Digital Commons Network^™

Dietary Intake Of Protein By Food Source And Incident Hypertension Among Diverse Us Adults: The Mesa Study, Ji Yun Tark, Ruosha Li, Bing Yu, Alexis C Wood, Nikhil S Padhye, Marcia C De Oliveira Otto

Faculty, Staff and Student Publications

Background: Dietary guidelines recommend adequate protein intake from diverse sources for optimal blood pressure; however, its role in hypertension risk remains unclear. We examined prospective associations of protein intake and diversity, overall and by source, with hypertension risk in the MESA (Multi-Ethnic Study of Atherosclerosis) study.

Methods and results: Among 2294 participants aged 45 to 84 years without hypertension at baseline, total, animal, and plant protein intake was assessed using a 120-item food frequency questionnaire. Protein diversity was evaluated using count and the dissimilarity index. Over a 9-year median follow-up, 1356 hypertension cases were identified through blood pressure measurements and …

Epigenome-Wide Dna Methylation Association Study Of Chip Provides Insight Into Perturbed Gene Regulation, Sara Kirmani, Tianxiao Huan, Joseph C Van Amburg, Roby Joehanes, Md Mesbah Uddin, Ngoc Quynh H Nguyen, Bing Yu, Jennifer A Brody, Myriam Fornage, Jan Bressler, Nona Sotoodehnia, David A Ong, Fabio Puddu, James S Floyd, Christie M Ballantyne, Bruce M Psaty, Laura M Raffield, Pradeep Natarajan, Karen N Conneely, Joshua S Weinstock, April P Carson, Leslie A Lange, Kendra Ferrier, Nancy L Heard-Costa, Joanne Murabito, Alexander G Bick, Daniel Levy

Faculty, Staff and Student Publications

With age, hematopoietic stem cells can acquire somatic mutations in leukemogenic genes that confer a proliferative advantage in a phenomenon termed CHIP. How these mutations result in increased risk for numerous age-related diseases remains poorly understood. We conduct a multiracial meta-analysis of EWAS of CHIP in the Framingham Heart Study, Jackson Heart Study, Cardiovascular Health Study, and Atherosclerosis Risk in Communities cohorts (N = 8196) to elucidate the molecular mechanisms underlying CHIP and illuminate how these changes influence cardiovascular disease risk. We functionally validate the EWAS findings using human hematopoietic stem cell models of CHIP. We then use expression quantitative …

Rapamycin Treatment For Alzheimer's Disease And Related Dementias: A Pilot Phase 1 Clinical Trial, Mitzi M Gonzales, Miranda E Orr, Yingxin He, Randall J Bateman, Et Al.

2020-Current year OA Pubs

BACKGROUND: Rapamycin has been shown to extend lifespan and acts on pathologies underlying Alzheimer's disease and related dementias in animal models. However, rapamycin's clinical application remains underexplored.

METHODS: We conducted a single-site open-label phase 1 clinical trial (ClinicalTrials.gov: NCT04200911) to examine the effects of rapamycin in humans. Eligible participants were people 55-85 years old with mild cognitive impairment or early-stage dementia, which was defined as having a Global Clinical Dementia Rating Scale Score of 0.5-1. All participants received rapamycin (1 mg/day) for eight weeks. The primary aim was to evaluate rapamycin's central nervous system penetrance by assaying drug levels in …

Effects Of Nicotine On Dopamine Signaling In Sprague Dawley Rats, Dominik Sretenovic, Kyle A. Marsh, Sabin Mulch, Gahnan Schaff, Anthony Jones, Sukhman Bains, David Daberkow

2025 Symposium

Nicotine influences dopamine (DA) release in the nucleus accumbens, a brain region associated with reward processing and addiction. This study examined nicotine’s effects on DA signaling using fast-scan cyclic voltammetry (FSCV) in anesthetized rats. Electrodes were implanted to stimulate DA release in the medial forebrain bundle and record signals in the ventral striatum. After administering saline or nicotine, DA levels were monitored in real-time, and electrode placement was later verified through histological analysis. Saline-treated rats showed minor DA fluctuations, with a peak signal detected at 50 minutes, while technical difficulties prevented complete nicotine data collection. However, previous experiments indicated significantly …

