Digital Commons Network^™

Vav1/2/3-Null Mice Define An Essential Role For Vav Family Proteins In Lymphocyte Development And Activation But A Differential Requirement In Mapk Signaling In T And B Cells, Keiko Fujikawa, Ana V. Miletic, Frederick W. Alt, Roberta Faccio, Tracie Brown, Jeremy Hoog, Jessica Fredericks, Shinzo Nishi, Shirly Mildiner, Sheri L. Moores, Joan Brugge, Fred S. Rosen, Wojciech Swat

Open Access Publications

No abstract provided.

Midwest Alcoholism Research Center: Future Directions, Andrew C. Heath

Posters

No abstract provided.

Ethical Curriculum Development And Teaching, Mary Eunice Mcbean

Theses Digitization Project

The purpose of this project is to develop a curriculum, which will examine the ethical methods or practices used by nurses in resolving ethical dilemmas in clinical practice utilizing the Moral Decision-Making Model for staff nurses at St.Bernardine Medical Center, Five Tower North.

Inadequate Substance Abuse Assessment As A Contributory Factor To Child Abuse And Neglect, Gary Eugene Graves

Theses Digitization Project

This study examined an important, yet underreported, area of family service agency assessments, the failure to adequately screen for substance abuse issues. A self-report screening instrument was used to accurately determine substance abuse frequency rates, instead of using the current clinician-directed questioning. New agency clients were randomly assigned to either the experimental group (self-report) or the control group (clinician-directed) to determine if assessment accuracy improved.

Social Phobia : Examining The Empirical Shortcomings Of The Most Prevalent Anxiety Disorder, Randall P. Schultz

Graduate Research Papers

Social phobia, which is notably the fear of being negatively evaluated, humiliated, or embarrassed by others in social situations, has become the most prevalent anxiety disorder and the third most diagnosed mental disorder in the nation (Orsillo & Hammond, 2001). Although social phobia is no longer considered to be the "neglected" anxiety disorder (Liebowitz, Gorman, Fyer, & Klein, 1987), it remains an often undertreated, misunderstood, and understudied anxiety disorder (Cuthbert, 2002). The purpose of this paper is to examine the numerous discrepancies and shortcomings within social phobia literature in regards to defining, diagnosing, measuring, and treating social phobia. Recommendations are …

The Effect Of Mirthful Laughter On Stress And Natural Killer Cell Activity, Mary P. Bennett, Janice M. Zeller, Lisa Rosenberg, Judith Mccann

Nursing Faculty Publications

No abstract provided.

Seasonal Prevalence Of Mosquitoes Collected From Light Traps In Korea (1999-2000), Kim Heung Chul, Kwan Woo Lee, Robert S. Richards, Sonya S. Schleich, William E. Herman, Terry A. Klein

United States Army: Publications

The Entomology Section, 5th Medical Detachment (MED DET) (Preventive Medicine) (PM), in coordination with the Department of Public Works (DPW), 8th US Army-Engineers, conducted annual mosquito surveillance programs at US military installations in the Republic of Korea (ROK) in accordance with Army Regulation (AR) 40-5 (Department of the Army, 1990). Mosquito populations and species distributions throughout the ROK, especially vector species, is of primary importance to US and ROK militaries since each expends substantial amounts of manpower and pesticides for mosquito control to reduce potential health risks to military personnel. Currently, the primary mosquito-borne disease of greatest concern in the …

The Process And Perspective Of The Therapist In The Treatment Of Self-Mutilation, Megan M. Parketon

Graduate Research Papers

Research for the past 35 years has involved inpatient mentally ill persons who have been institutionalized. Treatment for self-mutilation has also focused primarily on mentally ill and mentally retarded patients. There has been little research done on the specific topic of adolescent female self-mutilation. Self-mutilation has become increasingly prevalent among female adolescents.

In this paper the therapist's perspective of treatment and the therapist's process of treatment were researched. Treatment should be tailored to the specific needs of the adolescent and often involved multiple treatments. Eleven styles of treatment were addressed and the qualities that a therapist needs to possess were …

Childhood Depression And Schools, Jeni Barry

Graduate Research Papers

Depression in children is a problem that is becoming more prevalent. With children and adolescents under more stress and pressure than ever before, the seriousness of the issues children deal with is also intensifying. Depression in children is a major concern because it can interfere with school and academics, social functioning, and even lead to somatic symptoms. If depression is left untreated it can lead to other mental disorders. An important concern is that children who are depressed are at great risk of suicide. Population studies show that at any one time between 10 and 15 percent of the child …

Health And Environmental Effects Of Landfilling And Incineration Of Waste - A Literature Review, D. Crowley, A. Staines, C. Collins, J. Bracken, M. Bruen, J Fry, Victor Hrymak, D. Malone, B. Magette, M. Ryan, C Thunhurst

