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Articles 1591 - 1620 of 47751
Full-Text Articles in Entire DC Network
Interprofessional Collaboration In Inpatient Rehabilitation For Patient With Thiamine Deficiency-Related Sensorimotor And Cognitive Deficits – Case Report, Christina Thomas, Tahreem Hashmi, Joanne Delgado-Lebron, Rania Massad
Interprofessional Collaboration In Inpatient Rehabilitation For Patient With Thiamine Deficiency-Related Sensorimotor And Cognitive Deficits – Case Report, Christina Thomas, Tahreem Hashmi, Joanne Delgado-Lebron, Rania Massad
Journal of Interprofessional Practice and Collaboration
Purpose: We aim to describe the clinical presentation, interprofessional management, and functional outcomes of a patient with thiamine deficiency. Problem: Thiamine deficiency can result in peripheral polyneuropathy and cognitive deficits that limit function and participation. Despite deficits that warrant interprofessional neurorehabilitation, previous reports focus narrowly on medical management. Case: A 36-year-old female was admitted to inpatient rehabilitation with a diagnosis of Guillain Barre. She underwent evaluation by the interprofessional team that revealed cognitive deficits inconsistent with Guillain Barre. Further medical workup identified a thiamine deficiency. Comprehensive treatment included supplementation managed by the physiatrist; promotion of motor learning and neuroplasticity to …
High-Dose Oral Pyrophosphate Inhibits Connective Tissue Calcification In Abcc6 Null Mice But May Affect Bone Structure, Ibtesam Rajpar, Nicholas Yancy, Jacob Beiriger, Christina Shao, Syed Naqvi, Deana Mancuso, Fatemeh Niaziorimi, Ryan E Tomlinson, Koen Van De Wetering
High-Dose Oral Pyrophosphate Inhibits Connective Tissue Calcification In Abcc6 Null Mice But May Affect Bone Structure, Ibtesam Rajpar, Nicholas Yancy, Jacob Beiriger, Christina Shao, Syed Naqvi, Deana Mancuso, Fatemeh Niaziorimi, Ryan E Tomlinson, Koen Van De Wetering
Department of Orthopaedic Surgery Faculty Papers
Pseudoxanthoma elasticum (PXE) is a rare inherited disorder marked by abnormal calcium phosphate deposition in soft connective tissues, particularly the skin, arteries, and eyes. It is caused by inactivating mutations in the ABCC6 gene, which encodes a hepatic efflux transporter. Loss of ABCC6 function leads to reduced plasma levels of pyrophosphate (PPi), a key inhibitor of calcification, thereby promoting ectopic mineralization. Oral PPi therapy has emerged as a potential treatment, but its effectiveness is uncertain. Most ingested PPi is hydrolyzed in the gut to inorganic phosphate, which may worsen calcification. Moreover, its impact on mineralized tissues remains largely unexplored. Abcc6−/− …
Impact Of Apitegromab On Motor Function In Spinal Muscular Atrophy, Jordyn Linfield, Ashley Jacob, Haylee Whyde, Owen Fox, Kaitlyn Bowden, Connor Dains, Brenna Hissong, Manoranjan D'Souza
Impact Of Apitegromab On Motor Function In Spinal Muscular Atrophy, Jordyn Linfield, Ashley Jacob, Haylee Whyde, Owen Fox, Kaitlyn Bowden, Connor Dains, Brenna Hissong, Manoranjan D'Souza
Pharmacy and Wellness Review
Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder characterized by the progressive loss of alpha motor neurons in the anterior horn of the spinal cord, leading to muscle weakness, atrophy, and impaired motor function.1 SMA remains an extensive and difficult-to-treat condition, with only three disease-modifying therapies currently available to patients. A new investigational agent with a unique mechanism of action, apitegromab (SRK-015), has shown promising results in recent clinical trials. The safety and efficacy of apitegromab in patients with SMA have been explored in several clinical trials, with the TOPAZ and SAPPHIRE studies being the most notable. This …
Alcohol And The Endocrine System: A Critical Review Of Disruptions, Potential Mechanisms, And Health Implications, Patricia E. Molina, Liz Simon
Alcohol And The Endocrine System: A Critical Review Of Disruptions, Potential Mechanisms, And Health Implications, Patricia E. Molina, Liz Simon
School of Graduate Studies Faculty Publications
