Digital Commons Network^™

Cysteine Depletion Triggers Adipose Tissue Thermogenesis And Weight Loss, Aileen H Lee, Irina Shchukina, Prabhakar Sairam Andhey, Maxim N Artyomov, Et Al.

2020-Current year OA Pubs

Caloric restriction and methionine restriction-driven enhanced lifespan and healthspan induces 'browning' of white adipose tissue, a metabolic response that increases heat production to defend core body temperature. However, how specific dietary amino acids control adipose thermogenesis is unknown. Here, we identified that weight loss induced by caloric restriction in humans reduces thiol-containing sulfur amino acid cysteine in white adipose tissue. Systemic cysteine depletion in mice causes lethal weight loss with increased fat utilization and browning of adipocytes that is rescued upon restoration of cysteine in diet. Mechanistically, cysteine-restriction-induced adipose browning and weight loss requires sympathetic nervous system-derived noradrenaline signalling via …

Higher Vitamin K1 Intakes Are Associated With Lower Subclinical Atherosclerosis And Lower Risk For Atherosclerotic Vascular Disease-Related Outcomes In Older Women, Montana Dupuy, Liezhou Zhong, Simone Radavelli-Bagatini, Jack Dalla Via, Kun Zhu, Lauren C. Blekkenhorst, James Webster, Nicola P. Bondonno, Allan Linneberg, Carl Schultz, Wai Lim, Richard L. Prince, Jonathan M. Hodgson, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Purpose: Vitamin K may inhibit vascular calcification, a common attribute of atherosclerotic vascular diseases (ASVDs). We examined associations between dietary vitamin K1 intakes and both subclinical atherosclerosis and ASVD events, including hospitalisations and mortality, in older women.

Methods: 1,436 community-dwelling women (mean ± SD age 75.1 ± 2.7 years) were included. Vitamin K1 intakes were calculated from a validated food frequency questionnaire at baseline (1998), utilising a region-matched vitamin K food database. Common carotid artery intima–media thickness (CCA-IMT), a measure of subclinical atherosclerosis, was measured in 2001 (n = 1,090). Differences in CCA-IMT by quartiles (Q) of vitamin K1 intake …

Severe Gastrointestinal Manifestations In Childhood-Onset Lupus: A Single-Center Cohort And Review Of The Literature, James Orozco, Jessica Nguyen, Sara Mm Yasrebi, Marnie Blalock, Sara L Grisales, Craig L Jensen, Marietta M Deguzman

Faculty, Staff and Students Publications

Objective

Systemic lupus erythematosus (SLE) is a complex autoimmune condition with diverse manifestations. Childhood-onset SLE (cSLE) presents more severely than adult-onset disease with a higher incidence of severe neurologic or renal manifestations and lower estimated survival rates. There is limited literature on the range of severe gastrointestinal manifestations at presentation in cSLE, and this lack of information results in underappreciation of these potentially life-threatening complications and little guidance regarding management of these patients.

Methods

We reviewed cases of patients with cSLE and severe GI manifestations at presentation diagnosed at our institution and additionally provide a comprehensive review of existing cases …

Dosing Recommendations For Ampicillin And Ceftriaxone In The Treatment Of Pediatric Community-Acquired Pneumonia Using Monte Carlo- And Physiologic-Based Pharmacokinetic Simulations, Norint Tung, Dustin Huynh, Quang Dam, Tri Tran, Kristina G Hulten, Christopher J Harrison, Sheldon L Kaplan, Tyler H Do, Amartya Setty, Lana Hoang, John S Bradley, Jennifer Le

Faculty, Staff and Students Publications

Objective: Since 2011, Ampicillin (AMP) has been recommended as the parenteral antibiotic of choice for pediatric community-acquired pneumonia (CAP), but ceftriaxone (CRO) is recommended for unvaccinated children and those with complicated CAP. Using penicillin and CRO susceptibility data for pneumococcus, we evaluated the adequacy of currently recommended doses of AMP and CRO.

