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Articles 601 - 630 of 23187
Full-Text Articles in Entire DC Network
The Impact Of Bilingual Home Literacy Practices On The Emergent Literacy Skills Of Hispanic Youth, Sophie Watkins Roberts
The Impact Of Bilingual Home Literacy Practices On The Emergent Literacy Skills Of Hispanic Youth, Sophie Watkins Roberts
Student Theses and Dissertations
This study examined the impact of bilingual home literacy environments (HLEs) on the emergent literacy skills of Hispanic children enrolled in an after-school program in Jonesboro, Arkansas. Thirteen Spanish–English bilingual children in kindergarten through third grade and their parents participated. Parent-reported data were collected using an adapted Spanish–English Reading Questionnaire (SER-Q), and children’s literacy skills were assessed with the Dynamic Indicators of Basic Early Literacy Skills (DIBELS) and the Spanish Reading Inventory–Second Edition (SRI-2). Descriptive and correlational analyses explored within- and cross-language relationships between HLE practices and early reading performance. Results indicated that even modest access to books and daily …
Community And Individual Risk Factors Associated With Tuberculosis Treatment Outcomes: Ca, Md, And Oh, [2017-2021]., Kadiatu Banjoko
Community And Individual Risk Factors Associated With Tuberculosis Treatment Outcomes: Ca, Md, And Oh, [2017-2021]., Kadiatu Banjoko
Walden Dissertations and Doctoral Studies
There are unsuccessful treatment outcomes with Tuberculosis (TB) disease, although effective therapies exist. This study aimed to identify predictors of unsuccessful treatment using the socioecological model. A quantitative cross-sectional study and multinomial logistic regression analysis were used to measure the associations between long-term care (LTC), homelessness, correctional facility, Human Immunodeficiency Virus (HIV), diabetes, excess alcohol, illicit drug use, and TB treatment outcomes of death, lost to follow-up, and treatment refusal. The sample consisted of 7,589 individuals aged 15 and older with pulmonary TB between 2017 and 2021, residing in California, Ohio, and Maryland. Findings indicated a correlation between community factors …
Dietary Inflammatory Index And Risk Of Colorectal Cancer In Japanese Men, Ayaka Kotemori, Kumiko Kito, Motoki Iwasaki, Taiki Yamaji, James Hébert Scd, Junko Ishihara, Manami Inoue, Shoichiro Tsugane, Norie Sawada On The Behalf Of Jphc Study Group
Dietary Inflammatory Index And Risk Of Colorectal Cancer In Japanese Men, Ayaka Kotemori, Kumiko Kito, Motoki Iwasaki, Taiki Yamaji, James Hébert Scd, Junko Ishihara, Manami Inoue, Shoichiro Tsugane, Norie Sawada On The Behalf Of Jphc Study Group
Faculty Publications
Background/Objectives: Unhealthy lifestyles lead to chronic low-grade inflammation, increasing the risk of colorectal cancer. Few studies in East Asia have examined the association between the dietary inflammation potential and colorectal cancer incidence. Therefore, we aimed to investigate this association further in the Japanese population. Methods: This study included 38,807 men aged 45–74 years who participated in the Japan Public Health Center-based prospective study (JPHC Study). The energy-adjusted dietary inflammatory index (E-DII) was derived from a food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. Differences in risk due to a …
Dual-Task Effects On Spatiotemporal, Kinematic, And Kinetic Parameters And Their Variability During Running, Hsiang-Ling Teng, Jo Armour Smith, Will F.W. Wu
Dual-Task Effects On Spatiotemporal, Kinematic, And Kinetic Parameters And Their Variability During Running, Hsiang-Ling Teng, Jo Armour Smith, Will F.W. Wu
Physical Therapy Faculty Articles and Research
Background
Running in real-world environments often requires using cognitive resources simultaneously with the motor task (dual tasking, DT). Limited existing evidence suggests that DT reduces running speed. Movement variability is essential for a healthy, adaptable motor system. DT has been shown to affect movement variability during walking. Nonetheless, it remains unclear how DT affects spatiotemporal, kinematic, and kinetic parameters and their variability during running.
