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The Effect Of Ultra Low Dose Epidural Analgesia On Newborn Breastfeeding Behaviors, Sharon Radzyminski

Nursing Faculty Publications

Objective: To determine whether a difference in breastfeeding behaviors could be observed between newborns whose mothers received epidural analgesia for labor pain relief and those newborns whose mothers received no pain medication in labor. Design: There were two groups of neonates in this study. One group was born to mothers who received epidural analgesia, and one group was born to mothers who received no pain medication for labor. Both groups were observed for initial breastfeeding behaviors using the Premature Infant Breastfeeding Behavior Scale following birth and at 24 hours. Central nervous system functioning in the newborn was measured with the …

Water Quality Assessment In Cypress Creek Nature Preserve, Jason Flora

Masters Theses & Specialist Projects

Swamps are unique ecological communities that provide many valuable ecosystem services. In Kentucky, however, many swamps were altered by cypress removal and land development in their watersheds. Cypress Creek Swamp, which lies near Paducah in western Kentucky, is a good example of a swamp whose ecological integrity may be threatened by past and current nearby land use practices. This study was conducted to assess the water quality and macro- and microinvertebrate communities in the swamp. Three sites were monitored for temperature, dissolved oxygen, pH, specific conductivity, depth, phosphorus measured as orthophosphate, nitrite (NO2") and nitrate (NO3", NOx collectively), and ammonia …

Positive And Negative Modulatory Roles Of Platelet Endothelial Cell Adhesion Molecule-1 Signaling In Endothelial Cell Migration: Coordination Of Rho Signaling And Targeting Of Shp-2 Tyrosine Phosphatase Activity, Dita Gratzinger

Yale Medicine Thesis Digital Library

Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1), an immunoglobulin family adhesion molecule, is involved in endothelial migration and angiogenesis. We found that PECAM-1 deficient endothelial cells exhibit enhanced nondirected single cell motility and extension formation at the expense of wound-healing migration. These in vitro endothelial behaviors model aspects of highly developmentally and pathophysiologically relevant processes. Wound healing migration may model the reendothelialization of denuded vasculature following balloon angioplasty or the remodeling of vascular endothelium under variant flow conditions, while single cell motility is prominently involved in developmental processes such as endocardial-mesenchymal transition within the cardiac cushion. A specific deficiency of RhoGTP …

The Ignored Disease: The Aids Epidemic 1981–1987, Heather L. Graff, Heather Graff Bloom

College of Journalism and Mass Communications: Theses

Less than six months after Ronald Reagan was inaugurated as the 40th president of the United States, the federal Centers for Disease Control in Atlanta reported pneumocystis carinii pneumonia, in five gay men. In the United States, AIDS was first diagnosed among gay men in New York City and San Francisco. There were several media trends for AIDS coverage in the 1980s. In the early 1980s, AIDS was mainly thought of as a gay-related disease. In the mid- l 980s, AIDS cases were found in hemophiliacs, intravenous drug users and "celebrities." Coverage in the late 1980s focused on heterosexuals and …

Association Of Borrelia Garinii And B. Valaisiana With Songbirds In Slovakia, Klara Hanincova, Veronika Taragelova, Juraj Koci, Stefanie M. Schafer, Rosie Hails, Amy J. Ullmann, Joseph Piesman, Milan Labuda, Klaus Kurtenbach

United States Public Health Resources

In Europe, 6 of the 11 genospecies of Borrelia burgdorferi sensu lato are prevalent in questing Ixodes ricinus ticks. In most parts of Central Europe, B. afzelii, B. garinii, and B. valaisiana are the most frequent species, whereas B. burgdorferi sensu stricto, B. bissettii, and B. lusitaniae are rare. Previously, it has been shown that B. afzelii is associated with European rodents. Therefore, the aim of this study was to identify reservoir hosts of B. garinii and B. valaisiana in Slovakia. Songbirds were captured in a woodland near Bratislava and investigated for engorged ticks. Questing I. ricinus ticks …