Investigating Empathy In Rats: Behavioral Responses To Distress, Isabella Sophia Avery, Kolette Stuhmer, Jeffrey Schell

2025 Symposium

INTRODUCTION: Empathy can be defined as the ability to recognize, understand, and match one’s emotional state to that of another. Previous research has suggested that emotional contagion produces empathetic responses among familiar rats when their cage mate is exposed to a stressor. This study seeks to further explore this relationship and compare responses among familiar vs. unfamiliar rats. METHODS: Male and female Sprague-Dawley rats were divided into cohorts including an observer, demonstrator, and stranger rat. The demonstrator was exposed to shock paired with a tone and the demonstrator, its cage mate, was only exposed a tone but no shock. The …

Fear And Oxytocin: Effects Of Intraperitoneal Pretreatment In Rats, Daniel Yeromenko, Kelsie German, Eros Fuentes, Jenna Meade, Ben Bustos

2025 Symposium

INTRODUCTION: Oxytocin is a neuropeptide widely known for its role in social bonding and emotional regulation. Recent studies have suggested its involvement in modulating fear, stress, and anxiety responses, potentially offering therapeutic applications for trauma-related disorders such as PTSD. This study investigated whether pretreatment with oxytocin reduces behavioral and physiological fear responses in male and female Sprague-Dawley rats using a classical fear conditioning model. METHODS : Twenty-four Sprague-Dawley rats (12 males, 12 females) were assigned to one of four groups: control (no shock, no oxytocin), shock only, shock + low-dose oxytocin (0.5 mg/kg), and shock + high-dose oxytocin (1.0 mg/kg). …

Female Student Athlete’S Sprint Time And Performance Running Barefoot, In College Shoes, And Personal Shoes, M Foor, A Stoner, J Sterenberg, K Gallagher

International Journal of Exercise Science: Conference Proceedings

A

Preparation And In-Vitro Evaluation Of Dompridone Oral Thin Film, Fatima Mohammed Hussein Wais

Maaen Journal for Medical Sciences

The aim of the current study was to formulate and evaluatedompridone nanoparticles and loaded in oral fast dissolve film, for enhance the solubility of poor water soluble dompridone by nanoparticles and fasten the action by prepared as oral thin film and also to improve patient compliance. Domperidone is the recommended medication for nausea and vomiting brought on by viral infections, chemotherapy, migraines, and food poisoning.Domperidonenanoparticles were made using two type of polymers (hydroxypropyl methylcellulose HPMC-K15 and methylcellulose MC-A4C) in a range of ratios (1:1, 1:2, and 1:3) drug:polymer ratio by solvent antisolvent technique. In nanoparticle formulation, HPMC-K15 and MC-A4C were …

Human Endogenous Retroviruses (Hervs) Associated With Glioblastoma Risk And Prognosis, Harun Mazumder, Hui Yi Lin, Melody Baddoo, Wojciech Gałan, Diana Polania-Villanueva, Chindo Hicks, David Otohinoyi, Francesca Peruzzi, Zbigniew Madeja, Victoria P. Belancio, Erik K. Flemington, Krzysztof Reiss, Monika Rak

School of Medicine Faculty Publications

Emerging evidence suggests expression from human endogenous retrovirus (HERV) loci likely contributes to, or is a biomarker of, glioblastoma multiforme (GBM) disease progression. However, the relationship between HERV expression and GBM malignant phenotype is unclear. Applying several in silico analyses based on data from The Cancer Genome Atlas (TCGA), we derived a locus-specific HERV transcriptome for glioma that revealed 211 HERVs significantly dysregulated in the comparisons of GBM vs. normal brain (NB), GBM vs. low-grade glioma (LGG), and LGG vs. NB. Our analysis supported development of a unique HERV scoring algorithm that segregated GBM, LGG, and NB. Interestingly, lower HERV …

Myocardin Effector Proteins Affect Tgf-Beta-Induced Myofibroblast Differentiation In Ipf Cells, Allison Gonzalez