The endocrine system coordinates and integrates cellular activity throughout the body by regulating cellular and organ function and maintaining homeostasis. Homeostasis, the dynamic maintenance of internal balance despite changing external or internal conditions, is essential for proper cellular function. The endocrine system achieves this through a complex regulatory network of hormone-mediated signaling among multiple endocrine organs, relying on precisely regulated synthesis and release of hormones and specific hormone-receptor interactions. Endocrine-mediated actions coordinate critical physiological processes, including growth, metabolism, reproduction, stress adaptation, and circadian rhythms throughout the lifespan. Endocrine glands—such as the hypothalamus, pituitary, thyroid, parathyroid glands, pancreas, adrenal glands, and …
Development Of An Educational Intervention To Enhance Nurses’ Knowledge And Intent To Implement Evidence-Based Diabetes Self-Management In Clinical Practice, Anne Marie Sieyou Ngouane
Development Of An Educational Intervention To Enhance Nurses’ Knowledge And Intent To Implement Evidence-Based Diabetes Self-Management In Clinical Practice, Anne Marie Sieyou Ngouane
Walden Dissertations and Doctoral Studies
This Doctor of Nursing Practice (DNP) project was purposed with closing critical gaps in staff knowledge and adherence to diabetes self-management protocols in a busy primary care clinic. Rising readmission rates and uneven use of American Diabetes Association (ADA) standards signaled an urgent need for a structured approach to staff education. To address this, a one-hour interactive training session was created that blended teaching, evidence-based handouts, and a practical diabetes care checklist. Staff learning was measured through pretest and posttest, confidence and adherence used a 5-point Likert-scale survey, and 21day readmission data tracked patient outcomes. The project question asked if …
High-Sensitivity Cardiac Troponin I And Frailty: Associations With The Frailty Index And Fried Phenotype In Older Women, Jedd Pratt, Abadi K. Gebre, Carlos J. Toro-Huamanchumo, Elsa Dent, Trent Bozanich, Wai E. Lim, Elizabeth Byrnes, Julee Mcdonagh, Caleb Ferguson, Craig Sale, Kun Zhu, Carl Schultz, Richard L. Prince, Joshua R. Lewis, Marc Sim
High-Sensitivity Cardiac Troponin I And Frailty: Associations With The Frailty Index And Fried Phenotype In Older Women, Jedd Pratt, Abadi K. Gebre, Carlos J. Toro-Huamanchumo, Elsa Dent, Trent Bozanich, Wai E. Lim, Elizabeth Byrnes, Julee Mcdonagh, Caleb Ferguson, Craig Sale, Kun Zhu, Carl Schultz, Richard L. Prince, Joshua R. Lewis, Marc Sim
Research outputs 2022 to 2026
Despite the nexus between cardiovascular health and frailty, the relevance of high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, to frailty is poorly understood. We examined whether hs-cTnI concentrations were associated with frailty in a well-characterized cohort of older women. A total of 1151 community-dwelling women from the Perth Longitudinal Study of Aging Women (mean age ± SD = 75.2 ± 2.7 years) were included. Frailty was operationalized using a validated frailty index (FI) of cumulative deficits and a modified Fried phenotype. Plasma hs-cTnI were categorized into quartiles. Cross-sectional associations between hs-cTnI quartiles and frailty were assessed using …
Effects Of Acute And Multi-Day Beetroot Juice Supplementation On Power And Velocity Of Ncaa Division I Baseball Players, Justin M. Foster, Raymond T. Gerardo, Sydney N. Brennan, Trevor J. Molnar, Ryan Tran, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan
Effects Of Acute And Multi-Day Beetroot Juice Supplementation On Power And Velocity Of Ncaa Division I Baseball Players, Justin M. Foster, Raymond T. Gerardo, Sydney N. Brennan, Trevor J. Molnar, Ryan Tran, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan
International Journal of Exercise Science: Conference Proceedings
Dietary nitrate supplementation can enhance power via modulating type II muscle fiber contractility; however, no study has examined the ergogenic potential of nitrate in elite level power-based athletes that heavily rely on type II muscle fiber activation such as baseball players. Moreover, there are no nitrate dosing guidelines available for elite level athletes. PURPOSE: To investigate if acute and multi-day nitrate supplementation influences power and velocity during barbell back squat and barbell bench press in elite level baseball players. METHODS: Eighteen male collegiate baseball athletes (NCAA Division I) reported to the laboratory for 6 visits over ~8 weeks, and were …
