Digital Commons Network^™

Cancer Surveillance Series: Non-Hodgkin’S Lymphoma Incidence By Histologic Subtype In The United States From 1978 Through 1995, Frank D. Groves, Martha S. Linet, Lois B. Travis, Susan S. Devesa

United States Public Health Resources

Background: Clinical investigations have shown prognostic heterogeneity within the non-Hodgkin’s lymphomas (NHLs) according to histology, but few descriptive studies have considered NHLs by subgroup. Our purpose is to assess the demographic patterns and any notable increases in population- based rates of different histologic subgroups of NHL.
Methods: Using data collected by the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute, we calculated incidence rates for the major clinicopathologic categories of NHL by age, race, sex, geographic area, and time period.
Results: Among the 60 057 NHL cases diagnosed during the period from 1978 through 1995, total incidence …

A Creaturely Ethic: Veritatis Splendor And Human Nature, J. F. Owens

The Linacre Quarterly

No abstract provided.

Information Interface - Volume 28, Issue 4 - August/September 2000, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

Personal Health Screening Practices Among Female Nurse Practitioners, Lisa A. Dement

MSN Research Projects

The purpose of this study was to determine the extent to which female nurse practitioners within the state of Mississippi are in compliance with the United States Preventive Services Task Force Guidelines.

Prolonged Cyclooxygenase-2 Induction In Neurons And Glia Following Traumatic Brain Injury In The Rat, Kenneth I. Strauss, Mary F. Barbe, Renee Marshall Demarest, Ramesh Raghupathi, Samir Mehta, Raj K. Narayan

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Cyclooxygenase-2 (COX2) is a primary inflammatory mediator that converts arachidonic acid into precursors of vasoactive prostaglandins, producing reactive oxygen species in the process. Under normal conditions COX2 is not detectable, except at low abundance in the brain. This study demonstrates a distinctive pattern of COX2 increases in the brain over time following traumatic brain injury (TBI). Quantitative lysate ribonuclease protection assays indicate acute and sustained increases in COX2 mRNA in two rat models of TBI. In the lateral fluid percussion model, COX2 mRNA is significantly elevated (>twofold, p < 0.05, Dunnett) at 1 day postinjury in the injured cortex and bilaterally in the hippocampus, compared to sham-injured controls. In the lateral cortical impact model (LCI), COX2 mRNA peaks around 6 h postinjury in the ipsilateral cerebral cortex (fivefold induction, p < 0.05, Dunnett) and in the ipsilateral and contralateral hippocampus (two- and six-fold induction, respectively, p < 0.05, Dunnett). Increases are sustained out to 3 days postinjury in the injured cortex in both models. Further analyses use the LCI model to evaluate COX2 induction. Immunoblot analyses confirm increased levels of COX2 protein in the cortex and hippocampus. Profound increases in COX2 protein are observed in the cortex at 1-3 days, that return to sham levels by 7 days postinjury (p < 0.05, Dunnett). The cellular pattern of COX2 induction following TBI has been characterized using immunohistochemistry. COX2-immunoreactivity (-ir) rises acutely (cell numbers and intensity) and remains elevated for several days following TBI. Increases in COX2-ir colocalize with neurons (MAP2-ir) and glia (GFAP-ir). Increases in COX2-ir are observed in cerebral cortex and hippocampus, ipsilateral and contralateral to injury as early as 2 h postinjury. Neurons in the ipsilateral parietal, perirhinal and piriform cortex become intensely COX2-ir from 2 h to at least 3 days postinjury. In agreement with the mRNA and immunoblot results, COX2-ir appears greatest in the contralateral hippocampus. Hippocampal COX2-ir progresses from the pyramidal cell layer of the CA1 and CA2 region at 2 h, to the CA3 pyramidal cells and dentate polymorphic and granule cell layers by 24 h postinjury. These increases are distinct from those observed following inflammatory challenge, and correspond to brain areas previously identified with the neurological and cognitive deficits associated with TBI. While COX2 induction following TBI may result in selective beneficial responses, chronic COX2 production may contribute to free radical mediated cellular damage, vascular dysfunction, and alterations in cellular metabolism. These may cause secondary injuries to the brain that promote neuropathology and worsen behavioral outcome.