Research question
Does DT affect spatiotemporal, kinematic, and kinetic measures and their variability during running? Does running speed influence DT effects?
Methods
Thirty-one asymptomatic runners participated in this cross-sectional study. Three-dimensional running biomechanics were recorded while …
Simulated Complex Cells Contribute To Object Recognition Through Representational Untangling, Mitchell B Slapik, Harel Z Shouval
Simulated Complex Cells Contribute To Object Recognition Through Representational Untangling, Mitchell B Slapik, Harel Z Shouval
Faculty, Staff and Student Publications
The visual system performs a remarkable feat: it takes complex retinal activation patterns and decodes them for object recognition. This operation, termed "representational untangling," organizes neural representations by clustering similar objects together while separating different categories of objects. While representational untangling is usually associated with higher-order visual areas like the inferior temporal cortex, it remains unclear how the early visual system contributes to this process-whether through highly selective neurons or high-dimensional population codes. This article investigates how a computational model of early vision contributes to representational untangling. Using a computational visual hierarchy and two different data sets consisting of numerals …
The Evolution Of Public Health Statistical Modeling Approaches And How To Advance Their Incorporation Into Modern Arboviral Surveillance, Maggie Mccarter, Stella C W Self, Alex Ewing, Mufaro Kanyangarara, Sarah M Gunter, Melissa S Nolan
The Evolution Of Public Health Statistical Modeling Approaches And How To Advance Their Incorporation Into Modern Arboviral Surveillance, Maggie Mccarter, Stella C W Self, Alex Ewing, Mufaro Kanyangarara, Sarah M Gunter, Melissa S Nolan
Faculty, Staff and Students Publications
Statistical modeling of infectious disease transmission patterns has been in existence since the mid-1700s, evolving in their utility as the scientific and technological revolutions progressed. Despite the expansion of emerging mathematical and statistical methodologies over the past 250 yr, their usage has largely remained restricted to academic settings. This forum article will discuss the evolution of disease modeling techniques, the most common types of models in use today, and recommendations on how key archetypes can be incorporated into future public health practice. With the recent global impetus to predict and forecast novel pathogens, this article raises the question: Why are …
Table Of Contents
Journal of the South Carolina Academy of Science
No abstract provided.
A248: A Dual-Path Mechanism Study Of Internalization Of Track And Field Hurdling Skills In Vr, Ke Wang
A248: A Dual-Path Mechanism Study Of Internalization Of Track And Field Hurdling Skills In Vr, Ke Wang
International Journal of Physical Activity and Health
Athletic hurdles, as a high-complexity perceptual-motor task, relies on the deep synergy between perceptual and motor systems for skill internalization. Traditional training methods have limitations in motor skill feedback, and virtual reality technology provides a new paradigm for perceptual-motor fitness research through multimodal interaction. However, the dynamic mechanism of the perceptual-action dual pathway (epiphenomenal cognitive pathway and implicit automation pathway) on the internalization of hurdling skills in VR environments has not yet been clarified, which hinders the precise optimization of VR training systems. This study aims to break through the venue limitation, reduce the learning risk of high-risk maneuvers, and …
A273: Coupling Dilemmas And Strategies Of Physical And Health Education In Chinese Schools Under Physical-Medical Integration, Wei Zhong, Youliang Xu, Wen Xiong, Zijun Yan
A273: Coupling Dilemmas And Strategies Of Physical And Health Education In Chinese Schools Under Physical-Medical Integration, Wei Zhong, Youliang Xu, Wen Xiong, Zijun Yan
International Journal of Physical Activity and Health
"Physical-Medical Integration" combines sports science and medical disease prevention, supporting the "Healthy China 2030" strategy. Health education, originating from medicine, is vital for promoting youth health knowledge and is key to integrating with school sports. This study examines the challenges and solutions of combining school sports and health education under this integration. The study uses literature review, mathematical analysis, and logical reasoning. Core journal papers from databases like CNKI, Wanfang, and VIP were analyzed using keywords like "Physical-Medical Integration," "Health Education," and "School Sports" (2000-2025). CiteSpace is used for keyword clustering to support challenge diagnosis. The study also compares policy …