Methods: With nonlinear mixed-effects modeling v7.3, Monte Carlo simulations (MCS, N = 10,000) for AMP and CRO were conducted for 6 virtual patients aged 3 months, 1, 2, 5, 10, and 15 years. PK-Sim v9.0 was used to develop physiologic-based pharmacokinetic (PBPK) models for AMP (N = 4000) …

Mollusc And Crustacean Consumption In The First 1000 Days: A Scoping Review, Brietta M Oaks, Emmanuel A Gyimah, Eliza Kleban, Kathleen Ragsdale, Lora L Iannotti

2020-Current year OA Pubs

Mollusc and crustacean consumption in the first 1000 d may improve maternal and child health by providing essential nutrients. However, in some contexts, molluscs and crustaceans have been associated with allergies and environmental contamination, potentially leading to adverse health and development outcomes. It is unclear whether the health benefits of consuming molluscs and crustaceans, collectively classified as shellfish in nutrition, are outweighed by the potential risks to pregnant women and children. We conducted a scoping review (PROSPERO: CRD42022320454) in PubMed, Scopus and EBSCO Global Health of articles published between January 2000 and March 2022 that assessed shellfish consumption during pregnancy, …

Weight Recidivism Post-Bariatric Surgery: A Lifestyle Modifications Educational Intervention, Kimeshia N. Johnson

Electronic Theses and Dissertations

Weight recidivism after bariatric surgery is a frustrating phenomenon for bariatric surgery patients and healthcare professionals. A 90-day lifestyle modification intervention for patients at least 18 months postsurgery was performed in the primary care setting to determine if a structured program could promote or maintain weight loss. The intervention aimed to investigate if participation in a structured lifestyle modification program would impact the body mass index of bariatric patients at least 18 months postsurgical intervention. In coordination with a nutritionist specializing in addiction and obesity education, a booklet detailing the guidelines for a 12-week program was provided to 41 bariatric …

From Industrial Building To Affordable Senior Housing: An Idea Book Beyond Code, Weiyi Ma

Masters Theses

This thesis envisions a proposal to adaptively re-purpose Rhode Island’s extant industrial building stock into affordable housing tailored to the needs of its older and more vulnerable citizens. Architectural dignity, in terms of older citizens amidst this housing crisis, is the creation of living environments that honor their autonomy, comfort, and identity through design interventions that provide accessible, luminous, breathable, and socially enriching spaces, reaffirming their rightful place within the community. With humanistic care and logical rigor, it establishes a mathematical framework for assessment and execution, anchored in five criteria: light, air, space, accessibility, and livability, and presents itself in …

Social Eating Role In Ultra-Processed Food Consumption Among Urban Young Adults: The 2018 Indonesian Food Barometer, Imas Arumsari, Nabilla Ayusyah Putri, Siti Nur Lulu Lathifah, Gita Aisyah Astrid Rosalba, Helda Khusun, Judhiastuty Februhartanty, Rahmatika Nur Aini

Kesmas

This study investigated the differences in ultra-processed food (UPF), fruit, vegetable, and total fat consumption in different aspects of social eating among urban young adults. This cross-sectional study used the 2018 Indonesian Food Barometer dataset with 180 participants aged 18–25 years living in urban areas from 6 provinces in Indonesia. The data on social eating (cooking habits, eating out, and eating alone), UPF, fruits, and vegetables were obtained from an extended 24-hour food recall interview. The Mann-Whitney U test (CI 95%) was employed for data analysis. This study found that groups with less frequent cooking habits tended to have more …

Assessing The Impact Of The First Feeding Practice On Wasting Risk Among Indonesian Children Under The Age Of Five, Azrimaidaliza Azrimaidaliza, Annisa Dwi Apriliani, Mutiara Tirta Prabandari Lintang Kusuma

Kesmas

The problem of undernutrition among children under the age of five (the under-five) continues to be alarmingly high in Indonesia, including in West Sumatra Province. Various factors contribute to this issue, with studies suggesting a relationship between intergenerational causes and undernutrition. This study analyzed the main risk factors of wasting among children in Padang City. Data were collected from 174 under-five and divided into unmatched cases that were selected randomly and control groups. The mothers were interviewed using a questionnaire regarding their children’s feeding habits, and weight and height data were collected from primary health care. Multiple logistic regression analysis …

