Digital Commons Network^™

First Premolar Extraction Decisions And Effects, Ryan Gregory Bowles

Theses and Dissertations (ETD)

The most common method of resolving substantial tooth size-arch length discrepancies (TSALD) is to treat patients with the extraction of premolars. Not all of the extraction space, however, is needed to eliminate the patient's TSALD. Also, it is typical that some of the extraction space will be lost because the molars are used as anchorage units to retract the anterior teeth. OBJECTIVE: This study developed a method to measure changes in the positions of the canines and second premolars relative to the palatal rugae. These data were used to assess how the extraction space was used in resolving the malocclusion. …

Ductal Carcinoma In Situ (Dcis) In Karachi, Naila Kayani, Yasmin Bhurgri

Department of Pathology and Laboratory Medicine

Objective:
To study the frequency of ductal carcinoma in situ (DCIS) in a large pathology series. DCIS is a proliferation of non-invasive, malignant epithelial cells within the ductolobular system of the breast. It is a heterogeneous entity with several morphologic variants that differ in gross appearance, growth pattern, cytologic features, mammography, and malignant potential.
Methods:
The data of The Aga Khan University' Pathology Department, diagnosed on the basis of histopathology, during a 6-year period (1st January 1998 to 31st December 2003) was reviewed, all cases of DCIS studied, and data was analyzed with the help of analytical software SPSS.
Results: …

Somatostatin Regulates Intracellular Signaling In Human Bronchial Smooth Muscle Cells, Michael J. Alfonzo

Seton Hall University Dissertations and Theses (ETDs)

Somatostatin (somatotropin release inhibitory factor; SRIF), is an endogenous peptide family that controls cellular secretion and proliferation. While SRIF's cognate receptors and associated actions have been clearly identified in a range of tissues, such as the endocrine, gastrointestinal and immune systems, a role in human lung physiology remains unknown. Using primary human bronchial smooth muscle cells (hBSMC) as a model for studying SRIF's actions, we have investigated whether SRIF receptors are present and functional in human bronchial smooth muscle. Reverse transcriptase- polymerase chain reaction (RT-PCR) analysis ofhBSMC total mRNA demonstrated the presence of the sst, receptor subtype, providing a molecular …

Possible Effects Field Hockey Stick Weight May Have On Player Performance During A Penalty Stroke, Lee-Ann Sharp

All-Inclusive List of Electronic Theses and Dissertations

Context: Wooden sticks have been used in field hockey since the inception of the game. In recent years, there has been a growing trend among players to use modern composite sticks. However, there has been no research into the possible effects the weight of these composite sticks could have on player's performances. Objective: The purpose of this study was to examine the effect stick weight would have on player perfonnance, specifically ball velocity and player accuracy, during a series of penalty strokes. Design: All subjects were required to take twenty penalty strokes on goal with each of the two differently …

Modeling Of Immunoglobulin Uptake By N,N,N′,N′-Ethylenediaminetetramethylenephosphonic Acid-Modified Zirconia Particles Under Static And Dynamic Conditions, Sabyasachi Sarkar, Anuradha Subramanian

Papers in Biotechnology

A matrix developed from N,N,N′,N′-ethylenediaminetetramethylenephosphonic acid-modified zirconia beads (further referred to as r_PEZ); 25–38 μm in diameter and with a pore size of 22 ± 3 nm, was utilized for the separation of immunoglobulins (Igs). r_PEZ has been shown to bind to various Igs originating from a wide variety of species. To understand the mechanisms controlling the uptake of Igs by r_PEZ, static protein uptake experiments were carried out. The protein uptake profiles were further modeled with a kinetic rate constant model. Individual studies were undertaken for human immunoglobulin A, G and M (HIgA, HIgG and HIgM). The kinetic rate …

How Diverse Librarians Increased Access To Electronic Journals, Developed A Print/Electronic Collection Development Policy And Preserved The Collection, Kathe Obrig, Patricia Wilson, Cynthia Swope, Laura E. Abate, Anne Linton