The Lived Experience Of Latina Women Giving Birth In The United States, Ana-Maria Gallo Phd

Dissertations

As the Latino community continues to grow in the United States, it is essential that cultural considerations be addressed, particularly in health care. Cultural assessment is of the utmost importance when trying to understand the phenomena of childbirth. Childbirth is one of the most significant events in a woman's life. It is complicated when giving birth in a country other than one's own. Therefore, it is crucial to comprehend and appreciate how culture influences the birth experience. Nurses play an essential role in assisting women of diverse cultures to fulfill their expectations regarding traditions, beliefs, and practices regarding childbirth. The …

The Ethics Of Apology And The Role Of An Ombuds From The Perspective Of A Lawyer, Sharan Lee Levine, Paula A. Aylward

Center for the Study of Ethics in Society Papers

Papers presented for the Center of the Study of Ethics in Society Western Michigan University, March 20, 2003.

Hdl-Associated Estradiol Stimulates Endothelial No Synthase And Vasodilation In An Sr-Bi–Dependent Manner, Ming Gong, Melinda E. Wilson, Thomas Kelly, Wen Su, James Dressman, Jeanie Kincer, Sergey V. Matveev, Ling Guo, Theresa Guerin, Xiang-An Li, Weifei Zhu, Annette M. Uittenbogaard, Eric J. Smart

Pediatrics Faculty Publications

Cardiovascular diseases remain the leading cause of death in the United States. Two factors associated with a decreased risk of developing cardiovascular disease are elevated HDL levels and sex — specifically, a decreased risk is found in premenopausal women. HDL and estrogen stimulate eNOS and the production of nitric oxide, which has numerous protective effects in the vascular system including vasodilation, antiadhesion, and anti-inflammatory effects. We tested the hypothesis that HDL binds to its receptor, scavenger receptor class B type I (SR-BI), and delivers estrogen to eNOS, thereby stimulating the enzyme. HDL isolated from women stimulated eNOS, whereas HDL isolated …

Inside Unlv, Gian Galassi, Richard Morgan, Carol C. Harter

Inside UNLV

No abstract provided.

Oncolog, Volume 48, Number 05, May 2003, Katie Prout Matias, David Galloway, Ryuji Kobayashi Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Proteomics May One Day Revolutionize Cancer Detection, Staging, and Prognosis
• Depression in Patients with Cancer Is a Separate—and Treatable—Illness
• House Call: Facing Fatigue When You Have Cancer: What Can You Do?
• DiaLog: Proteomics: The Creation of a New Field of Study, by Ryuji Kobayashi, PhD, Professor, Department of Molecular Pathology, Director, Proteomics Program

Parent-Adolescent Communication About Sex: Retrospective Reports By Latino College Students, Marcela Raffaelli, Stephanie Green

Department of Psychology: Faculty Publications

Latina female (n = 97) and Latino male (n = 69) college students (M age =21.4 years) completed self-report surveys regarding family of origin experiences, including sexual communication with parents while growing up. Latino parents of this comparatively highly educated sample tended to use direct rather than indirect strategies for communicating about sexuality with their children. Young women reported higher levels of sexual communication with mothers while growing up than did young men, and respondents reported less communication with fathers than mothers. Among young women, sexual communication with mother was positively associated with non-Mexican origin and negatively associated with having …

Competency-Based Education: Implications For Curricular Development Of The Allied Dental Science Program At The Jordan University Of Science And Technology, Suhair Ref' At Obeidat

Dental Hygiene Master's Papers and Projects

Preface:

The content of this document represents a review of the best practices and principles in competency-based dental and allied dental education. This information is offered in the spirit of collegiality with the intent of improving the allied dental education in general and the dental hygiene education in particular in Jordan. Recommendations presented should serve as a basis for discussion and decision-making by all involved in the Allied Dental Science Program education and administration at the Jordan University of Science and Technology, including the Dean of the Applied Medical Sciences Department and the Allied Dental Science Program Director and Faculty.

