Digital Commons Network^™

Role Of Natural Killer Cells In Innate Protection Against Lethal Ebola Virus Infection, Kelly L. Warfield, Jeremy G. Perkins, Dana L. Swenson, Emily M. Deal, Catharine M. Bosio, M. Javad Aman, Wayne M. Yokoyama, Howard A. Young, Sina Bavari

Open Access Publications

No abstract provided.

Molecular Basis Of Inward Rectification: Polyamine Interaction Sites Located By Combined Channel And Ligand Mutagenesis, Harley T. Kurata, L. Revell Phillips, Thierry Rose, Gildas Loussouarn, Stefan Herlitze, Hariolf Fritzenschaft, Decha Enkvetchakul, Colin G. Nichols, Thomas Baukrowitz

Open Access Publications

No abstract provided.

Laboratory Automation Education, James D. Sterling

Business and Information Technology Faculty Research & Creative Works

No abstract provided.

The Reproduction Biology Of Chub (Leuciscus Cephalus L. 1758) In Topçam Dam Lake (Aydın, Turkey), Hüseyi̇n Şaşi

Turkish Journal of Veterinary & Animal Sciences

In this study, the reproduction biology of 332 chub (Leuciscus cephalus L. 1758) was studied from June, 1999, to June, 2000, on a monthly basis in Topçam Dam Lake. Egg numbers were estimated in 65 females caught just prior to spawning. The sex and age compositions of chub were determined. The specimens were composed of 27.11% males and 72.89% females. Male and female chub become sexually mature in the second year of their life spans. Spawning is in March and April. The fecundity of chub varies from 2100-66,400 per female. The average egg diameter was between 0.391 and 0.744 mm …

Comparisons Among Parent Reports And Self-Reports Of Sleep In Adhd And Normal School-Aged Children, Diana M. Turner-Eadie

Psychology Theses & Dissertations

The objective of the study was to investigate whether school-aged children diagnosed with Attention-Deficit Hyperactivity Disorder (ADHD) experience greater sleep disturbance than do normally-developing children. Participants included 33 parents and their children with ADHD (mean age = 10.7 ± 1.7 years) and 33 parents and their children without ADHD (mean age = 10.7 ± 1.6 years). Both parents and their children completed sleep questionnaires developed to assess a number of sleep variables. Based on parental report, the Total Sleep Disturbance score was significantly greater for the ADHD group than for the comparison group. Parents indicated that children with ADHD had …

Toothbrushing, Flossing, And Preventive Dental Visits By Richmond-Area Residents In Relation To Demographic And Socioeconomic Factors, Kim T. Isringhausen

Theses and Dissertations

Purpose. This study was conducted to identify factors that influence preventive dental behaviors and, from the results, target groups for intervention.Methods. Data were collected using the 1997 Behavioral Risk Factor Surveillance System (BRFSS) resulting in a probability sample of 399 dentate adults living in Richmond City, Henrico, Chesterfield and Hanover Counties in Virginia. All analyses were performed using the statistical software program STATA. Initial hypothesis testing was performed using univariate logistic regression models. Multivariate logistic regression models were used to test the significance of independent variables while controlling for other possible predictors of behavior.Results. Females were more likely than males …

Effect Of Repeated Dosing Of Delta 9-Tetrahydrocannabinol, The Major Psychoactive Ingredient Of Marijuana, On Memory In Mice, Floride Niyuhire

Theses and Dissertations

Purpose: Marijuana is the most widely used illicit drug in the United States. However, marijuana and cannabinoid derivatives have potential therapeutic uses. Studies in cannabis users have yielded contradictory results with regard to long-term effects on cognitive functions. There is no prospective study assessing this issue, and such studies may raise ethical issues in humans, whereas mice have been shown to exhibit similar cannabinoid-mediated behaviors as humans. The purpose of this study was to assess the consequences of chronic administration of Δ9-THC, the major psychoactive component of marijuana, in a mouse memory model. Methods: In Experiment 1, the dose-response relationship …

Antioxidants As Risk Factors For Gingival Bleeding, Hee-Jeong Bahng

Theses and Dissertations

Background: Studies of gingival bleeding and the effects of antioxidants on extracellular matrix and immunologic and inflammatory responses provide a rationale for hypothesizing that antioxidants reduce the risk for gingival bleeding.Methods: This study evaluated the role of antioxidants as contributing risk factors for gingival bleeding utilizing the Third National Health and Nutrition Examination Survey (NAHNES III). A sample of 18,825 adults (20 to ≥ 90 years of age), with dental measurement and assessment of serum levels of antioxidants were included in the study. Gingival bleeding was defined as those who had more than 30 percent of gingival bleeding in 28 …