Himmelfarb Library Faculty Posters and Presentations

This poster reports on a project initiated to establish a framework for evaluating our serials collection in order to preserve the collection from a flat budget and ever increasing serial costs and to meet patron demand for expanded access to electronic resources. An additional outcome was the development of a combined print and electronic serials collection development policy. A Journals Committee was formed to assess the value and most appropriate format(s) of individual journal titles. Methods used included a mathematical formula calculating a title's relative value and a faculty survey soliciting most-used titles and preferred format. Faculty department heads were …

Cart: An Hrs/Actinin-4/Berp/Myosin V Protein Complex Required For Efficient Receptor Recycling, Thomas A Vida

Faculty, Staff and Student Publications

Altering the number of surface receptors can rapidly modulate cellular responses to extracellular signals. Some receptors, like the transferrin receptor (TfR), are constitutively internalized and recycled to the plasma membrane. Other receptors, like the epidermal growth factor receptor (EGFR), are internalized after ligand binding and then ultimately degraded in the lysosome. Routing internalized receptors to different destinations suggests that distinct molecular mechanisms may direct their movement. Here, we report that the endosome-associated protein hrs is a subunit of a protein complex containing actinin-4, BERP, and myosin V that is necessary for efficient TfR recycling but not for EGFR degradation. The …

Dietary Omega-3 Fatty Acids And Ionizing Irradiation On Human Breast Cancer Xenograft Growth And Angiogenesis, W. Elaine Hardman, Luzhe Sun, Nicholas Short, Ivan L. Cameron

Biochemistry and Microbiology

Background

The effects of an omega-3 (n-3) fatty acid enriched diet alone and in combination with gamma irradiation (IR) therapy in nude mice bearing a human MDA-MB231 breast cancer xenograft were tested. The cancer cells were injected into the mammary fat pad of young female mice. Six weeks later, mice were randomly divided into two diet groups: 1) mice with 10% corn oil (rich in omega 6 fatty acids) in their food, 2) mice consuming a 10% fat diet that was enriched in n-3 fatty acids. After two weeks on the diet, treatment with 200 cGy of IR every second …

Ll5Β: A Regulator Of Postsynaptic Differentiation Identified In A Screen For Synaptically Enriched Transcripts At The Neuromuscular Junction, Masashi Kishi, Terrance T. Kummer, Stephen J. Eglen, Joshua R. Sanes

Open Access Publications

No abstract provided.

Deep-Etch Em Reveals That The Early Poxvirus Envelope Is A Single Membrane Bilayer Stabilized By A Geodetic "Honeycomb" Surface Coat, John Heuser

Open Access Publications

No abstract provided.

Tularemia: Emergence/Re-Emergence, Jeannine M. Petersen, Martin E. Schriefer

Zoonotics and Wildlife Disease: Publications

Francisella tularensis is a gram-negative coccobacillus and the etiologic agent of the zoonotic disease tularemia. First described in 1911 in Tulare County, California, it has since been reported throughout the Northern Hemisphere, with natural infections reported among an unusually wide range of vertebrates and invertebrates. In recent years, tularemia has emerged in new geographic locations, populations, and settings. This review will serve to highlight mechanisms contributing to the recent emergence of tularemia as well as a repertoire of diagnostic tools useful for detecting and diagnosing disease.

Comparison Of Amplification Enzymes For Hepatitis C Virus Quasispecies Analysis., Stephen J Polyak, Daniel G Sullivan, Michael A Austin, James Y Dai, Margaret C Shuhart, Karen L Lindsay, Herbert L. Bonkovsky, Adrian M Di Bisceglie, William M Lee, Chihiro Morishima, David R Gretch