Colorectal Cancer And The Risk Of Mortality Among Individuals With Suicidal Ideation, Srikanta Banerjee, Jagdish Khubchandani, Stanley Nkemjika

Department of Psychiatry and Human Behavior Faculty Papers

Suicide is a major public health problem that has grown at alarming rates in the last two decades. Colorectal cancer (CRC) is one of the most common causes of cancer deaths in the United States in both males and females. However, the influence of suicidal ideation (SI) on the association between CRC and risk of mortality has not been well examined.

METHODS: For this study, the 2005-2018 National Health and Nutrition Examination Survey (NHANES), a nationally representative survey of United States adults aged 20 years or older, was utilized. CRC survivorship was determined from self-reported data on CRC, and mortality …

Characterizing Genetic, Epigenetic, Nutritional, And Clinico-Biochemical Profile Of Women With Polycystic Ovary Syndrome: A Case-Control Study, Woroud M. Majd Chaker, Raghda Mohammed Adi, Mohamed Madkour, Nada Farhat, Dana N. Abdelrahim, Maha Saber-Ayad, Jibran Sualeh Muhammad, Ghada Mohammed, Noha Ahmed Mousa, Ameenah Saadi, Arathy Lakshmi, Mai Kazim, Nagla Elhadi Abdalla, Nariman Awad, Fatme Al Anouti, Moezalislam E. Faris

All Works

Objectives: Polycystic ovary syndrome (PCOS) is among the most frequently encountered endocrinopathies in women. This study aimed to characterize the genetic (INSR, FTO, DENND1A, and Nrf2) expressions and epigenetic (DNA methylation) modifications, nutritional, metabolic, inflammatory, and hormonal markers for patients with PCOS in comparison with their age-matched healthy controls. Design & Methods: The study also aimed to assess the genetic expressions concerning vitamin D status. Sixty-six patients with PCOS and 69 age-matched healthy controls were recruited. Fasting blood samples were used to measure genetic and biochemical variables. Real-time PCR was used to assess gene expressions, the bisulfite conversion method was …

Factors Associated With Caregivers' Concern In Maintaining The Oral Function Of Elderly Living In Long-Term Care Facilities, Susiana Nugraha, Tri Budi Wahyuni Rahardjo, Misako Higashijima, Yuko Hirano

Kesmas

This study investigated the attentiveness of elderly caregivers in long-term care facilities in maintaining oral function. A cross-sectional approach was used to achieve the study's purpose. The sample size formula accounted for 213 caregivers randomly selected from 18 long-term care facilities in 4 provinces. A self-reported questionnaire of sociodemographic characteristics and an adapted Leopold’s oral care checklist was distributed. The average age of study participants was 35.24 (±11.2 SD; aged 18–70 years), dominated by females (62.9%), and only 39% had experienced long-term care training. Multiple linear regression analysis indicated that younger caregivers likely pay more attention in the swallowing periods …

Food Hygiene And Sanitation Of The University Canteens In South Sumatra Province, Indonesia, Anita Rahmiwati, Fatmalina Febry, Fenny Etrawati, Indah Purnama Sari, Yeni Yeni, Virgina Putri Sabila, Erike Septa Prautami, Maretalinia Maretalinia

Kesmas

Food safety is a critical public health issue, especially in institutional settings such as university canteens, where large populations are served daily. Inadequate hygiene and sanitation practices by food handlers can lead to foodborne illnesses, placing students and staff at risk. This study evaluated hygiene and sanitation conditions in the canteens of a leading public university in South Sumatra Province, Indonesia, known for its active food service facilities. This study examined food handlers’ knowledge, attitudes, and practices and assessed the microbiological safety of chicken curry by testing for Escherichia coli (E. coli) contamination and total plate count. Using a cross-sectional …