A277: Nanchang’S Adolescents Community Sports Under The "Double Reduction" Policy: Current Situation And Countermeasures, Xin Yu
International Journal of Physical Activity and Health
Recently, the "Double Reduction" policy has been introduced by the Central Committee of the Communist Party of China and the State Council. It has not only provided strong policy support for the promotion of sports and health for the whole society but also provided a "safety net" for the healthy development of children and adolescents. To some extent, it has curbed the continuous decline in the physical health of adolescents in China. However, the biggest weakness in the healthy growth of adolescents lies in the community, where there is often a lack of sufficient sports facilities and organized activities. Therefore, …
A266: A Study On The Health Promotion Mechanisms And Practical Paths Of Traditional Lion Dance Sports, Jiahao Leng, Jingshuo Wang
A266: A Study On The Health Promotion Mechanisms And Practical Paths Of Traditional Lion Dance Sports, Jiahao Leng, Jingshuo Wang
International Journal of Physical Activity and Health
As a living cultural heritage of Chinese traditional sports, lion dance combines physical exercise, cultural heritage, and social cohesion. Although its health value is widely recognized in folk practices, there is a lack of systematic and theoretical mechanism analysis in academia. This study aims to reveal the promotion mechanism of lion dance sport on individual physical and mental health and social adaptation through multi-dimensional analysis, and to propose its practical path in modern health governance. The literature method was used to systematically sort out the relevant literature during the period of 2006-2025 and establish a theoretical analysis framework. The expert …
A289: Challenges And Strategies For Pe Teachers In The Ai Era, Xiaoli Huang
A289: Challenges And Strategies For Pe Teachers In The Ai Era, Xiaoli Huang
International Journal of Physical Activity and Health
In the era of artificial intelligence (AI), physical education (PE) teachers face unprecedented challenges in integrating advanced technologies into their teaching practices. This study aims to identify the specific challenges PE teachers encounter in the AI era and propose practical strategies to enhance the quality and relevance of school-based physical education. This study employed a multi-method approach, including literature review, mathematical statistics, questionnaire surveys, and expert interviews. The participants were 120 PE teachers from urban and rural schools across different regions. The study began with a literature review to establish a theoretical foundation. Questionnaires were used to gather teachers' perceptions …
A037: Necessity Of Moderate Exercise For High School Girls During Menstruation, Meng Zheng
A037: Necessity Of Moderate Exercise For High School Girls During Menstruation, Meng Zheng
International Journal of Physical Activity and Health
To challenge the traditional belief that girls should not exercise during their menstrual period, this study aims to propose appropriate ways for high school girls to engage in sports during menstruation, enhance their overall health, and foster good exercise habits and a correct sports concept. Method: The literature method was employed, utilizing databases such as China Knowledge Network, Google Scholar, and Wanfang to search for relevant studies using keywords like “girls”, “physical exercise”, “sports participation”, and “physical activity”. This helped understand the current research status. Books were also consulted to provide analytical methods and theoretical foundations. The questionnaire method investigated …
A050: Research On Digital Empowerment Of Mass Sports Life Within The Context Of National Fitness, Yuanchao Li, Yifeng Li
A050: Research On Digital Empowerment Of Mass Sports Life Within The Context Of National Fitness, Yuanchao Li, Yifeng Li
International Journal of Physical Activity and Health
This study commences with a focus on national fitness, conducting an in-depth analysis of the conceptual significance of digital technology and the widespread implementation of mass sports. It elucidates their current developmental status and scrutinizes the practical challenges impeding the digitization of mass sports. Using digital technology as a springboard, this paper investigates the optimal trajectory for the advancement of digitized mass sports, with the aim of fostering superior development in this field. Methodology: This study examines the digital empowerment of mass sports within the framework of national fitness for all. Utilizing research methodologies such as expert interviews, mathematical statistics, …
