Digital Commons Network^™

Overexpression Of The D-Alanine Racemase Gene Confers Resistance To D-Cycloserine In Mycobacterium Smegmatis, Nancy E. Caceres, N. Beth Harris, James F. Wellehan, Zhengyu Feng, Vivek Kapur, Raul G. Barletta

School of Veterinary and Biomedical Sciences: Faculty Publications

D-Cycloserine is an effective second-line drug against Mycobacterium avium and Mycobacterium tuberculosis. To analyze the genetic determinants of D-cycloserine resistance in mycobacteria, a library of a resistant Mycobacterium smegmatis mutant was constructed. A resistant clone harboring a recombinant plasmid with a 3.1-kb insert that contained the glutamate decarboxylase (gadA) and D-alanine racemase (alrA) genes was identified. Subcloning experiments demonstrated that alrA was necessary and sufficient to confer a D-cycloserine resistance phenotype. The D-alanine racemase activities of wild-type and recombinant M. smegmatis strains were inhibited by D-cycloserine in a concentration-dependent manner. The D-cycloserine resistance phenotype in the …

External Quality Assessment For Radioimmunoassay Ofthyroid And Related Hormones: Third-Year Scheme, Paungpayom Prichakas, Makumkrong Poshyachinda, Tawatchai Chaiwatanarat

Chulalongkorn Medical Journal

No abstract provided.

Assembly And Regulation Of The Cd40 Receptor Complex In Human B Cells, Michelle R. Kuhné, Michael Robbins, John E. Hambor, Matthew F. Mackey, Yoko Kosaka, Toshihide Nishimura, Jason P. Gigley, Randolph J. Noelle, David M. Calderhead

Dartmouth Scholarship

CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily. Studies with human B cells show that the binding of CD154 (gp39, CD40L) to CD40 recruits TNF receptor– associated factor 2 (TRAF2) and TRAF3 to the receptor complex, induces the downregulation of the nonreceptor-associated TRAFs in the cell and induces an increased expression of Fas on the cell surface. Combined signaling through the interluekin 4 receptor and CD40 induces an increased expression of Fas with a commensurate increase in the level of TRAF2, but not TRAF3, that is recruited to the receptor complex. In contrast, engagement of the …

Attempting To Learn From History: Nato, Anti-Drug Policies, And Intelligence Assets, Ibpp Editor

International Bulletin of Political Psychology

This article describes some political psychological aspects of being allied with security organizations infiltrated by adversaries.

Summer 1997, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Summer 1997

Pharmacology Of Antiparkinsonian Agents, Robert P. Soltis

Scholarship and Professional Work – COPHS

The following is a summary of a two hour class on the basic pharmacology of antiparkinsonian agents. It is presented to fourth-year pharmacy students in pharmacotherapeutics III, a course structured using team-taught modules. Faculty from the Department of Pharmacy Sciences provide instruction on the basic pharmacology of therapeutic agents and faculty from the Department of Pharmacy Practice follow up with a discussion of the therapeutic applications of these agents. This course is lecture-based with opportunities for in-class discussion. One week prior to the lecture sequence on the basic pharmacology of antiparkinsonian drugs, students are provided a handout that includes the …

Update - July 1997, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Practicing on Newly Dead Bodies
-- Life versus Death: The Ethical Imperative to Practice and Teach Using the Newly Dead
-- You Can't Always Get What You Want
-- MA in Clinical Ethics
-- MA in Clinical Ministry

Dentalgram - Vol. 11, No. 07, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• Bikers take over Colorado Plateau
• Climb Every Mountain
• New faculty
• Department news
• Longtime friends meet for first time
• New advanced education students

The Flame, Summer-Fall 1997, Mennonite College Of Nursing

The Flame (1985-present)

The Flame is a newsletter of Illinois State University's Mennonite College of Nursing

Nsu Summer Instruction Master's Program In Life Span Care And Administration: “The Profession And Public Policy, Family Systems In Substance Abuse Counseling, Group Theory And Practice” July–August, 1997, Nova Southeastern University

Abraham S. Fischler College of Education and School of Criminal Justice College Archive

No abstract provided.

