Digital Commons Network^™

A Neuropsychological Perspective On The Efficacy Of Typical And Atypical Medication Treatment For Chronic Schizophrenia Regarding Executive Functioning, Eric Hart

Masters Theses

This study investigated the efficacy of current medication treatment procedures for chronic schizophrenics on neuropsychological measures. A total of twenty participants from the Coles County Mental Health Center, who met DSM-IV criteria for chronic schizophrenia, volunteered to be administered the Wisconsin Card Sorting Test (WCST)-64 card version as a means of assessing neuropsychological executive functioning. A total of twenty participants free of any diagnosable psychological disorder also volunteered to be administered the WSCT-64, which served as a control group. The staff psychiatrist at the Coles County Mental Health Center completed the Positive and Negative Syndrome Scale (PANSS) in order to …

Synapsis: Philadelphia Campus (2001), Philadelphia College Of Osteopathic Medicine

All Yearbooks

This yearbook includes A Capella, American Holistic Medical Association, AHMA, American College Of Osteopathic Family Practitioners, ACOFP, Association Of Military Osteopathic Physicians and Surgeons, AMOPS, American Medical Association Medical Student Society, AMA-MSS, American Medical Women's Association, AMWA, Asian Pacific American Medical Student Association, APAMSA, Community of Italian American Osteopaths, CIAO, Christian Medical And Dental Society, CMDS, Emanuel Fliegelman, DO Obstetrics and Gynecology, Ob/Gyn, Daniel Wisely Surgery, Emergency Medicine, Ethics Committee, Follies, Founders' Day Follies, Geriatrics, Islamic Medical Association, IMA, Golf, Internal Medicine, Nutrition, Jewish Physicians Network, National Boricua Latino Health Organization, NBLHO, Physicians for Social Responsibility. PSR, Pathology, Public Health, …

Research On Faith And Health: New Appoaches To Old Questions, Thomas G. Plante, Allen C. Sherman

Psychology

Does religious faith influence health? Are religious practices associated with altered risks for morbidity or mortality? Do religious or spiritual individuals tend to enjoy better well-being or mental health across the lifespan? Does spiritual or religious involvement change the way individuals adapt to the demands of chronic illness? This volume brings together some of the leading investigators who have explored these intriguing questions. Though research is in its early phases, the chapters that follow review some of what we have learned and begin to trace the outlines of the many mysteries that remain.

Molecular Genetics Of Breast Cancer, Emel Ergül, Ali̇ Sazci

Turkish Journal of Medical Sciences

Recent advances in molecular biology enable researchers to understand the basis of breast cancer much better and show that hereditery breast cancer may result from mutations on several specific gene loci including BRCA1, BRCA2, p53, ATM and PTEN. These genes are tumor supressor genes and although their functions are different, they are all involved in the maintenance of genomic stability after DNA damage. Mutations that impair the function of these genes may adversely affect the manner in which DNA damage is processed. It is likely that the risk of breast cancer development is increased through this mechanism. Moreover, there are …

Department Of Radiation Oncology And Kimmel Cancer Center, Thomas Jefferson University, The Intronic G13964c Variant In P53 Is Not A High-Risk Mutation In Familial Breast Cancer In Australia., Anna Marsh, Amanda B Spurdle, Bruce C Turner, Sian Fereday, Heather Thorne, Gulietta M Pupo, Graham J Mann, John L Hopper, Joseph F Sambrook, Georgia Chenevix-Trench

Department of Radiation Oncology Faculty Papers

BACKGROUND: Mutations in BRCA1 and BRCA2 account for approximately 50% of breast cancer families with more than four affected cases, whereas exonic mutations in p53, PTEN, CHK2 and ATM may account for a very small proportion. It was recently reported that an intronic variant of p53--G13964C--occurred in three out of 42 (7.1%) 'hereditary' breast cancer patients, but not in any of 171 'sporadic' breast cancer control individuals (P = 0.0003). If this relatively frequent occurrence of G13964C in familial breast cancer and absence in control individuals were confirmed, then this would suggest that the G13964C variant plays a role in …

A Comparison Of Ultimate Pullout Strength Of Four Bioabsorbable Tacks, Benjamin Bleess

