Digital Commons Network^™

Mitigating Cancer Therapy-Related Cognitive Impairment By Targeted Activation Of Undruggable Phosphatase., Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang

PCOM Scholarly Works

Cancer therapy-related cognitive impairment (CTRCI) is a debilitating neurotoxic condition adversely impacting cancer patients during and post-cancer treatments. The cancer treatments linked to CTRCI include chemotherapy, hormone therapy, targeted therapy, and immunotherapy. Despite CTRCI severely affecting the psychological and social, cognitive functions, and the overall quality of life of cancer survivors, no effective medications are available currently. Our prior studies have indicated hippocampal tyrosine phosphatase protein tyrosine phosphatase receptor type O (PTPRO) as a putative target for CTRCI. However, phosphatase is historically considered undruggable, and delivering drugs across the blood-brain barrier (BBB) is challenging. Here, we developed a novel delivery …

The Fourth Trimester: Enhancing Postpartum Depression Detection In Primary Care Through Early Screening And Patient Education, Riley Goldschmidt

DNP Projects

Background:
Postpartum depression (PPD) is a common and often underrecognized complication, with many cases going undetected due to inconsistent screening practices in primary care. Delayed identification can negatively impact maternal well-being, infant bonding, and overall family health outcomes. This quality improvement project aimed to improve early detection of PPD by implementing routine screening and patient education during newborn visits in a primary care clinic.

Methods:
The intervention integrated the Edinburgh Postnatal Depression Scale (EPDS) into the existing newborn visit workflow and introduced an evidence-based educational toolkit containing information on PPD symptoms, guidance for seeking care, and a QR code for …

Improving Outpatient Provider Preparedness Through Simulation-Based Training: A Quality Improvement Project, Kristina Weyer

DNP Projects

Introduction:
Simulation-based training is an effective educational strategy, particularly for high-acuity, low-frequency events such as patient decompensation in outpatient settings. However, there is a gap in both literature and practice regarding provider participation in simulation, as competing clinical demands often limit engagement. Local organizational leaders identified limited opportunities for outpatient providers to practice management of acute decompensating patients. The purpose of this project was to evaluate provider competence and confidence in managing a decompensating patient in the outpatient setting and to assess perceptions of the value of time spent in simulation.

Methods:
This quality improvement project evaluated providers who participated …

Targeted Nursing Bootcamps For Critical Access Hospital Nurses: A Program Evaluation., Nicholas Popp

DNP Projects

Background: Registered Nurses employed in critical access hospital settings are required to care for patients across the lifespan with varying levels of acuity. The registered nurse (RN) must be competent in providing medical, surgical, pediatric, obstetric, and intensive care-level services. However, the additional training they receive to care for their patients may be minimal or nonexistent, leading them to seek employment at other facilities due to safety concerns. Leadership within the organization believed that implementing targeted monthly nursing skills boot camps could increase nurses’ competence, confidence, and retention in critical access hospital settings.

Aims: This program evaluation project aimed to …

Nurse-Led Quality Improvement Asthma Self-Management In Primary Care, Jolene Steinert-Abderhalden

DNP Projects

Background:
Poorly controlled asthma contributes to preventable morbidity, yet many adults lack consistent self-management support. Local Problem: Baseline assessment at a rural Midwestern clinic revealed limited asthma knowledge, inconsistent action-plan use, and low confidence among adults with Asthma Control Test (ACT) scores below 20.

Methods:
This quality improvement project used a pre- and post-intervention design guided by Lean methodology and the Plan-Do-Study-Act (PDSA) framework. Interventions: Registered nurses delivered standardized asthma education, inhaler-technique review, and action plan reinforcement with monthly structured follow-up for 16 weeks.

Results:
Among four enrolled participants, three completed follow-up. Mean ACT scores improved from 17.5 at baseline …

Evaluating An Educational Intervention On Penicillin Allergy De-Labeling Among Graduate Nursing Students, Allison Desmond

DNP Projects

Background
Approximately 10% of patients report a penicillin allergy; however, up to 90% of these individuals are not truly allergic. Inaccurate penicillin allergy labels contribute to inappropriate antibiotic use, increased healthcare costs, and antimicrobial resistance. Education on penicillin allergy testing remains limited among future Family Nurse Practitioners (FNPs).