Direct Evidence For A Membrane Deforming Motif In Endophilin: Implications Beyond Synaptic Vesicle Recycling, Khashayar Farsad

Yale Medicine Thesis Digital Library

Effective neurotransmission is dependent on fast, reproduceable synaptic vesicle recycling. The synaptic vesicle recycling process is a complex event involving both protein-protein, as well as protein-lipid interactions. A central part of the retrieval process of synaptic vesicles lies in the ability of soluble proteins to deform the plasma membrane into a nascent bud which will eventually reform a fully competent synaptic vesicle upon fission. This process involves clathrin-coat proteins, which form a protein scaffold around the vesicle bud, as well as proteins which have more recently been thought to be involved in generating the high curvature membranes present at the …

Addressing The Decline In Reproductive Performance Of Lactating Dairy Cows: A Researcher’S Perspective, William J. Silvia

Animal and Food Sciences Faculty Publications

No abstract provided.

Lysosomal Membrane Permeabilization Induces Cell Death In A Mitochondrion-Dependent Fashion, Patricia Boya, Karine Andreau, Delphine Poncet, Naoufal Zamzami, Jean-Luc Perfettini, Didier Metivier, David M. Ojcius, Marja Jäättelä, Guido Kroemer

All Dugoni School of Dentistry Faculty Articles

A number of diseases are due to lysosomal destabilization, which results in damaging cell loss. To investigate the mechanisms of lysosomal cell death, we characterized the cytotoxic action of two widely used quinolone antibiotics: ciprofloxacin (CPX) or norfloxacin (NFX). CPX or NFX plus UV light (NFX*) induce lysosomal membrane permeabilization (LMP), as detected by the release of cathepsins from lysosomes. Inhibition of the lysosomal accumulation of CPX or NFX suppresses their capacity to induce LMP and to kill cells. CPX- or NFX-triggered LMP results in caspase-independent cell death, with hallmarks of apoptosis such as chromatin condensation and phosphatidylserine exposure on …

Protection Of Pifithrin-Α And Melatonin Against Doxorubicin-Induced Cardiotoxicity., Xuwan Liu

Electronic Theses and Dissertations

The current studies were designed to explore the protective effects of pifithrin-α and melatonin against doxorubicin-induced cardiotoxicity. Doxorubicin was injected at a dose of 22.5 mg/kg (i.p.) in mice to induce cardiotoxic effects. Meanwhile, doxorubicin caused a significant increase of cardiac cell apoptosis following injection (14.2 ± 1.1% for doxorubicin-5 d vs. 1.8 ± 0.12% for control, P < 0.01). Ribonuclease protection assays and Western blot analyses revealed that doxorubicin upregulated the p53-dependent genes Bax, BclxL, and MDM2 at least 2-fold. p53 was phosphorylated at Ser 15 in mouse hearts 1 h following doxorubicin injection, and p38 and ERK1/2 MAPKs mediated the phosphorylation of p53. In addition, caspases-3 and -9 were activated 24 h after doxorubicin injection. A p53 inhibitor, pifithrin-α, inhibited doxorubicin-induced apoptosis when administered at a dose of 2.2 mg/kg. Pifithrin-α abolished p53 transactivation activity, but did not influence doxorubicin-induced phosphorylation at Ser 15. By effectively inhibiting the expression of p53-dependent genes, pifithrin-α blocked doxorubicin-induced activation of caspases-3 and -9, thereby preventing cardiac apoptosis. In addition, pifithrin-α attenuated doxorubicin-induced structural and functional damages, without diminishing its anti-tumor efficacy on p53-null PC-3 cancer cells. The protective effects of melatonin and its metabolite 6-hydroxymelatonin on doxorubicin-induced cardiac dysfunction were evaluated in an isolated perfused mouse hearts and in vivo doxorubicin-treated mice. While perfusion of mouse hearts with 5 μM doxorubicin for 60 min resulted in a 50% suppression of HRxLVDP and a 50% reduction of coronary flow, pre-exposure of hearts to 1 μM melatonin or 6-hydroxymelatonin eased the cardiac …

