Digital Commons Network^™

Impaired Differentiation Of Osteoclasts In Trem-2–Deficient Individuals, Marina Cella, Cecilia Buonsanti, Carey Strader, Takayuki Kondo, Andrea Salmaggi, Marco Colonna

Open Access Publications

No abstract provided.

Antiadhesive Role Of Apical Decay-Accelerating Factor (Cd55) In Human Neutrophil Transmigration Across Mucosal Epithelia, Donald W. Lawrence, Walter J. Bruyninckx, Nancy A. Louis, Douglas M. Lublin, Gregory L. Stahl, Charles A. Parkos, Sean P. Colgan

Open Access Publications

No abstract provided.

Involvement Of Fatty Acid Pathways And Cortical Interaction Of The Pronuclear Complex In Caenorhabditis Elegans Embryonic Polarity, Chad A. Rappleye, Akiko Tagawa, Nathalie Le Bot, Julie Ahringer, Raffi V. Aroian

Open Access Publications

No abstract provided.

Analysis And Functional Classification Of Transcripts From The Nematode Meloidogyne Incognita, James P. Mccarter, Makedonka Dautova Mitreva, John Martin, Mike Dante, Todd Wylie, Uma Rao, Deana Pape, Yvette Bowers, Brenda Theising, Claire V. Murphy, Andrew P. Kloek, Brandi J. Chiapelli, Sandra W. Clifton, David Mck Bird, Robert H. Waterston

Open Access Publications

No abstract provided.

Power, Knowledge And Childbirth Practices : An Ethnographic Exploration In Bangladesh, Kaosar Afsana

Theses: Doctorates and Masters

The intent of this study is to explore why and in what ways rural, poor women in Bangladesh adhere to indigenous birth practices and resist cosmopolitan obstetric care. To understand the complexities of childbirth, a multidimensional framework encompassing culture, gender, socio-economic, political economy and historical perspectives is used. I used ethnographic methods to have deeper understanding of childbirth practices predominantly from women's voices, but strengthened by multiple other voices and my observational experiences. I gathered information in Apurbabari village, the adjacent Thana Health Complex and the Medical College Hospital using in-depth interviews and participant observation, in particular.

Covert Violence In Nursing, Susette Bakker

Theses: Doctorates and Masters

There is no official avenue in nursing for the reporting of incidences of covert violence to staff and so they remain unrecorded and often stressful. This study sought to collect data from currently employed nurses concerning covert violence in their workplace, and to collate the information to obtain a valid assessment of this hidden problem. A qualitative methodology was used to report on the experiences of nurses in relation to covert violence directed at them by their peers, other health professionals, patients and patients' families. The participants were all registered nurses employed by a suburban health service. Each was given …

Occupational Hazards And Radiation Safety In Veterinary Practice Including Zoo Veterinary Practice In Australia, Joseph S. Jeyaretnam

Theses: Doctorates and Masters

This thesis contains reviews and research on the occupational hazards of zoo veterinary practitioners in Australia. Although occupational hazards have long been recognised in the veterinary profession, little information is available on the number and magnitude of injuries to veterinarians in Australia, the United Kingdom or the United States. Apart from anecdotal accounts and some limited data, most of the available information is on occupational zoonoses, generally well recognized by veterinarians. Other occupational hazards to which veterinarians are exposed have received scant attention. The veterinary practitioner in a zoo environment has to treat a range of captive wild species which …

Cell Surface Glycoprotein Pzr Is A Major Mediator Of Concanavalin A-Induced Cell Signaling, Runxiang Zhao, Abdelmadjid Guerrah, Hua Tang, Z. Joe Zhao

School of Medical and Biological Sciences Faculty Publications and Presentations

PZR is an immunoglobulin superfamily cell surface protein containing a pair of immunoreceptor tyrosine-based inhibitory motifs. As a glycoprotein, PZR displays a strong association with concanavalin A (ConA), a member of the plant lectin family. Treatment of several cell lines with ConA caused tyrosine phosphorylation of a major cellular protein. Immunoblotting and immunoprecipitation studies indicated that this protein corresponded to PZR. Tyrosine phosphorylation of PZR was accompanied by recruitment of SHP-2 and was inhibited by PP1, a selective inhibitor of the Src family tyrosine kinases. Furthermore, c-Src was constitutively associated with PZR and was activated upon treatment of cells with …

Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase with or without a substrate bound in the active site.

