethnic identity, as measured by the Multigroup Ethnic Identity Measure (MEIM) were analyzed. Results indicate that Mexican-American adolescents are at increased risk for depressive symptomatology and suicidal ideation. Results showed that there is no higher incidence of Major Depressive Episode (MDE) in Mexican-American adolescents but an increased risk for depressive symptomatology was found. Ethnic identity and …

Urinary N-Acetyl-Beta-D-Glucosaminidase In Rheumatoid Arthritis, M P. Iqbal, A A. Ali, M A. Waqar, N Mehboobali

Department of Biological & Biomedical Sciences

Excretion of urinary N-acetyl beta-D-glucosaminidase (NAG) and its isoenzyme patterns were studied in two groups of patients with rheumatoid arthritis (RA) and in normal control subjects. Urine samples were collected from 30 seropositive RA patients, 19 seronegative RA patients, and 15 normal healthy subjects. All the patients and normal subjects were assessed to have normal liver and kidney functions. A small portion of the urine sample was dialyzed against 0.01 M phosphate buffer, pH 7.0 and NAG activity was monitored. Mean +/- SD values of urinary NAG in seropositive RA patients, in seronegative RA patients and in normal healthy subjects …

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1998), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1998 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• PCOM Updates
• Approaching 100: Our Centennial
• Commencement ‘98
• Remembering David Heilig, Do, '44, OMM Professor Emeritus
• Alumni Make their Mark in the Military
• Profiles
• AHEC Exposes Students to Rural Medicine
• Class Notes
• Just Published
• In Memoriam
• Send Us Your News for Digest!
• Coming Events

The Location Of The Carboxy-Terminal Region Of Γ Chains In Fibrinogen And Fibrin D Domains, Michael W. Mosesson, Kevin R. Siebenlist, David A. Meh, Joseph S. Wall, James F. Hainfeld

Biomedical Sciences Faculty Research and Publications

Elongated fibrinogen molecules are comprised of two outer “D” domains, each connected through a “coiled-coil” region to the central “E” domain. Fibrin forms following thrombin cleavage in the E domain and then undergoes intermolecular end-to-middle D:E domain associations that result in double-stranded fibrils. Factor XIIIa mediates crosslinking of the C-terminal regions of γ chains in each D domain (the γXL site) by incorporating intermolecular ɛ-(γ-glutamyl)lysine bonds between amine donor γ406 lysine of one γ chain and a glutamine acceptor at γ398 or γ399 of another. Several lines of evidence show that crosslinked γ chains extend “transversely” between the strands of …