Digital Commons Network^™

The Biological Response Of Human Np Cells To Soluble Collagen Vi, Jonathan Dalton, Srikanth N. Divi, Yasmine Eichbaum, Panya Luksanapruksa, Mitchell K. Ng, Rachel Huang, Alan S. Hilibrand, Alex R. Vaccaro, Dessislava Z. Markova, Christopher K. Kepler

Department of Orthopaedic Surgery Faculty Papers

Extracellular matrix (ECM) dysregulation plays a significant role in the development of intervertebral disc disease (IVDD). The ECM around the chondrocytes in the nucleus pulposus (NP) is unique in that it contains ColVI. While linked to chondrocyte proliferation in cartilage, ColVI's specific role in IVD degeneration is less clear. Our aim was to determine the expression of ColVI in NP cells from degenerative IVDs, along with the effects of soluble ColVI on NP cells. Thus, we compared the expression levels of ColVI in human degenerated IVD samples, along with the effect of soluble ColVI on primary human NP cells. A …

Mystery Archives: Administrative File Management & Retention, Mia Mancebo, Amy Kintz, Jonathan Davidson Mba, Mabc, Pmp

Research Scholars

No abstract provided.

Using Fecal Diagnostic Tests To Assess The Prevalence Of Fasciola Hepatica In The United States Sheep Population, Brooke A. Delcambre

LSU Master's Theses

Fasciola hepatica, the common liver fluke, is endemic in the Pacific Northwest and Gulf Coast of the United States. To provide updated information on F. hepatica prevalence, as part of the USDA National Animal Health Monitoring System Sheep 2024 study, sheep operations in the top 30 sheep-producing states were identified, and producers were invited to participate. For each operation, feces were collected from at least eight sheep and pooled to form a single composite sample. Two methods were used to identify sheep infected with F. hepatica: fecal sedimentation and indirect sandwich ELISA. At the national level, across 318 operations, 7.1 …

Walking The Talk For Dementia: Building Social Networks And Collaborations, Walter D. Dawson, Jenn Reed, Fernando Aguzzoli-Peres, Kate Irving, Sherril B. Gelmon

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: Dementia is one of the greatest global health challenges requiring multimodal efforts to address its impact on people and societies. Walking the Talk for Dementia (WTD) is a unique global initiative designed to challenge the stigma that surrounds dementia, foster intergenerational dialogue, build a community, and inspire a renewed sense of purpose among participants. A social network analysis (SNA) was conducted to provide greater detail and contextualization of the connections made during WTD and insights into the collaborations that arose from this immersive event which may influence dementia policy, care, and services. Methods A robust, comprehensive, and minimally intrusive …

Analysis Of Care And Outcomes For Stage Iv Melanoma Patients At Lehigh Valley Topper Cancer Institute (2017-2023), Jake M. Panzer, Suresh G. Nair Md, Melissa Kratz Rn, Msn, Aocn

Research Scholars

No abstract provided.

Assessing The Impact Of A Pharmacy Driven Adult Mrsa Nasal Screening Protocol, Priyal Prabhu, Jarrod W. Kile Rphd, Golda Peysakhova Pharmd, Kathryn Zaffiri Mph, Eric Young Md

Research Scholars

No abstract provided.

The Environmental Polycyclic Aromatic Hydrocarbon (Pah) Benzo[A]Pyrene (Bp) Alters Sars-Cov-2 Pathogenesis In A Mouse Model Of Disease, Yike Jiang, Weiwu Jiang, Sarah Strobel, Fong W Lam, Bhagavatula Moorthy, Shannon E Ronca

Faculty, Staff and Students Publications

Since emerging in late 2019, SARS-CoV-2 has caused over 7 million deaths globally and remains a public health concern. Understanding SARS-CoV-2 pathogenesis is vital, especially as factors like environmental exposures are still poorly understood. Polycyclic aromatic hydrocarbons (PAHs), like benzo[a]pyrene (BP), found in pollutants like cigarette smoke, diesel exhaust, and charcoal-broiled steaks, are known to injure the lungs. We aimed to evaluate if BP exacerbates SARS-CoV-2 pathogenesis in a mouse model of disease. One day following intranasal administration of BP (20 mg/kg) or vehicle control, we infected male and female K18-hACE2 mice with ancestral SARS-CoV-2 and assessed lung viral load, …