Morphological, Molecular, And Biogeographical Variation Within The Imperiled Virginia Spiraea, Constance Anders

Masters Theses & Specialist Projects

Spiraea virginiana Britton is a rare federally listed rhizomatous shrub endemic to the southern Blue Ridge and Appalachian Plateau physiographic provinces. Populations of S. virginiana are found restricted to scoured sections of high gradient streams within the Ohio River drainage. Present evidence indicates the species is reproducing asexually, most probably through the deposition of rhizomes from upstream populations forming new downstream ramets. Phenotypic variation was examined through a morphometric evaluation of 25 leaf measurements and analyzed using Principal Components Analysis (PCA) and discriminant function analysis. Identity and structure at the molecular level as examined with Randomly Amplified Polymorphic DNA (RAPDs) …

Com Outlook August 2000, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Children Of Alcoholics: An Update., D Z Lieberman

Psychiatry and Behavioral Sciences Faculty Publications

One of four children in the United States lives in a family in which the child is exposed to alcoholism. Children of alcoholics (COAs) are two to ten times more likely to develop alcoholism than non-COAs. This paper reviews studies that have attempted to identify risk factors that mediate the increased vulnerability and the protective factors that moderate the risk. Factors discussed include parental antisocial personality disorder, externalizing behavior, internalizing symptoms, differential response to the effects of alcohol, and positive and negative alcohol-related expectancies. The heterogeneous nature of COAs is emphasized, and some of the challenges related to treatment and …

Regional Variation In Recruitment Of Hemlock Seedlings And Saplings In The Upper Great Lakes, Usa, Thomas P. Rooney, Ronald J. Mccormick, Stephen L. Solheim, Donald M. Waller

Biological Sciences Faculty Publications

Mature eastern hemlock–northern hardwood forest cover decreased drastically in the upper Midwest following European settlement and has yet to rebound substantially. Previous studies show that stands retaining substantial hemlock canopy coverage have low hemlock seedling and sapling densities. Results from various geographically restricted studies suggest several possible mechanisms that could cause low seedling or sapling density. We examined the relative importance of these proposed mechanisms in the Southern Superior Uplands Section of the Laurentian Forest Province. We surveyed 294- m2 plots in 100 hemlock stands in northern Wisconsin and western upper Michigan to assess how these proposed mechanisms affect the …

Bipolar Disorder And Locus Of Control: Implications For Treatment Compliance, Linda J. Ryan-Cox

Theses

Theoretically, a paradigm shift in the 1960s made community-based care and out-patient treatment an acceptable alternative to institutionalization of the chronically mentally ill. Utilizing the Levenson Multidimensional Locus of Control Scale for Psychiatric Patients, the author conducted a causal-comparative study to determine if a link exists between having bipolar disorder, a chronic mental illness, and an external locus of control, a link which might explain the inability of this population to maintain their optimal level of mental health utilizing the out-patient treatment model. Though the study failed to demonstrate any significant differences in external measures of loci of control between …

La Notion De Danger, Jean M. Kanellopoulos, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Pendant de nombreuses années, les recherches en immunologie ont été centrées sur la réponse immunitaire adaptative, et la plupart des immunologistes considéraient que sa fonction principale était de faire la distinction entre soi et non soi. Plus récemment, plusieurs équipes ont proposé que la fonction principale du système immunitaire est en réalité d’éliminer les agents pathogènes. Or, c’est le système immunitaire inné, longtemps négligé, qui joue un rôle essentiel dans l’induction d’une réponse contre les microorganismes. Ce système réagit précocement aux infections, voire instantanément, puis il induit et oriente la réponse du système adaptatif. Plusieursthéories ont été élaborées pour expliquer …

Free Radical Production In Hypoxic Pulmonary Artery Smooth Muscle Cells, David W. Killilea, Raymond Hester, Ron Balczon, Pavel Babal, Mark N. Gillespie

University Faculty and Staff Publications

This study used an inexpensive and versatile environmental exposure system to test the hypothesis that hypoxia promoted free radical production in primary cultures of rat main pulmonary artery smooth muscle cells (PASMCs). Production of reactive species was detected by fluorescence microscopy with the probe 2', 7'-dichlorodihydrofluorescein, which is converted to the fluorescent dichlorofluorescein (DCF) in the presence of various oxidants. Flushing the airspace above the PASMC cultures with normoxic gas (20% O(2), 75% N(2), and 5% CO(2)) resulted in stable PO(2) values of approximately 150 Torr, whereas perfusion of the airspace with hypoxic gas (0% O(2), 95% N(2), and 5% …