Development Of Audiovisual Media For Reproductive Health Education For Parents Of Adolescents, Tanjung Anitasari Indah Kusumaningrum, Nurul Latifatul Inayati, Setia Asyanti, Ayu Khoirotul Umaroh, Wardhatul Livia, Ramadani Nur Laili, Trijaya Trijaya, Ririn Cahya Dewanti, Yuli Kusumawati, Izzatul Arifah

Kesmas

Parents are the primary source of information for adolescents, but many parents lack an understanding of health materials. For knowledge to be increased, health media, one of which is audiovisual media, are desirable. This study aimed to develop audiovisual media on adolescents’ reproductive health. Media development utilized the analyze, design, develop, implement, and evaluate (ADDIE) model. The respondents in this study were parents of adolescents aged 10–14 years, comprising 10 parents in the small group evaluation, 20 in the field evaluation, and 10 in the implementation stage. The effectiveness of the media was tested through pretests and posttests. Using a …

Staff Education To Improve Knowledge Of Wound Documentation Skills Among Inpatient Nurses, Rouine Kay Patron Litorja

Walden Dissertations and Doctoral Studies

While many healthcare organizations have established wound documentation protocols, maintaining consistent, high-quality documentation remains a widespread challenge in clinical practice. In this staff education project, I addressed the implementation of a staff education program to increase nurses' knowledge about evidence-based practices regarding wound documentation. The staff education initiative was conducted in a medical telemetry unit, with 17 nurses participating. A pretest-posttest design was employed to evaluate the impact of the education. The aggregate pretest and posttest scores were analyzed using the Normalized Learning Gain (NLG) formula. The NLG gain of 0.37, equated to a 37% improvement in knowledge a moderate …

Increasing Exposure To Interprofessional Roles: Creating A Culture Of Appreciation And Collaboration Across Manning Family Children's Interprofessional Groups, William Arnold Md, Alexandra Glaser Md, Andree Judd Do, Anne Reed Md, Courtney Suiter Md, Caroline T. Moreau Md

Quality Improvement & Patient Safety Forum

No abstract provided.

Increasing The Detection Of Pediatric Oncology Patients At Risk For Malnutrition Using A Specialized Screening Tool, Casey Treuting Md, Cori A. Morrison Md, Jourdan A. Mills Rd

Quality Improvement & Patient Safety Forum

No abstract provided.

Nutraceutical Benefits And Neuro-Protective Potent Of Four Colored Peppers (Capsicum Annuum Var. Grossum), Ya-Chen Yang, Chih-Lung Lin, Mei-Chin Yin

BioMedicine

Background: Four colored peppers (Capsicum annuum var. grossum), orange, purple, yellow and red, are plant foods served as salad or stir-fry for meals in Taiwan and many countries.

Purpose: This study aimed to investigate the multiple nutraceutical properties of aqueous extracts prepared from colored peppers.

Methods: Vitamin C content and phytochemical profiles of these peppers were analyzed. In vitro effects of anti-oxidative, anti-a-amylase, anti-a-glucosidase, antilipase and anti-acetylcholinesterase (AchE) of pepper aqueous extracts at 0.25, 0.5 and 1 mg were evaluated. The neuronal protective potent of pepper aqueous extracts at 0.5 and 1 mg in high glucose treated nerve growth factor …

Implementation Outcomes And Associated Constructs From The Consolidated Framework For Implementation Research Among Churches Trained Online To Implement Faith, Activity, And Nutrition In A National Implementation Study, Sara Wilcox Phd, Ruth P. Saunders Phd, Andrew T. Kaczynski Ph.D., Caroline Rudisill Ph.D., Msc, Ye Sil Kim Phd, Jasmin Parker-Brown, Kelsey R. Day

Faculty Publications

Churches hold promise for reaching populations with high rates of chronic disease, yet few faith-based large-scale implementation studies exist. The study purpose was to examine 12-month implementation outcomes and associated Consolidated Framework for Implementation Research (CFIR) constructs after converting in-person training to online for an evidence-based intervention designed to improve church organizational practices related to physical activity (PA) and healthy eating (HE). US churches recruited from 2020 to 2022 participated in eight online lessons prior to implementation. Each church’s coordinator completed an online baseline and 12-month survey assessing church practices for PA/HE components targeted in the Faith, Activity, and Nutrition …