Reports

A literature review on the health effects of landfill and incineration is presented together with an application to Ireland of the findings

Farm Disease Crises In The United Kingdom: Lessons To Be Learned, Michael C. Appleby

State of the Animals 2003

Over the last fifteen years, a diverse succession of disease-related crises has befallen farm animal and food industries in the United Kingdom. Some have involved animal health, with little risk to humans. Some have involved human health, with animals acting as a reservoir for infection but little affected themselves. Some, however— including the most alarming— have involved both animal and human health through zoonoses, diseases transmittable from animal to human. All of these crises are linked in the public mind and in many commentaries, and indeed there are issues that many of them share. The most common of these is …

What It Is To Be A Dog: A Qualitative Method For The Study Of Animals Other Than Humans, Kenneth J. Shapiro

Experimentation Collection

No abstract provided.

Toxicology And New Social Ethics For Animals, Bernard E. Rollin

Experimentation Collection

The issue of animal treatment has emerged as a major social concern over the past three decades. This ramified in a new ethic for animal treatment that goes beyond concern about cruelty and attempts to eliminate animal pain and suffering, whatever its source. This is evidenced by laws governing animal research in many countries. Insofar as toxicology can entail significant and prolonged animal suffering, it is at loggerheads with this new ethic. Ways are suggested for the toxicological community to put itself in harmony with the ethic and thereby preserve its autonomy.

Nsu Achievements - Winter 2003, Nova Southeastern University

NSU Achievements

No abstract provided.

Ehrlichia Chaffeensis: A Prototypical Emerging Pathogen, Christopher D. Paddock, James E. Childs

Zoonotics and Wildlife Disease: Publications

In April 1986, a medical intern scanning the peripheral blood smear of a severely ill man with an unexplained illness observed peculiar intracytoplasmic inclusions in several of the patient’s monocytes. The patient described multiple tick bites sustained approximately 2 weeks earlier during a visit to a rural area in northern Arkansas, and a presumptive diagnosis of Rocky Mountain spotted fever had been made (104, 174). Clinicians and scientists subsequently identified these inclusions as clusters of bacteria belonging to the genus Ehrlichia, previously known in the United States solely as veterinary pathogens (174). Within the next 5 years, the organism …

Cd21-Positive Follicular Dendritic Cells A Possible Source Of PrpSc In Lymph Node Macrophages Of Scrapie-Infected Sheep, Lynn M. Herrmann, William P. Cheevers, William C. Davis, Donald P. Knowles, Katherine I. O'Rourke

Zoonotics and Wildlife Disease: Publications

Natural sheep scrapie is a prion disease characterized by the accumulation of PrP^Sc in brain and lymphoid tissues. Previous studies suggested that lymph node macrophages and follicular dendritic cells (FDC) accumulate PrP^Sc. In this study, lymph nodes were analyzed for the presence of PrP^Sc and macrophage or FDC markers using dual immunohistochemistry. A monoclonal antibody (mAb) to the C-terminus of PrP reacted with CD172a+ macrophages and CD21+ FDC processes in secondary follicles. However, a PrP N-terminus- specific mAb reacted with CD21+ FDC processes but not CD172a+ macrophages in secondary follicles. Neither the PrP N-terminus nor C-terminus-specific …

Effects Of Childhood Exposure To Paternal Alcoholism On Substance Use Disorders In Adolescents And Young Adults, A. E. Duncan, Q. Fu, Kathleen K. Bucholz, J. F. Scherrer, T. Jacob, W. R. True

Posters

No abstract provided.

A Mathematical Model Of Immune Response To Tumor Invasion, Lisette De Pillis, Ami Radunskaya

All HMC Faculty Publications and Research

Recent experimental studies by Diefenbach et al. [1] have brought to light new information about how the immune system of the mouse responds to the presence of a tumor. In the Diefenbach studies, tumor cells are modified to express higher levels of immune stimulating NKG2D ligands. Experimental results show that sufficiently high levels of ligand expression create a significant barrier to tumor establishment in the mouse. Additionally, ligand transduced tumor cells stimulate protective immunity to tumor rechallenge. Based on the results of the Diefenbach experiments, we have developed a mathematical model of tumor growth to address some of the questions …

Santa Clara Magazine, Volume 45 Number 3, Winter 2003, Santa Clara University

Santa Clara Magazine

10 - ACADEMIC EXCELLENCE AT SCU By Paul Locatelli, S.J. ln an adaptation of his convocation address, SCU 's president describes the University's goal to educate "the whole person."