Characterization Of 50s Ribosomal Subunit Assembly Inhibition In Erythromycin Treated Escherichia Coli Cells., Jerry Edward Usary

Electronic Theses and Dissertations

Erythromycin has long been recognized for its ability to inhibit protein synthesis by interfering with mRNA translation on the bacterial ribosome. We have recently shown that erythromycin also inhibits the assembly of the 50S ribosomal subunit in growing bacterial cells. The nature of this assembly inhibition has been investigated using ³H-uridine pulse-chase labeling of control and erythromycin treated E. coli cells.

Subunit assembly was examined by sucrose gradient centrifugation of labeled cell lysates. Normal assembly kinetics of subunit assembly were observed in control cells at 37°C. Formation of the 30S subunit was completed by 7.5 minutes and assembly of …

Differential Infectivity And Division Of Toxoplasma Gondii In Human Peripheral Blood Leukocytes, Jacqueline Y. Channon, Rosanne M. Seguin, Lloyd H. Kasper

Dartmouth Scholarship

When tachyzoites were incubated with human peripheral blood leukocytes in vitro, more monocytes and dendritic cells than neutrophils or lymphocytes were infected. Although tachyzoites were able to divide in each of these cell types, monocytes and dendritic cells were more permissive to rapid tachyzoite division than neutrophils or lymphocytes.

Comparison Of Health Promotion Behaviors And Performance On The Navy Physical Readiness Test Among Active Duty Shipboard Personnel With And Without Anterior Knee Pain, Robin Theresa Mckenzie Phd, Msn, Rn

Dissertations

Health promotion is the number one health priority of the nation, yet, health promoting behaviors (HPB) are rarely part of the management plan for persons with anterior knee pain (AKP). In an active duty military population, AKP can interfere with performance on the required, semi-annual physical readiness test (PRT). The purpose of this descriptive, comparative study was to compare the relationships among HPB, AKP and performance on the PRT between two groups of active duty Navy shipboard personnel (those with AKP and those without AKP). Pender's (1996) Health Promotion Model (HPM) served as the theoretical framework. Subjects completed demographic and …

Factors Influencing Smoking In Adolescents, Jeff J. Mitchell

MSN Research Projects

Adolescents' use of tobacco products is an ever-growing sector of today's society. Adolescents continue to smoke cigarettes at an alarming rate. Early adolescent cigarette smoking between the ages of 11 and 13 years was found to be related to peer pressure and family role-modeling. Another influence cited was the use of media catering to adolescents. The ease at which adolescents acquire cigarettes is evidence that further restrictions need to be applied to those who sell to adolescents. The purpose of this study was to further explore influencing factors to adolescent smoking. The research question was what are the factors that …

Pagophagia And Hemoglobin Levels In Pregnant Women, Contessa Ward

MSN Research Projects

Pica is a behavior characterized by the compulsive, persistent ingestion of non-food substances. It is a longstanding practice that has far-reaching implications for prevention and treatment. Pagophagia, or the excessive, compulsive consumption of ice, is a subcategory of pica. Although pica has been documented for centuries, there are limited studies regarding pagophagia and its effects in pregnant women. A comparative descriptive study was conducted to determine whether pagophagia is related to hemoglobin levels during pregnancy. Becker's Health Belief Model was utilized as the theoretical framework. Data were gathered by means of retrospective chart audit. The hypothesis was there would be …

A New Role For A Snare Protein As A Regulator Of The Ypt7/Rab-Dependent Stage Of Docking, Christian Ungermann, Albert Price, William Wickner

Dartmouth Scholarship

The homotypic fusion of yeast vacuoles occurs in an ordered cascade of priming, docking, and fusion. The linkage between these steps has so far remained unclear. We now report that Vam7p (the vacuolar SNAP-23/25 homolog) signals from the cis-SNARE complex to Ypt7p (the vacuolar Rab/Ypt) to initiate the docking process. After Vam7p has been released from the cis-SNARE complex by Sec18p-mediated priming, it is still required for Ypt7p-dependent docking and it needs Ypt7p to remain on the vacuole.