Physical Therapy Scholarly Projects

The purpose of this study was to evaluate the pullout strength, both parallel and perpendicular to that tack shaft, of four different bioabsorbable tacks: Suretac A, Suretac B, Bionx A, and Bionx B. These tacks were fixated into a foam block and tension was placed on each tack until point of failure between the tack-foam interface. Results indicated that the Bionx B tack withstood the greatest mean ultimate parallel pullout strength at 292.04 Nand failed at a force significantly higher than all other tack types (p=.OOO). The Bionx A failed at 150.25 N, Suretac B at 147.64 N, and Suretac …

Thermal Capsulorrhaphy Of The Shoulder: Literature Review And Clinical Outcome For One Collegiate Tennis Player, Kelsey J. Kean

Physical Therapy Scholarly Projects

Glenohumeral joint instability is a clinical problem in both the athletic and general populations. When 3 months of conservative physical therapy treatments fail to stabilize the lax shoulder joint, surgery is indicated. Recently thermal capsulorrhaphy, an arthroscopic procedure that uses a heat probe to shrink redundant capsular tissue, has been offered as one alternative to tighten the lax glenohumeral joint capsule. There are numerous published reports describing the effects of thermal energy on joint capsular tissue, but only a few clinical outcome studies have been published regarding thermal capsulorrhaphy of the shoulder. Some initial reports of this surgical technique seem …

Reliability And Validity Of Angular Joint Velocity Using Peak Motus 2000 Motion Analysis And Kin-Com Isokinetic Dynamometer, Meaghan Kuklok

Physical Therapy Scholarly Projects

Background and Purpose: Use of motion analysis systems for the study of human motion in research settings and clinical settings are becoming more prevalent. In a traditional sense, motion analysis systems are used for gait analysis; most recently, they are being utilized to analyze spinal motion, foot motion, and components of motion during sporting activities. Questions about the accuracy of these computerized motion analysis systems and the precision and reliability of the digitizing process remains. The purpose of this study is to determine the validity of the Peak Motus 2000 motion analysis system® (Peak Performance) in calculating dynamic velocities and …

Cannabinoids And The Immune System, Thomas W. Klein, Catherine A. Newton, Herman Friedman

Molecular Medicine Faculty Publications

The effect of cannabimimetic agents on the function of immune cells such as T and B lymphocytes, natural killer cells and macrophages has been extensively studied over the past several decades using human and animal paradigms involving whole animal models as well as tissue culture systems. From this work, it can be concluded that these drugs have subtle yet complex effects on immune cell function and that some of the drug activity is mediated by cannabinoid receptors expressed on the various immune cell subtypes. However, the overall role of the cannabinoid system of receptors and ligands in human health and …

Stabilization Of Partially Folded Conformation During Α-Synuclein Oligomerization In Both Purified And Cytosolic Preparations, Vladimir N. Uversky, He-Jin Lee, Jie Li, Anthony L. Fink, Seung-Jae Lee

Molecular Medicine Faculty Publications

Aggregation of α-synuclein is tightly associated with many neurodegenerative diseases, such as Parkinson's disease, dementia with Lewy body, Lewy body variant of Alzheimer's disease, multiple system atrophy, and Hallervorden-Spatz disease, implicating a crucial role of aggregated forms of α-synuclein in the pathogenesis. Here, we examined the effect of elevated temperature on the oligomerization and structural changes of α-synuclein in the early stage of aggregation and show that self-assembly is crucial for the stabilization of a partially folded conformation. The efficiency of α-synuclein oligomerization increased proportional to the temperature increase, both in purified form and in crude cytosolic preparation. This oligomerization …

Oncolog, Volume 46, Number 01, January 2001, Kerry L. Wright, Dawn Chalaire, Emil J. Freireich Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• New Melanoma Staging System Reflects Key Prognostic Factors
• House Cell: Preventing Cancer: Food for Thought
• Educational Conferences Explore Issues Related to Cancer Care and Research
• DiaLog: Leukemia: Setting the "Stage" for Effective Treatments, by Emil J. Freireich, MD, Professor, Department of Leukemia
• Updated M. D. Anderson Website Designed to Meet the Online Needs of Patients and Physicians

Whose Education Counts? The Impact Of Grown Children's Education On The Physical Functioning Of Their Parents In Taiwan, Zachary Zimmer, Albert I. Hermalin, Hui-Sheng Lin