Revising A Clinical Assessment Tool: A Community College Dental Hygiene Program Case Study, Kristen Portner-Lauerman Dhsc, Mha, Rdh

Oral Health

This article examines how one community college dental hygiene program implemented revisions to a clinical assessment tool to better support novice learners. A review of the literature explores the characteristics of early learners, psychomotor skill acquisition, the Dreyfus model, and assessment tools. The method used was a descriptive case study designed to address the research question: What processes did a dental hygiene program use to implement revisions to a clinical assessment tool to support students’ development of essential clinical skills? The findings highlight the importance of aligning assessment tools with learners’ developmental stages to enhance clinical education and offer a …

Improving Provider Adherence To Adolescent Depression Screening: Implementation Of A Standardized Phq-A Workflow In Pediatric Primary Care, Taylor P. H. Wamser

Student Scholarly Projects

Practice Problem: Adolescent depression is frequently under identified in pediatric primary care because of inconsistent implementation of routine depression screening despite national recommendations. This practice gap may delay diagnosis and treatment which may increase the risk of adverse mental health outcomes.

PICOT: The PICOT question that guided this project was: In pediatric primary care providers, how does the implementation of a standardized PHQ-A (Patient Health Questionnaire for Adolescents) workflow compared to informal screening practices affect provider adherence to depression screening guidelines over 12 weeks?

Evidence: Current evidence and national clinical practice guidelines support routine adolescent depression screening using validated tools …

Policy Brief: North Dakota Maternal Mortality Committee, Kilyn R. Parisien

Public Health Student Publications

The following policy brief was created to examine North Dakota policies that are specific to maternal mortality and morbidity reviews. The North Dakota Maternal Mortality Committee (NDMMRC) is responsible for conducting maternal mortality and morbidity reviews in the state of North Dakota. This brief is guided by policies from North Dakota and MMRC reviews from surrounding states to inform six recommendations intended that guarantee the highest quality data collection and data reporting on maternal mortality and morbidity.

Tiny Hearts, Big Questions: Navigating Research And Clinical Trials In Pediatric Cardiology, Madison Dollar, Monica Ganaden, Gracie Gilbert, Mena Mohamedaman, Bellina Osei, Savine Valenzuela, Zachary Xayaphanh

2025

No abstract provided.

Wmdds Bulletin Spring 2026

West Michigan District Dental Society Bulletin

In the Spring 2026 issue, the reader will find introductions to the 2026-2027 WMDDS Board, recognition of WMDDS members for recent Michigan Dental Association awards, and "Pearls from Local Dentists" on the subject of Caring for Patients with Cleft Lip and Palate. Also included are your monthly tripartite updates, news from West Michigan counties, the President's Message, and the Editor's Letter.

Clinical Corner: Pearls From Local Dentists

West Michigan District Dental Society Bulletin

"Clinical Corner: Pearls from Local Dentists" is a section of the WMDDS Bulletin where local dentists share clinical wisdom for fellow practitioners. This edition's topics include Behavior Guidance in Pediatric Dentistry, occupational pain, and occupational hearing loss

Wmdds Bulletin Winter 2026

West Michigan District Dental Society Bulletin

In the Winter 2026 issue, the reader will find articles detailing West Michigan District Dental Society's delegation notice and election results, an Ionia/Montcalm County spotlight, and "Pearls from Local Dentists" on the subjects of Behavior Guidance in Pediatric Dentistry, occupational pain, and preventing hearing loss. Also included are your monthly tripartite updates, news from West Michigan counties, the President's Message, and the Editor's Letter.

Abstract Book (Pdf), Lsu Health School Of Medicine

Summer Research Internship Program

Abstract Book for the 20XX Summer Research Internship Program.

Participants are listed alphabetically by last name.

Accessibility statement: The attached document has been formatted to meet PDF/UA v1 standards.