A057: Research On High-Quality Development Path Of Sports Tourism Boutique Projects In The Yellow River Basin, Yan Wang, Jinsheng Liu
A057: Research On High-Quality Development Path Of Sports Tourism Boutique Projects In The Yellow River Basin, Yan Wang, Jinsheng Liu
International Journal of Physical Activity and Health
Background/Purposes: The boutique sports tourism initiative in the Yellow River Basin constitutes a comprehensive regional development strategy that integrates competitive events, scenic attractions, and travel itineraries across nine provincial administrations. The study aims to reveal the spatial distribution characteristics and explore the path of high-quality development of sports tourism boutique projects in the Yellow River Basin. (1) Through using the methods of mathematical statistics, 129 projects were selected for analysis, categorized under “scenic spot”, “line”, “event”, and “destination” of sports tourism boutique projects. The data sourced from the “China Sports Tourism Boutique Project” announced by the State Sports General Administration, …
A061: Analysis Of The Current Situation Of Table Tennis Players' Burnout, Rongqing Yu
A061: Analysis Of The Current Situation Of Table Tennis Players' Burnout, Rongqing Yu
International Journal of Physical Activity and Health
Burnout is a significant issue among athletes, especially those undergoing high-intensity training and facing competitive pressures. Table tennis players, due to the demands of their sport, are particularly vulnerable. Burnout can impair performance, mental health, and lead to training interruptions or early career termination. This study investigates the prevalence of burnout among table tennis players, examining differences based on gender, age, sports grade, and training duration, to inform targeted interventions. Method: The study utilized a comprehensive approach to data collection and analysis. Firstly, a literature review was conducted to establish a theoretical framework for understanding athlete burnout. Subsequently, a questionnaire …
A210: The Influence Of Applications Of Digital Technology On The Effect Of Competitive Aerobics Training, Guangqi Yang, Fuzhou Zhang, Jiawen Ding
A210: The Influence Of Applications Of Digital Technology On The Effect Of Competitive Aerobics Training, Guangqi Yang, Fuzhou Zhang, Jiawen Ding
International Journal of Physical Activity and Health
In recent years, with the development of information technology, the application of digital means in the field of sports has become increasingly extensive and deep. Competitive aerobics, as a traditional advantage project in the high-level university sports team, the innovation of its training methods is of great significance for improving athletic performance. However, the traditional training methods still have problems, such as inefficient and insufficient pertinence, which makes it difficult to meet the needs of modern training. Therefore, this paper designs the training method of university competitive aerobics from a digital background, obtains a scientific training strategy of university competitive …
Protocol For The Development Of The Who Gestational Weight Gain Charts, Thais Rangel Bousquet Carrilho, Olufemi Taiwo Oladapo, Jennifer A. Hutcheon, Giovanna Gatica-Domínquez, Kathleen M. Rasmussen, Monica C. Flores-Urrutia, Richard Kumapley, Ӧzge Tunçalp, Dang Bahya-Batinda, Amel A. Fayed, Annick Bogaerts, Aris T. Papageorghiou, Cinthya Muñoz-Manrique, Dayana Rodrigues Farias, Eric Ohuma, Harshpal Sachdev, Hayfaa A. Wahabi, Helena J. Teede, Molin Wang, Nandita Perumal Phd
Protocol For The Development Of The Who Gestational Weight Gain Charts, Thais Rangel Bousquet Carrilho, Olufemi Taiwo Oladapo, Jennifer A. Hutcheon, Giovanna Gatica-Domínquez, Kathleen M. Rasmussen, Monica C. Flores-Urrutia, Richard Kumapley, Ӧzge Tunçalp, Dang Bahya-Batinda, Amel A. Fayed, Annick Bogaerts, Aris T. Papageorghiou, Cinthya Muñoz-Manrique, Dayana Rodrigues Farias, Eric Ohuma, Harshpal Sachdev, Hayfaa A. Wahabi, Helena J. Teede, Molin Wang, Nandita Perumal Phd
Faculty Publications
Introduction Gestational weight gain (GWG) is an important indicator of maternal nutrition to be monitored during pregnancy. However, there is no evidence-based tool that can be used to monitor it across all geographic locations and pre-pregnancy body mass index (BMI) categories. The WHO is undertaking a project to develop GWG charts by pre-pregnancy BMI category, and to identify GWG ranges associated with the lowest risks of adverse maternal and infant outcomes. This protocol describes all the steps that will be used to accomplish the development of these GWG charts.