Poverty, Gender, and Youth

Research has identified education as an important predictor of physical functioning in old age. Older adults in Taiwan tend to experience close ties to family members and high rates of adult child coresidence, much more so than is typical in Western cultures. These circumstances might imply additional health-related benefits stemming from the education of grown children. This association could arise in a number of ways, for instance through the sharing of health-related information between child and parent, the quality of caregiving efforts, monetary assistance for medical and other services, or through other psychosocial avenues. In this study, a nationally representative …

The End Of The Fertility Transition In The Developed World, John Bongaarts

Poverty, Gender, and Youth

By the late 1990s fertility in the developed world had declined to 1.6 births per woman, a level substantially lower than projected in the 1980s. This study examines recent trends and patterns in fertility in the developed world with particular emphasis on the effects and implications of changes in the timing of childbearing. The main objective is to demonstrate that while fertility in these countries is indeed low, women’s childbearing levels are not as low as period measures such as the total fertility rate suggest. To obtain a full understanding of the various dimensions of fertility change, several indicators are …

Methods Used In Evaluating Telomerase Activity, Mübeccel Durusoy, Kami̇le Öztürk

Turkish Journal of Medical Sciences

No abstract provided.

Relationship Between Psychopathology And Regional Cerebral Blood Flow Detected By Tc-99m Hmpao Spect In Patients With Predominantly Positive Or Negative Schizophrenic Symptoms, Nazan Aydin, Erhan Varoğlu, Mehmet Dumlu Aydin, Hati̇ce Uslu, Ali̇ Çayköylü

Turkish Journal of Medical Sciences

We investigated whether rCBF values obtained with the SPECT technique are different in schizophrenics with predominantly positive or negative symptoms and assessed the biological underpinnings of psychotic phenomena, which has been done repeatedly in the past, with somewhat varied results. Twenty-nine schizophrenic patients were examined to investigate the relationship between regional cerebral blood flow (rCBF) and psychopathology according to SANS, SAPS and BPRS scores. Using the Tc-99m HMPAO SPECT method at rest, rCBF was assessed in 15 patients with predominantly positive (group I) and 14 with predominantly negative (group II) symptoms. Ten age-matched normal healthy volunteers comprised the control group. …

Determination Of Some Population Parameters And Reproduction Period Of Whiting (Merlangius Merlangus Euxinus Nordmann, 1840) On The Trabzon-Yomra Coast In The Eastern Black Sea, Erhan Çi̇loğlu, Cemaletti̇n Şahi̇n, Mustafa Zengi̇n, Yaşar Genç

Turkish Journal of Veterinary & Animal Sciences

In this study, the growth, age composition, sex ratio, condition factor and spawning period of whiting (Merlangius merlangus euxinus Nordmann, 1840) on the eastern part of the Trabzon-Yomra coast were investigated. During the study, a total of 1730 fish (1122 females and 608 males) ranging in age from group I to IX were examined. The chi squared test was used to calculate ratios between female and male specimens and no significant difference was found (P>0.05), and the relative growth length and the relative growth weight differences between females and males were not found to be statistically significant (P>0.05). …

Bovine Tuberculosis In Brushtail Possums (Trichosurus Vulpecula): Studies On Vaccination, Experimental Infection, And Disease Transmission, L. A. L. Corner

Michigan Bovine Tuberculosis Bibliography and Database

The objectives of the research program were to obtain a better understanding of BCG as a tuberculosis vaccine in possums, and assess its potential as a tool for controlling tuberculosis in wild possum populations. A series of vaccination and challenge experiments were conducted, as well as studies on alternative experimental infection procedures. The program included two field studies, one on the epidemiology of tuberculosis in a population of possums regenerating after localised possum eradication, and the other examined the efficacy of BCG vaccine in a wild population in which tuberculosis was endemic.

The first experiments confirmed the earlier published findings …

Movement Patterns And Behavior At Winter-Feeding And Fall Baiting Stations In A Population Of White-Tailed Deer Infected With Bovine Tuberculosis In The Northeastern Lower Peninsula Of Michigan, Mark Stephen Garner

Michigan Bovine Tuberculosis Bibliography and Database

In 1994 bovine tuberculosis (Mycobacterium bovis) was discovered in a single free ranging white-tailed deer (Odocoileus virginianus) in northeastern Michigan (Deer Management Unit 452 @MU 452)). By the end of the 2000 hunting season, 325+ deer within the DMU 452 had been detected with M. bovis and it was generally believed that the disease had radiated from a single focus of infection. However, the presence of three TB positive deer discovered in 1999 well outside of DMU 452 suggested that M. bovis may be endemic at extremely low levels in Michigan white-tailed deer.

