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Adverse Drug Reaction Reporting In Dental Practice And The Importance Of Pharmacovigilance In Dental Education, Radhakrishna Lagishetty, Lakshmi Ramya T, Kvr Barath Raju, Mohan Kumar Pasupuleti

Journal of Dentistry Indonesia

Background: Adverse drug reactions (ADRs) are a critical component of patient safety; however, ADR monitoring remains underutilized in dentistry. This study aimed to assess knowledge, attitudes, and practices regarding ADR reporting among undergraduate and postgraduate students and practicing dentists.

Methods: A cross-sectional observational study was conducted using a structured, validated 19-item questionnaire covering socio-demographics, knowledge (6 items), attitude (4 items), and practice (5 items), which was distributed both in person and online. A total of 258 complete responses were analyzed out of 300 individuals contacted (response rate: 86%). Descriptive statistics and Chi-square tests were applied, with p < 0.05 considered statistically significant.

Results …

Flaxseed Ethanolic Extract Modulates Β-Catenin And Dkk1 Expressions During Osteoblast Differentiation Of Dental Pulp-Derived Stem Cells, Nur Sazwi Nordin, Khairani Idah Mokhtar, Omar Abdul Jabbar Abdul Qader, Basma Ezzat Mustafa, Widya Lestari, Deny Susanti Darnis, Thirumulu Ponnuraj Kannan, Azlina Ahmad, Solachuddin Jauhari Arief Ichwan

Journal of Dentistry Indonesia

Background: WNT signaling regulates osteogenic differentiation of mesenchymal stem cells (MSC) through the canonical WNT pathway. β-catenin; an important molecule of WNT pathway, and DKK1; a WNT antagonist, play important roles in regulating bone formation. Although flaxseed (Linum usitatissimum) has various health benefits, including promoting bone health, our previous study showed that flaxseed ethanolic extract (FEE) reduced the osteoblast differentiation potential of stem cells from human exfoliated deciduous teeth (SHED). This study aimed to determine the effects of FEE on WNT pathway-related molecules, β-catenin and DKK1, during osteoblast differentiation of SHED.

Methods: RNA at Day 7, 14, …

The Correlation Between Medication Adherence, Blood Glucose Levels, And Quality Of Life In Patients With Type 2 Diabetes Mellitus At Ciamis Regional Hospital, Amyla Putri Nurul Nazmi, Nur Rahayuningsih, Lusi N

Pharmacology and Clinical Pharmacy Research

Type 2 diabetes mellitus is a chronic condition requiring continuous treatment, including patient adherence to prescribed medication. This study aimed to explore the relationship between medication adherence, blood glucose levels, and quality of life in patients with type 2 diabetes mellitus at Ciamis Regional Hospital, conducted from January to March 2025, the research employed a quantitative, prospective cross-sectional design involving 49 hospitalized patients. Data included blood glucose levels (RPG, FPG, 2hPG), medication adherence measured using the Medication Adherence Report Scale (MARS-5), and quality of life assessed via the Diabetes Quality of Life-Brief Clinical Inventory (DQOL-BCI). The chi-square test was used …

The Phytochemical Content And Antibacterial Activity Of Purified Extract Of Mangifera Indica L. Against Gram Positive Pathogen, Dewi Andini Kunti Mulangsri, Masduki Faqih, Sugar Arifin, Mutiara Trie Sieya Agustin

Pharmacology and Clinical Pharmacy Research

The purified extract of arum manis mango leaves contained flavonoid compounds by TLC methods and antibacterial activity against Gram-positive and negative pathogens. This research aimed to identify and determine the phytochemical content (mangiferin and flavonoids content) and antibacterial activity against other Gram-positive pathogens. Purification of ethanol extract of arum manis mango leaves by liquid-liquid fraction method. Determination of total flavonoid content and identification of mangiferin used respectively by aluminum chloride and Thin Layer Chromatography method. The disk diffusion method was used to assay antibacterial activity against S. epidermidis, and B. subtilis bacteria with the concentration of the sample such …

Development Of Ultrafast Protein Digestion And Standards Free Quantitation Methods For Mass Spectrometric Analysis, Praneeth Ivan Joel Fnu

Dissertations

A wide variety of biologically important molecules, such as enzymes, antibodies, hormones, transporters and receptors are proteins by composition and they play key roles in biological functions such as cellular regulation, communication, metabolism and physiological function. Protein dysfunctions and abnormalities are associated with numerous diseases, making proteins critical targets for understanding disease mechanisms and developing therapeutic interventions. Protein-based therapeutics such as monoclonal antibodies, hormones and vaccines gained popularity due to their high specificity, efficacy, and ability to treat complex diseases that are often difficult to address with small-molecule drugs.