The Prevalence Of The Need For Esthetic Crown Lengthening In Post Orthodontically Treated Subjects, David Clark Johnson

Theses and Dissertations

The problem of excess gingival display is difficult to diagnose and treat. By studying one aspect of excess gingival display, namely the size relationships of the clinical crowns of teeth, we can begin to quantify reasonable goals of therapy. In this study, two hundred plaster models were used as subjects. These represented two hundred patients before and after orthodontic therapy. The six anterior teeth were measured for length and width and compared to known ideals. Teeth that did not meet ideal standards may require treatment. It was found that the mean tooth length after orthodontic therapy was approximately two millimeters …

The Association Between Periodontal Disease And C-Reactive Protein In Patients With A History Of Heart Attack, Robert Lee Fletcher Iii

Theses and Dissertations

The patient population consisted of a maximum of 18,570 subjects who completed the NHANES III questionnaire and examination from 1988 - 1994. The physical examination included such things as body mass index and serum samples, social and medical history. The periodontal examination recorded probing depth, attachment loss and gingival bleeding. Serum samples were analyzed for CRP levels, cholesterol levels etc. Demographic, cardiovascular and oral health variables were compared in subjects with a history of heart attack. Result showed that history of heart attack is associated with increased odds ratio for elevated CRP, diabetes, hypertension, cholesterol, male gender, non-white race and …

Bonding Properties Of Newly Erupted And Mature Human Premolars, Diana Marie-Skinner Almy

Theses and Dissertations

Following eruption of a tooth into the oral cavity, enamel is thought to continue to calcify. The continued calcification and maturation of enamel is described as "post-eruptive enamel maturation." It is believed that an observed decrease in enamel pore size and increase in the calcification of enamel matrix over time can be attributed to this process. In recent years, there has been a significant increase in the number of adult patients seeking orthodontic treatment. Since orthodontic attachments are bonded directly to the etched enamel using composite resin, post-eruptive enamel maturation may affect the bonding process. The purpose of this study …

Use Of A Portland Cement Accelerator With Mineral Trioxide Aggregate, M. Scott Monts

Theses and Dissertations

The use of Mineral Trioxide Aggregate (MTA) is gaining popularity among clinicians. Despite the many ideal qualities it possesses, it is often difficult to manipulate and often requires a second appointment for placement of a restoration to allow for setting. If the time to set of MTA can be accelerated to a single appointment time frame without significantly altering its properties, then MTA may gain even wider acceptance. The purpose of this study is to identify the percentage of a Portland Cement Accelerator (PCA), that when added to MTA, will decrease the time to set of MTA towards a single …

Determinants Of Prenatal Care And Supplement Use: The Case Of Honduras, Catherine E. Henze

Theses and Dissertations

Context: Literature suggests that prenatal care and prenatal supplement use improves pregnancy outcomes. However, we do not know the factors associated with prenatal care and supplement use in Honduras.Objective: To identify characteristics of Honduran women who are the least and most likely to use prenatal care and supplements.Methods: Data from a 2001 Honduras cross-sectional survey of women was used to assess their use of prenatal care and supplements. All data was weighted, resulting in a sample size of n = 5647 women who had a live birth since January 1996. Bivariate and multivariate analyses were used to examine factors associated …

Rabies In Virginia, 1989-2003: With Particular Attention To Animals, Geographic Distribution, And Virus Variant, William Andrew Holzgrefe

Theses and Dissertations

Objectives: The description of the raccoon rabies epizootic in Virginia over fifteen years (1989-2003). Methods: Using simple statistical methods and a geographic information system (GIS)-based approach, and fifteen years worth of animal surveillance data, the progress of this epizootic has been charted in terms of the geographic spread of the disease, the major animal species affected by the disease and its spread, and the exposure and risk to humans and livestock animals presented by the expansion of the geographic range. Results: The resulting descriptive study illustrates the eastward expansion of the epizootic, the mushrooming of the disease in the northern …

Muscle Fatigue And The Mechanisms For Task Failure, Sandra K. Hunter, Jacques Duchateau, Roger M. Enoka

Exercise Science Faculty Research and Publications

An alternative approach in the study of muscle fatigue is to address the question, “What causes task failure during a fatiguing contraction?” This approach is described by considering how variation in the type of load supported and contraction intensity influence both the time to task failure and the centrally mediated adjustments in reflex activity and motor unit behavior

