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Synthesis And Chemistry Of Naphthalene Annulated Trienyl Iron Complexes: Potential Anticancer Dna Alkylation Reagents, Traci Means

Inquiry: The University of Arkansas Undergraduate Research Journal

Iron complex chemistry that opens a new door to the medicinal and pharmaceutical worlds is the aim of this research. Specifically, ortho-quinone methide moieties are intermediates in several antitumor drugs and have been identified as bioreductive alkylators of DNA. In our research, a class of iron compounds has been targeted to resemble these quinone methides. It is hoped that these new compounds could be modified to provide a window of opportunity toward the discovery of a selective mode of drug delivery. We have focused our efforts on generating a reactive transition metal complexed 5-membered ring analog of o-quinone methide based …

Ata2-Mediated Amino Acid Uptake Following Partial Hepatectomy Is Regulated By Redistribution To The Plasma Membrane, Thomas L. Freeman, Geoffrey M. Thiele, Dean J. Tuma, Tina K. Machu, Mark E. Mailliard

United States Public Health Resources

System A, the Na⁺-dependent amino acid transport activity, is encoded by the ATA2 gene and up-regulated following partial hepatectomy (PH), and its competitive inhibition interferes with liver regeneration. Rabbit polyclonal antibody was raised against a portion of the ATA2 gene product followed by immunodetection of ATA2 in isolated liver plasma membrane and lysate. The level of ATA2 increased in the plasma membrane following PH, while the relatively high quantity of ATA2 found in liver lysate remained constant. We also have shown that Northern analysis of steady-state ATA2 mRNA revealed no significant change following PH. These data show that …

Focusing Feedback On Interpersonal Skills: Practice Makes Perfect A Web-Based Tutorial For Standardized Patients, Tamara Owens, Zhong Xie, Peggy Gregg, Cynthia Phelps, Craig W. Johnson

Faculty, Staff and Student Publications

Focusing Feedback on Interpersonal Skills: Practice Makes Perfect is a Web-Based learning environment enabling standardized patients (SPs) to develop, practice and enhance constructive feedback skills. The Web-based training environment for SPs features realistic professional healthcare provider/patient video scenarios, graphics, audio and immediate feedback in a student-centered self-instructional environment. SPs, who are trained to simulate an illness and portray a patient in a realistic and consistent way, subsequently provide feedback from a patient's perspective to students undergoing communication and interpersonal skills training in health science fields like medicine and nursing.

Improved Energy Model For Membrane Electroporation In Biological Cells Subjected To Electrical Pulses, R. P. Joshi, Q. Hu, K. H. Schoenbach, H. P. Hjalmarson

Bioelectrics Publications

A self-consistent model analysis of electroporation in biological cells has been carried out based on an improved energy model. The simple energy model used in the literature is somewhat incorrect and unphysical for a variety of reasons. Our model for the pore formation energy E(r) includes a dependence on pore population and density. It also allows for variable surface tension, incorporates the effects of finite conductivity on the electrostatic correction term, and is dynamic in nature. Self-consistent calculations, based on a coupled scheme involving the Smoluchowski equation and the improved energy model, are presented. It is shown that E(r) becomes …

Peer Nutrition Education: A Model For Nutrition Education Among Spanish-Language Participants Of The Special Supplemental Nutrition Program For Women, Infants And Children (Wic), Maximino Alfredo Mejía

Loma Linda University Electronic Theses, Dissertations & Projects

Despite the steady improvement in the health status of Americans, Hispanics are a minority in the United States with greater prevalence of several infectious and chronic diseases and less health knowledge than the average citizen. Nearly half of the Hispanics living in this country die of preventable nutrition-related conditions, with heart disease and cancer being the leading causes. Since this minority has limited access to health care and preventive services, there is a need for an inexpensive, viable model of health education for this underserved segment of the population in order to lower the excess of preventable diseases. We trained …

Development Of Dose Conversion Coefficients For Radionuclides Produced In Spallation Neutron Sources, Phillip W. Patton, Mark Rudin