Given the important role of proteins in a variety of biological …

Association Between Athletic Trainers And Frequency Of Pediatric Orthopedic Visits, Abaigeal Field, James M. Mensch, Courtney Meyer, Susan W. Yeargin

Clinical Practice in Athletic Training

Context: There is sparse research on the relationship between athletic trainer (AT) employment and the number of athletes presenting to orthopedic clinics with sports-related injuries. The purpose of this study is to determine if athletic training services are associated with the frequency of first-time orthopedic office visits for sports-related injuries.

Methods: A retrospective chart review collected injuries between January 1, 2018 and December 31, 2020 from the electronic health records system for a hospital network in the Southeast United States with 6 orthopedic clinics and included 48 high schools hosting 20 sports with at least 1 AT per school. Patients …

Transmutation Of Psychological Phenomena (Academic Burnout And Fomo) Into Cyanotype Art Creation, Zulfan Ali Mujtaba, Adi Kuntoro

Paradigma: Jurnal Kajian Budaya

The pressure of hustle culture and the Fear of Missing Out (FOMO) in the digital era have triggered an escalation of academic burnout among students, demanding alternative psychological recovery interventions beyond verbal clinical approaches. This research aims to explore the creation of alternative Cyanotype photography as a medium for catharsis and resistance against toxic productivity. Utilizing a Practice-Based Research methodology with an autoethnographic approach, data were extracted from the researcher's subjective experiences and transmuted into a visual artifact titled "Metamorfosis yang Lelah". The cultural studies approach and wabi-sabi aesthetics are specifically applied to analyze visual elements in the Prussian Blue …

Cultural Responsiveness: Examining Assessments Of Therapists For Ethical And Clinical Outcomes (Create Clout), Tsotso T. Ablorh

Graduate Doctoral Dissertations

The Multicultural Counseling Competencies (MCC) and Multicultural and Social Justice Counseling Competencies (MSJCC) are well-researched and supported counseling practices for decreasing microaggressions in therapy and consequent attrition, lack of satisfaction, and maltreatment (Ratts et al., 2016; Sue et al., 1982). However, scholars critique existing methods for measuring therapists’ cultural responsiveness for being disconnected from therapeutic process and outcomes (Hays, 2020; Wilcox et al., 2020). This study examined which MSJCC measures associated with variables clinically and ethically relevant to better treatment outcomes and lower microaggressive, neglectful, and stereotypical treatment for hypothetical Black, female clients by White therapists. 62 White psychologists in …

Understanding Factors Influencing Multiple Tobacco Product Use Among Adolescents In Thailand: A Structural Equation Modeling Approach, Chaowalit Srisoem

Graduate Doctoral Dissertations

Tobacco use among Thai adolescents is shaped by personal, environmental, and product-related factors. However, the pathways linking these influences to actual behavior remain unclear. This study examined how personal, environmental, and product-related factors, along with intentions to use, relate to tobacco use among Thai adolescents. A cross-sectional secondary analysis was conducted using data from the 2022 Thailand Global Youth Tobacco Survey of 6,235 students aged 13–15 years. Survey weights methods were applied to produce nationally representative estimates. Confirmatory factor analysis and structural equation modeling assessed latent constructs, and multinomial logistic regression examined predictors of single, dual, and multiple product use. …

Isolation, Structural Characterization, And In Vitro Bioactivity Assessment Of Extracellular Vesicles Derived From Lacticaseibacillus Paracasei, Dwi Liza Ramadiani, Ratika Rahmasari, Tri Wahyuni, Kusmiati Kusmiati, Herman Irawan, Khatarina Meldawati Pasaribu