12 - 'BECKHAM' BOOSTS SCU SOCCER By Victoria Hendel De La O. References to SCU in the hit movie have brought international attention to the women's soccer program.

14 - SEEKING SOLUTIONS Experts vi sit campus to discuss the issue of clergy abuse and work on a book about the topic.

18 - UNEARTHING THE PAST By Connie Skipitares. SCU archaeologists, anthropologists, and students probe a site near campus to learn …

Differential Requirement For The Nonhelical Tailpiece And The C Terminus Of The Myosin Rod In Caenorhabditis Elegans Muscle, Pamela E. Hoppe, Rebecca C. Andrews, Payal D. Parikh

Open Access Publications

No abstract provided.

Osteopontin Deficiency Produces Osteoclast Dysfunction Due To Reduced Cd44 Surface Expression, M. A. Chellaiah, N. Kizer, R. Biswas, U. Alvarez, J. Strauss-Schoenberger, L. Rifas, S. R. Rittling, D. T. Denhardt, K. A. Hruska

Open Access Publications

No abstract provided.

Lens Connexins Α3cx46 And Α8cx50 Interact With Zonula Occludens Protein-1 (Zo-1), Peter A. Nielsen, Amos Baruch, Valery I. Shestopalov, Ben N.G. Giepmans, Irene Dunia, E. Lucio Benedetti, Nalin M. Kumar

Open Access Publications

No abstract provided.

Down-Regulation Of Cd46 By Piliated Neisseria Gonorrhoeae, Darcy B. Gill, Michael Koomey, Janne G. Cannon, John P. Atkinson

Open Access Publications

No abstract provided.

Targeted Inactivation Of The Il-4 Receptor Α Chain I4r Motif Tromotes Allergic Airway Inflammation, Frank Blaeser, Paul J. Bryce, Nga Ho, Vidya Raman, Fatma Dedeoglu, Debra D. Donaldson, Raif S. Geha, Hans C. Oettgen, Talal A. Chatila

Open Access Publications

No abstract provided.

Interferon-Producing Cells Fail To Induce Proliferation Of Naive T Cells But Can Promote Expansion And T Helper 1 Differentiation Of Antigen-Experienced Unpolarized T Cells, Anne Krug, Ravi Veeraswamy, Andrew Pekosz, Osami Kanagawa, Emil R. Unanue, Marco Colonna, Marina Cella

Open Access Publications

No abstract provided.

Targeted Chemical Disruption Of Clathrin Function In Living Cells, Howard S. Moskowitz, John Heuser, Timothy E. Mcgraw, Timothy A. Ryan

Open Access Publications

No abstract provided.

Virginia Dental Journal (Vol. 80, No. 3, 2003)

Virginia Dental Journal

No abstract provided.

Monte Carlo Assessments Of Goodness-Of-Fit For Ecological Simulation Models, Lance A. Waller, David Smith, James E. Childs, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

One often develops stochastic ecologic simulation models based on local interactions between individuals or groups and bases systemic conclusions on trends summarized over multiple data sets generated from the model. In many cases, such models generate data sets (“realizations”) each violating the usual assumptions associated with traditional statistical tests of goodness-of-fit, most notably that of independent observations. Monte Carlo hypothesis tests applied to multiple realizations from such models provide appropriate goodness-of-fit tests regardless of within-model peculiarities. The Monte Carlo tests address the question “Do the observed data appear consistent with the model?” in contrast to the usual question “Does the …

Genealogical Relationships Influence The Probability Of Infection With Bovine Tuberculosis And Microgeographic Genetic Structure In Free-Ranging White-Tailed Deer, Julie Anne Blanchong

Michigan Bovine Tuberculosis Bibliography and Database

Zoonoses are of increasing importance to wildlife conservation and human health. It has become increasingly recognized that wildlife ecology plays a key role in disease transmission in wildlife populations. In domestic populations, contacts among individuals are controlled by humans and disease transmission is often density dependent. Unlike domestic animals, wildlife populations often have complex social systems in whch contacts among individuals are not solely density dependent, and can play an important role in the transmission and maintenance of disease.

A Priori Prediction Of Disease Invasion Dynamics In A Novel Environment, Colin A. Russell, David L. Smith, Lance A. Waller, James E. Childs, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

Directly transmitted infectious diseases spread through wildlife populations as travelling waves away from the sites of original introduction. These waves often become distorted through their interaction with environmental and population heterogeneities and by long-distance translocation of infected individuals. Accurate a priori predictions of travelling waves of infection depend upon understanding and quantifying these distorting factors. We assess the effects of anisotropies arising from the orientation of rivers in relation to the direction of disease-front propagation and the damming effect of mountains on disease movement in natural populations. The model successfully predicts the local and large-scale prevaccination spread of raccoon rabies …