Molecular Genetic Investigation Of Autosomal Dominant Hemifacial Microsomia, Rebecca Watt

Theses: Doctorates and Masters

The overall purpose of this project was to explore the underlying pathogenesis of Hemifacial microsomia (HFM), investigate treatment and management options identify likely candidate genes and screen candidate genes for mutation(s) causing the form of HFM segregating on chromosome 11 in a West Australian family. Hemifacial microsomia is a congenital malformation arising from the derivatives of the first and second branchial arches. It is both clinically and genetically heterogeneous and can occur sporadically or segregate within families in an autosomal fashion. HFM is characterised by significant undergrowth to one side of the face and is a common birth defect with …

The Effect Of Strength Training On 3km Performance In Recreational Female Endurance Runners, Cherina M. Rice

Theses: Doctorates and Masters

The purpose of this study was to investigate whether a strength training program, as an additive to endurance training, would cause significant improvements in 3km run time in a group of recreational female endurance runners when compared to endurance training only. Subjects were 16 active women, randomly assigned to either a running only group (control group, n=9) or a combined strength and endurance training group (experimental group, n=7). The ten-week training program for both groups consisted of an endurance running program three times per week, which included steady-state endurance running, tempo runs and interval training. The experimental group however, participated …

Molecular Functionalization Of Carbon Nanotubes And Use As Substrates For Neuronal Growth, Mark P. Mattson, Robert C. Haddon, Apparao M. Rao

Sanders-Brown Center on Aging Faculty Patents

A cell and substrate system and nerve regeneration implant are disclosed including a carbon nanotube and a neuron growing on the carbon nanotube. Both unfunctionalized carbon nanotubes and carbon nanotubes functionalized with a neuronal growth promoting agent may be utilized in the invention. A method is also disclosed for promoting neuronal growth.

Riboflavin Synthase Of Schizosaccharomyces Pombe. Protein Dynamics Revealed By 19f Nmr Protein Perturbation Experiments., Markus Fischer, Ann-Kathrin Schott, Kristina Kemter, Richard Feicht, Gerald Richter, Boris Illarionov, Wolfgang Eisenreich, Stefan Gerhardt, Mark S. Cushman, Stefan Steinbacher, Robert Huber, Adelbert Bacher

Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications

Background

Riboflavin synthase catalyzes the transformation of 6,7-dimethyl-8-ribityllumazine into riboflavin in the last step of the riboflavin biosynthetic pathway. Gram-negative bacteria and certain yeasts are unable to incorporate riboflavin from the environment and are therefore absolutely dependent on endogenous synthesis of the vitamin. Riboflavin synthase is therefore a potential target for the development of antiinfective drugs.

Results

A cDNA sequence from Schizosaccharomyces pombe comprising a hypothetical open reading frame with similarity to riboflavin synthase of Escherichia coli was expressed in a recombinant E. coli strain. The recombinant protein is a homotrimer of 23 kDa subunits as shown by sedimentation equilibrium …

Semiparametric Estimation Of Time-Dependent: Roc Curves For Longitudinal Marker Data, Yingye Zheng, Patrick Heagerty

UW Biostatistics Working Paper Series

One approach to evaluating the strength of association between a longitudinal marker process and a key clinical event time is through predictive regression methods such as a time-dependent covariate hazard model. For example, a time-varying covariate Cox model specifies the instantaneous risk of the event as a function of the time-varying marker and additional covariates. In this manuscript we explore a second complementary approach which characterizes the distribution of the marker as a function of both the measurement time and the ultimate event time. Our goal is to flexibly extend the standard diagnostic accuracy concepts of sensitivity and specificity to …

Sexual Risk Taking In Adolescence: The Role Of Self-Regulation And Attraction To Risk, Marcela Raffaelli, Lisa J. Crockett

Department of Psychology: Faculty Publications

Precursors of adolescent sexual risk taking were examined in a multiethnic sample consisting of 443 children (51% girls) of National Longitudinal Survey of Youth participants. Respondents were 12–13 years old in 1994 and 16–17 in 1998. Controlling for demographic and contextual factors, self-regulation—but not risk proneness—was significantly (modestly) associated with overall sexual risk taking 4 years later, Analyses of individual sexual behaviors indicated that self-regulation may affect choices made after becoming sexually active (e.g. number of partners) rather than the initiation of sexual activity. Measures of parent and peer influence had independent effects on sexual risk taking but did not …

Research News: 2003, No. 4, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants, publications, technology transfer, special announcements

Flavone: The Molecular And Mechanistic Study Of How A Simple Flavonoid Protects Dna From Oxidative Damage., Jennifer Dawn Dean