The Correlation Between Zinc Intake And Superoxide Dismutase Activity With Cognitive Function In The Elderly, Rima Khuzaimah, Fiastuti Witjaksono, Novi Silvia Hardiany

Sultan Qaboos University Medical Journal

Objectives: This study aimed to analyse the correlation between zinc intake and superoxide dismutase (SOD) with cognitive function in the elderly. Thus, the role of zinc as a structural component of SOD, along with SOD’s contribution to cognitive function, can be established. Methods: This cross-sectional study was conducted at Panti Sosial Tresna Wredha Budi Mulia 1 in Jakarta, Indonesia, from July to September 2024. Elderly men and women were included. Zinc intake was assessed using the Semi-Quantitative Food Frequency Questionnaire, while plasma SOD activity was measured by spectrophotometer. Cognitive function was assessed using the Montreal Cognitive Assessment-Indonesia version. Data …

From Childhood To Adult Cognitive Health: Analyzing Adverse Experiences And Subjective Cognitive Decline Using Brfss 2020-2023 Dataset, Kyaolin Rajbhandary

NYMC Student Theses and Dissertations

The chronic impact of early-life experiences on long-term health is a critical area of investigation, especially regarding cognitive health in adulthood. Adverse childhood experiences (ACEs) have been linked to an increased risk of developing various health issues in adulthood, including mental health disorders, substance abuse, and chronic diseases. The connection between ACEs, substance abuse and cognitive health, particularly subjective cognitive decline (SCD), remains relatively underexplored. The aim of this study is to examine the intricate relationships between ACEs, alcohol abuse, and SCD in adulthood. This study draws on trauma theory and the biopsychosocial model to conceptualize the long-term impact of …

Improving Self-Reported Hydration Using Refillable Bottles And Clean Water Access, Erica Short, Adam Dill, Ali Bradley, Kaito Gao, Jennifer Hanks, Hayat Muhammad, Mai Ngo

Nursing Leadership in Community Engagement Projects

In Washington State, around 18.5% of individuals aged 12 and older, about 1.4 million people, struggle with substance use each year (Substance Abuse and Mental Health Services Administration, 2023). Many also face housing instability and limited access to basic health needs like clean drinking water. Our agency supports Seattle residents in recovery, and during our initial assessment, we identified inadequate hydration as a common concern. As a team of seven nursing students, we developed a community health project to improve self-reported hydration among this population. This paper outlines our process from assessment to intervention and our efforts to support healthier …

Tavr In Older Adults With Cardiogenic Shock: Current Practice And Future Direction, Min Ji Kwak, Jorge A Irizarry-Caro, Paola Rodriguez Martinez, James Going, Jessica Lee, Dana Giza, Nuzah Amjad, Ana Leech, Rachel Jantea, Renee Flores, Nahid Rianon, Abhijeet Dhoble

Faculty, Staff and Student Publications

Aortic stenosis (AS) is one of the most common types of valvular heart disease in older adults, with age being significantly associated with the development of AS. The transcatheter aortic valve replacement (TAVR) procedure, since it was first performed in 2002, has emerged as a preferred treatment option for patients who are at intermediate to high surgical risk due to advanced age or medical comorbidities. Older adults with severe AS may present with acute decompensated heart failure leading to cardiogenic shock (CS). Among patients 65 years and older with AS presenting for TAVR, 4.1% were reportedly in acute CS. Regardless …

Enhancing Health Literacy In Adolescents At A Homeless Shelter, Raymond Don N. Razon, Lauren Snedeker, Janice Ou, Chau V. Nguyen, Makenna Johnston, Ruweyda Salim, Garett W. Walters

Nursing Leadership in Community Engagement Projects

Enhancing Health Literacy in Adolescents at a Homeless Shelter

Over the past two months, our group of seven Seattle Pacific Nursing Students collaborated with a local nonprofit homeless shelter for families. After meeting with the agency’s health services coordinator, we decided to focus on the teen population and enhance their health literacy. This choice was due to our population primarily not being exposed to the American healthcare system. Our team gathered information from the teens and found that nutrition, sleep, and mental health were of particular interest. Based on this, we planned and implemented a health literacy intervention tailored to …

Vol 5 May '25 Cover, Publishing, And Table Of Contents, Donna L. Williams

Journal of the Louisiana Public Health Association

No abstract provided.