SoM Articles

BACKGROUND: Hepatitis C virus (HCV) circulates as quasispecies (QS), whose evolution is associated with pathogenesis. Previous studies have suggested that the use of thermostable polymerases without proofreading function may contribute to inaccurate assessment of HCV QS. In this report, we compared non-proofreading (Taq) with proofreading (Advantage High Fidelity-2; HF-2) polymerases in the sensitivity, robustness, and HCV QS diversity and complexity in the second envelope glycoprotein gene hypervariable region 1 (E2-HVR1) on baseline specimens from 20 patients in the HALT-C trial and in a small cohort of 12 HCV/HIV co-infected patients. QS diversity and complexity were quantified using heteroduplex mobility assays …

Trefoil Factor 2 (Tff2) Deficiency In Murine Digestive Tract Influences The Immune System, M. Baus- Loncar, J. Schmid, El-Nasir Lalani, I. Rosewell, R. A. Goodlad, H. G.W. Stamp, N. Blin, T. Kayademir

Department of Pathology and Laboratory Medicine

Background & Aims:

The gastrointestinal trefoil factor family (TFF1, TFF2, TFF3) peptides are considered to play an important role in maintaining the integrity of the mucosa. The physiological role of TFF2 in the protection of the GI tract was investigated in TFF2 deficiency.

Methods:

TFF2-/- mice were generated and differential expression of various genes was assessed by using a mouse expression microarray, quantitative real time PCR, Northern blots or immunohistochemistry.

Results:

On an mRNA level we found 128 differentially expressed genes. We observed modulation of a number of crucial genes involved in innate and adaptive immunity in the TFF2-/- mice. …

Evaluation Of Glucocorticoid Sensitivity In 697 Pre-B Acute Lymphoblastic Leukemia Cells After Overexpression Or Silencing Of Map Kinase Phosphotase-1, Marc T. Abrams, Noreen Robertson, Gerald Litwack, Eric Wickstrom

Department of Biochemistry and Molecular Biology Faculty Papers

PURPOSE: To determine the effect of reducing MAP kinase phosphatase-1 (MKP-1) levels on cell death induced by glucocorticoid (GC) or hydroxyurea (HU) treatment in the human pre-B acute lymphoblastic leukemia cell line 697.

METHODS: Stable MKP-1 overexpressing transformants of the 697 pre-B ALL cell line were created and tested for sensitivity to the GC triamcinolone acetonide (TA) and HU, and compared to a control 697 cell line containing normal MKP-1 expression levels. Small interfering RNAs (siRNAs) were designed to inhibit MKP-1 expression and evaluated for their effect on GC-mediated cell death.

RESULTS: MKP-1 overexpression caused a phenotype of partial resistance …

Ada News - 04/18/2005, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Histories Of Childhood Maltreatment In Schizophrenia: Relationships With Premorbid Functioning, Symptomatology, And Cognitive Deficits, Lindsay S. Schenkel, William D. Spaulding, David Dilillo, Steven M. Silverstein

Department of Psychology: Faculty Publications

A number of studies have demonstrated an increased rate of histories of childhood maltreatment among adults with serious mental illness. The present investigation documented the presence of childhood maltreatment in a sample of 40 psychiatric inpatients with schizophrenia spectrum disorders. The type (neglect, physical abuse, sexual abuse), duration, and severity of childhood maltreatment was examined along with measures of premorbid functioning, current symptomatology, and cognitive functioning. Participants with histories of maltreatment were significantly more likely to have poorer peer relationships in childhood, more diffi culty in school, an earlier age at first hospitalization, more previous hospitalizations, elevated symptoms of anxiety, …

Ocular Surface Epithelia Contain Abcg2-Dependent Side Population Cells Exhibiting Features Associated With Stem Cells., Murat T Budak, Onder S Alpdogan, Mingyuan Zhou, Robert M Lavker, M A Murat Akinci, J Mario Wolosin