Biotechnology Theses

Idiopathic pulmonary fibrosis (IPF) is an incurable interstitial lung disease defined by the progressive, irreversible scarring of the tissues between the lung’s alveoli. To date, only two drugs have received approval for treatment. However, these medications are not considered cures since they do not stop the progression of the disease. A deeper understanding of the mechanisms underlying IPF could aid in discovering a cure. We recently found that myocardin (MyoCD) regulates SMAD2/3 transcription factors in the TGF-β signaling pathway and governs the genes involved in pleural fibrosis. However, it is unclear whether MyoCD plays a critical role in IPF by …

Intouch Week Of May 19, 2025, New York Medical College

InTouch

• Vikas Grover, Ph.D., CCC-SLP, and Ronnie Myers, D.D.S., Named Healthcare Heroes by Westchester Magazine
• Annual Louis Del Guercio, M.D., Research Day Showcases Outstanding Surgical Research
• NYMC Celebrates Homecoming 2025 with Alumni, Students, and Campus Tours
• Teaching and Learning Symposium Brings Faculty Together to Enrich Their Educational Practice
• Philip Kuehl, Ph.D., Addresses Drug Development Problem Statements at the Neighborhood Science Seminar Series
• 185 TCDM Students Don White Coats as They Head to Touro Dental Health Clinics in New York and New Mexico
• Student Spotlight: David Zuckerman to Address Graduates Before Beginning Neurology Residency at NYU

Ccaat/Enhancer-Binding Proteins Α And Β Regulate Ovulation And Gene Expression Via Dose- And Stage-Dependent Mechanisms, Hanxue Zhang, Rainer B Lanz, Jimmy Dhillon, Paul D Soloway, Bo Shui, Yi Athena Ren

Faculty, Staff and Students Publications

The preovulatory luteinizing hormone (LH) surge orchestrates complex cellular and molecular events leading to ovulation. CCAAT/enhancer-binding proteins α and β (C/EBPα/β) are transcription factors acutely induced by the LH surge and crucial for ovulation and granulosa cell luteinization. However, biological processes (BPs) and their regulatory mechanisms downstream of C/EBPα/β in the preovulatory ovary are not completely understood. To address this knowledge gap, we generated Cebpa/bfl/fl;Pgr-Cre mutants and compared them with Cebpa/bfl/fl;Cyp19a1-Cre mutant female mice: Cebpa/bfl/fl;Cyp19a1-Cre mutants have undetectable levels of C/EBPα/β throughout the preovulatory stages and do not ovulate, aligning with previous reports; and Cebpa/bfl/fl;Pgr-Cre mutants present gradual depletion of …

The Impact Of Functional Disabilities On The Quality Of Life Of Older U.S. Adults, Bernadette Lavender

Walden Dissertations and Doctoral Studies

Among older U.S. adults, functional disabilities are critical determinants of quality of life (QoL), influencing mobility, social engagement, and independence. Despite growing evidence of these impacts, limited research examines how healthcare access, social support, and socioeconomic factors moderate this relationship. This quantitative study explored the effects of functional disabilities on QoL, operationalized through self-reported health, while examining the moderating roles of key social determinants. Using a cross-sectional design, secondary data from the Health and Retirement Study (HRS) were analyzed. The sample included 42,405 participants aged 60 years and above from all 50 states. Multiple regression analyses and ANOVA were employed …

Dual-Responsive Synthetic Gene Circuit For Dynamic Biologic Drug Delivery Via Inflammatory And Circadian Signaling Pathways, Amanda Cimino, Fiona Pat, Omolabake Oyebamiji, Christine T N Pham, Erik D Herzog, Farshid Guilak

2020-Current year OA Pubs

BACKGROUND: Engineered cells provide versatile tools for precise, tunable drug delivery, especially when synthetic stimulus-responsive gene circuits are incorporated. In many complex disease conditions, endogenous pathologic signals such as inflammation can vary dynamically over different time scales. For example, in autoimmune conditions such as rheumatoid arthritis or juvenile idiopathic arthritis, local (joint) and systemic inflammatory signals fluctuate daily, peaking in the early morning, but can also persist over long periods of time, triggering flare-ups that can last weeks to months. However, treatment with disease-modifying anti-rheumatic drugs is typically provided at continuous high doses, regardless of disease activity and without consideration …