Methods and analysis This project will involve the analysis of individual …
Volumetric Wear Analysis Of Polyethylene Orthopedic Liners Using Point Clouds, Gabriel Landi
Volumetric Wear Analysis Of Polyethylene Orthopedic Liners Using Point Clouds, Gabriel Landi
Dartmouth College Master’s Theses
In vivo wear of ultra-high molecular weight polyethylene (UHMWPE) orthopedic bearings represents a major problem in shoulder and knee arthroplasty, with significant amounts of devices failing due to the complication itself, and even more due to associated reasons for retrieval, including aseptic loosening. However, quantification of UHMWPE wear has largely been limited to linear and in vitro volumetric analyses, obscuring the understanding of the amount of clinically relevant material loss. This study proposes new methods to measure articular, rim, and backside surfaces of retrieved shoulder and knee UHMWPE liners, centered around the coordinate measuring machine (CMM)-based collection of high density …
The Relationship Between The Health Science Reasoning Test And Successful Completion Of An Associate Degree Nursing Program: A Retrospective Predictive Study, Joyce A.Ajkuce Kucerovy
The Relationship Between The Health Science Reasoning Test And Successful Completion Of An Associate Degree Nursing Program: A Retrospective Predictive Study, Joyce A.Ajkuce Kucerovy
Doctoral Dissertations and Projects
The purpose of this study was to retrospectively identify whether the addition of an entrance exam such as the Health Science Reasoning Test (HSRT) to the current admission criteria of an associate degree nursing (ADN) education program would aid in selecting students with the highest chance of successfully completing the program and entering the workforce. A nonexperimental, retrospective, quantitative, predictive correlational study design was used. A retrospective convenience sample of 320 first-year nursing students in an ADN education program was obtained. The G* power analysis showed a minimum sample size of 107 students was needed. Statistical analysis involved a multiple …
Molecular Survival Strategies Against Kidney Filtration: Implications For Therapeutic Protein Engineering, William Heaps, Anna Elise Packard, Kristina M. Mccammon, Tyler P. Green, Joseph P. Talley, Bradley C. Bundy, Dennis Della Corte
Molecular Survival Strategies Against Kidney Filtration: Implications For Therapeutic Protein Engineering, William Heaps, Anna Elise Packard, Kristina M. Mccammon, Tyler P. Green, Joseph P. Talley, Bradley C. Bundy, Dennis Della Corte
Faculty Publications
The glomerular filtration barrier poses a significant challenge for circulating proteins, with molecules below ~60–70 kDa facing rapid renal clearance. Endogenous proteins have evolved sophisticated evasion mechanisms including oligomerization, carrier binding, electrostatic repulsion, and FcRn-mediated recycling. Understanding these natural strategies provides blueprints for engineering therapeutic proteins with improved pharmacokinetics. This review examines how endogenous proteins resist filtration, evaluates their application in protein engineering, and discusses clinical translation including established technologies (PEGylation, Fc-fusion) and emerging strategies (albumin-binding domains, glycoengineering). We address critical challenges of balancing half-life extension with tissue penetration, biological activity, and immunogenicity—essential considerations for the rational design of next-generation …
Identifying Priority Research Questions For Decentralized Wastewater, Bryan W Brooks, Timothy Callahan, Jacob K Stanley, Jamie Holodak, Kevin M Stroski, Alissa H Cox, Thomas W Groves, Anish Jantrania, Jeff C Moeller, Kris Neset, Christopher Walker, Harry Zhang, Amal Bakchan, Kelly D Alley, Jim Bell, Allison Blodig, Eric Casey, Donna Cosper, Victor D'Amato, Mark A Elliott, Greg Graves, Roxanne Groover, Robert Himschoot, Mary G Lusk, Jillian Maxcy-Brown, David Meints, Rojelio Mejia, Matt Pace, Benjamin J Ryan, Brian Scheffe, Tom Schimelfenig, June E Wolfe, Sara F Heger