Transmutation Sciences Physics (TRP)

For the first year of this effort, the UNLV research team set out four objectives. First, the university and laboratory consortium had to be established. This consortium was tasked with helping to determine the methodology for determining the dose coefficients, and to ensure that the resulting DCs will be of use to the national programs developing accelerator-driven nuclear systems (such as the SNS or an accelerator-driven transmutation system) and to the health physics community as a whole. The second goal of this program was to determine a methodology and then prioritize the radionuclides so that the research effort would address …

Development Of Dose Coefficients For Radionulides Produced In Spallation Neutron Sources: Annual Report, Phillip W. Patton, Mark Rudin

Transmutation Sciences Physics (TRP)

The University of Nevada, Las Vegas (UNLV) Transmutation Research Program has been tasked to support U.S. Department of Energy (DOE) efforts to assess the health risks associated with the operation of each of their accelerator-driven nuclear facilities for both NEPA and PSAR development. Quantifying the radiological risks to workers will have to be addressed during the design and siting of each of these facilities. U.S. Environmental Protection Agency (EPA) Federal Guidance Report No. 11 “Limiting Values of Intake and Air Concentration and Dose Conversion Factors for Inhalation, Submersion, and Ingestion”, developed two derived guides, Annual Limit on Intake (ALI) and …

Dynamics Of Bovine Tuberculosis In Wild White-Tailed Deer In Michigan, Graham J. Hickling

Michigan Bovine Tuberculosis Bibliography and Database

In mid-2001, the author of this report was invited to undertake an exploratory analysis of Michigan Department of Natural Resources’ data on bovine tuberculosis (TB) infection in wild white-tailed (Odocoileus virginianus) in the northeastern Lower Peninsula of the state. The aims of this analysis were:
• to quantify the geographic spread of tuberculous deer in Michigan;
• to investigate key factors influencing the prevalence of disease in the core of the infected area;
• to interpret the results in light of overseas experience with wildlife TB, with a view to
recommending how current management of the disease might …

Derivation Of Risk Based Wipe Surface Screening Levels For Industrial Scenarios, Lisa M. May, Bonnie Gaborek, Tony Pitrat, Laura Peters

Uniformed Services University of the Health Sciences

The environmental characterization of building interiors and other surfaces has generally been performed with wipe-sampling because it is a non-destructive technique. There is no consensus, however, as to the interpretation of the results of wipe-sampling. Specifically, there is not a standardized method to determine if chemicals found at sampled levels pose a threat to human health. A methodology was developed, based on acceptable health risk levels, to derive screening levels for evaluating wipe-sampling results pertaining to industrial scenarios. The methodology was based on the United States Environmental Protection Agency (USEPA) Region IX Preliminary Remediation Goal (PRG) approach; a multi-exposure methodology …

Search For Intracranial Aneurysm Susceptibility Gene(S) Using Finnish Families, Jane M. Olson, Sompong Vongpunsawad, Helena Kuivaniemi, Antti Ronkainen, Juha Hernesniemi, Markku Ryynã¤Nen, Lee-Lian Kim, Gerard Tromp

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Cerebrovascular disease is the third leading cause of death in the United States, and about one-fourth of cerebrovascular deaths are attributed to ruptured intracranial aneurysms (IA). Epidemiological evidence suggests that IAs cluster in families, and are therefore probably genetic. Identification of individuals at risk for developing IAs by genetic tests will allow concentration of diagnostic imaging on high-risk individuals. We used model-free linkage analysis based on allele sharing with a two-stage design for a genome-wide scan to identify chromosomal regions that may harbor IA loci.