Effect Of Sodium Bicarbonate On Gastrointestinal Injury During Repeated Sprints In The Heat, Ozan Kumbasar, Jonathan W. Specht, Marissa Ramirez, Jennifer Raef, Mackenzie Schwartz, Alyssa R. Bailly, Oscar Chavez Jr., Jade X. Dawson, Jessica Apodaca, Raul Freire, Withley C. Atkins, Flávio De Castro Magalhães, Jason Siegler, Fabiano T. Amorim
Effect Of Sodium Bicarbonate On Gastrointestinal Injury During Repeated Sprints In The Heat, Ozan Kumbasar, Jonathan W. Specht, Marissa Ramirez, Jennifer Raef, Mackenzie Schwartz, Alyssa R. Bailly, Oscar Chavez Jr., Jade X. Dawson, Jessica Apodaca, Raul Freire, Withley C. Atkins, Flávio De Castro Magalhães, Jason Siegler, Fabiano T. Amorim
International Journal of Exercise Science: Conference Proceedings
Sodium bicarbonate (SB) is a widely used supplement that can enhance repeat sprint performance; however, a common side effect is gastrointestinal (GI) distress. Exercise in the heat can cause intestinal injury and endotoxemia, but no study has examined whether SB heightens this injury. PURPOSE: To determine whether SB ingestion exacerbates intestinal discomfort, injury, and endotoxemia during repeated sprints in the heat. METHODS: Ten endurance-trained athletes (6 male) completed randomized, counterbalanced, double-blind trials in which they ingested capsules containing SB (0.2 g·kg⁻¹ body mass) or placebo following a high-carbohydrate meal. The trials consisted of a 22-min warm-up followed by …
Dietary Nitrate Supplementation Worsens Resistance Exercise Performance In Resistance-Trained Females, Sydney N. Brennan, Raymond T. Gerardo, Trevor J. Molnar, Justin M. Foster, Ryan Tran, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan
Dietary Nitrate Supplementation Worsens Resistance Exercise Performance In Resistance-Trained Females, Sydney N. Brennan, Raymond T. Gerardo, Trevor J. Molnar, Justin M. Foster, Ryan Tran, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan
International Journal of Exercise Science: Conference Proceedings
Dietary nitrate supplementation appears to preferentially target type II muscle fibers for beneficial effects; however, research examining the efficacy of nitrate in females and resistance exercise is scarce. PURPOSE: To investigate if dietary nitrate, provided as concentrated nitrate-rich beetroot juice (BR), improved resistance exercise performance in back squat and bench press compared to nitrate-depleted beetroot juice (PL) in resistance-trained females. METHODS: Eighteen resistance-trained females aged reported to the lab for a total of four visits over a 2-week period. Participants performed a one repetition maximum protocol (1RM) and familiarization to the experimental protocol, and were assigned in a randomized, double-blind …
Acute And Chronic Dietary Nitrate Supplementation On Resistance Exercise Performance In Healthy Resistance-Trained Adults., Trevor J. Molnar, Sydney N. Brennan, Justin M. Foster, Ryan Tran, Raymond T. Gerardo, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan
Acute And Chronic Dietary Nitrate Supplementation On Resistance Exercise Performance In Healthy Resistance-Trained Adults., Trevor J. Molnar, Sydney N. Brennan, Justin M. Foster, Ryan Tran, Raymond T. Gerardo, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan
International Journal of Exercise Science: Conference Proceedings
The efficacy of dietary nitrate supplementation for enhancing resistance exercise remains unclear, and nitrate dosing guidelines are relatively unexplored. PURPOSE: To determine whether acute and chronic dietary nitrate supplementation, provided in the form of nitrate-rich beetroot juice (BR), can improve resistance exercise performance in resistance-trained males. METHODS: Thirty-six resistance-trained males and females will be recruited. Participants will complete a standardized one-repetition maximum (1RM) test in barbell back squat and barbell bench press and a familiarization prior to experimental visits. In a randomized, double-blind, controlled, fashion, participants will complete two conditions of 14-day supplementation periods to consume: (1) nitrate-depleted beetroot juice …