The primary mode …

Out Of Africa: Origins Of The Taenia Tapeworms In Humans, Eric P. Hoberg, Nancy L. Alkire, Alan De Queiroz, Arlene Jones

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Phylogenetic and divergence date analyses indicate that the occurrence of Taenia tapeworms in humans pre-dates the development of agriculture, animal husbandry and domestication of cattle (Bos spp.) or swine (Sus scrofa) Taeniid tapeworms in Africa twice independently colonized hominids and the genus Homo prior to the origin of modern humans. Dietary and behavioural shifts, from herbivory to scavenging and carnivory, as early Homo entered the carnivore guild in the Pliocene/Pleistocene, were drivers for host switching by tapeworms to hominids from carnivores including hyaenids and felids. Parasitological data provide a unique means of elucidating the historical ecology, foraging behavior …

Legionella Pneumophila Entry Gene Rtxa Is Involved In Virulence, Suat L. G. Cirillo, Luis E. Bermudez, Sahar H. El-Etr, Gerald Duhamel, Jeffrey D. Cirillo

School of Veterinary and Biomedical Sciences: Faculty Publications

Successful parasitism of host cells by intracellular pathogens involves adherence, entry, survival, intracellular replication, and cell-to-cell spread. Our laboratory has been examining the role of early events, adherence and entry, in the pathogenesis of the facultative intracellular pathogen Legionella pneumophila. Currently, the mechanisms used by L. pneumophila to gain access to the intracellular environment are not well understood. We have recently isolated three loci, designated enh1, enh2, and enh3, that are involved in the ability of L. pneumophila to enter host cells. One of the genes present in the enh1 locus, rtxA, is homologous to repeats …

Mutation Of The Gene Encoding Cytotoxic Necrotizing Factor Type 1 (Cnf1) Attenuates The Virulence Of Uropathogenic Escherichia Coli, Karen E. Rippere-Lampe, Alison D. O'Brien, Richard Conran, Hank A. Lockman

Uniformed Services University of the Health Sciences

Cytotoxic necrotizing factor type 1 (CNF1) is a 115-kDa toxin that activates Rho GTPases and is produced by uropathogenic Escherichia coli (UPEC). While both epidemiological studies that link CNF1 production by E. coli with urinary tract disease and the cytopathic effects of CNF1 on cultured urinary tract cells are suggestive of a role for the toxin as a UPEC virulence factor, few in vivo studies to test this possibility have been reported. Therefore, in this investigation, we evaluated the importance of CNF1 in a murine model of urinary tract infection (UTI) by comparing the degree of colonization and damage induced …

Salmonella Typhimurium Translocates Flagellin Across Intestinal Epithelia, Inducing A Proinflammatory Response, Andrew T. Gewirtz, Peter O. Simon Jr., Clare K. Schmitt, Laura J. Taylor, Curt H. Hagedorn, Alison D. O'Brien, Andrew S. Neish, James L. Madara

Uniformed Services University of the Health Sciences

This study investigated whether soluble paracrine factors mediated Salmonella-induced IL-8 expression in polarized model intestinal epithelia. We found that the basolateral media of model epithelia that had been apically infected with Salmonella typhimurium for a short period (10 minutes) could activate IL-8 secretion in virgin model epithelia, demonstrating that a proinflammatory factor (PIF) was indeed present. Initial characterization found that PIF was a heat-stable protein with a molecular mass of about 50 kDa that acts on the basolateral, but not apical, surface of model intestinal epithelia to elicit IL-8 secretion. PIF was not present in the media of model …

Kronos [2001], State University Of New York At Stony Brook, School Of Medicine

Kronos (School of Medicine)

This edition of Kronos, published in 2001, is the official yearbook of the State University of New York at Stony Brook, School of Medicine. Hard-bound.