Feline Immunodeficiency Virus Integration In B-Cell Lymphoma Identifies A Candidate Tumor Suppressor Gene On Human Chromosome 15q151, Julia Beatty, Anne Terry, Julie Macdonald, Elizabeth Gault, Stanley Cevario, Stephen J. O'Brien, Ewan Cameron, James C. Neil

Biology Faculty Articles

Infection with immunosuppressive lentiviruses is associated with increased cancer risk,but most studies have implicated indirect mechanisms as the tumor cells generally lack integrated viral sequences.An exception wasfound in a B-cell lymphoma (Q254) where the tumor cells contained a single integrated feline immunodeficiency virus genome. Additional analysis now indicates that feline immunodeficiency virus integration in lymphoma Q254 resulted in promoter insertion and truncation of a conserved gene on feline chromosome B3, whereas the unaffected allele of the gene appeared to be transcriptionally down-regulated. The orthologous human gene (FLJ12973), is expressed ubiquitously and encodes a WD-repeat protein with structural similarity …

Dose-Response Effects Of Lithium On Spatial Memory In The Black Molly Fish., Thomas Kyle Creson

Electronic Theses and Dissertations

Lithium continues to be widely prescribed for the management of bipolar disease, yet cognitive impairment-related side effects promote noncompliance of the treatment regimen. We have introduced a novel animal model, the black molly fish, to study dose-response effects of lithium on short-term (STM) and long-term (LTM) memories. We developed a method utilizing capillary ion analysis (CIA), to measure plasma and brain lithium levels employed in our behavioral studies. We then developed an appropriate testing environment to ascertain learning capacities of these fish. We established that black mollies could adequately perform a forced-choice spontaneous alternation (SA) task used extensively in rodents …

Activation Of Ca2+-Activated K+ Channels And Cell Migration By Hepatocyte Growth Factor/Scatter Factor In Madin-Darby Canine Kidney Cells., Min Jin

Electronic Theses and Dissertations

Hepatocyte Growth Factor/Scatter Factor (HGF/SF) stimulates migration of various cells and has been linked via Met tyrosine kinase signaling to transformation and the metastatic phenotype. HGF/SF-Met signaling also plays a role in malignancy. Migration of transformed MDCK-F cells depends on activation of a charybdotoxin (ChTX)-sensitive, volume-activated membrane K⁺ current. Patch-clamp electrophysiology and transwell migration assays were used to study the effects of HGF/SF on membrane K⁺ currents and cell migration in MDCK II cells. HGF/SF activated membrane K⁺ currents that increased over 24 hr, and these could be modulated by altering intracellular free calcium concentration [Ca^{2+ …}

Louisiana State University Health Sciences Center - 2002 - 122nd Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 122nd Commencement of LSU Health Sciences Center - New Orleans held December 12, 2002.

Abalone Cultivation In Thailand: A Case Study, Nattakan Tun, Perasut Pianpijit, Suksan Juhong, Channarong Rodkum, Janenuj Wongtavatchai

The Thai Journal of Veterinary Medicine

Abalone are high cost seafoods regarded as delicacy. The decline of world abalone fishery has initiated the development of cultured abalone production in some countries. Thailand possesses geographical areas which are suitable for abalone habitats and the commercial abalone farming is currently promoted by the government. Commercial fishery for abalone in Thailand are presently unfamiliarity of their biology. This report describes the basis biology of abalone, development of abalone culture in tropical regions; selection and management of broodstock, in tank spawning, rearing of larvae through grow-out culture of advanced juveniles, to meet the requirement of consumers' seafood standard.

Description Of A Poorly Differentiated Carcinoma Within The Brainstem Of A White Whale (Delphinapterus Leucas) From Magnetic Resonance Images And Histological Analysis, Sam H. Ridgway, Lori Marino, T. P. Lipscomb

Veterinary Science and Medicine Collection

In this study we used magnetic resonance imaging (MRI) to investigate neuroanatomical structure in the brain of a white whale (Delphinapterus leucas) that died from a large tumor within the brainstem. This specimen was also compared with a normal white whale brain using MRI. MRI scans of the white whale specimen show how the tumor deformed surrounding brain structure. Histopathological analysis indicated a poorly differentiated carcinoma of uncertain origin. These analyses demonstrate the usefulness of supplementing histological analyses of pathology with studies of gross morphology facilitated by MRI.