Identifying Priority Research Questions For Decentralized Wastewater, Bryan W Brooks, Timothy Callahan, Jacob K Stanley, Jamie Holodak, Kevin M Stroski, Alissa H Cox, Thomas W Groves, Anish Jantrania, Jeff C Moeller, Kris Neset, Christopher Walker, Harry Zhang, Amal Bakchan, Kelly D Alley, Jim Bell, Allison Blodig, Eric Casey, Donna Cosper, Victor D'Amato, Mark A Elliott, Greg Graves, Roxanne Groover, Robert Himschoot, Mary G Lusk, Jillian Maxcy-Brown, David Meints, Rojelio Mejia, Matt Pace, Benjamin J Ryan, Brian Scheffe, Tom Schimelfenig, June E Wolfe, Sara F Heger
Faculty, Staff and Students Publications
Decentralized wastewater treatment and reuse represent critical infrastructure across the rural-periurban-urban continuum around the world. Effective, efficient, resilient, and equitable implementation of on-premise technologies and management systems is part of a One Water approach and necessary to protect public health and the environment, yet inconsistent delivery of essential public health services persists in many regions, including across states, tribes, and territories of the United States. We initiated a groundbreaking effort to understand challenges and to identify research opportunities related to the science and practice of decentralized wastewater. A horizon scanning exercise using a bottom up and transparent key questions approach …
Confluence, Vol. 4, Iss. 2, Full Issue
From Asylums To Hospitals To Prisons: The History Of Institutional Psychiatric Care In America, Mary E. Horton
From Asylums To Hospitals To Prisons: The History Of Institutional Psychiatric Care In America, Mary E. Horton
History of Medicine Seminar
No abstract provided.
Sociodemographic And Hiv-Related Characteristics Associated With Mental Health Diagnoses Among People Living With Hiv, Monique J. Brown Ph.D., Mph, Jiayang Xiao, Xueying Yang Ph.D., Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D.
Sociodemographic And Hiv-Related Characteristics Associated With Mental Health Diagnoses Among People Living With Hiv, Monique J. Brown Ph.D., Mph, Jiayang Xiao, Xueying Yang Ph.D., Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D.
Faculty Publications
Mental health diagnoses have been linked to poor HIV treatment outcomes and poorer quality of life among people living with HIV (PLWH). Therefore, this study aimed to investigate the association between sociodemographic and HIV-related characteristics, and common and serious mental health disorders among PLWH in South Carolina (SC). Data were obtained from the integrated system of statewide electronic health record (EHR) data in SC (2006–2019; N = 8,124). Multivariable logistic regression models were used to determine the associations between sociodemographic and HIV-related characteristics, and common mental health disorders and serious mental health disorders. Among the study population, 4% were 60 …
Daily Locomotor Activity Declines With Tumor Growth And Disease Progression In Glioblastoma, Maria F Gonzalez-Aponte, Sofia V Salvatore, Anna R. Damato, Ruth Gn Katumba, Grayson R. Talcott, Omar H. Butt, Jian L. Campian, Jingqin Luo, Joshua B. Rubin, Olivia J. Walch, Erik D. Herzog
Daily Locomotor Activity Declines With Tumor Growth And Disease Progression In Glioblastoma, Maria F Gonzalez-Aponte, Sofia V Salvatore, Anna R. Damato, Ruth Gn Katumba, Grayson R. Talcott, Omar H. Butt, Jian L. Campian, Jingqin Luo, Joshua B. Rubin, Olivia J. Walch, Erik D. Herzog
2020-Current year OA Pubs