An Investigation Of Pre-Nursing And Second-Year Baccalaureate Nursing Students' Perception Of Spirituality, Jacquelyn Kay R. Williams

Theses and Dissertations - UTB/UTPA

This pilot study investigated whether spiritual care education is a part of the baccalaureate nursing curriculum at a south Texas university. This study used two standardized scales to compare the pre-nursing students' and senior baccalaureate nursing students' attitude about spirituality at different levels in the nursing program. Two quantitative questionnaires were used to investigate the nursing students' personal spiritual involvement and beliefs and their opinions about the spiritual role of the nurse in meeting patient spiritual needs. No statistically significant differences in the two group's personal spiritual involvement and beliefs were found. Statistically significant differences were found in the opinions …

Factors Influencing Treatment Patterns In Breast Cancer Patients Age 75 And Over, Arti Hurria, Denis H. Y. Leung, Kathleen Trainor, Patrick Borgen, Larry Norton, Clifford Hudis

Research Collection School Of Economics

To retrospectively determine the factors influencing treatment decisions in older breast cancer patients at a single center. Experimental Design: 216 patients age > or = 75 seen in post-treatment follow-up between January, 1997 and June, 2000 were identified in the Memorial Sloan-Kettering breast cancer database. Eligible patients were > or = 75 years old at diagnosis, had a diagnosis of stage I, II, or III breast cancer, and received their follow-up care at Memorial Sloan Kettering Cancer Center. A retrospective chart review was performed. Patients were stratified by: (1) prognostic factors (age (75-79 or > or = 80), Charlson comorbidity score, tumor size, …

Studies On The Regulation Of Mu Opioid Receptor Mrna Expression In Shsy-5y Human Neuroblastoma Cells, Xin Yu

Seton Hall University Dissertations and Theses (ETDs)

Prolonged exposure to morphine down-regulates mu opioid receptors (MOR) on both undifferentiated and differentiated (retinoic acid or phorbol ester treated) SHSY-5Y cells. However, morphine pretreatment does not alter MOR receptor affinity for morphine. To investigate the molecular basis for MOR regulation after exposure to its selective agonists, we have developed a quantitative competitive reverse transcriptase-polymerase chain reaction (QC-RT PCR) to quantify the expression of MOR in SHSY-SY cells. Differentiation of SHSY-5Y cells with retinoic acid or phorbol ester up regulated MOR mRNA expression by 30 % and 78%, respectively. A 24 hours treatment with morphine (10 µM) down regulated MOR …

Genomic And Proteomic Profiling Of Responses To Toxic Metals In Human Lung Cells, Angeline S. Andrew, Amy J. Warren, Aaron Barchowsky, Kaili A. Temple, Linda Klei, Nicole V. Soucy, Kimberly A. O'Hara, Joshua W. Hamilton

Dartmouth Scholarship

Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response. Using a 1,200 gene nylon array, we examined changes in gene expression following low-dose, acute exposures of cadmium, chromium, arsenic, nickel, or mitomycin C (MMC) in BEAS-2B human bronchial epithelial cells. Total RNA was isolated from cells exposed to 3 M Cd(II) (as cadmium chloride), 10 M Cr(VI) (as sodium dichromate), 3 g/cm2 Ni(II) (as nickel subsulfide), 5 M or 50 M As(III) (as sodium arsenite), or …

Special Article. Commentaries On A World At War: Sars, Weapons Of Mass Destruction, Preemption, The United Nations, International Respect And Confidence, And Truth., Ibpp Editor

International Bulletin of Political Psychology

This article highlights cognitive difficulties exposed by examples of contemporary security conflict.