Bridging The Gap: Critical Resources For Grandparent Caregivers And Their Grandchildren, Kathy Dial, Cara Tonn, Omotomilola Jegede, Cindy Kekeh, Loriena Yancura, Michele Kekeh

GrandFamilies: The Contemporary Journal of Research, Practice and Policy

US population estimates indicate that approximately 2.5 million children live apart from both parents. Family relatives, often called kinship caregivers, care for 70% to 90% of these children, with grandparents making up the largest category (Radel et al., 2016). This study aimed to identify the most helpful resources and sources for grandparent caregivers to support the overall well-being of their families. Phone or Zoom interviews were conducted among a purposive sample of 24 grandparent caregivers from February to March 2022 to examine their initial experiences as caregivers, the current support services and resources they received, and other resources and services …

Montana Kinship Navigator Program: A Statewide Frontier Initiative Promoting Kinship Family Health And Wellness, Daniel J. Koltz Dr., Peyton Vining, Yu Jiang

GrandFamilies: The Contemporary Journal of Research, Practice and Policy

This practice brief report describes the development, implementation, and new updates of the Montana Kinship Navigator Program (MTKNP), a statewide initiative designed to support kinship caregivers in a large, rural frontier context. Montana’s geographic isolation, limited infrastructure, and sparse population create significant barriers for kinship families, including restricted access to healthcare, transportation, childcare, and social services. These challenges are compounded when caregivers unexpectedly assume responsibility for children, often with limited resources and support. MTKNP addresses these gaps through a comprehensive, evidence-informed model that integrates information and referral services with individualized case management. The program serves both formal and informal kinship …

The Health And Well-Being Of Grandparents Who Report Major Responsibilities For Grandchildren: Perceived Physical Health, Depressive Affect, And Life Satisfaction, Tze-Li Hsu Phd, Patricia Drentea Phd

GrandFamilies: The Contemporary Journal of Research, Practice and Policy

This study examines how grandparents who report major responsibilities for their grandchildren experience perceived physical health, depressive affect, and life satisfaction compared to grandparents who do not report these responsibilities. Using data from the third wave of MIDUS (2013–2014), a nationally representative dataset focused on mid to later life (n = 1,819), we analyzed a sample of grandparents. Ordered logistic regression was used for perceived physical health, and ordinary least squares (OLS) regression was used for depressive symptoms and life satisfaction. Results indicate that grandparents with caregiving responsibilities are more likely to be women, non-White, and have lower incomes and …

Enhancing Chronic Kidney Disease Awareness And Early Identification Through Community Health Worker Education In Rural Arkansas, Samantha L.M. Smith

Walden Dissertations and Doctoral Studies

The doctoral project was focused on improving staff education and development to prevent chronic kidney disease (CKD) through community health worker (CHW) education. The practice problem was the delayed identification of CKD risk factors and late referral to nephrology services, particularly among rural and underserved populations. Because CKD often progresses without symptoms, early education and awareness are critical to improving outcomes and reducing disease progression. The purpose of the project was to develop and implement a structured CKD educational curriculum for CHWs to improve their confidence in kidney health, CKD risk factors, prevention strategies, early identification, and referral awareness. The …

Depression And Psychotic Disorders Elevate Inpatient Burden After Posterior Cervical Decompression And Fusion: Prioritizing Screening And Targeted Discharge Planning, Leonidas E. Mastrokostas, Paul G. Mastrokostas, Daniel Yusupov, Abigail Razi, Aaron B. Lavi, Luke B. Schwartz, Sean Inzerillo, Mohamed Said, Alexander Kucherina, Pemla Jagtiani, Arie Monas, John K. Houten, Christopher K Kepler, Jad Bou Bou Monsef, Afshin E. Razi, Mitchell K. Ng

Rothman Institute Papers

CONTEXT: Psychiatric comorbidity has been associated with worse perioperative outcomes and greater healthcare utilization after spine surgery.

AIMS: This study compared complications and healthcare utilization among posterior cervical decompression and fusion (PCDF) patients with depression, psychotic disorders, or no mental-health diagnosis.

SETTINGS AND DESIGN: Retrospective cohort analysis of the National Inpatient Sample from 2016 to 2022.

MATERIALS AND METHODS: The database was queried for elective adult PCDF encounters. Mental-health exposures were defined using Elixhauser indicators for depression and psychoses. Outcomes included medical complications, non-routine discharge, inpatient mortality, length of stay (LOS), and costs.