Glioblastoma (GBM) is an aggressive brain tumor that often progresses despite resection and treatment. Timely and continuous assessment of GBM progression is critical to expedite secondary surgery or enrollment in clinical trials. However, current progression detection requires costly and specialized MRI examinations, which, in the absence of new symptoms or signs, are usually scheduled every 2-3 months. Here, we hypothesized that changes in daily activity are associated with GBM growth and disease progression. We found that wheel-running activity in GBM-bearing mice declined as tumors grew and preceded weight loss and circadian breakdown by over a week. Temozolomide treatment in the …
Utilizing Machine Learning Techniques For Computer-Aided Covid-19 Screening Based On Clinical Data, Honglun Xu, Andrews T. Anum, Michael Pokojovy, Sreenath Chalil Madathil, Yuxin Wen, Md. Fashiar Rahman, Tzu-Liang Bill Tseng, Scott Moen, Eric Walser
Utilizing Machine Learning Techniques For Computer-Aided Covid-19 Screening Based On Clinical Data, Honglun Xu, Andrews T. Anum, Michael Pokojovy, Sreenath Chalil Madathil, Yuxin Wen, Md. Fashiar Rahman, Tzu-Liang Bill Tseng, Scott Moen, Eric Walser
Engineering Faculty Articles and Research
The COVID-19 pandemic has highlighted the importance of rapid clinical decision-making to facilitate the efficient usage of healthcare resources. Over the past decade, machine learning (ML) has caused a tectonic shift in healthcare, empowering data-driven prediction and decision-making. Recent research demonstrates how ML was used to respond to the COVID-19 pandemic. This paper puts forth new computer-aided COVID-19 disease screening techniques using six classes of ML algorithms (including penalized logistic regression, random forest, artificial neural networks, and support vector machines) and evaluates their performance when applied to a real-world clinical dataset containing patients’ demographic information and vital indices (such as …
3d Reconstruction Of Spatial Transcriptomics With Spatial Pattern Enhanced Graph Convolutional Neural Network, Chen Tang, Yuansheng Zhou, Xue Xiao, Lei Dong, Lei Yu, Qiwei Li, Guanghua Xiao, Lin Xu
3d Reconstruction Of Spatial Transcriptomics With Spatial Pattern Enhanced Graph Convolutional Neural Network, Chen Tang, Yuansheng Zhou, Xue Xiao, Lei Dong, Lei Yu, Qiwei Li, Guanghua Xiao, Lin Xu
Faculty, Staff and Student Publications
Spatially resolved transcriptomics (SRT) is a promising new technology that enables simultaneous analysis of gene expression and spatial information for biomedical research. However, the existing statistical and deep learning algorithms used for analyzing SRT data rely solely on two-dimensional (2D) spatial coordinates, which limits their ability to accurately identify spatial domains, spatially variable genes (SVGs), cell-to-cell communications, and developmental trajectories in a three-dimensional (3D) spatial manner. To address these limitations, we introduced Spa3D, which utilized the anti-leakage Fourier transform and graph convolutional neural network model to reconstruct 3D-based spatial structures from multiple 2D SRT slices. We demonstrate that Spa3D is …
Pathways, Outputs And Impact Of Nih-Supported Bioinformatics And Genomics Graduate Trainees In Africa, Daudi Jjingo, Andrew Walakira, Suhaila Hashim, Cisse Cheickna, Ronald Galiwango, Caleb Kibet, Florence N Kivunike, Gerald Mboowa, Fredrick Elishama Kakembo, Babajide Ayodele, Jean-Baka Domelevo Entfellner, Santie De Villiers, Karen Wambui, Segun Fatumo, Tinashe Chikowore, John Mukisa, Alfred Ssekagiri, Nicholas Bbosa, Julius Mulindwa, Samuel Kyobe, Mike Nsubuga, Grace Kebirungi, Eric Katagirya, Savannah Mwesigwa, Ibra Lujumba, Rogers Kamulegeya, Samuel Kirimunda, Stephen Kanyerezi, Shahiid Kiyaga, Ivan Sserwadda, Davis Kiberu, Bernard S Bagaya, Julius Okwir, Patricia Nabisubi, Grace Nabakooza, Mugume Twinamatsiko Atwine, Ricard Sserunjogi, Rolanda Julius, Mariam Quiñones, Meghan Mccarthy, Phillip Cruz, Karlynn Noble, Christopher J Whalen, Darrell Hurt, Maria Y Giovanni, Michael Tartakovsky, Deogratius Ssemwanga, John M Kitayimbwa, Steven J Reynolds, Christopher C Whalen, Andrew Kambugu, Neil A Hanchard, Li Jian, Peter Amoako-Yirenkyi, Graeme Mardon, I King Jordan, Samson Pandam Salifu, Mamadou Wele, Ezekiel Adebiyi, Jeffrey G Shaffer, Seydou Doumbia, David Patrick Kateete, Michelle Skelton, Nicola Mulder, Jonathan K Kayondo, Daniel Masiga, H3africa Consortium