The Cellular And Molecular Dynamics Of The Queuosine Modification In Transfer Rna: Definition, Modulation, Deficiencies And Effect Of The Queuosine Modification System, Rana C. Morris

Theses and Dissertations in Biomedical Sciences

The presence of the queuosine modification in the wobble position of tRNA^asn, tRN^asp, tRNA^his, and tRNA^tyr is associated with a decrease in cellular growth rate, an increase in the ability to withstand environmental stress, and differentiation of pleuripotent cells into mature phenotypes. The loss of this normal modification is strongly correlated with neoplastic transformation and tumor progression of a wide variety of cancers.

The "normal" system for formation of the queuosine modification in tRNA was studied in human fibroblast cell cultures and in mouse, rat and human liver tissues. The queuosine modification system …

Oral Health Assessment Of Renal Transplant Recipients Undergoing Immunosuppressant Therapy, Coral Diaz

Dental Hygiene Theses & Dissertations

The purpose of this investigation was to assess the oral health, prevalence of intraoral manifestations/infections. and periodontal disease status of renal transplant recipients undergoing immunosuppressive therapy to determine their oral health needs. A purposive sample was selected via the Renal Transplant Center. Sentara Norfolk General Hospital. and Nephrology Associates of Tidewater LTD from which 22 renal transplant recipients who agreed to participate were examined. Three subgroups of the population were studied: individuals with a renal transplant for less than one year. individuals with a renal transplant for one to three years and individuals with a renal transplant for more than …

Characterization Of The Fast Axonally Transported Proteins In The Rat Optic Pathway, Surafel Mulugeta

Theses and Dissertations in Biomedical Sciences

The fast axonally transported proteins represent a subset of neuronal proteins that are conveyed anterogradely as secretory vesicle constituents from the perikarya. Although fast transport displays properties consistent with the general secretory pathway, neuronal structure presents special problems which may require modifications of the general pathway. The elucidation of these special modifications is essential for a more complete understanding of neuronal function both in normal and pathological conditions. In order to characterize the fast transported (FT) proteins and to better understand fast transport trafficking, the FT of radiolabeled retinal ganglion cell (RGC) proteins in the adult rat optic pathway was …

Endothelial Nitric Oxide Synthase And Growth Factor Regulation Of Flow-Mediated Vascular Remodeling, David Anthony Tulis

Theses and Dissertations in Biomedical Sciences

This study was designed to characterize structural remodeling of male Wistar rat mesenteric arteries exposed to elevated blood flow in vivo for 1, 3, or 7 days. A series of arterial ligations induced blood flow increases in ileal and second-order branch arteries compared to same animal control vessels. Neither mean carotid nor local mesenteric arterial pressures changed significantly pre- to post-ligation. The primary flow-mediated force in both vessels was shear stress with possible involvement of acute stretch-induced wall stress in the ileal artery. Significant luminal expansion and medial wall hypertrophy occurred in the ileal and second-order arteries in a time-dependent …

Department Of Radiology-Annual Report-July 1, 1996 To June 30, 1997, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1996 to June 30, 1997. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 108 pages.

Privacy And Information Technology, Judith Wagner Decew

Center for the Study of Ethics in Society Papers

Presented March 17, 1997 for the Center for the Study of Ethics in Society

Bovine Oviductal And Embryonic Insulin-Like Growth Factor Binding Proteins: Possible Regulators Of "Embryotrophic" Insulin-Like Growth Factor Circuits., Q A Winger, P De Los Rios, V K Han, D T Armstrong, D J Hill, A J Watson

Obstetrics & Gynaecology Publications

Bovine oviductal monolayer and vesicle primary cultures express insulin-like growth factor (IGF)-I and -II mRNAs and polypeptides. Early bovine embryos also express IGF-I, IGF-II, IGF-I receptor, IGF-II receptor, and insulin receptor mRNAs. This study reports the expression of IGF binding protein (IGFBP) mRNAs and polypeptides in bovine oviduct primary cultures and IGFBP mRNAs in preattachment embryos. Release of immunoreactive IGF-I and IGF-II by oviduct cultures and bovine blastocysts was also determined. IGFBP-2, -3, -4, and -5 transcripts were observed in oviduct primary cultures throughout an 8-day interval. IGFBP-1 and -6 mRNAs were consistently not detected in the oviduct. Messenger RNAs …