Methods
A quantitative quality improvement project using a pretest-posttest design was conducted among second- and third-year Doctor of Nursing Practice–Family Nurse Practitioner (DNP-FNP) students enrolled in Pharmacology II or Advanced Practice Nursing III at a Midwestern liberal arts college. Participants completed a 15-minute voiceover PowerPoint educational intervention on penicillin allergy testing and …

Improving Provider Knowledge And Confidence In Hormone Replacement Therapy Through A Quality Improvement Educational Intervention, Caitlin Schmidt

DNP Projects

Background
Menopause is associated with symptoms that can significantly diminish quality of life. Hormone replacement therapy (HRT) remains the most effective intervention for moderate to severe menopausal symptoms. Despite evidence-based guidelines endorsing its use in appropriately selected patients, HRT utilization remains limited.

Local Problem
A gap in provider knowledge and confidence regarding HRT prescribing was identified in a rural primary care clinic in the Midwestern United States. The clinical needs assessment revealed an absence of standardized menopause-specific education and highlighted an opportunity to improve evidence-based menopause management.

Methods
This quality improvement project employed a pre-post educational design guided by the …

Metastatic Large Cell Neuroendocrine Carcinoma: A Rare Cause Of Hypopituitarism, Smriti Nair, Taskeen Ahmed, Jessica Watari

Division of Internal Medicine Faculty Papers & Presentations

Pituitary metastases from pulmonary large cell neuroendocrine carcinoma (LCNEC) are exceedingly rare but should be considered in patients presenting with arginine vasopressin deficiency and panhypopituitarism in the context of known or suspected metastatic lung cancer. Early recognition and prompt initiation of hormonal replacement therapy are essential to prevent life-threatening endocrine crises and to improve symptom burden. We describe a case of a 43-year-old male who presented with dyspnea, weight loss, and weakness who was found to have metastatic LCNEC involving the liver. Endocrine evaluation revealed central hypothyroidism, central adrenal insufficiency, and later arginine vasopressin deficiency manifested by polyuria and hypernatremia. …

Elucidation Of Micro/Nanoplastic Signature Of Human And Murine Lung Tissue Utilizing Pyrolysis-Gas Chromatography/Mass Spectrometry, Aerlin D. Decker

Pharmaceutical Sciences ETDs

Micro-and Nanoplastics (MNPs) are ubiquitous biological pollutants that have been identified throughout a variety of biological samples. MNPs have been detected in several human tissues, such as the brain, kidneys, and liver. Lung tissue remains understudied for MNP accumulation despite the large surface area and clear path for exposure. Using Pyrolysis-Gas Chromatography Mass Spectrometry (Py-GC/MS), human lung tissue was evaluated for 12 different polymers, enabling quantification of total plastic per gram of tissue to be identified. Further analysis was performed with Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to investigate heavy metal accumulation in human lung samples and determine whether a …

Ophthoevidence Report: Comparative Effects Of Prophylactic Strategies For Post-Intravitreal Injection Endophthalmitis: Protocol For A Systematic Review And Network Meta-Analysis, Maryam Ghadimi, Dena Zeraatkar, João Pedro Lima, Jinhui Ma, Sunir J. Garg, Peter Kaiser, David Steel, Tien Yin Wong, Sobha Sivaprasad, Charles Wykoff, Varun Chaudhary

Wills Eye Hospital Papers

BACKGROUND: Endophthalmitis is a rare but serious complication of intravitreal injections (IVI). To mitigate the risk of post-injection endophthalmitis (PIE), retinal specialists use different strategies, combining various prophylactic measures. However, existing systematic reviews have evaluated the effects of these measures in isolation, which does not consider their concurrent use in practice. A trustworthy systematic review with network meta-analysis (NMA) by providing a framework for simultaneous comparisons of different prophylactic combinations is essential to guide decision-making.

OBJECTIVES: To present a protocol for addressing the comparative effects of different strategies for the prevention of PIE.

METHODS: We will search Medline, EMBASE, Cochrane …

Notch Signaling Regulates The Secretion Of Pro-Metastatic Factors In Extracellular Vesicles In Liposarcoma, Menchus Quan, Yi-Kai Liu, Ying Zhao, Madeline Kay, Kai Sun, Timothy P Gavin, Raphael E Pollock, W Andy Tao, Shihuan Kuang

The Brown Foundation: Institute of Molecular Medicine

Notch signaling is an emerging regulator of liposarcoma (LPS), but its role in mediating communication with the tumor microenvironment (TME) is unclear. Here, we investigate how Notch activation (NICD overexpression) alters the proteomes of LPS-derived extracellular vesicles (EVs). We used quantitative mass spectrometry to profile the EV proteome in multiple contexts: cultured LPS cells, LPS tumor, circulating EVs of LPS-bearing mice, and human LPS samples. We found that Notch signaling increases the secretion of EV proteins that favor tumor progression and metastasis but suppresses immune responses in murine LPS cells. Overlapping murine and human LPS data identifies 18 proteins that …