Pathways, Outputs And Impact Of Nih-Supported Bioinformatics And Genomics Graduate Trainees In Africa, Daudi Jjingo, Andrew Walakira, Suhaila Hashim, Cisse Cheickna, Ronald Galiwango, Caleb Kibet, Florence N Kivunike, Gerald Mboowa, Fredrick Elishama Kakembo, Babajide Ayodele, Jean-Baka Domelevo Entfellner, Santie De Villiers, Karen Wambui, Segun Fatumo, Tinashe Chikowore, John Mukisa, Alfred Ssekagiri, Nicholas Bbosa, Julius Mulindwa, Samuel Kyobe, Mike Nsubuga, Grace Kebirungi, Eric Katagirya, Savannah Mwesigwa, Ibra Lujumba, Rogers Kamulegeya, Samuel Kirimunda, Stephen Kanyerezi, Shahiid Kiyaga, Ivan Sserwadda, Davis Kiberu, Bernard S Bagaya, Julius Okwir, Patricia Nabisubi, Grace Nabakooza, Mugume Twinamatsiko Atwine, Ricard Sserunjogi, Rolanda Julius, Mariam Quiñones, Meghan Mccarthy, Phillip Cruz, Karlynn Noble, Christopher J Whalen, Darrell Hurt, Maria Y Giovanni, Michael Tartakovsky, Deogratius Ssemwanga, John M Kitayimbwa, Steven J Reynolds, Christopher C Whalen, Andrew Kambugu, Neil A Hanchard, Li Jian, Peter Amoako-Yirenkyi, Graeme Mardon, I King Jordan, Samson Pandam Salifu, Mamadou Wele, Ezekiel Adebiyi, Jeffrey G Shaffer, Seydou Doumbia, David Patrick Kateete, Michelle Skelton, Nicola Mulder, Jonathan K Kayondo, Daniel Masiga, H3africa Consortium
Faculty, Staff and Students Publications
Global biomedical and health research is increasingly relying on genomic and computational approaches, largely driven by the increasing volumes of nucleic acid sequencing. Concurrently, epidemiological studies and clinical records are generating enormous amounts of data amenable to disease modeling, machine learning, and artificial intelligence techniques. Bioinformatics and data science expertise is therefore essential for improved population health. Accordingly, in 2012, the US National Institutes of Health (NIH) in partnership with the Wellcome Trust, and with support from the African Society for Human Genetics, initiated the H3Africa (Human Heredity and Health in Africa) consortium. One of its key goals was to …
Multiple Myeloma Risk Linked To Dna Damage Response Genes, Michael Conry, Irina Ostrovnaya, Yelena Kemel, Saloni Sinha, Linda B. Baughn, Brian Avery, Kylee Maclachlan, Victoria Groner, Lauren Banaszak, Aaron Norman, Nicholas J. Boddicker, Alyssa I. Clay-Gilmour Ph.D., Shaji Kumar, Ellen Kim, Sita Dandiker, Mitul Waghmare, Susan Slager, Douglas Sborov, Judy Garber, Elizabeth E. Brown, Michelle Hildebrandt, Et. Al.
Multiple Myeloma Risk Linked To Dna Damage Response Genes, Michael Conry, Irina Ostrovnaya, Yelena Kemel, Saloni Sinha, Linda B. Baughn, Brian Avery, Kylee Maclachlan, Victoria Groner, Lauren Banaszak, Aaron Norman, Nicholas J. Boddicker, Alyssa I. Clay-Gilmour Ph.D., Shaji Kumar, Ellen Kim, Sita Dandiker, Mitul Waghmare, Susan Slager, Douglas Sborov, Judy Garber, Elizabeth E. Brown, Michelle Hildebrandt, Et. Al.
Faculty Publications
Background DNA damage response genes (DDRG), implicated in several cancers as both predisposing risk factors as well as biomarkers for aggressiveness, have not been fully explored in multiple myeloma (MM).
Methods Herein, we analyzed disease associations of pathogenic variations in nine putative candidate genes using 3 446 MM cases and 323 233 cancer-free controls.
Results Increased MM risk was found to be associated with inherited rare pathogenic mutations in TP53, ATM, CHEK2, KDM1A, and ARID1A, with an enrichment of these variants among individuals with early onset or family history of MM. Individuals with TP53 or ATM germline mutations are also …