Susceptibility To Eccentric Contractions-Induced Locomotor Muscle Injury In Cigarette Smoke-Exposed Mice, David Tran, Leonardo Nogueira
Susceptibility To Eccentric Contractions-Induced Locomotor Muscle Injury In Cigarette Smoke-Exposed Mice, David Tran, Leonardo Nogueira
International Journal of Exercise Science: Conference Proceedings
Chronic exposure to tobacco cigarette smoke (CS) leads to pulmonary damage, inflammation, exercise intolerance, and skeletal muscle contractile and repair dysfunction, as our group has shown that CS exposure also delays muscle repair after eccentric contractions. This study investigated whether chronic CS exposure increases the susceptibility of locomotor muscles to injury from a session of eccentric contractions, as previous studies have shown that smokers have a greater risk of muscle injuries. Methods: Young adult (8 weeks old) wild-type mice (C57BL/6J, IACUC 25-071, n=24) were exposed to daily periods of CS or air (as controls) for eight consecutive weeks. After the …
Empowering Black Girls Through Joy, Strength, And Sisterhood: The Smart Fit Girls, Black Girl Joy Program, Alexis O. Pope, Kellie Amanda Walters
Empowering Black Girls Through Joy, Strength, And Sisterhood: The Smart Fit Girls, Black Girl Joy Program, Alexis O. Pope, Kellie Amanda Walters
International Journal of Exercise Science: Conference Proceedings
BACKGROUND: Compared to adolescent boys, girls are more likely to be obese, sedentary, and experience psychosocial distress such as depression, anxiety, and low self-esteem. Physical activity (PA) is strongly linked to psychosocial well-being, particularly in girls, yet girls of color face fewer opportunities to engage in structured PA programs. PURPOSE: Smart Fit Girls, Black Girl Joy (SFG BGJ) is a culturally immersive 7-week program combining PA, nutrition, and psychosocial lessons to strengthen psychosocial well-being in Black middle school girls. METHODS: A mixed-methods design was used with 6th–8th graders in the Long Beach Unified School District. Quantitative data was collected …
Concurrent Heart Rate Validity And Reliability Of Polar Verity Sense Devices During Light And Moderate Intensity Resistance Training In Recreationally Active Adults, Kynlee Sperry, Catalina Kerwin, Juni Timmins, Jamaal Bovell, Jose Vasquez, Satereh (Star) Zarei, Jeff Guzman, Nathaniel Bodell, James W. Navalta Facsm, Marcus M. Lawrence
Concurrent Heart Rate Validity And Reliability Of Polar Verity Sense Devices During Light And Moderate Intensity Resistance Training In Recreationally Active Adults, Kynlee Sperry, Catalina Kerwin, Juni Timmins, Jamaal Bovell, Jose Vasquez, Satereh (Star) Zarei, Jeff Guzman, Nathaniel Bodell, James W. Navalta Facsm, Marcus M. Lawrence
International Journal of Exercise Science: Conference Proceedings
Our laboratory previously determined that while wrist-worn wearable technology devices (e.g. Garmin watches) are not valid or reliable for heart rate, bicep-worn wearable technology devices (e.g., Polar Verity Sense) were valid and reliable for heart rate during light intensity resistance training (RT). However, these devices have never been tested for validity or reliability with varied intensities during resistance training. PURPOSE: To determine the concurrent validity and reliability of identical Polar Verity Sense bicep-worn devices to assess valid measures of average and maximum heart rate (HR) during light and moderately heavy RT. METHODS: Twenty adults (n=16 male, n=4 female, age: 25.65±8.59 …
The Impact Of Deadlift Exercise Intensity On Rating Of Perceived Exertion, Perceived Fatigue And Anxiety During An Acute Session In Recreationally Active Adults, Juni Timmins, Kynlee Sperry, Catalina Kerwin, Jae Bovell, Jose Vasquez, Setareh Zarei, Jeff Guzman, Nathaniel Bodell, James W. Navalta Facsm, Marcus M. Lawrence
The Impact Of Deadlift Exercise Intensity On Rating Of Perceived Exertion, Perceived Fatigue And Anxiety During An Acute Session In Recreationally Active Adults, Juni Timmins, Kynlee Sperry, Catalina Kerwin, Jae Bovell, Jose Vasquez, Setareh Zarei, Jeff Guzman, Nathaniel Bodell, James W. Navalta Facsm, Marcus M. Lawrence
International Journal of Exercise Science: Conference Proceedings