Neuroanatomy Of The Common Dolphin (Delphinus Delphis) As Revealed By Magnetic Resonance Imaging (Mri), L. Marino, Keith Sudheimer, D. Ann Pabst, William A. Mclellan, David Filsoof, John I. Johnson

Veterinary Science and Medicine Collection

In this study, magnetic resonance (MR) images of the brain of an adult common dolphin (Delphinus delphis) were acquired in the coronal plane at 66 antero-posterior levels. From these scans a computer-generated set of resectioned virtual images in orthogonal planes was constructed using the programs VoxelView and VoxelMath (Vital Images, Inc., Michigan State Univ.). Sections in all three planes reveal major neuroanatomical structures. These structures in the adult common dolphin brain are compared with those from a fetal common dolphin brain from a previously published study as well as with MR images of adult brains of other odontocetes. …

Mentha (Lamiaceae) Phylogenetic Analysis Using Chloroplast Trnl-Trnf And Nuclear Ribosomal Dna Its Sequences, Jiranan Bunsawatt

Masters Theses & Specialist Projects

Mentha (Nepetoideae, Lamiaceae) is a taxonomically complex genus that includes economically important members such as spearmint and peppermint and species of global conservation interest. Mentha is considered challenging systematically due to its high incidence of polyploidy, diverse morphology, variation in base chromosome number, and frequent interspecific hybridization. Our objectives were to test the monophyly of Mentha and each of its traditionally recognized sections, assess phylogenetic relationships of the Mentha species, test hypotheses of hybridization for the putative stabilized allopolyploids (M spicata and M. canadensis), and determine the ancestral base chromosome number using DNA sequence data from the chloroplast trnL-trnF and …

Review Of "The Human Embryonic Stem Cell Debate: Science, Ethics, And Public Policy (Basic Bioethics)," Edited By Suzanne Holland, Karen Lebacqz, And Laurie Zoloth, James Steele

The University of New Hampshire Law Review

[Excerpt] "Perhaps like others, I started "The Human Embryonic Stem Cell Debate" not knowing many of the finer points of embryonic stem cell research, but I certainly had an opinion. This issue is far more complex than I had initially imagined. The editors do a commendable effort of compiling a sample of the innumerable arguments surrounding the debate."

Roles And Regulation Of Nf-Κb In Platelet-Derived Growth Factor Transformed Cells, Takeshi Shimamura

Dissertations

Platelet-derived growth factor (PDGF) is overexpressed in various cancer cells and the overexpression may be correlated with the prognosis of several types of cancers. Binding of PDGF to its receptors induces receptor dimerization and subsequent autophosphorylation of tyrosine residues in the receptor’s cytoplasmic domains. The phosphorylated tyrosine residues interact with the secondary signaling molecules to initiate signaling cascades that trigger cellular changes by affecting downstream effectors. In our recent publication, we have shown that a NF-κB mediates the transformation of mouse fibroblast cells overexpressing PDGF B chain. Though there is a significant correlation between PDGF stimulation and NF-κB activity, it …

Acknowledgements, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Implementation Of Gy-Eq For Deterministic Effects Limitation In Shield Design, John W. Wilson, Myung-Hee Y. Kim, Giovanni De Angelis, Francis A. Cucinotta, Nobuaki Yoshizawa, Francis F. Badavi

Mathematics & Statistics Faculty Publications

The NCRP has recently defined RBE values and a new quantity (Gy-Eq) for use in estimation of deterministic effects in space shielding and operations. The NCRP's RBE for neutrons is left ambiguous and not fully defined. In the present report we will suggest a complete definition of neutron RBE consistent with the NCRP recommendations and evaluate attenuation properties of deterministic effects (Gy-Eq) in comparison with other dosimetric quantities.

Co-Occurring Disorders And Selective Substance Use In Females Ages 10 To 25 Diagnosed With Attention Deficit Hyperactivity Disorder, Nancy A. Clinton

Dissertations

The paucity o f research on females diagnosed with attention deficit hyperactivity disorder (ADHD) precipitated this exploratory investigation into co-occurring disorders and selective substance use in females (n = 70), ranging in age between 10 and 25, diagnosed with ADHD and substance use disorder (SUD). Data extracted from archived substance abuse treatment center records were tested via chi-square analyses to determine proportional differences between frequencies in predetermined co-occurring disorder groups (disruptive behavior disorders, moodanxiety disorders, and learning disorders) and predetermined substance groups (stimulant, depressant, and cannabis) for the total ADHD cohort and for specific diagnoses (inattentive, hyperactive-impulsive, combined, and with …