Medical Recommendations And Bmi Among Black And Hispanic Adolescent Females, Dorothea Polk

Walden Dissertations and Doctoral Studies

Adolescent obesity persists as a critical public health challenge in the United States, with Black and Hispanic adolescent females experiencing elevated rates. Adolescent obesity contributes to serious long-term health risks, but provider counseling may support body mass index (BMI) management. Guided by the social-ecological model, this study examined whether receiving medical recommendations to control or lose weight was associated with BMI among Black and Hispanic adolescent females aged 16–19 years and whether meal preparation habits and food security status moderated this association, controlling for age, household income, and race/ethnicity. This quantitative, cross-sectional secondary analysis used multiple linear regression analyses to …

Civilian Threat Reduces Distance Perceptions And Officer Punishment In Police Use-Of-Force Encounters, Stephanie A. Cárdenas, Kristyn A. Jones, Yael Granot, Emily Balcetis

Psychology: Faculty Publications

People turn to video evidence to make judgments about the justifiability of an officer’s actions in use-of-force incidents. Despite beliefs that video offers an objective account of events, use-of-force footage elicits different judgments among those watching it. Across four experiments (Ntotal = 2615), we investigated whether discrepant punishment judgments arise in part because of differences in perceptions of the physical space that separates an officer and civilian. We focus on third-party observers’ subjective perceptions, as they shape public discourse and justice outcomes, influence institutional accountability, and fuel public response. Despite watching the same video, civilians appeared physically closer to officers …

Enhancing Nursing Self-Efficacy In Advance Care Planning Conversations Through Role-Play Education: A Quality Improvement Project, Rachel Williams

DNP Projects

Background:
Advance care planning (ACP) conversations are essential for ensuring that patient healthcare preferences are understood and respected; however, nurses often report limited confidence and self-efficacy when initiating these discussions. Educational interventions that emphasize communication skills may improve nurses' preparedness to engage in ACP conversations.

Methods:
A quality improvement project utilizing a pre-post intervention design was conducted on three adult inpatient medical units within a regional Midwestern hospital. Registered nurses participated in an educational intervention consisting of ACP education, role-playing case scenarios, guided discussion, and debriefing. A modified 22-item Advance Care Planning Self-Efficacy Questionnaire was administered before and after the …

Mapping And Modeling Threat-Evoked Brain States After Early Life Adversity, Taylor W. Uselman

Biomedical Sciences ETDs

Early life adversity (ELA) increases lifelong neuropsychiatric vulnerability. Yet how ELA reorganizes brain-wide activity and circuit coordination across later experience remains unclear. This dissertation tests the hypothesis that ELA alters adult brain-wide activity and responses to threat through disrupted coordination among neural systems that regulate emotional experience, including prefrontal-limbic and monoaminergic systems. Longitudinal manganese-enhanced MRI of adult mice exposed to standard or fragmented early care, combined with computational processing and statistical modeling, quantified brain states before, during, and long after innate predator threat. These studies established that acute threat evokes large-scale, distributed brain activity that evolves over time. ELA potentiates …

Technology Platform (Peer Plus) Supporting The Work Of Peer Recovery Coaches And The Communication Needs Of Individuals In Recovery From Substance Use Disorder: Protocol For An R21 Development And Usability Trial., Amanda Coupe, Jessica Pater, Rachel Pfafman, Victor P Cornet, Elisabeth Andrews, Mindy Flanagan, Dana Albright, Abhinay Balasani, Christopher Becker, Brian Parise, Erik Hess, Tammy Toscos

Health Services and Informatics Research

BACKGROUND: Substance use disorder (SUD) represents a significant public health concern in the United States. SUD recovery is complex and individualized, and support provided by peer recovery coaches (PRCs) can improve outcomes. The PRC-client relationship requires bidirectional mediated communication that is often informal but should be trackable, efficient, and aligned with health care privacy and security regulations. Current workflows and available apps do not meet these needs, illustrating the opportunity for client-centered technology tools. We have developed Peer PLUS (People Leveraging Urgent Support; Parkview Health System, Inc), a HIPAA (Health Insurance Portability and Accountability Act)-compliant mobile app and client management …