Most literature examining the influence of exercise intensity on anxiety symptoms has been aerobic training and has found high-intensity efforts to be more beneficial than low-intensity on reducing symptoms. Yet, no study has directly assessed resistance training exercise intensity on anxiety symptoms and other perceptual outcomes acutely. PURPOSE: To determine the impact of deadlift exercise intensity on rating of perceived exertion (RPE), perceived fatigue and anxiety during an acute session. METHODS: 20 recreationally active adults (n=4 females, n=16 males, age: 25.7±8.6 yrs; mass: 92.8±29.7 kg; height: 179.4±9.8 cm) completed 4 sets of 6 repetitions of the deadlift exercise at a …
The Impact Of Resistance Exercise Intensity And Position Of Wrist-Worn Wearable Technology Devices Measuring Heart Rate Validity During An Acute Session In Recreationally Active Adults, Catalina M. Kerwin, Jae Bovell, Kynlee Sperry, Juni Timmins, Jose Vasquez, Setareh Zarei, Jeff Guzman, Nathaniel Bodell, James W. Navalta Facsm, Marcus M. Lawrence
The Impact Of Resistance Exercise Intensity And Position Of Wrist-Worn Wearable Technology Devices Measuring Heart Rate Validity During An Acute Session In Recreationally Active Adults, Catalina M. Kerwin, Jae Bovell, Kynlee Sperry, Juni Timmins, Jose Vasquez, Setareh Zarei, Jeff Guzman, Nathaniel Bodell, James W. Navalta Facsm, Marcus M. Lawrence
International Journal of Exercise Science: Conference Proceedings
Wearable technology is widely used in recreational exercise. We recently found that wrist-worn devices (e.g., Garmin Instinct) were not valid or reliable for measuring average or maximal heart rate (HR) during resistance training (RT). We postulated that lack of accuracy could be due to the intensity of RT or even positioning of the device on the wrist. PURPOSE: To determine the impact of RT intensity or wrist position on average or maximal HR validity and reliability of identical wrist-worn Garmin Instincts. METHODS: 21 recreationally active adults (n=4 females, n=17 males, age: 25.7±8.6 yrs; mass: 92.8±29.7 kg; height: 179.4±9.8 cm) completed …
Neuromuscular Performance In Strength Or Endurance Trained Individuals: Construct Validity Of Mcpet Variables, Jeff Moore, Paolina Chavez Ibarra, Daniel T. Cannon, Harry B. Rossiter Facsm, Carrie Ferguson
Neuromuscular Performance In Strength Or Endurance Trained Individuals: Construct Validity Of Mcpet Variables, Jeff Moore, Paolina Chavez Ibarra, Daniel T. Cannon, Harry B. Rossiter Facsm, Carrie Ferguson
International Journal of Exercise Science: Conference Proceedings
The musculo-cardiopulmonary exercise test (mCPET) assesses neuromuscular performance during a standard ramp-incremental cycle ergometer exercise test using the addition of brief (5s), maximal effort isokinetic cycling power (Piso) measurements at baseline and intolerance. mCPET quantifies 4 additional variables: maximum voluntary isokinetic power (Baseline Piso); the fraction of Baseline Piso achieved at V̇O2peak (Aerobic Power Index, API); neuromuscular fatigability between baseline and intolerance Piso (Fatigue Index, FI); and the difference between peak ramp power and Piso at intolerance (Power Reserve, PR), reflecting the degree neuromuscular performance limits the exercise. PURPOSE: To determine construct validity of the mCPET using …
Time-Of-Day And Sex-Dependent Effects Of Exercise On Cardiometabolic Health In Mice With Social Jetlag, Graham R. Mcginnis
Time-Of-Day And Sex-Dependent Effects Of Exercise On Cardiometabolic Health In Mice With Social Jetlag, Graham R. Mcginnis
International Journal of Exercise Science: Conference Proceedings
Physiology has adapted to function on a 24 hour time scale, referred to as the circadian rhythm. Operating outside of this time scale leads to circadian rhythm disruption, which invariably leads to pathological outcomes. Social jetlag (SJL), a common form of circadian rhythm disruption, occurs when an individual’s sleep/wake schedule differs throughout the week (i.e. – staying up late on the weekends), and has been associated with obesity and cardiovascular disease. Exercise is a potential intervention to prevent SJL-induced impairments, but the time of day at which exercise is most effective is unknown.