Historical Development Of The Linear Nonthreshold Dose-Response Model As Applied To Radiation, Ronald L. Kathren

The University of New Hampshire Law Review

[Excerpt] "Despite the nearly universal adoption of the linear nonthreshold dose response model (LNT) as the primary basis for radiation protection standards for the past half century, the LNT remains highly controversial and a contentious topic of discussion among health physicists, radiation biologists, and other radiological scientists. Indeed, it has been pointed out that the LNT has assumed the status of a paradigm, synonymous with an ideal, standard, or paragon or perhaps to some, a sacred cow. Reduced to its very basics, the LNT postulates that every increment of ionizing radiation dose, however small, carries with it a commensurate increase …

A New Immunoassay For Quantification Of A Novel Cancer Antigen In Serum And Immunostaining Of Carcinoma Tissues And Cultured Cells Revealing The Antigenic Cellular Location., Emily Christine Mcduffee

Electronic Theses and Dissertations

The purpose of this study is 1) to examine the presence of the antigen in serum by employing a newly developed ELISA immunoassay that quantifies the total antigen and bound antigen (antigen-antibody complex) using polyclonal chicken antibodies directed against an IgM-binding epitope of the new antigen, and 2) to determine the location of the antigen in carcinoma and normal cells. Sera from healthy volunteers (n = 147) and cancer patients (n = 26) were compared for both bound and total antigen concentrations using the new ELISA. Healthy volunteers were subdivided into three groups: those with a personal history of cancer …

Urinary Excretion Of Dithiocarbamates And Selfreported Cruciferous Vegetable Intake: Application Of The ‘Method Of Triads’ To A Foodspecific Biomarker, Jay H. Fowke, James R. Hébert, Jed W. Fahey

Faculty Publications

Objective: Greater intake of Cruciferous vegetables (e.g. broccoli) may prevent cancer at several sites. Urinary excretion of isothiocyanate conjugates (dithiocarbamates, DTC) provides a specific biomarker of Cruciferous vegetable consumption suitable for epidemiological investigations. However, no gold-standard referent is available for evaluating urinary DTC levels as an estimator of Cruciferous vegetable consumption. We compared urinary DTC levels to intake as measured by two selfreported dietary assessment techniques. Design: Cruciferous vegetable consumption was measured before and after a behavioural dietary intervention using multiple 24-hour recalls (24HR), a foodcounting questionnaire (VFQ) and urinary DTC excretion levels. Analysis included a structural equation approach (Method …

Arkansas Animal Science Department Report 2002, Zelpha B. Johnson, D. Wayne Kellogg

Arkansas Agricultural Experiment Station Research Series

No abstract provided.

Special Education Teachers' And Speech Therapists' Knowledge Of Autism Spectrum Disorder., Carol Hendrix Whaley

Electronic Theses and Dissertations

The purpose of this study was to survey special education teachers and speech therapists in eleven school districts in Northeast Tennessee regarding their knowledge level (etiology and educational programming) of autism spectrum disorder (ASD). The primary focus of the study was to identify effective programs and methods used by special educators in this region, comparing them to the latest techniques and teaching methods prescribed by recent research. In addition, identified weaknesses were used to recommend future training and staff development to enable educators to provide the best possible programs for children with autism.

Five hundred fifty-two surveys were disseminated to …

Depression: A Decade Of Progress, More To Do, Veronica V. Goff

National Health Policy Forum

This issue brief discusses the most recent findings on depression prevalence and cost; examines trends in outpatient treatment, including the dramatic growth in antidepressant use; discusses efforts to improve treatment in primary care; and explores possible public policy avenues for improving treatment access and quality.

Medical Education Digest, Vol. 4 No. 6 (November 15, 2002), Nova Southeastern University

Medical Education Digest

No abstract provided.

Prescription Drugs In Nursing Homes: Managing Costs And Quality In A Complex Environment, Dan Mendelson, Rajeev Ramchand, Richard Abramson, Anne Tumlinson

National Health Policy Forum

This issue brief provides a description of prescription drug use in nursing homes and a summary of policy issues in this area. It first profiles the nursing home pharmaceutical market, outlining the major trends in demographics and drug utilization, the supply chain by which drugs go from manufacturers to pharmacies to nursing home residents, and the alternative arrangements by which prescription drugs in nursing homes are financed. The paper then provides a synopsis of current policy issues, focusing in turn on cost containment and quality improvement initiatives.