Electronic Theses and Dissertations

Dietary flavonoids are ubiquitous and are marketed as supplements. Characterized as antioxidants, they offer protection against a number of degenerative diseases. Flavonoid mechanics involve free radical scavenging, metal chelation, and substrate association. The skeletal structure of flavonoids is a fused ring system modified by hydroxyl, sugar, and carbohydrate additions. Flavone is a structurally simple flavonoid. Quercetin and its glycosidic analog rutin are complex structures. Using a DNA oxidation/cleavage assay, flavone reduces DNA nicking by 91%. Depending on the solvent system used, quercetin can either increase or decrease DNA oxidation. Rutin exhibits neither pro- nor antioxidant activity. The molecular interactions responsible …

The Role Of Erp57 In Hras Intracellular Trafficking And Function., Jaime Lyn Parman

Electronic Theses and Dissertations

Ras is a central player in signal transduction that mediates cellular proliferation and differentiation. Recent evidence has shown that lipid and non-lipid modified domains participate in Ras traffic and that plasma membrane association is mediated by vectorial vesicular transport from the endomembrane system. ERp57, an ER chaperone, has been shown to specifically bind farnesylated Hras but not non-farnesylated Hras. The objective of this study was to determine if ERp57 participates in Ras trafficking and function. First, the effect of ERp57 knock down by siRNA technology on Hras function was studied; there was a reduction in ERp57 cellular levels that led …

Louisiana State University Health Sciences Center - 2003 - 125th Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 125th Commencement of LSU Health Sciences Center - New Orleans held December 11, 2003.

Tolerance Of The Fetus By The Maternal Immune System: Role Of Inflammatory Mediators At The Feto-Maternal Interface, Colette Kanellopoulos-Langevin, Stephane M. Caucheteux, Philippe Verbeke, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

The adaptive immune system of placental mammals has evolved to tolerate the fetus. Rejection of the fetus by adaptive immune responses is therefore a rare event, with abortion being caused more frequently by inflammation in the placenta. This review will cover recent aspects of immune privilege and the innate immune system at the feto-maternal interface, citing examples of the role played by microbial infections in fetal demise.

Modeling The Incubation Period Of Anthrax, Ron Brookmeyer, Elizabeth Johnson, Sarah Barry

Johns Hopkins University, Dept. of Biostatistics Working Papers

Models of the incubation period of anthrax are important to public health planners because they can be used to predict the delay before outbreaks are detected, the size of an outbreak and the duration of time that persons should remain on antibiotics to prevent disease. The difficulty is that there is little direct data about the incubation period in humans. The objective of this paper is to develop and apply models for the incubation period of anthrax. Mechanistic models that account for the biology of spore clearance and germination are developed based on a competing risks formulation. The models predict …

Serotonergic Agents And Alcoholism Treatment: A Simulation, Scott F. Stoltenberg

Department of Psychology: Faculty Publications

Background: Those with early-onset alcoholism may better respond to ondansetron (a 5-HT3 receptor antagonist) than to selective serotonin reuptake inhibitor (SSRI) treatment, whereas those with late-onset alcoholism may present the reverse response pattern. Johnson and colleagues proposed a model that attempts to explain the observed treatment response patterns of those with early and late alcoholism onset by focusing on the influence of a common genetic variant in the serotonin transporter regulatory region (5-HTTLPR) on serotonin (5-HT) and dopamine (DA) system function.
Methods: The present study formalizes and extends Johnson’s descriptive model into a computer simulation consisting of differential equations. For …

Bacteriolytic Activity Of Selected Vertebrate Sera For Borrelia Burgdorferi Sensu Stricto And Borrelia Bissettii, Amy J. Ullmann, Robert S. Lane, Klaus Kurtenbach, Michael Miller, Martin E. Schriefer, Nordin Zeidner, Joseph Piesman

United States Public Health Resources

An in vitro assay to evaluate the bacteriolytic activity of the complement pathway was applied to 2 strains of Borrelia bissettii, CO501 and DN127, and compared with that of B. burgdorferi sensu stricto B31. Sera from mule deer ( Odocoileus hemionus) and the Western Fence lizard ( Sceloporus occidentalis) were completely borreliacidal for B. burgdorferi and for both strains of B. bissettii. Serum from Bobwhite quail ( Colinus virginianus) was nonlytic for B. burgdorferi and partially lytic for B. bissettii strains, CO-501 and DN127. Serum from a New Zealand White rabbit ( Oryctolagus cuniculus) …

Acknowledgements, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.