Methods

We previously estimated sibling relative risk in the Finnish population at between …

Développement D'Un Modèle Intégré Informatique Pour La Planification De La Ventilation Dans Les Mines Souterraines, Kostas Fytas

Rapports de recherche scientifique

Ce projet de recherche financé par IRSST consistait à élaborer un logiciel moderne qui permettrait de modéliser un réseau de ventilation minière. Le département de mines et métallurgie de l’Université Laval avait déjà mis au point un tel logiciel depuis 1988. Deux versions existaient, l’une en DOS et l’autre en Windows. Bien qu’utile et fiable, le logiciel comportait certaines lacunes qui limitaient son utilisation dans le milieu minier québécois. Ses faiblesses les plus importantes étaient l’absence d’une interface graphique et l’absence de branches avec un ventilateur. Par ailleurs, ce logiciel ne pouvait pas tenir compte de la compressibilité de l’air …

Design And Development Of A New Rockbold Load Measuring Device, Hani S. Mitri

Rapports de recherche scientifique

Cliquez ici pour la version française de ce rapport

Une nouvelle technologie permettant de mesurer la charge axiale des boulons d'ancrage mécaniques et des « rebars » (boulons à la résine) dans les mines souterraines a été conçue et développée en laboratoire. Cette technologie repose sur un système désigné du nom de SAFEBOLT (Stress And Force Evaluator in BOLTs), qui réunit trois composantes : 1) le mesureur de charge SAFEBOLT installé dans la tête des boulons, 2) un module d'affichage et 3) un câble de raccordement. Un banc d'essai adapté a été construit en laboratoire afin d'assurer le calibrage et …

Prevention Of Physiologic Maladaptation To Night-Shift Work By Phototherapy, Diane B. Boivin, Francine O. James

Rapports de recherche scientifique

Cliquez ici pour la version française de ce rapport

Au Québec, on estime qu'un tiers des emplois permanents sont comblés en dehors des heures conventionnelles. On note en particulier une prédominance du travail de nuit à plein temps dans les secteurs qui requièrent (hôpitaux, protection publique) ou qui choisissent (manufactures) 24 heures de service par jour. Il est bien connu que le travail de nuit ou en rotation s’accompagne de privation importante de sommeil, de troubles de vigilance et de performance, et d’un risque accru d’accidents graves en milieu de travail. De plus, ces troubles d’adaptation s’accroissent avec l’âge alors …

Étude De L'Effet Du Sautage Adouci Sur La Fracturation Des Parois D'Une Excavation Souterraine, Richard Simon

Rapports de recherche scientifique

Dans les mines souterraines, les chutes de terrain demeurent encore aujourd'hui une cause importante d'accidents mortels et autres accidents graves. L'écaillage et l'installation du soutènement sont les activités qui présentent le plus de risques de blessures liées aux chutes de roches. En effet, celles-ci nécessitent que le travailleur soit exposé à un massif rocheux non soutenu où des roches peuvent se détacher du toit.

Trois facteurs principaux affectent la difficulté des opérations d'écaillage et d'installation du soutènement: l'état initial du massif rocheux et les structures géologiques, les contraintes induites à la paroi de la galerie pouvant amener des instabilités, et …

Conception Et Développement D'Un Nouveau Mesureur De Charge Des Boulons D'Ancrage, Hani S. Mitri

Rapports de recherche scientifique

Click here for the English version of this report

Une nouvelle technologie permettant de mesurer la charge axiale des boulons d'ancrage mécaniques et des « rebars » (boulons à la résine) dans les mines souterraines a été conçue et développée en laboratoire. Cette technologie repose sur un système désigné du nom de SAFEBOLT (Stress And Force Evaluator in BOLTs), qui réunit trois composantes : 1) le mesureur de charge SAFEBOLT installé dans la tête des boulons, 2) un module d'affichage et 3) un câble de raccordement. Un banc d'essai adapté a été construit en laboratoire afin d'assurer le calibrage et …

Cancer Dose-Response Modeling Of Low Dose Radiation Exposure, Gizelle Susette Baker

MUSC Theses and Dissertations

Many late effects from exposure to ionizing radiation, including cancers, have been described in the literature. The identification and quantification of radiation-induced health effects is an important and complex issue. Recommendations for radiation safety and protection from the International Commission on Radiological Protection are made using a linear no threshold risk model on epidemiological data. A major obstacle in this process is the limited availability of data to directly measure the health effects of radiation on human populations. One way to circumvent this problem IS to use experimental data from laboratory animals and extrapolate across species to man. The cancer …