STATISTICAL ANALYSIS USED: Chi-square and multivariate logistic …

Simbinder-If: Structure-Aware Antibody Affinity Optimization Via Efficient Preference Learning, Xinyan Zhao, Yi-Ching Tang, Rivaaj Monsia, Victor J Cantu, Ashwin Kumar Ramesh, Siyu Yang, Xiaozhong Liu, Zhiqiang An, Xiaoqian Jiang, Yejin Kim

The Brown Foundation: Institute of Molecular Medicine

Motivation: Antibody therapeutic efficacy depends on high-affinity target engagement, yet laboratory affinity maturation is slow and costly. Most protein language models (PLMs) lack explicit training for high affinity, and current preference optimization methods introduce computational overhead without clear affinity improvements. Therefore, structure-aware and parameter-efficient approaches for antibody affinity optimization are urgently needed.

Results: We propose SimBinder-IF, a structure-aware antibody optimization model trained by freezing the Evolutionary Scale Modeling inverse folding (ESM-IF) structure encoder and fine-tuning only its decoder via Simple Preference Optimization (SimPO) to prefer stronger binders. In generalization tests across seven held-out complexes (93 477 mutants), SimBinder-IF shows a …

Higher Mortality And Distinct Complications After Anterior Cervical Discectomy And Fusion In Dialysis Patients, Despite Improvements Over Prior Decade: A National Inpatient Study, Mitchell K. Ng, Leonidas E. Mastrokostas, Paul G. Mastrokostas, William A. Green, Joshua Mathew, Gregorio Baek, Yasmine Eichbaum, Yulia Lee, Morgan Hitchner, Jonathan Dalton, Adam Fano, Alec Giakas, Rajendra Singh, Brendan Reitman, Afshin E. Razi, Daniel R. Fassett, Alan S. Hilibrand, Alex R. Vaccaro, Christopher K. Kepler, Gregory D. Schroeder, Andrew P. Alvarez

Rothman Institute Papers

Introduction: Dialysis patients undergoing anterior cervical discectomy and fusion (ACDF) face elevated perioperative risk due to complex comorbidities. This study aimed to (1) identify associations between dialysis status and perioperative complications after ACDF, (2) quantify differences in length of stay (LOS), hospitalization costs, and discharge disposition, and (3) provide a contemporary national benchmark for outcomes in this high-risk population. Materials and Methods: The 2016–2022 National Inpatient Sample was queried for adult elective ACDF cases. Dialysis dependence was identified through International Classification of Diseases-10 codes for end-stage renal disease with hemodialysis or peritoneal dialysis. Demographics, comorbidities, complications, LOS, costs, and discharge …

Time Series Analysis Of Temperature And Pollen Exposure On Asthma Outcomes In Atlanta, Georgia, Victoria Okereke-Viktorsson

Walden Dissertations and Doctoral Studies

The effects of climate change contribute to volatile temperature changes, which coupled with pollen exposure pose a significant threat to asthmatic people, potentially impacting methods for asthma management. The purpose of this ecological time-series study was to use the carbon dioxide theory of climate change, Dutch hypothesis, and social ecological model to estimate the relationship between average temperature and average pollen concentrations on average asthma morbidity outcomes for adults living in metropolitan Atlanta from 2020 to 2022 (N = 37,913). Results varied in terms of years, socioeconomic status (SES) vulnerability, gender, and racial group. Overall, a linear regression model revealed …

Effects Of Non-Surgical Periodontal Therapy On Dental Plaque Microbiome

Faculty, Staff and Student Publications

Periodontitis, a chronic inflammatory disease affecting approximately 40% of U.S. adults aged 30 years and older, is characterized by dysbiosis of the dental plaque microbiome. However, although scaling and root planing (SRP) is the cornerstone of periodontal treatment, its effects on the taxonomic composition and functional potential of the dental plaque microbiome remain incompletely understood. In this study, we used whole-metagenome shotgun sequencing to characterize taxonomic composition and functional potential in dental plaque microbiomes collected from 39 patients with Stage II or III generalized periodontitis before and 3–4 months after SRP. Consistent with clinical improvement, periodontal therapy significantly reduced probing …

Dnp Final Report: Improving Length Of Stay Outcomes Using Structured Barrier Rounds: A Quality Improvement Project, Martha Kwamboka Apella