PURPOSE: Determine if early or late phase …
Acute Sleep Reduction Impairs Heart Rate Variability And Heart Rate Recovery Following Aerobic Exercise In Healthy Adults, Jocelyn Kaveney, Gracie Dupuis, Eric Lessard, Braden Wilson, Grahm Mcginnis, Ryan Perkins
Acute Sleep Reduction Impairs Heart Rate Variability And Heart Rate Recovery Following Aerobic Exercise In Healthy Adults, Jocelyn Kaveney, Gracie Dupuis, Eric Lessard, Braden Wilson, Grahm Mcginnis, Ryan Perkins
International Journal of Exercise Science: Conference Proceedings
INTRODUCTION: According to the CDC, ~35% of American adults are receiving an inadequate amount of sleep (/night). PURPOSE: This study aimed to investigate the effects of acute sleep reduction on heart rate variability (HRV) and heart rate recovery (HRR) following aerobic exercise. METHODS: Healthy, active adults (n=11; 26.4±5.4 yr; 45% female) were screened to ensure eligibility (i.e., meeting the CDC’s sleep recommendations of 7-9hr/night, apparently healthy, recreationally active, and non-smoking), characterize body composition via DXA and measure maximal cardiovascular capacity (VO2max). Utilizing a within subjects, repeated measures design, participants completed an initial 7d period of habitual sleep (CON) followed …
Effects Of Acute Sleep Reduction And Aerobic Exercise On Metabolic Function In Healthy Adults, Eric Lessard, Gracie Dupuis, Jocelyn Kaveney, Braden Wilson, Grahm Mcginnis, Ryan Perkins
Effects Of Acute Sleep Reduction And Aerobic Exercise On Metabolic Function In Healthy Adults, Eric Lessard, Gracie Dupuis, Jocelyn Kaveney, Braden Wilson, Grahm Mcginnis, Ryan Perkins
International Journal of Exercise Science: Conference Proceedings
INTRODUCTION: The number of adults who receive insufficient sleep is progressively increasing, impacting the established relationship between sleep and metabolic function. PURPOSE: The purpose of this study was to explore the effects of acute sleep reduction on metabolic variables at rest and during aerobic exercise. METHODS: Healthy, active adults (n=11; 26.4±5.4 yr; 45% female) were screened to ensure eligibility (i.e., meeting the CDC’s sleep recommendations of 7-9hr/night, apparently healthy, recreationally active, and non-smoking), characterize body composition via DXA and measure maximal cardiovascular capacity (VO2max). Utilizing a within subjects, repeated measures design, participants completed an initial 7d period of …
Interleukin-6 As A Mediator Of Circadian And Sex Differences In Exercise-Induced Stat3 And Autophagy Signaling, Srushti Wagh, Ariana Khzarjyan, Joshua Corpuz, Elias M. Malek, Charli Aguilar, Michael Dial, Paula Martinez, Graham Mcginnis
Interleukin-6 As A Mediator Of Circadian And Sex Differences In Exercise-Induced Stat3 And Autophagy Signaling, Srushti Wagh, Ariana Khzarjyan, Joshua Corpuz, Elias M. Malek, Charli Aguilar, Michael Dial, Paula Martinez, Graham Mcginnis
International Journal of Exercise Science: Conference Proceedings
Circadian rhythms are highly conserved across tissues and play an important role in regulating how the heart responds to physiological and pathological stress. Exercise is known to be cardioprotective, yet the impact of exercise timing on molecular signaling is still being explored. Interleukin-6 (IL-6) is an exercise-induced cytokine which has been shown to be important to cardioprotection and metabolism. It is currently unknown how exercise timing modulates the IL-6 signaling pathway in the heart.
PURPOSE: To investigate how time-of-day and IL-6 influence exercise-induced activation of STAT3 and its downstream signaling pathways in male and female mouse hearts.