Vol 5 May '25 Full Issue, Donna L. Williams

Journal of the Louisiana Public Health Association

No abstract provided.

Mechanisms Of Placental Impairment And The Upregulation Of Fetuin-B During Maternal Undernourishment, Mia Camilliere

NYMC Student Theses and Dissertations

Proper nutrition is crucial during pregnancy to support fetal and placental development. Failure to meet these nutritional needs can result in adverse health outcomes for both mother and baby. Despite its high prevalence in underdeveloped countries, maternal undernourishment is a public health issue worldwide. There are several possible causes of maternal undernourishment, and these can occur alone or in combination, such as poor access to nutrition, hyperemesis gravidarum, and drug use. This condition can adversely affect placental development and function to the extent of placental insufficiency, perturbing the entire pregnancy. The placenta is responsible not only for hormonally and physically …

Prevalence And Determinants Of Poor Glycemic Control In Adult Diabetic Patients In A Nigerian Tertiary Hospital, Jideuma Ikenna Egwim, Hope Igbonagwam, Adanna Vivian Egwim, Hadi Danawi, Ifeoma Ogugua

Journal of Social, Behavioral, and Health Sciences

Diabetes mellitus (DM) is a significant public health concern globally and in Owerri, southeast Nigeria. The deleterious effects of diabetes have been linked to poor glycemic control. According to the International Diabetes Federation, poor glycemic control is reflected in glycosylated hemoglobin (HbA1c) levels > 7.0%, which are associated with substantial morbidity and mortality. Studies have shown a dramatic rise in diabetic complications in Nigeria, particularly in Owerri. However, evidence is lacking regarding the specific risk factors associated with poor glycemic control among DM patients in Owerri. This study assessed the predictors of poor glycemic control in a hospital setting in Owerri. …

Candidate Interventions For Integrating Hypertension And Cardiovascular-Kidney-Metabolic Care In Primary Health Settings: Hearts 2.0 Phase 1, Andres Rosende, Mark D Huffman, Et Al.

2020-Current year OA Pubs

BACKGROUND: HEARTS in the Americas is the regional adaptation of the WHO Global HEARTS Initiative, aimed at helping countries enhance hypertension and cardiovascular disease (CVD) risk management in primary care settings. Its core implementation tool, the HEARTS Clinical Pathway, has been adopted by 28 countries. To improve the care of hypertension, diabetes, and chronic kidney disease (CKD), HEARTS 2.0 was developed as a three-phase process to integrate evidence-based interventions into a unified care pathway, ensuring consistency across fragmented guidelines. This paper focuses on Phase 1, highlighting targeted interventions to improve and update the HEARTS Clinical Pathway.

METHODS: First, the coordinating …

Staff Education To Improve Nurses’ Knowledge To Prevent Hospital-Acquired Pressure Ulcers/Injuries, Aarinola Abosede Omisola

Walden Dissertations and Doctoral Studies

The quality improvement education project aimed to address a significant increase in hospital-acquired pressure injuries (HAPIs) at a veteran medical center in Indiana, where statistics showed a 40% increase in Stage 2 pressure ulcers and a 60% increase in deep tissue injuries in Quarter 3 in 2023. Recognizing the serious complications associated with pressure injuries, along with their significant financial burden, the project aimed to answer the question: Will a staff education program focusing on an evidence-based, comprehensive approach to preventing pressure injuries increase nurses’ knowledge about implementing strategies to prevent them? The objective was to enhance adherence to the …