DNP Final Reports

Prolonged length of stay (LOS) in the acute care setting is a challenging issue driven by multiple factors. Increased LOS is associated with mortality, hospital-acquired infections, patient safety events, functional impairment, decreased quality of life, social isolation, and increased cost of care. The causes of increased LOS in the medical-surgical unit are unclear, necessitating an evidence-based project to address the problem. The purpose of this quality improvement initiative was to implement structured interdisciplinary barrier rounds and evaluate their effect on LOS, opportunity days, and estimated cost of care in a medical-surgical unit. The facility complex care coordinator (CCC) was identified …

Loss Of Nemp1 Disrupts Female Meiosis And Activates A Conserved Atm-Chk2 Checkpoint, Bilal Ahmad Hakim, Yonit Tsatskis, Ling Zhang, Esther Choi, Ying Zhang, Didier Hodzic, Que Wu, Muyun Zhang, Maryam Pashaei, Kyungwon Ha, Jannette Rusch, Julie A Brill, Miguel Angel Brieño-Enríquez, Andrea Jurisicova, Helen Mcneill

2020-Current year OA Pubs

Female germ cells must preserve the integrity of their genome and generate genetic diversity via meiotic recombination. This challenging process is error prone. Highly conserved checkpoint pathways detect errors in recombination and DNA damage, inducing the death of defective oocytes. Nuclear Envelope Membrane Protein (NEMP) homologs are highly conserved proteins critical for fertility in flies, worms, fish and mice. They localize to the inner nuclear envelope where they provide mechanical support. However, why NEMP homologs are specifically required for fertility is still unclear. Using both Drosophila and mouse models, we establish that loss of NEMP homologs leads to activation of …

Dnp Final Report: Community-Based Advance Care Planning Education For Older Adults: A Quality Improvement Project, Teresa Hill

DNP Final Reports

Background: Advance care planning (ACP) supports patient autonomy and promotes care aligned with individual values and preferences. Despite these benefits, fewer than half of adults aged 50–80 have completed formal ACP documentation, and community-dwelling older adults rarely engage in ACP before serious illness, representing a persistent gap in early engagement.

Purpose: This quality improvement (QI) project evaluated the effectiveness of a community-based ACP educational intervention in improving ACP knowledge, confidence, and engagement among older adults.

Methods: A nurse facilitator trained in the Five Wishes framework delivered a structured, 60-minute ACP workshop at a senior center in North Texas. A pre–post …

Trust, Participation, And Power: Community Perspectives From The Equity In Public Health Initiative, Shaniece Criss, Roger S. Abim-Karmon, Jody Teel, Vanessa Rodríguez, Adia Bennon, Sally Wills, Sarah Gonzales, Dalmondeh D. Nayreau, Vaishnavi Bharadwaj, Hannah G. Kim, Jennifer Woollery, Melissa Fair

Health Sciences Publications

Health disparities arise from unequal power relations shaping resource allocation, governance, and community agency. Community power is a key mechanism for addressing disparities. This study examines how visible, hidden, and invisible power operate within a U.S. county to inform inclusive governance. We conducted seven focus groups with Black and Hispanic residents (n = 68) and sixteen semi-structured interviews with elected officials, government staff, and advocacy leaders in Greenville County, South Carolina. Data were collected between March and December 2024. Transcripts were collaboratively coded in NVivo and analyzed using thematic analysis guided by Heller et al.’s Three Faces of Power …

Health Effects Of Adolescent Vaping, Marco Ashraf Fekry, Kimberly D. Smith Rrt-Accs

Research Scholars

No abstract provided.

Risk Factors For Metabolic Syndrome Among U.S.-Born And Non-U.S.-Born Hispanics In The United States, Banessa Maldonado

Walden Dissertations and Doctoral Studies

Current knowledge regarding risk factors for metabolic syndrome (METS) among Hispanic individuals of Mexican descent remains limited. Using data from NHANES 2017–2020, this study compared factors contributing to METS and included U.S.-born and non-U.S.-born Hispanic adults of Mexican descent aged ≥ 18 years living in the USA (N = 949) with assessed METS. Grounded in the social ecological model and social determinants of health, this research evaluated dietary habits, lifestyle patterns, and acculturation processes using multivariate logistic regression and stratified analyses. Educational attainment was associated with METS, but the association was not statistically significant in adjusted models p = 0.528. …