Cellular Responses In Escherichia Coli To Lethal And Sublethal Doses Of Ozone, Indira Ruth Komanapalli

Loma Linda University Electronic Theses, Dissertations & Projects

Ozone is a major component of photochemical smog. High levels of this pollutant, sufficient to affect human health are found in many urban areas worldwide. Though limited studies in humans are supported by extensive findings from animal experiments, a difficulty in interpreting the results of these experiments has lead to an ambiguity on the biochemical mechanism of ozone toxicity. To elucidate the mechanism by which ozone causes cell damage and eventual cell death we conducted a comprehensive study using Escherichia coli K-12 as a model.

Studies on the comparative inactivation of bacteriophage lambda (λ), Escherichia coli, and Candida albicans …

Effects Of Sperm Preparation On In Vitro Fertilization In Pig, Mongkol Techakumphu, Wichai Tantasuparak

The Thai Journal of Veterinary Medicine

The aim of these experiments was to investigate the effects of sperm preparation on the success rate of in vitro fertilization in the pig. Three factors, the time period for capacitation, the type of sperm and the sperm motility-stimulating factors were studied by investigating their effect on the cleavage of pig follicular oocytes, after IVM-IVF-IVC. A total of 1,235 immature oocytes, collected from 3 to 6 mm follicles of gilt ovaries gathered at slaughterhouse were allocated to 3 experiments. Immature oocytes were cultivated in TCM199 NaHCO3 supplemented with 10 μg/ml of FSH/LH and 1 μg/ml of Estradiol-17ẞ for 44 hrs. …

1997 - The Second Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Second Annual Symposium of Student Scholars, held on May 23rd, 1997. Includes abstracts from the presentations and posters.

1997 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

Black English, Karen Tibbitts Filimoehala

Undergraduate Honors Capstone Projects

Black English has recently entered the media spotlight with the passing of the Ebonics resolution by the Oakland School Board on Dec. 18, 1996. In this resolution, the school board unanimously voted to recognize Black English or "Ebonics" (a term which combines the words "ebony" and "phonetics")(LeLand & Joseph, 1997, p. 78) as the primary language of many of its students, and to teach students in their primary language in order to maintain the "legitimacy and richness" of the language, and to help students master standard English. Needless to say, the resolution was met with highly charged arguments - some …

Fetal Alcohol Syndrome: Information And Intervention Strategies For School, Home, And Therapeutical Settings, Mindy Dawn Anderson

Undergraduate Honors Capstone Projects

I was introduced into the world of Fetal Alcohol Syndrome winter quarter, 1996. My goals for that year included researching this topic in order to understand what it was physically, behaviorally, and on a cognitive level. My assignment involved writing a research paper around those characteristics, along with the development of their speech and language, presenting my findings to my classmates, and competing at the USU Scholar's Day competition in May of 1996. I received 2nd place at this competition. During the summer of that year, I researched FAS more to receive the needed resources to compile an annotated bibliography …

A Southeastern Community's Knowledge, Attitudes, Intentions, And Beliefs Regarding The Role Of The Nurse Practitioner, Susan Robinson

Masters Theses and Doctoral Dissertations

The purpose of this quantitative descriptive study was to examine consumer knowledge,attitudes, intention, and beliefs about nurse practitioners(NPs ),to determine whether a relationship existed between knowledge,attitudes, intentions, and beliefs, and demographic variables of age, gender, ethnicity,education,degree, profession, type of insurance, :frequency of visits to a primary care provider in the past 12 months, and consumer exposure to nurse practitioners.A conceptual :framework combining Orem's self care deficit theory and Ajzen and Fishbein's theory of reasoned action.This framework was used to explain the relationship between knowledge,attitudes,intention, beliefs, and behavior and the nurse practitioner's role in intervening to affect change in that relationship.Subjects(n=202)from …

The Experiences Of Taiwanese Women Caregiving For Parents-In-Law, Shu-Yuan Chao Dnsc