Tic-Related Functional Impairment Drives The Relationship Between Tics And Depression In Youth With Tourette Syndrome, Steve Barash, Mark F Gordon, Jordan Stiede, Eric A Storch

Faculty, Staff and Students Publications

Although many youth with Tourette syndrome (TS) have at least 1 comorbid psychiatric condition (eg, obsessive-compulsive disorder), the extent to which TS is associated with depression remains unclear. This cross-sectional study examined relationships among tic severity, tic-related functional impairment, and depressive symptoms in 277 youth with TS. Tic-related impairment, but not tic severity, was associated with both self- and parent-reported depressive symptoms. An age × sex interaction emerged, such that among younger participants, females reported higher depressive symptoms than males; however, this effect was observed only for self-report, not parent report. Additionally, both depressive symptoms and tic severity were associated …

Cross-Species Efficacy Of Combinatorial Gene Therapy For Osteoarthritis And Correction Of Neuro-Inflammatory Pain Mechanisms., Jiansen Yan, Camilla Majano, Matthew Woodman, Oscar Ruiz, Joud Al Azaat, Duncan Crosby, Racel Cela, Sarah Pownder, Julie B Engiles, Donna Palmer, Mingming Jiang, Carolina Leynes, Ismail Yaman, Mira Jeong, Gerhard Sponder, Stanislav Plutziki, Lisa Yuva, Surabi Veeraragavan, Russell S Ray, Joshua D Wythe, Benjamin R Arenkiel, Rui Chen, Kim C Worley, Philip Ng, Masataka Suzuki, Kilian Guse, Yangjin Bae, Nele A Haelterman, Heidi Reesink, Brendan Lee

Faculty, Staff and Students Publications

Osteoarthritis is a leading cause of chronic pain and disability, which lacks disease-modifying treatment. Given the complex multi-tissue and multifactorial drivers behind disease progression, effective treatments will require simultaneously targeting several mechanisms underlying joint degeneration and pain. Here, we developed and evaluated a combinatorial gene therapy, consisting of a high-capacity adenoviral vector carrying two therapeutic genes to target distinct pathological mechanisms: inflammation (IL-1Ra) and chondrocyte health (PRG4). Intra-articular delivery of this treatment improved functional, structural, and pain outcomes in murine and equine osteoarthritis models. In addition, treatment normalized inflammatory environments in joint tissues, as well as in the dorsal root …

Interpretable Case-Control Inference Through Log-Linear General Location Models, Zacharia Stuart

Mathematics & Statistics ETDs

This dissertation analyzes one of the few publicly available NFL injury datasets to study field type and non-contact lower-limb injuries. Field type is studied jointly with other risk factors to understand how these factors interact to affect injury risk. The data were gathered through a case-control sampling scheme, which limits direct inference on absolute injury probabilities. While not the most common approach for case-control data, this dissertation models the retrospective distribution directly through Log-Linear General Location Models (Log-Linear GLOMs). Through a log-linear structure placed on a log-odds-ratio reparameterization, the model provides directly interpretable marginal and interaction contributions to injury log-odds …

Clinicopathologic Spectrum Of Renal Disease In Sars-Cov-2 Infection And Post-Covid-19 Vaccination, Naya Williams, Mohammed S. Razzaque

School of Medicine Publications

Both SARS-CoV-2 infection and COVID-19 vaccination have been associated with renal complications. In the context of SARS-CoV-2 infection, kidney injury is primarily attributed to a complex interplay of systemic immune dysregulation and vascular damage. Severe infection triggers a cytokine-mediated inflammatory response characterized by elevated levels of pro-inflammatory mediators, resulting in systemic hemodynamic instability, increased capillary permeability, and renal hypoperfusion, ultimately leading to acute tubular injury. In addition, virus-induced endothelial activation promotes a prothrombotic state, microvascular injury, and further impairment of renal perfusion. Collectively, these processes converge to produce acute kidney injury (AKI) and, in severe or prolonged cases, may contribute …

Feasibility Of An Onboarding Program To Facilitate The Transition From Practitioner To Educator, Jennifer R. Washko, Nancy E. Krusen

Innovations in Health Sciences Education Journal

The study examined the feasibility of a faculty onboarding program to support the transition from practitioner to educator. Researchers applied Orsmond’s feasibility objectives (2015). We applied the theoretical model of Occupational Adaptation to analyze program data using Relative Mastery Scale (RMS) scores and satisfaction surveys (n=11). Evaluation suggested program processes were feasible, with outcomes indicating statistically significant change (p < .05) in participants’ perceived effectiveness, efficiency, and satisfaction. Evaluating feasibility supports the implementation of onboarding programs. We recommend additional study to consider the usefulness of onboarding for health or social service professionals transitioning to faculty roles.