Approach To The Patient: From Endocrinopathy To The Diagnosis Of A Histiocytic Disorder, Polyzois Makras, Dana Erickson, Caroline J Davidge-Pitts, Eli L Diamond, Carl E Allen, Kenneth L Mcclain, Jithma P Abeykoon, Ronald S Go, Krishmita Siwakoti, Houman Sotoudeh, Aishwarya Ravindran, Lucinda M Gruber, Gaurav Goyal

Faculty, Staff and Students Publications

Endocrinopathies are frequently the initial presentation of histiocytic neoplasms, which are rare hematologic disorders affecting multiple organ systems. Langerhans cell histiocytosis and Erdheim-Chester disease are 2 such disorders known to infiltrate the hypothalamus and/or pituitary gland, leading to arginine vasopressin deficiency (AVP-D) and anterior pituitary dysfunction (APD) in 20% to 30% of cases, often as the first manifestation. Conversely, histiocytic disorders account for a notable proportion (10-15%) of all pituitary stalk lesions. The diagnosis of histiocytoses is often delayed in such cases due to the nonspecific presentation of endocrinopathies and pituitary involvement. Consequently, endocrinologists are at the frontline and uniquely …

Synergy Of Stress: Examining The Effects Of Proinflammatory Stimuli On C8-D1a Astrocytes, Asher Stang

Undergraduate Theses and Capstone Projects

Neuroinflammation is a complex synergy of different cells within the central nervous system. Astrocytes play a key role in the maintenance of neural functioning, but take a special part in the inflammatory process as well. By releasing pro-inflammatory modulators like cytokines, chemokines, and reactive oxygen species, astrocytes modulate the inflammatory response in the brain. Astrocytes can be activated into this proinflammatory state in response to pathogen derived molecules such as bacterial lipopolysaccharides (LPS). Lipopolysaccharides are glycoproteins derived from gram negative bacteria and commonly used to stimulate cells in vitro to produce an inflammatory response. To look at the effects of …

A Comparison Of Muscular Strength And Power Development In Unilateral And Bilateral Lower Body Exercises, Natalie Pickeral

Undergraduate Theses and Capstone Projects

The purpose of this study was to compare muscle strength and power development following training programs that involved unilateral and bilateral lower-body exercises. A randomized between-groups research design was used in which results from a pretest and posttest were compared across the unilateral and bilateral groups. Sled machine one repetition maximum (1-RM) testing was used as a measure of strength, and countermovement vertical jump (CMVJ) testing was used as a measure of absolute power. Total body bioelectrical impedance analysis testing was used to predict lean body mass in both the left and right legs. Six college-aged female students who were …

Synthesizing Palladium-Unnatural Amino Acid Complexes: Structural Analysis And Potential For Anti-Cancer Biological Activity, Jillian Francis

Undergraduate Theses and Capstone Projects

Cisplatin is a potent anticancer drug that has been widely used in the treatment of several cancers. The drug works by stopping the DNA replication process in cancer cells, preventing them from rapidly multiplying. Despite its effectiveness in treating many cancers, cisplatin has several toxic side effects that hinder its use. Platinum is the central metal in cisplatin, but research has not explored other transition metals, specifically palladium, as an alternative central metal in similar structural complexes. Palladium, being a more reactive species than platinum, offers the potential for a new and improved anticancer drug through the formation of palladium-non-natural …

An Inside Look At Para Sport Concussion Care: Para Sport Healthcare Providers' Perspectives, Alexander Derstine

Undergraduate Theses and Capstone Projects

No abstract provided.