METHODS: Wild-type and …
Circulating Tumor Dna: Reducing Burden In Hpv+ Oropharyngeal Cancer Surveillance, Liza M. Joseph Pa-C
Circulating Tumor Dna: Reducing Burden In Hpv+ Oropharyngeal Cancer Surveillance, Liza M. Joseph Pa-C
Lynchburg Journal of Medical Science
This review examines the rising prevalence of human papillomavirus-related (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) and evaluates the role of circulating tumor HPV DNA (ctHPVDNA) in diagnosis and post-treatment surveillance. A comprehensive literature search of electronic databases, including PubMed, Medline, Cochrane Library, and Google Scholar, identified studies that validated ctHPVDNA as a biomarker with high sensitivity and specificity, assessed its cost-effectiveness, and explored patient and provider perceptions. Clinical evidence supports that plasma-based ctHPVDNA is the most accurate method for detecting disease recurrence and quantifying tumor burden. Patient perception studies reported high confidence in ctHPVDNA testing, while providers viewed it as …
Management Of Difficult Patient Situations, Sangeetha Larsen Mpas, Pa-C
Management Of Difficult Patient Situations, Sangeetha Larsen Mpas, Pa-C
Lynchburg Journal of Medical Science
The purpose of this paper is to provide strategies for clinicians to manage difficult patient interactions. A comprehensive search of PubMed was conducted, identifying articles that identified the root cause of difficult patient interactions and assessed methods for successfully navigating these situations. The term “difficult patient” reflects the interaction of patient behavior, clinician perception, and systemic constraints rather than an inherent patient flaw. Effective management involves reframing difficult behavior as an expression of unmet needs and responding with empathy, active listening, clear boundaries, and collaborative decision-making. System-level strategies reduce patient distress and clinician burnout. Ultimately, the difficult patient represents strained …
Predictors Of Mortality Among Under-Five Children Hospitalized With Severe Community-Acquired Pneumonia. A Retrospective Observational Study, Marwa Taha
Journal of Medicine in Scientific Research
Background Severe community-acquired pneumonia (SCAP) remains a critical public health issue and a leading cause of childhood mortality and morbidity, especially in developing countries. Identifying predictors of death in children with SCAP and early recognition of high-risk patients could significantly improve survival rates. Objective This study aims to identify possible predictors of mortality in pediatric SCAP, facilitating the early recognition of high-risk children. Patients and Methods This retrospective observational study included 120 children under the age of five who were admitted with SCAP, based on World Health Organization (WHO) guidelines. Demographic data, clinical characteristics, laboratory findings, and hospital outcomes were …
Influence Of Frailty On The Outcome Of Surgical Patients Over 70 Years Old With Admission Criteria In The Icu At Shebin El-Kom Teaching Hospital, Talal Ibrahim Mostafa Hagag Dr, Shimaa Mohamed Kalama
Influence Of Frailty On The Outcome Of Surgical Patients Over 70 Years Old With Admission Criteria In The Icu At Shebin El-Kom Teaching Hospital, Talal Ibrahim Mostafa Hagag Dr, Shimaa Mohamed Kalama
Journal of Medicine in Scientific Research
Background: In older adults, frailty is a complex condition marked by diminished functional reserves and heightened susceptibility to stressors. It is a more accurate predictor of unfavorable postoperative outcomes in the context of surgical operations than a patient's age or preexisting medical problems. Objectives: This study aimed to investigate the effects of frailty, as assessed by the Clinical Frailty Scale (CFS) and the 5-item Modified Frailty Index (MFI-5), on important clinical outcomes, including length of stay in the intensive care unit (ICU), hospitalization mortality, and the chance of readmission within 30 days, in older adults undergoing major abdominal surgeries. Methods: …
Assessment Of Body Fat Percentage In Emirati Females: A Comparative Analysis Of Bia Vs. Dxa, Dalia Haroun, Aseel Ehsanallah
Assessment Of Body Fat Percentage In Emirati Females: A Comparative Analysis Of Bia Vs. Dxa, Dalia Haroun, Aseel Ehsanallah
All Works
Introduction: Obesity is a significant health issue in the UAE. Accurate body composition assessment is crucial for managing obesity-related health risks. This study aimed to evaluate the agreement between bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) in measuring body composition among Emirati females. Methods: This cross-sectional study involved 95 healthy Emirati females aged 17–27 years. Paired samples t-tests, correlation analyses, and Bland-Altman plots were used to compare the two methods (BIA vs. DXA). Results: BIA significantly underestimated % fat and fat mass (FM) while overestimating fat-free mass (FFM) compared to DXA. The mean difference in % fat was …
Predictors Of Caregiver Burden Among The Caregivers Of Bedridden Patients In Muscat, Oman, Rawan Al Abdulsalam, Hajer Al Shaaibi, Manar Al Sanaa Al Zeedi, Rahma Al Hadhrami
Predictors Of Caregiver Burden Among The Caregivers Of Bedridden Patients In Muscat, Oman, Rawan Al Abdulsalam, Hajer Al Shaaibi, Manar Al Sanaa Al Zeedi, Rahma Al Hadhrami
Sultan Qaboos University Medical Journal
Objectives: Caring for bedridden patients is physically and emotionally demanding, often resulting in significant caregiver burden. This study aimed to assess caregiver burden and associated factors among caregivers of adult bedridden patients in Muscat, Oman. Methods: This cross-sectional study was conducted from January 2024 to February 2025 among caregivers of adult bedridden patients registered to get community services in Muscat Governorate and provided care for more than 1 month. Data were collected using the 12-item Zarit Burden Interview and the Katz Index of Independence in Activities of Daily Living. Results: A total of 200 caregivers participated; 66% were female, with …
Food Insecurity. A Factor In Criminal Behavior?, Jerrod Brown, Jeremiah Schimp, Leanne Skehan, Janina Cich
Food Insecurity. A Factor In Criminal Behavior?, Jerrod Brown, Jeremiah Schimp, Leanne Skehan, Janina Cich
Nutritional Neurocriminology Today
This article examines how food insecurity and limited access to nutritionally adequate foods impair cognitive function, emotional regulation, decision-making, and impulse control. Emerging research purports that individuals experiencing food insecurity face increased risks of mental and physical health problems, violent behavior, delinquency, heightened childhood vulnerability, and criminal justice involvement across the lifespan. The article advocates for increased awareness, routine screening, and specialized training for professionals in mental health, social services, and the criminal justice system to address food insecurity, thereby supporting long-term policy and community-level strategies that reduce criminal behavior and improve outcomes for vulnerable populations.