Prognostic Impact Of P53 Status In Ewing Sarcoma, E. De Alava, C. Antonescu, A. Panizo, Denis H. Y. Leung, P. Meyers, A. Huvos, F. J. Pardo-Mindan, J. Healey, M. Ladanyi

Research Collection School Of Economics

Disease stage at the time of diagnosis and response to therapy are the main prognostic factors for patients with Ewing sarcoma or peripheral neuroectodermal tumor (ES/PNET). The primary genetic alteration in ES/PNET, the fusion of the EWS gene with FLI1 or ERG, is diagnostically highly specific for these tumors, and molecular variation in the structure of the EWS-FLI1 fusion gene also is of prognostic significance. In contrast, secondary genetic alterations, such as P53 alterations, are relatively uncommon in ES/PNET, and their prognostic impact has not been extensively studied. METHODS: Prechemotherapy, paraffin embedded, nondecalcified, primary tumor material in a well-characterized series …

The Political Psychology Of Abortion: Some Implications Of Free Choice, Ibpp Editor

International Bulletin of Political Psychology

This article describes some logical implications of a "free choice" position on abortion public policy.

Trends. Biopolitics And Anthrax: A United States Fiasco?, Ibpp Editor

International Bulletin of Political Psychology

This article discusses the biopolitical issues involved with the mass inoculation of United States military forces against anthrax.

Ada News - 07/17/2000, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Trends. The Attack On Mbeki: Praising Through Damning, Ibpp Editor

International Bulletin of Political Psychology

This article discusses the controversial contention by President Thabo Mbeki of the Republic of South Africa that poverty and lack of health infrastructures are the causes of AIDS and HIV in Africa instead of limiting his analysis to the biological line of virus inducing disease.

The Import Of Political Psychology For Global Health And Security: The Case Of Aids, Ibpp Editor

International Bulletin of Political Psychology

This article describes a number of applied research areas that political psychologists can explore to help manage the threat to global health and security from acquired immune deficiency syndrome (AIDS).

What's Happening: July 5, 2000, Maine Medical Center

What's Happening

No abstract provided.

Thomas Jefferson University 2000 Annual Report, Douglas J. Macmaster, Jack Farber, Paul C. Brucker

Thomas Jefferson University Administrative Documents and Reports

No abstract provided.

Dentalgram - Vol. 14, No. 07, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• Masters degree awarded
• Long-time faculty and staff retire
• Dentistry employees honored for years of service
• ADA recognizes service learning caregivers
• Student News
• Advanced education and IDP students enter roster
• Department news
• Alumnus wins CDA essay content

Nsu Achievements - Summer 2000, Nova Southeastern University

NSU Achievements

No abstract provided.

Santa Clara Magazine, Volume 42 Number 1, Summer 2000, Santa Clara University

Santa Clara Magazine

8 - ATTACK OF THE KILLER TOMATOES? By Miriam Schulman. Beyond the hype of the headlines, there are no simple answers to the ethical questions raised by genetically modified food.

14 - BRAVE NEW WORLD By Tamara Straus. Now the lawyers want inside your head as they struggle to answer, "Who owns an idea?" Just the mere question is changing the face of legal education.

18 - THE GREAT GRADE GIVEAWAY By Jeff Zorn. Today's grades don't mean jack. So says one Santa Clara professor in this memoir and commentary on the evils of modern day grade inflation.

22 - …

Vitamin A And Cancer, Richard M. Niles

Biochemistry and Microbiology

Vitamin A, its physiological metabolites and synthetic derivatives (retinoids) have been shown to have protective effects against the development of certain types of cancer. In addition, pharmacological amounts of retinoids have been used with some success in the treatment of a few human tumors. The chemoprevention effect of retinoids is most likely exerted at the tumor promotion phase of carcinogenesis. Retinoids block tumor promotion by either inhibiting proliferation, inducing apoptosis, inducing differentiation, or a combination of these actions. Clinically, isotretinoin (13-cis-retinoic acid) significantly decreases the incidence of second primary tumors in patients with head and neck cancer and also reduces …