The Effects Of Stress On Injury And Sickness Rates Of Middle-Distance And Distance Division Iii Athletes, Hailey Smith

Undergraduate Theses and Capstone Projects

Running training intentionally stresses the body to experience positive physiological changes, however, maladaptions such as suppressed immune function and growth hormone production may occur without adequate recovery. Male distance and middle distance athletes (n = 14) participated in this study. For 6 weeks, heart rate variability (HRV), resting heart rate (HRrest), perceived stress, and cortisol levels were assessed as indicators of recovery and stress. It was anticipated that indicators of physical stress, such as higher resting heart rates and lower heart rate variability, would correspond with greater perceived stress and higher occurrence of injury and sickness. Cortisol (n = 2, …

Optimizing Genetic Ancestry Adjustment In Dna Methylation Studies: A Comparative Analysis Of Approaches, Kira D Höffler, Seyma Katrinli, Matthew W Halvorsen, Anne-Kristin Stavrum, Kevin S O'Connell, Alexey Shadrin, Srdjan Djurovic, Ole A Andreassen, James J Crowley, Jan Haavik, Kristen Hagen, Gerd Kvale, Kerry Ressler, Bjarne Hansen, Jair C Soares, Gabriel R Fries, Alicia K Smith, Stéphanie Le Hellard

Faculty, Staff and Student Publications

Background: Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs) calculated from CpG sites that overlap with common SNPs to adjust for ancestry when genotyping data is not available. However, this method does not remove technical and biological variations, such as sex and age, prior to calculating the PCs. The first PC is therefore often associated with factors other than ancestry.

Methods: We developed and adapted the adapted EpiAnceR + approach, which includes 1) residualizing the CpG data overlapping with common SNPs for …

Using Natural Materials In Art Therapy To Address Accessibility And Well-Being In Low-Income Older Adults, Ahlyana J. Richardson

Expressive Therapies Theses

This study investigated the implementation of natural materials during the artmaking processes in an older adult art therapy group (eco-art therapy), and its effects on their well-being and the role of accessibility in their lives. An open-studio approach was applied to emphasize the artmaking process being driven by the participants independently, while also sharing a collaborative space and creating community with each other. There was an exception to this condition in this study, being that the participants were encouraged to ask for assistance in using unconventional materials in their artwork if they felt they needed it. The participants were older …

How Can Tattoos Be Understood As Intermodal Expressive Arts Therapy?: Integrating Visual Art, Personal Narrative, And Embodied Experience: Development Of A Method, Rachel S. Hall

Expressive Therapies Theses

This paper explores the inherent intermodal nature of tattoos through the lens of expressive arts therapy, demonstrating how tattoos integrate visual art, personal narrative, and embodied experience. A group intervention was designed and implemented in an outpatient setting, drawing on existing literature and the Expressive Therapies Continuum (ETC) to examine how tattoos function as therapeutic tools that support identity formation, emotional healing, and self-expression. The intervention guided participants through an intermodal process that began with reflective writing on identity-forming experiences, followed by visual art-making and somatic engagement. This approach illuminated the transformative potential of tattoo conceptualization within a therapeutic context, …

A Proposal For The Theoretical Integration Of Cognitive Behavioral Therapy And Dance/Movement Therapy, Sarah Crain

Expressive Therapies Theses

A recognized integration of cognitive behavioral therapy (CBT) and dance/movement therapy (DMT) has not been developed because the concept currently lacks a strong philosophical and theoretical background. Observations from adjacent integrative expressive therapies and clinical practice provide encouragement that these models may provide a unique contribution to the field of psychotherapy. CBT would support the field of DMT toward better establishing an evidence-based theoretical background and framework. It is proposed that a well-supported approach to CBT and DMT should be built from a theoretical integration that upholds integrity of both models while identifying connective philosophical roots. This literature review initiates …

How Can Art Therapy Be Utilized To Support Emotional Communication For Autistic Individuals With An Alexithymic Profile?, Kathryn L. Cohen

Expressive Therapies Theses

The expressive nature of art therapy can aid those with communication and sensory processing differences. Art making allows for the individual to access and emote in a way that spoken language cannot. This literature review will investigate and explore the features of the processing differences related to autism, interoception and alexithymia. The findings from the research explore the effectiveness of utilizing art therapy as a method to expand emotional communication. There are many challenges pertaining to emotional regulation and communication for autistic individuals. Accessing mental health resources and service providers familiar with communication differences is another challenge for this population. …