National Survey Of Physical Therapists’ Participation As Health Educators In Physical Activity Promotion Among Older Adults, Casey Nicole Mokres
National Survey Of Physical Therapists’ Participation As Health Educators In Physical Activity Promotion Among Older Adults, Casey Nicole Mokres
Walden Dissertations and Doctoral Studies
Physical inactivity among older adults remains a major national and global public health concern linked to preventable morbidity, mortality, and rising healthcare costs. Physical therapists are uniquely positioned to promote physical activity (PA) through health education, yet their engagement in this role is not well defined. This quantitative cross-sectional study examined associations between clinical practice factors—years of experience, board certification status, and practice setting—and three domains of the theoretical domains framework (knowledge, skills, and behavioral regulation) related to PA promotion among older adults. The framework guided identification of behavioral and contextual factors influencing therapists’ delivery of PA promotion interventions. Data …
Association Of Short Interpregnancy Interval Among Multigravid “Pregnant Youth” In A Tertiary Hospital, Eileen Feliz Cortes-Garcia
Association Of Short Interpregnancy Interval Among Multigravid “Pregnant Youth” In A Tertiary Hospital, Eileen Feliz Cortes-Garcia
The Lasallian Journal of Health
Introduction: Pregnancy among the youth is in creasing not only in the Philippines but worldwide. Studies have shown that a short interpregnancy inter val of 18 months or less is associated with an in creased risk of fetal and maternal complications. However, limited data are available regarding fetal and maternal outcomes among pregnant youth with short interpregnancy intervals, particularly in the Philippines. Objectives: The objective of the study was to deter mine the association between a short interpregnancy interval of <18 months and adverse fetomaternal out comes among pregnant youth aged 15 to 24 years who had their first pregnancy at De La Salle Univer sity Medical Center (DLSUMC) from 2017 to 2019. Methods: This was a retrospective cohort study in volving 130 participants who delivered at DLSUMC from 2017 to 2019 either by vaginal spontaneous delivery, assisted vaginal delivery, or cesarean sec tion. Results: Of these, 84 (66.15%) were 22 to 24 years old and the majority had their first pregnancy at the age of 18 to 21 years (59 [45.38%]). This study demonstrated that preterm delivery, postpartum hem orrhage, and hypertension were significantly associ ated with a short interpregnancy interval. Conclusions: Short interpregnancy interval is associ ated with an increased risk of preterm delivery, hy pertension, and postpartum hemorrhage among mul tiparous pregnant youth. Counseling and proper edu cation, including family planning, are important for both maternal and fetal health. The use of different family planning methods should be discussed and made accessible to young women.
Development Of Research Productivity Appraisal Tool (Reprodapt): Validity And Reliability, Daisy Alberto, Roberto C. Sombillo, Danaida Marcelo, Juanito O. Cabanias
Development Of Research Productivity Appraisal Tool (Reprodapt): Validity And Reliability, Daisy Alberto, Roberto C. Sombillo, Danaida Marcelo, Juanito O. Cabanias
The Lasallian Journal of Health
Objectives: The aim of this study is to develop a research productivity appraisal tool (ReProdApT) and determine its validity, reliability/reproducibility, feasibility, and usability for De La Salle Medical and Health Sciences Institute.
Methods: The ReProdApT has a set of indicators and an academic relative value unit as recommended by several authors for measuring academic research productivity [1-3]. Through a non-experimental, crosssectional design, the tool underwent content validation by experts, inter- and intra- rater reliability testing and assessment of feasibility and usability. Results: Of the 22 faculty members from different colleges who participated in the study, 13 were females and nine …