Study On The Accuracy Of Varian Eclipse Mlc Modeling When Mlcs Are Open Beyond The Jaw In Breast Cancer Patient Planning Using Aaa And Acuros With Both Dual-Isocentric Technique And Mono-Isocentric Technique., Amy Rogers

Masters Projects

Accurate dose delivery at the chest wall-supraclavicular (CW-SCV) junction remains an important challenge in breast irradiation, especially when multileaf collimator (MLC) leaves are intentionally opened beyond the collimator jaws to improve junction coverage. This study evaluated the dosimetric accuracy of the Varian Eclipse treatment planning system (TPS) at the CW-SCV junction using the Anisotropic Analytical Algorithm (AAA) and Acuros XB calculation algorithms with mono-isocentric and dual-isocentric treatment techniques. A prospective phantom-based study was performed using a solid water phantom and a Varian TrueBeam linear accelerator. Twenty-four unique three-dimensional conformal treatment plan configurations were created using combinations of beam energy (6 …

Exercise Self-Efficacy And Physical Wellness In A Worksite Wellness Program: Exploring Factor Structure And Perceptions, Micah B. Mcglathery

Dissertations

Exploring Perceptions of Exercise Self-Efficacy and Physical Wellness in a Worksite Wellness Program

Abstract

Worksite wellness programs are increasingly adopted to address insufficient exercise participation and other health-related behaviors that put employees at risk of chronic disease. Although quantitative outcomes are well-documented, there is limited research exploring how employees perceive these programs' impact on personal behavior change, particularly in relation to exercise self-efficacy. Guided by the Social Cognitive Theory and the Exercise is Medicine initiative, this study qualitatively investigates employee perceptions of a worksite wellness program’s influence on physical wellness and confidence to exercise. A phenomenological approach using semi-structured interviews …

Genetic Associations With Pulmonary Embolism Among Those With A Deep Vein Thrombosis: The International Network Against Venous Thrombosis Consortium, Susana Lozano-Esparza, Gabrielle E Shakt, Jennifer A Brody, Angel Martinez-Perez, Matthew P Conomos, Marine Germain, Katharine R Clapham, Maris Teder-Laving, Astrid Van Hylckama Vlieg, Anni Kauko, Florian Thibord, Ohanna C L Bezerra, Girish N Nadkarni, Gaëlle Munsch, Therese Haugdahl Nøst, Ellen L Goode, Yuekai Ji, Daniel I Chasman, Alexander P Reiner, Constance Turman, Kerri L Wiggins, Colleen M Sitlani, Juan Carlos Souto, Pamela L Lutsey, Tiffany Bellomo, Estonian Biobank, Million Veteran Program, Ruifang Li-Gao, Aleksi Kristian Winstén, Ming-Huei Chen, Ron Do, Lénaick Gourhant, Kristian Hveem, Sebastian M Armasu, Noémie Saut, Nathan Pankratz, Franco Giulianini, Jeffrey Haessler, Mingyang Song, Robert Olaso, Eric Boerwinkle, Daniel Dochtermann, Jose Manuel Soria, Stephen S Rich, David Smadja, Satoshi Koyama, Frits R Rosendaal, Teemu Niiranen, France Gagnon, Ha My T Vy, Neil Zakai, Catherine Lemarie, Anne Heidi Skogholt, Jean-François Deleuze, James S Pankow, Paul M Ridker, Yuxi Liu, Kenneth M Rice, Saiju Pyarajan, Mary Cushman, Jospeh Emmerich, Bruce M Psaty, Pradeep Natarajan, Andrew D Johnson, Marc A Rodger, Pierre Suchon, Francis Couturaud, Pierre-Emmanuel Morange, Weihong Tang, Charles Kooperberg, Christopher Kabrhel, Maria Sabater-Lleal, David-Alexandre Trégouët, Alisa S Wolberg, Scott M Damrauer, Nicholas L Smith

Children’s Nutrition Research Center Staff Publications

Background: Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE), the latter of which often originates from DVT and can be fatal.

Objectives: The aim of this study was to identify causal genetic factors that alter risk of PE among those with a presumed DVT.