Effects Of Perinatal Factors On The Duration And Cost Of Hospitalisation For Preterm Infants In A Neonatal Intensive Care Unit In Istanbul, İpek Akman, Di̇lşad Cebeci̇, Eren Özek, Sebahat İmamoğlu

Turkish Journal of Medical Sciences

Long hospitalisation and high hospital charges of premature infants are important concerns for parents and health providers. In this study we determined the length of stay and hospital cost of preterm babies and assessed the predictive value of perinatal factors on the duration and the cost of hospitalisation. We reviewed hospital charges and length of stay for a retrospective cohort of 72 premature infants discharged from the neonatal intensive care unit of Marmara University Hospital between January 1999 and January 2000. The perinatal factors were analysed using forward stepwise multiple linear regression analysis. The median gestational age and birth weight …

The Role Of Diet And Physical Activity For Ovarian Cancer Results From The Adventist Health Study, Fatemeh Kiani

Loma Linda University Electronic Theses, Dissertations & Projects

A few aspects of the epidemiology of ovarian cancer are well understood, such as the inverse relationship with parity and oral contraceptive (OC) use. The role of other factors such as the potential influence of diet or physical activity is far from being established. A few studies, however, have been able to identify dietary risk factors for ovarian cancer. In this dissertation, I have conducted two studies that investigate the relationship between dietary factors and physical activity and the three endpoints: 1) nonfatal ovarian cancer (1976-1982; time to diagnosis), 2) fatal ovarian cancer (1976-1988; time to death), and 3) total …

Outlook Magazine, Winter 2002

Outlook Magazine

No abstract provided.

Determination Of Traces Of Heavy Elements (Pb, Zn, Cu, Cd, Ca And Mg) In Human Teeth From Klang Valley And Malacca Using Icp-Aes And Xrf Techniques, Chea Beng Lee

Student Works (2000-2009)

X-ray Fluorescence (XRF) and Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES) have been used to study the concentration of heavy metals in human teeth. XRF technique has been used to determine Pb concentration in human teeth with the excitation source ofTc-99m combined with an XR-IOOT-CZT detector. The sensitivity of this system to determine the concentration of Pb lower than 800 ppm was constrained by Tc-99m's y-ray energy of 140.5 keV. High percentage errors in the calculation of average mean of differences for each concentration (from 100 ppm to 800 ppm) were found if compared with the respective background measurements which caused …

Working Length Determination In Palatal Roots Of Maxillary Molars, Melanie A. Kim-Park

Theses and Dissertations

The aim of this study was to determine if a buccal curvature in the palatal roots of maxillary molars affected the clinician’s ability to accurately determine working length. Twenty-seven extracted, human maxillary molars were sorted by palatal root curvatures as J- and C-type and the angle of curvature was determined. Straight-line access was made and a #20 file was placed into the canal until the tip was visible at the apical foramen then withdrawn. The file, tooth and calibration wire were radiographed on one image using the RVG. Actual (file) and radiographic (tooth) lengths were determined using the RVG ruler. …

The Intervention Of Music On Perceptions Of Chronic Pain, Depression, And Anxiety In Ambulatory Individuals With Cancer., Marquetta Flaugher

All ETDs from UAB

No abstract provided.

University Of Texas At Tyler Catalog, 2002-2004, University Of Texas At Tyler

Catalogs

Archives Space instance: https://archivesspace.uttyler.edu/repositories/2/archival_objects/22361

Internet Usage Among Medical Doctors In Malaysia, Surendran Jaganathan

Student Works (2000-2009)

In Malaysia, there were 20,000 Internet subscribers in 1996, 1.5 Million in 2000 and it is predicted to reach 4.5 Million in 2004. Malaysia is experiencing an explosive growth of Internet users. There is also a growing importance of "e -health businesses" as shown in the existing 20,000 healthcare sites currently online with an additional 1,500 sites being added every month. This translates to increasing healthcare site users for instance in America alone, out of 11 o million Internet users, 70 million searched the Web for health information. For healthcare consumers worldwide, the Internet has now become a tool for …