Pharmaceutical Sciences and Research

The field of study on extracellular vesicles (EVs) has recently focused on probiotic bacteria, due to their ability to exhibit a wide variety of biological activity. Therefore, this study aims to evaluate the effect of nutrient modulation during Lacticaseibacillus paracasei cultivation on EVs production and bioactivity. EVs were isolated by ultrafiltration method and were characterized using NTA and cryo-TEM. An in vitro evaluation was used to assess the bioactivities, antioxidant properties, anti-inflammatory potential, and ability to inhibit α-glucosidase activity. The results showed that the 2 LPEV exhibited the characteristics of vesicles with size of 96.04–100.29 nm. Cultivation in 50% MRS …

Nicotine Pouches: Harm Reduction Or Initiation Pathway? A Pharmacy-Focused Review, Emmanuel Fashesin Souza, Keykavous Parang

Pharmacy Faculty Articles and Research

Background

Nicotine pouches (NPs) are a rapidly growing category of tobacco-free oral nicotine products increasingly available in the community, including pharmacies. Whether NPs primarily function as harm-reduction tools for existing tobacco users or as a novel initiation pathway into nicotine and tobacco use, particularly among youth, remains a critical and unresolved clinical and public health question.

Objectives

To synthesize current evidence on the pharmacology, harm-reduction potential, and initiation risk of NPs; to compare NPs with U.S. Food and Drug Administration-approved nicotine replacement therapy and combustible cigarettes; and to identify implications and counseling priorities for pharmacy practice.

Methods

A narrative evidence …

Reducing Inpatient Falls Through Staff Education, Courage Duin Chiangeh

Walden Dissertations and Doctoral Studies

Patient falls remain a major patient safety concern, particularly among hospitalized stroke patients who are at increased risk because of impaired mobility, neurological deficits, and cognitive changes. The inpatient stroke unit selected for this quality improvement project consistently reported the highest fall rates within the hospital system, highlighting the need for evidence-based interventions. The purpose of this project was to determine whether a structured fall-prevention education program incorporating evidence-based practices and the 4Ps of purposeful rounding (pain, potty, position, and possessions) would improve staff knowledge, increase compliance with fallprevention practices, and reduce patient falls over a 2-month period. Guided by …

Microemulsion Eyedrop For Delivery Of A Pparα Agonist To Improve Diabetic Keratopathy Corneal Wound Healing., Ehsan Kaffash, Wentao Liang, Rudra Pangeni, Joseph M Clayton, Tianyi Li, Sagun Poudel, Shiya Han, Long Zhao, Jian-Xing Ma, Qingguo Xu

PCOM Scholarly Works

Diabetic keratopathy (DK) is characterized by delayed corneal wound healing in diabetes, and recent studies have linked this defect to impaired mitochondrial respiration and reduced peroxisome proliferator-activated receptor-α (PPARα) signaling in the corneal epithelium. The PPARα agonist fenofibrate (Feno) has shown therapeutic potential in diabetic corneal disease, but prior topical and oral approaches still face formulation and translational limitations. In this study, we developed a Feno-loaded microemulsion (Feno microemulsion) eyedrop to improve drug solubility, precorneal residence, and ocular bioavailability of Feno for the treatment of DK. Potential excipients were first screened in primary human corneal epithelial cells (HCECs) to identify …

Ethical Considerations In Cosmetic Dentistry

Journal IDA

Dentistry is both an art and a science. Patient care revolves around treatment for pain, missing teeth while also ensuring that appearances or the esthetic outcomes are maintained or enhanced. These two facets are not contradictory, but are intertwined for optimal, complete and customizable care for each patient. Dentists are often faced with requests from patients for a stereotypical “perfect” smile, which includes perfectly aligned teeth that are white in color resembling the image commonly conveyed by the media. As clinicians, we respond in our own way to these increasingly demanding esthetic demands. Some specialize in developing “esthetic” treatments; others …

Overview Of Indiana Health Records Law

Journal IDA

Inquires regarding the use, access, ownership, retention and disposal of health records have ranked in the top three questions from dentists, dental offices and patients over the last 25 years. As every dental office has dental health records, it is important to understand the legal and professional liability implications for properly handling and safeguarding records.

Dental Treatment: Who Has The Final Say On Oral Health Care?

Journal IDA

Is a patient's autonomy really his or her own? Or like an onion with many skins, is it buried under layers of financial factors, insurance coverage, quality of discussion with the dentist, family obligations and emotional health, and so much more!