Methods: Using a case-only design of VTE, we conducted meta-analyses of genome-wide association studies (GWASs) in the International Network Against Venous Thrombosis Consortium. Among participants diagnosed with VTE, each study identified those who had a clinically reported PE, with or without a clinically reported DVT; those remaining had isolated DVT. Logistic regression …

Correction To: A Double‑Edged Sword: Ethical And Psychological Implications Of Apoe Genotype Disclosure Across The Lifespan, Diego Iacono

Department of Neurology Faculty Papers

No abstract provided.

Intouch Week Of July 27, 2026, New York Medical College

InTouch

• NYMC Receives $2.7 Million HECap Award
• The Inquiring Minds of Student Research
• Grasslands Garden Blooms into a Community Gathering Space
• Incoming M.D. Students Celebrate Completion of Pre-Matriculation Program
• White Plains Youth Bureau Explore Health Care Careers at NYMC
• Hispanics with Met-ALD Face Higher Rates of Serious Liver Complications
• TCDM Welcomes Class of 2030
• Faculty Spotlight: Jin Li, M.D., Ph.D. ’01: A Lifetime Dedicated to Neurology, Education, and Community Service

Dnp Final Report: Improving Rehospitalization Rates And Caregiver Quality Of Life In Outpatient Hospice, Carrie M. Judd

DNP Final Reports

Background: Hospital readmissions among home hospice patients disrupt continuity of care, increase healthcare costs, and may compromise end-of-life preferences.

Purpose: This quality improvement project evaluated the feasibility of implementing a telehealth communication intervention in an outpatient hospice organization. Project aims were to reduce Type I live hospice discharges by at least 2.5% and improve caregiver quality of life (QOL).

Methods: Zoom for Healthcare® video visits and three-way telephone communication supplemented standard nurse practitioner hospice visits during a three-month implementation period. Type I live discharge rates were compared with the organization's baseline quality metrics. Caregiver QOL was measured pre- and post-intervention …

Multiclass Diagnostic Performance And Error Patterns Of A Multimodal Large Language Model In Oral Histopathology: A Who-Aligned Study, Mai Hafez, Fatma E.A Hassanein, Muhammad Talha Hassan, , Mariya Javed, Mai Hamouda, Mohamed Amer, Fatma Saad, Gihan Madkhour, Asmaa Bakr

Dentistry

Objectives: To evaluate the diagnostic performance, feature-level agreement, and error patterns of a multimodal large language model (MLLM) across the oral dysplasia–malignancy continuum. Methods: In this retrospective diagnostic accuracy study, 300 histopathology images representing normal oral mucosa (n = 100), oral potentially malignant disorders (OPMD) (n = 100), and oral squamous cell carcinoma (OSCC) (n = 100) were evaluated using a standardized two-stage prompting framework consisting of morphological feature extraction followed by structured diagnostic classification. Reference diagnoses were established by three experienced oral pathologists. Interobserver agreement among pathologists was assessed using Fleiss' κ statistics. Primary outcomes included overall accuracy, macro-F1 …

The Role Of Social Emotional Learning In Utah’S Implementation Of Essa, Sharon Walles

Transforming Communities

The Every Student Succeeds Act (ESSA), as a policy, offers an additional tool to address the escalating adolescent mental health crisis. By acknowledging the critical link between student well-being, academic success, and evidence-based practices, this policy analysis explores how funding from ESSA can be leveraged to integrate Social Emotional Learning (SEL) within Utah’s schools. Experts, educators, and parents can be voices to combat misinformation surrounding the recent politicization of SEL and its implementation. This analysis connects Bronfenbrenner’s Ecological Theory, which highlights the interconnectedness of the environment, with the importance of prioritizing mental health within schools to help adolescents with issues …

The Biological Response Of Human Np Cells To Soluble Collagen Vi, Jonathan Dalton, Srikanth N. Divi, Yasmine Eichbaum, Panya Luksanapruksa, Mitchell K. Ng, Rachel Huang, Alan S. Hilibrand, Alex R. Vaccaro, Dessislava Z. Markova, Christopher K. Kepler

Department of Orthopaedic Surgery Faculty Papers

Extracellular matrix (ECM) dysregulation plays a significant role in the development of intervertebral disc disease (IVDD). The ECM around the chondrocytes in the nucleus pulposus (NP) is unique in that it contains ColVI. While linked to chondrocyte proliferation in cartilage, ColVI's specific role in IVD degeneration is less clear. Our aim was to determine the expression of ColVI in NP cells from degenerative IVDs, along with the effects of soluble ColVI on NP cells. Thus, we compared the expression levels of ColVI in human degenerated IVD samples, along with the effect of soluble ColVI on primary human NP cells. A …