Department of Medical Oncology Faculty Papers

When cell populations are incubated with the DNA-binding dye Hoechst 33342 and subjected to flow cytometry analysis for Hoechst 33342 emissions, active efflux of the dye by the ABCG2/BCRP1 transporter causes certain cells to appear as a segregated cohort, known as a side population (SP). Stem cells from several tissues have been shown to possess the SP phenotype. As the lack of specific surface markers has hindered the isolation and subsequent biochemical characterization of epithelial stem cells this study sought to determine the existence of SP cells and expression of ABCG2 in the epithelia of the ocular surface and evaluate …

Changes In Nursing Student Attitudes Toward Mental Illness, Jared Rogge

Honors Theses

People who suffer from mental illness comprise a highly vulnerable population, and encounter adversity from two directions. Not only do they have to contend with their illness and the management of its symptoms, but they also have to brace themselves against the societal backlash and devaluation produced by the stigma that accompanies mental illness. Stigmatization can drastically alter the life chances of individuals with mental illness and have negative outcomes in regards to employment, income (Markowitz, 1998), social integration(Chan, 2004), self esteem(Blankertz, 2001), health care, insurance, and access to justice (Sayce, 1998.)

Current Mood And Food Choices: The Relation Between Positive Affect And Dietary Behavior, Kristi E. White, Amy M. Humke, Marc T. Kiviniemi

Department of Psychology: Faculty Publications

Colloquially, much is made of the relation between food and mood. For example, “comfort foods” are eaten in the service of affect regulation. Affect can influence behavioral choices in a number of ways. We investigated whether college students’ mood when making dietary choices influenced the nutritional value of the foods chosen. Sixty-five participants completed a questionnaire immediately prior to eating a meal in a college dining hall. The questionnaire included a measure of current positive affect. Following the meal, participants reported what they ate for dinner. Using nutritional data from the college dining services, we used participants’ self reported food …

2005 - The Tenth Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Tenth Annual Symposium of Student Scholars, held on April 8, 2005. Includes abstracts from the presentations and posters.

Proopiomelanocortin Neurons In Nucleus Tractus Solitarius Are Activated By Visceral Afferents: Regulation By Cholecystokinin And Opioids, Suzanne M. Appleyard, Timothy W. Bailey, Mark W. Doyle, Young-Ho Jin, James L. Smart, Malcolm J. Low, Michael C. Andresen

Faculty Publications - Department of Biological & Molecular Science

The nucleustractus solitarius (NTS) receives dense terminations from cranial visceral afferents, including those from the gastrointestinal (GI) system. Although the NTS integrates peripheral satiety signals and relays this signal to central feeding centers, little is known about which NTS neurons are involved or what mechanisms are responsible. Proopiomelanocortin (POMC) neurons are good candidates for GI integration, because disruption of the POMC gene leads to severe obesity and hyperphagia. Here, we used POMC– enhanced green fluorescent protein (EGFP) transgenic mice to identify NTS POMC neurons. Intraperitoneal administration of cholecystokinin (CCK) induced c-fos gene expression in NTS POMC–EGFP neurons, suggesting that they …

Microsomal Prostaglandin E Synthase-1: The Inducible Synthase For Prostaglandin E2, Annaleise V. Sampey, Seetha Monrad, Leslie J. Crofford

Internal Medicine Faculty Publications

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE2 observed in inflammatory arthritis. The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis.

Addressing The Marion County Health Department’S Need For A Comprehensive Resource Detailing Florida Medicare’S Medical Necessity Policies

Florida Public Health Review

No abstract provided.

Molecular And Clinical Analyses Of Greig Cephalopolysyndactyly And Pallister-Hall Syndromes: Robust Phenotype Prediction From The Type And Position Of Gli3 Mutations, Jennifer J. Johnston, Isabelle Olivos-Glander, Christina Killoran, David Tilstra Md

Articles

Mutations in the GLI3 zinc-finger transcription factor gene cause Greig cephalopolysyndactyly syndrome (GCPS) and Pallister-Hall syndrome (PHS), which are variable but distinct clinical entities. We hypothesized that GLI3 mutations that predict a truncated functional repressor protein cause PHS and that functional haploinsufficiency of GLI3 causes GCPS. To test these hypotheses, we screened patients with PHS and GCPS for GLI3 mutations. The patient group consisted of 135 individuals: 89 patients with GCPS and 46 patients with PHS. We detected 47 pathological mutations (among 60 probands); when these were combined with previously published mutations, two genotype-phenotype correlations were evident. First, GCPS was …

Disparity Of Breast Cancer Survival In African American Women Vs. Caucasians: Examination Of Potential Origins, Mary Collier

Graduate Research Projects

No abstract provided.