Factor V Leiden Heterozygosity And Hypertriglyceridemia In 88 Patients With Chronic Jaw Pain And Alveolar Osteonecrosis

Journal IDA

Objectives: Our specific aim was to evaluate the relationships of thrombophilia-hypofibrinolysis and hyperlipidemia with alveolar osteonecrosis of the jaws in 88 patients with chronic jaw pain who had failed to respond to conventional medical and dental treatments.

Study Design: In the temporal order of referral, we evaluated 88 patients with persistent idiopathic facial pain to assess whether and to what degree thrombophilia-hypofibrinolysis and hyperlipidemia were pathoetiologic for biopsy proven alveolar osteitis-necrosis.

Results: Of the 88 cases, 14 (16 percent) had Factor V Leiden heterozygosity compared to 2 of 109 (2 percent) healthy controls without jaw disease, p=.0004. Fasting plasma triglycerides …

Journal Ida 2025 104 2

Journal IDA

In the Spring 2025 issue, the reader will find the following feature articles:

• Teaching the Next Generation: Challenging the Narrative and Shifting Perspectives
• Recent Advances in Periodontolgy
• Role of Microsurgery in the Evolution of Periodontal Surgery
• Diagnostic ChallengeL Oral Pathology
• Factor V Lieden Heterozygosity and Hypertriglyceridemia in 88 Patients with Chronic Jaw Pain and Alveolar Osteonecrosis
• Guided Tissue Regeneration of Localized Deep Combined 3-to-3 Wall Angular Defects: A Clinical Case Report with 15-Month Follow-up

This issue also includes regular columns from the editor, the executive director as well as membership news.

Introduction To The Friday Events: An Inspired Ida Initiative

Journal IDA

Professional organizations in general that depend on membership to effectively function are facing challenges because of lower membership renewals as well as a seeming lack of interest among new members that are joining organizations. The ADA, which represents a significant portion of U.S. dentists, has seen declines in membership, with some reports showing around 57 percent market share in 2022 and a decrease to roughly 115,731 active members by late 2024. Recent data point to around 152,000 to over 160,000 total members out of a total of approximately 202,485 active dentists in the USA.

Is It True? Rumors And Misinformation Surrounding Dentists, The Ada And The Ida

Journal IDA

The professional organizations that represent dentists across Indiana and the United States, set standards for dental care, promote oral health, and advocate for the dental profession. Despite its long-standing reputation and contributions, both the ADA and the IDA have often been the target of misinformation and myths. The public also often gather misinformation about dental care and then question their dentist about it. This article aims to shed light on some of the most common misconceptions about organized dentistry, discuss member benefits, and answer the question ‘why you should be a member.

Journal Ida 2025 104 4

Journal IDA

In the Fall 2025 issue, the reader will find the following feature articles:

• 12 What If There Was No IDA or ADA? Would You Be Able to Practice the Same Way As You Do Today?
• Is it True? Rumors and Misinformation Surrounding Dentists, the ADA and the IDA
• The Tortuous Path of a Bill: From Conception to Implementation
• Introduction to the FrIDAy Events: An Inspired IDA Initiative
• A View from the Podium: Preparation for the IDA House of Delegates
• Health Insurance Options for Dentists and Employees

This issue also includes regular columns from the editor, the executive director as well …

Journal Ida 2025 104 3

Journal IDA

In the Summer 2025 issue, the reader will find the following feature articles:

• Dental Sticky Situations
• Defining Prescriptive Supervision and Delegation in Indiana: The Essential Roles of the Dental Hygienist and the Dental Assistant on the Dental Team
• Safeguarding Ethics: The Work of the Indiana State Board of Dentistry
• Dental Treatment: Who Has the Final Say on Oral Health Care?
• Overview of Indiana Health Records Law
• Ethical Considerations in Cosmetic Dentistry
• Protecting Dentistry’s Ethics: IDA’s Peer Review Program
• An Annotated Walkthrough of Dental and Dental Hygiene Professional Oaths Using AI Search Engines
• Radiation Safety in Dental Offices: Where Do We …

Journal Ida 2025 104 1

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2024 103 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2024 103 3

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2024 103 2

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2024 103 1

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2023 102 2

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2023 102 1

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2022 101 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.