Magnetic Resonance Image Search Database System Using Active Shape Modeling Technique, Jayanthy Maniam

Student Works (2000-2009)

Image processing has gained popularity in the medical field as there are many illnesses which requires X-rays, CT scans and Magnetic Resonance (MR) imaging in order to enable accurate diagnosis of diseases. Magnetic Resonance is one of the popularly known imaging techniques used to aid diagnosis. The images collected through Magnetic Resonance (MR) imaging technique require a database for efficient storage, search and retrieval. Medical image indexing, storage, and retrieval based on image content is an important feature of image database systems. A shape based image search system can be used as a diagnostic decision support tool and as a …

An Analysis Of Presentation Rates To A Paediatric Emergency Department, Andrew Hiskins

Theses : Honours

The health care industry b a very expensive one, constituting a significant proportion of the government budgets. Princess Margaret Hospital (PMH) for children is the only tertiary paediatric centre in Western Australia. PMH has over 40,000 children aged 0-16 years of age who present to the emergency department each year. PMH is one of many hospitals funded from government sources. The emergency department is a high cost area and an area with limited ability to curtail services due to financial constraints. A busy hospital will over a period of time have a constantly changing number of people presenting to the …

Efficacy Of A Pneumatic Oxygen Conserving Device In The Oxygenation Of Copd Patients During Sleep, Ronda Z. Bradley

Theses

For the greater than one million Americans who rely on supplemental oxygen for survival, the vast majority of them struggle with ambulatory oxygen sources which restrict their ability to move freely about within and out of their homes. Liquid oxygen sources can provide the smallest and longest lasting ambulatory oxygen supply. However, the cost of the provision on liquid oxygen has historically been cost prohibitive under our current Medicare reimbursement schedule. The HELiOS™ Oxygen System by Puritan-Bennett a division of Mallinckrodt. has developed an oxygen system, which allows for the smallest, lightest weight and longest lasting oxygen system ever developed. …

Evaluating The Prevalence, Content And Readability Of Complementary And Alternative Medicine (Cam) Web Pages On The Internet, Smitha Sagaram, Muhammad Walji, Elmer Bernstam

Faculty, Staff and Student Publications

Complementary and alternative medicine (CAM) use is growing rapidly. As CAM is relatively unregulated, it is important to evaluate the type and availability of CAM information. The goal of this study is to deter-mine the prevalence, content and readability of online CAM information based on searches for arthritis, diabetes and fibromyalgia using four common search engines. Fifty-eight of 599 web pages retrieved by a "condition search" (9.6%) were CAM-oriented. Of 216 CAM pages found by the "condition" and "condition + herbs" searches, 78% were authored by commercial organizations, whose pur-pose involved commerce 69% of the time and 52.3% had no …

Evaluating A Medical Error Taxonomy, Juliana Brixey, Todd R. Johnson, Jiajie Zhang

Faculty, Staff and Student Publications

Healthcare has been slow in using human factors principles to reduce medical errors. The Center for Devices and Radiological Health (CDRH) recognizes that a lack of attention to human factors during product development may lead to errors that have the potential for patient injury, or even death. In response to the need for reducing medication errors, the National Coordinating Council for Medication Errors Reporting and Prevention (NCC MERP) released the NCC MERP taxonomy that provides a standard language for reporting medication errors. This project maps the NCC MERP taxonomy of medication error to MedWatch medical errors involving infusion pumps. Of …

Clinic Management Information System (Cmis), Choong Leong Wong

Student Works (2000-2009)

Clinic Management Information System or in short (CMIS) is a system that computerize the clinics activities. In the current manual system, lots of problems exist in the management of a clinic. Hand written records are difficult to read. Besides, records are written in papers and placed in the cupboard. There are possibilities that the files misplaced or lost. The stocks of the drugs are difficult to be keeping track. CMIS however eliminate most of the problem facing by manual system. Records are stored securely in the database. Records are easily referred by the users of the system. CMIS is developed …