Dissertations

Using grounded theory, a semi-structured in-depth interview was conducted to explore the experiences of Taiwanese women who were caregivers for their parents-in-law. Thirty-one Taiwanese women aged 23 to 58 participated in this study. Just Doing was identified as the core category to indicate the caregivers' striving process once they committed to their in-laws' care. Recognizing Duty, Experiencing Trials, and Responding to Caregiving were subcategories and reflected how a caregiver perceived her role, how she was affected by caregiving tasks, and what responses she had to the caregiving situation. The findings also suggested that caregiving behaviors were influenced by cultural expectations …

Living With Changing Health: Perimenopause Among Chinese Women In Taiwan, Lee-Ing Tsao Dnsc, Mnsc, Rn

Dissertations

The purpose of this qualitative study was to generate theory about women's perimenopausal life experiences. Thirty-five Taiwanese women aged 40 to 59 who perceived themselves as perimenopausal and who were not using hormone therapy were interviewed. Data were generated from interviews which were conducted in Mandarin. Living with Changing Health was the core category for describing and guiding the process of perimenopause. During this process, Awareness was identified as the antecedent condition. Once the woman became aware, she would begin the process of living with her changing health. This process would be marked by action and interaction among the categories …

Determinants Of Health-Promoting Lifestyle Among Nurses In Taiwan, Chou Chuan-Chiang Yao Dnsc, Ms, Rn

Dissertations

This two-phase study was undertaken to: (1) determine the relationships of self-efficacy, perceived health status, perceived social support, age, marital status, education, work shift, work setting, and years employed as a registered nurse (RN) to the practice of a health-promoting lifestyle; (2) determine the combination of predictor variables explaining the variance in the practice of a health-promoting lifestyle; and (3) investigate other personal and environmental cues and characteristics related to health-promoting lifestyles among nurses (N = 218) in Taiwan. Findings of the quantitative approach in Phase One indicated that a health-promoting lifestyle was significantly related to self-efficacy, perceived health status, …

Fetal Alcohol Syndrome: Information And Intervention Strategies For School, Home, And Therapeutical Settings, Mindy Dawn Anderson

Undergraduate Honors Capstone Projects

I was introduced into the world of Fetal Alcohol Syndrome winter quarter, 1996. My goals for that year included researching this topic in order to understand what it was physically, behaviorally, and on a cognitive level. My assignment involved writing a research paper around those characteristics, along with the development of their speech and language, presenting my findings to my classmates, and competing at the USU Scholar's Day competition in May of 1996. I received 2nd place at this competition. During the summer of that year, I researched FAS more to receive the needed resources to compile an annotated bibliography …

Alterations In Human B Cell Calcium Homeostasis By Polycyclic Aromatic Hydrocarbons: Possible Associations With Cytochrome P450 Metabolism And Increased Tyrosine Phosphorylation, Barbara J. Mounho

Pharmaceutical Sciences ETDs

Polycyclic aromatic hydrocarbons (PAHs), are known immunotoxicants in animals, and are suspect toxins to the human immune system. The mechanism(s), however, by which PAHs exert immunosuppression have not been fully elucidated. Previous studies conducted in our laboratory have shown that PAHs, such as 7,12-dimethylbenz(a)- anthracene (DMB A) and benzo(a)pyrene (BaP) may exert their immunotoxic effects by altering intracellular calcium (Ca2+) homeostasis in lymphocytes. Intracellular Ca2+ is an important second messenger in the immune response, and the mobilization of Ca2+ is critical in the transduction of intracellular signals from the plasma membrane to the nucleus. The overall objective of this project …

Santa Clara Magazine, Volume 39 Number 1, Spring 1997, Santa Clara University

Santa Clara Magazine

6 - BLUE SKY INVASION Searching for the American Dream, aerospace workers transform the Santa Clara Valley. By David Beers '79, Illustrations by Dug Waggoner

15 - SEEING IS BELIEVING Professor Sally Wood develops software to help students visualize basic engineering concepts. By Laura Trujillo '92

18 - CONFRONTING THE SCARS OF CENTURIES A legal challenge to California's Proposition 209 is the latest round in a long- running debate over affirmative action. By Margaret M. Russell

26 - SHADOWY ALLIANCE A recent expose alleging CIA links to the crack cocaine epidemic in California's inner cities raises questions about responsibility and …