Advances In Graduate Nursing Education: Beyond The Advanced Practice Nurse, Sharon Radzyminski

Nursing Faculty Publications

Historically, graduate education in nursing has been primarily concerned with the clinical role. In recent years it has been suggested that graduate education needs to consider alternate programs of study that prepare nurses for clinical leadership that are distinct from management and advanced practice roles. Graduate education is needed that focuses on the skills required to coordinate care and implement outcome-based practice and quality improvement strategies. Two models are currently being proposed that meet these objectives. The first is the population health nurse expert that functions on the macrosystems approach and the second is the clinical nurse leader which is …

A Mathematical Model For Treatment-Resistant Mutations Of Hiv, Helen Moore, Weiqing Gu

All HMC Faculty Publications and Research

In this paper, we propose and analyze a mathematical model, in the form of a system of ordinary differential equations, governing mutated strains of human immunodeficiency virus (HIV) and their interactions with the immune system and treatments. Our model incorporates two types of resistant mutations: strains that are not responsive to protease inhibitors, and strains that are not responsive to reverse transcriptase inhibitors. It also includes strains that do not have either of these two types of resistance (wild-type virus) and strains that have both types. We perform our analysis by changing the system of ordinary differential equations (ODEs) to …

Santa Clara Magazine, Volume 46 Number 4, Spring 2005, Santa Clara University

Santa Clara Magazine

8 - 'AN EXTRAORDINARY EVENT' By Elizabeth Kelley Gillogly '93. SCU Music Professor Hans Boepple is a gifted pianist and dedicated teacher.

10 - EMBRACING DIFFERENCES By Adam Breen. Senior Aaron Uchikura spent a summer helping children in Moscow orphanages.

12 - THE KOKO CONNECTION By Victoria Hendel De La O. Senior Tierra Wilson's perseverance landed her a job as a gorilla research assistant and caregiver.

16 - A ROTATION IN ETHICS By Rita Beamish '74. Students learn about the ethics of health care by shadowing doctors and nurses at O'Connor Hospital in San Jose.

Unlv Magazine, Erin O'Donnell, Gian Galassi, Deana Martin, Patti Shock, John Stefanelli, John Bowen, Paul J. Traudt, Jeffrey J. Matthews, Gillian Silver, Regina Barcolas, Jennifer Robison, Doug Mcinnis, Cate Weeks

UNLV Magazine

No abstract provided.

26Al-Containing Acidic And Basic Sodium Aluminum Phosphate Preparation And Use In Studies Of Oral Aluminum Bioavailability From Foods Utilizing 26Al As An Aluminum Tracer, Robert A. Yokel, Aaron A. Urbas, Robert A. Lodder, John P. Selegue, Rebecca L. Florence

Pharmaceutical Sciences Faculty Publications

We synthesized ²⁶Al-containing acidic and basic (alkaline) sodium aluminum phosphates (SALPs) which are FDA-approved leavening and emulsifying agents, respectively, and used them to determine the oral bioavailability of aluminum incorporated in selected foods. We selected applicable methods from published syntheses (patents) and scaled them down (∼3000- and 850-fold) to prepare ∼300–400 mg of each SALP. The ²⁶Al was incorporated at the beginning of the syntheses to maximize ²⁶Al and ²⁷Al equilibration and incorporate the ²⁶Al in the naturally-occurring Al-containing chemical species of the products. Near infrared spectroscopy (NIR) and X-ray powder diffraction (XRD) were used …