2003 - The Eighth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Eighth Annual Symposium of Student Scholars, held on April 18, 2003. Includes abstracts from the presentations and posters.

Aquaporin Proteins In Murine Trophectoderm Mediate Transepithelial Water Movements During Cavitation., Lisa C Barcroft, Hanne Offenberg, Preben Thomsen, Andrew J Watson

Obstetrics & Gynaecology Publications

Mammalian blastocyst formation is dependent on establishment of trophectoderm (TE) ion and fluid transport mechanisms. We have examined the expression and function of aquaporin (AQP) water channels during murine preimplantation development. AQP 3, 8, and 9 proteins demonstrated cell margin-associated staining starting at the 8-cell (AQP 9) or compacted morula (AQP 3 and 8) stages. In blastocysts, AQP 3 and 8 were detected in the basolateral membrane domains of the trophectoderm, while AQP3 was also observed in cell margins of all inner cell mass (ICM) cells. In contrast, AQP 9 was predominantly observed within the apical membrane domains of the …

Mammalian Erv46 Localizes To The Endoplasmic Reticulum–Golgi Intermediate Compartment And To Cis-Golgi Cisternae, Lelio Orci, Mariella Ravazzola, Gary J. Mack, Charles Barlowe, Stefan Otte

Dartmouth Scholarship

Yeast endoplasmic reticulum (ER) vesicle protein Erv46p is a novel membrane protein involved in transport through the early secretory pathway. Investigation of mammalian Erv46 (mErv46) reveals that it is broadly expressed in tissues and protein-secreting cells. By immunofluorescence microscopy, mErv46 displays a crescent-shaped perinuclear staining pattern that is characteristic of the Golgi complex. Quantitative immunoelectron microscopy indicates that mErv46 is restricted to the cis face of the Golgi apparatus and to vesicular tubular structures between the transitional ER and cis-Golgi. Minor amounts of mErv46 reside in ER membranes and later Golgi cisternae. On Brefeldin A treatment, mErv46 redistributes to punctate …

The U.S. Health Workforce: Definitions, Dollars, And Dilemmas, Karen Matherlee

National Health Policy Forum

This background paper provides a comprehensive view of the structure of the health workforce. It explores public and private insurance coverage and payment policies, as well as discretionary grant programs, that govern it. The paper also looks at health workforce concerns: supplies of certain types of physicians, health workforce mix, challenges from complementary and alternative medicine, shortages of nurses and pharmacists (and some other practitioners), maldistribution issues, and lack of diversity in response to demographic changes. It presents proposals that are on the table to reform the health workforce, at a time when it is demanding greater attention from health …

Seventeen Amino Acid Peptide (Peptide P) For Treating Ischemia And Reperfusion Injury, Peter R. Oeltgen, Mark S. Kindy

Molecular and Cellular Biochemistry Faculty Patents

Peptide P, having the amino acid sequence Tyr-D-Ala-Phe-Ala-Asp-Val-Ala-Ser-Thr-Ile-Gly-Asp-Phe-Phe-His-Ser-Ile-NH2, is useful to treat ischemia.

Mesangial Cells Organize The Glomerular Capillaries By Adhering To The G Domain Of Laminin Alpha5 In The Glomerular Basement Membrane, Yamato Kikkawa, Ismo Virtanen, Jeffrey H. Miner

Open Access Publications

No abstract provided.

Healthnet News V.18:No.1 Spring 2003, Judith S. Kronick, Alberta Richetelle

Articles - Patient Care

A newsletter for public librarians and others interested in consumer health information services.

Com Outlook Spring 2003, College Of Osteopathic Medicine

COM Outlook

No abstract provided.

Yale Nurse: Yale University School Of Nursing Alumnae/I Newsletter, Spring 2003, Yale University School Of Nursing

Yale School of Nursing Alumni Newsletters and Magazines

This issue has a feature article on community health beyond borders in Oaxaco, Mexico.

Please contact the Medical Historical Library if you need a higher resolution version.