Crossing The Line: Case Studies Of Identity Development In First Generation College Women, Phyllis A. Wentworth, Bill E. Peterson

Psychology: Faculty Publications

In this paper we present four case studies of adult women from working class backgrounds who attended Hillside College (a pseudonym for one of the “seven-sister” colleges) during the early 1990s. Although research on women has led, over the past few decades, to a more complex picture of the contexts in which women develop their identities, one important context that has been underexplored is social class. Drawing on data from three lengthy interviews with each of our four participants, our purpose was to explore the identity concerns of adult women from working class backgrounds in their experience getting to and …

The Girl Who Cried Pain: A Bias Against Women In The Treatment Of Pain, Diane E. Hoffmann, Anita J. Tarzian

Faculty Scholarship

In general, women report more severe levels of pain, more frequent incidences of pain, and pain of longer duration than men, but are nonetheless treated for pain less aggressively. The authors investigate this paradox from two perspectives: Do men and women in fact experience pain differently - whether biologically, cognitively, and/or emotionally? And regardless of the answer, what accounts for the differences in the pain treatment they receive, and what can we do to correct this situation?

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 2001), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 2001 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Opening Remarks
• In the Mail
• PCOM Updates
• Meet the Prez
• This Doctor Gets Personal
• Founders Day Honorees
• PCOM MEDNet
• Board Profile
• Alumni Board Profile
• Off to Camp – With Some Very Special Children
• Class Notes
• In Memoriam
• My Turn: New Essay Section
• 2^nd Annual PCOM Alumni Weekend
• Coming Events

Human Health Improvement In Sub-Saharan Africa Through Integrated Management Of Arthropod Transmitted Diseases And Natural Resources., J. Baumgärtner, M. Bieri, G. Buffoni, G. Gilioli, H. Gopalan, J. Greiling, G. Tikubet, I. Van Schayk

All Peer-Reviewed Publications

A concept of an ecosystem approach to human health improvement in Sub-Saharan Africa is presented here. Three factors mainly affect the physical condition of the human body: the abiotic environment, vector-transmitted diseases, and natural resources. Our concept relies on ecological principles embedded in a social context and identifies three sets of subsystems for study and management: human disease subsystems, natural resource subsystems, and decision-support subsystems. To control human diseases and to secure food from resource subsystems including livestock or crops, integrated preventive approaches are preferred over exclusively curative and sectorial approaches. Environmental sustainability - the basis for managing matter and …

The Effect Of Supportive-Educative Nursing Interventions On The Hospital Readmission Rates Of Patients With Heart Failure, Patrice M. Whitaker

Masters Theses

The prevalence of heart failure (HF) is increasing and patients with HF are frequently readmitted to hospitals soon after discharge, at great cost. Improving self-care and reducing hospitalizations in this group is vital. This study, based on Dorothea Orem’s ( 1995) self-care deficit theory, evaluated supportive-educative vs. placebo nursing interventions. The study results were drawn from a larger longitudinal study done by Dr. Kay Setter-Kline, Ph.D., R.N.

The study sought to determine if supportive-educative nursing interventions reduced the rehospitalization rate for patients with HF. The Self-Management Tool was utilized for data collection, after being adapted from the Chronic Disease Self-Management …

Parental Compliance: Its Role In Terimination Of Parental Rights Cases, Eve M. Brank, Angela L. Williams, Victoria Weisz, Robert E. Ray

Department of Psychology: Faculty Publications

This Article examines the current state of termination of parental rights law, along with the results of an appellate case review, an exploratory project, and an empirical investigation of decision-making related to these cases. Section I begins with an overview of termination of parental rights law. The focus of this section will be recent statutory changes in the area, highlighting some key differences between the former and the current law. In Section II, the focus shifts to a review of the foundations for the empirical study that will be described later in the Article. Section III more specifically addresses the …

Vireo Song Repertoires And Migratory Distance: Three Sexual Selection Hypotheses Fail To Explain The Correlation, D. James Mountjoy, Daniel Leger

Department of Psychology: Faculty Publications

Previous studies have found a relationship between migration and the degree of elaboration of sexually selected traits, but investigators have differed in the mechanisms they proposed to account for this association. We examined the relationship between song repertoire size and distance migrated among birds in the genus Vireo. There is a strong positive relationship between migratory distance and repertoire size in this genus, but our data do not support the specific predictions of any of the three proposed mechanisms (the “rapid pairing,” “good migrations,” and “territory lottery” hypotheses). Migration distance is presumably correlated with other life-history characteristics that influence the …