To Bear Witness: Analyzing Dmt As An Effective Trauma-Informed Approach For Treating Youth & Adolescents: A Critical Review Of The Literature, Jade Dennis

Expressive Therapies Theses

This literature review proposes dance/movement therapy (DMT) as a trauma-informed intervention for children and adolescents who have experienced psychological, emotional, or physical trauma. The project, inspired by internship experiences with young trauma survivors, explores the ways in which trauma manifests in the body, indicating that DMT may offer effective pathways toward healing. Many children exposed to potentially traumatic events exhibit emotional dysregulation, insecure attachment patterns, and behavioral or somatic symptoms that are not easily addressed through traditional talk therapy. As a body-based expressive arts modality, DMT engages the sensory, emotional, and relational aspects of trauma by supporting nonverbal expression, self-regulation, …

Therapeutic Qualities And Applications Of Clay In Expressive Arts Therapy: A Literature Review, Julia Caruso

Expressive Therapies Theses

This literature review investigates the therapeutic qualities and clinical applications of clay within the framework of expressive arts therapy (ExAT), with particular focus on sensorimotor, somatic, and developmental interventions. Drawing upon the expressive therapies continuum (ETC), this review synthesizes emerging research highlighting clay's kinesthetic and tactile properties as key mechanisms for facilitating emotional expression, accessing unconscious material, and promoting psychological resilience. Evidence is presented for specialized therapeutic modalities such as clay art therapy (CAT) and Clay Field Work, which engage the body-mind connection to support trauma integration and emotion regulation. Findings demonstrate that clay's inherent adaptability and sensory richness allow …

A Comparative, Quantitative Analysis Of Birth Outcomes Among Women With Intellectual Or Developmental Disabilities, Jocelyn T. Reddix

MUSC Theses and Dissertations

Women who are pregnant or planning to give birth deserve equitable resources, respect, and assurances to ensure a healthy and safe pregnancy, including women of childbearing age who are diagnosed with intellectual or developmental disabilities (IDD). These women are more likely to experience negative perinatal, delivery, and postpartum health outcomes (Tarasoff et al., 2020). Healthcare providers, clinicians, and the family and friends of those with IDD must understand the impact and implications of the prenatal and postpartum journey for this group of women. This comparative research examined 2021 birth outcomes of women in the United States with IDD compared to …

Addressing Socioeconomic Disparities In The Treatment Of Antimicrobial-Resistant Infections: The Role Of Pharmacists In Mitigating Barriers, Arin Wade, Danielle Egbujor, Anna Spalvieri, Owen Fox, Marisa Petrunich, Joshua Honaker, Samantha Mccord, Kasie Landin

Pharmacy and Wellness Review

Antimicrobial resistance is an escalating global threat driven by inappropriate antibiotic use and shaped by socioeconomic disparities. Social determinants of health, including limited healthcare access, poverty, low health literacy, and environmental conditions, contribute to higher rates of resistant infections and poorer treatment outcomes in underserved populations. Barriers such as pharmacy deserts, self-medication, and inadequate stewardship infrastructure amplify these risks. Pharmacists, as accessible and highly trained healthcare professionals, play a critical role in combating antimicrobial resistance by optimizing antibiotic use, delivering culturally competent education, and leading antimicrobial stewardship programs across settings. Community and clinical pharmacists are especially well positioned to bridge …

Guidelines For The Creation And Implementation Of A School-Based Vision Program For The Greater Seattle Area, Suzanna P. Gill

Honors Projects

Proper vision care contributes to a child’s ability to perform academically as well as their overall health and wellbeing. Pediatric vision care begins with vision screening, which occurs in public schools in Washington state. These vision screenings allow for possible vision issues to be identified in children. They are not, however, a replacement for eye examinations that help determine what is causing the problem and provide treatment. A substantial proportion of children that are recommended to receive the exams will not, partially because Washington does not require parents to take their children to eye care professionals. These children are more …