Digital Commons Network^™

The Splicing Of U12-Type Introns Is A Rate-Limiting Step In Gene Expression, Abhijit A. Patel

Yale Medicine Thesis Digital Library

Metazoan genes have recently been found to contain a novel class of introns that display non-canonical consensus sequences and are excised by a distinct splicing machinery. These introns occur very rarely, and have been called U12-type introns because recognition of their branch point sequences requires the U12 snRNP, which performs an analogous function to the U2 snRNP in splicing major-class introns. The persistence of two spliceosomes throughout virtually all of metazoan evolution suggests that the two spliceosomes play distinct and probably indispensable cellular roles. One enticing possibility is that the U12-type spliceosome functions in post-transcriptional regulation, serving as the rate-determining …

Prenatal Maternal Attachment: The Lived Experience, Regina Ann Leva-Giroux Dnsc

Dissertations

Prenatal maternal attachment and the practice of health promoting behaviors during pregnancy are considered universal phenomena to women. Yet, the understanding of these phenomena from the lived experiences of pregnant women has not been well researched. The purpose of this phenomenological study was to describe the experience of maternal attachment to the unborn child and how that attachment might relate to the practice of these behaviors during pregnancy. The participants in this study were ten English speaking women, college educated, professionally employed, who were pregnant for the first time. Unstructured interviews were conducted with the participants at 14–16 weeks and …

Factors Influencing Self-Rated Preparedness For Graduate School: A Survey Of Graduate Students, Matthew T. Huss, Brandy A. Randall, Marc Patry, Stephen F. Davis, David J. Hansen

Department of Psychology: Faculty Publications

Numerous studies have found a host of factors that are likely to result in more successful applications to graduate schools. This study was a retrospective examination of the variables that distinguish graduate students who believed they were better prepared for graduate school. We examined several of these factors, including variables associated with undergraduate education and the individual for their relation to self-rated preparedness for graduate school. Our findings highlighted quality faculty interactions and participation in research as important factors in graduate students’ post hoc ratings of their preparedness for graduate school. We also found that different types of institutions differed …

2002 - The Seventh Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Seventh Annual Symposium of Student Scholars, held on April 5, 2002. Includes abstracts from the presentations and posters.

Comparative Genomic Hybridization Array Analysis, Annette M. Molinaro, Mark J. Van Der Laan, Dan H. Moore

U.C. Berkeley Division of Biostatistics Working Paper Series

At the present time, there is increasing evidence that cancer may be regulated by the number of copies of genes in tumor cells. Through microarray technology it is now possible to measure the number of copies of thousands of genes and gene segments in samples of chromosomal DNA. Microarray comparative genomic hybridization (array CGH) provides the opportunity to both measure DNA sequence copy number gains and losses and map these aberrations to the genomic sequence. Gains can signify the over-expression of oncogenes, genes which stimulate cell growth and have become hyperactive, while losses can signify under-expression of tumor suppressor genes, …

Santa Clara Magazine, Volume 43 Number 4, Spring 2002, Santa Clara University

Santa Clara Magazine

3 - BIG GIFT FOR BUSINESS SCHOOL BUILDING By SCM Staff. Silicon Valley investor Don Lucas donates $15 million to the Leavey School of Business.

8 - REACHING THE GOAL By Barry Holtzclaw. The women's soccer program has steadily become a national power.

16 - THE ART OF ADMISSION By John Kovacevich. The admissions office shapes the classes of the future by seeking a mix of diversity, creativity, and promise .

The Reliability Of Emg Normalization Procedures For Three Muscles Involved In Knee Extension, Gerrik J. Schepel

Masters Theses

This retrospective study analyzed the three muscles involved in knee extension: vastus medialis, rectus femoris, and vastus lateralis. lt was conducted to determine the reliability of normalization procedures when evaluating the EMG response detected from a muscle. During a maximal voluntary isometric contraction {MVIC), the EMG response of the muscle was recorded and the iEMG moment per unit area was determined. The iEMG response ofthe quadriceps muscles during dynamic exercise was normalized using the MVIC. Subjects (N = 44) performed two consecutive MVICs with a 2-min rest between trials at 110°, 90°, 70°, 50°, and 30° of knee flexion, …

Production Of A Monoclonal Antibody Against Benzo[Α]Pyrene Diol Epoxide Dna Adducts, Brian Peden Austin

Chemistry & Biochemistry Theses & Dissertations

Benzo[α]pyrene is a ubiquitous pollutant produced from the incomplete combustion of organic material such as fossil fuels. It is found in the workplace, urban air, drinking water, and the food supply. Recently, it has been proposed that benzo[α]pyrene may be the causative agent in the formation of lung adenocarcinomas among some Taiwanese women exposed to cooking oil fumes without adequate ventilation. In this study, calf thymus DNA was modified in vitro with benzo[α]pyrene-diol epoxide (BPDE) to a level consistent with that found in biological samples. This DNA of low modification was used as an immunogen in the production of a …

Western Michigan University Occupational Therapy Department Web Page, Holly Pietrzak, Melissa Byrne

Honors Theses

Website designed for WMU's Occupational Therapy department.

Generalizing The Dynamic Field Theory Of The A-Not-B Error Beyond Infancy: Three-Year-Olds’ Delay- And Experience-Dependent Location Memory Biases, Anne R. Schutte, John P. Spencer

Department of Psychology: Faculty Publications

Thelen and colleagues recently proposed a dynamic field theory (DFT) to capture the general processes that give rise to infants’ performance in the Piagetian A-not-B task. According to this theory, the same general processes should operate in noncanonical A-not-B-type tasks with children older than 12 months. Three predictions of the DFT were tested by examining 3-year-olds’ location memory errors in a task with a homogeneous task space. Children pointed to remembered locations after delays of 0 s to 10 s. The spatial layout of the possible targets and the frequency with which children moved to each target was varied. As …

Breast Cancer On The World Wide Web: Cross Sectional Survey Of Quality Of Information And Popularity Of Websites, Funda Meric, Elmer V Bernstam, Nadeem Q Mirza, Kelly K Hunt, Frederick C Ames, Merrick I Ross, Henry M Kuerer, Raphael E Pollock, Mark A Musen, S Eva Singletary

Faculty, Staff and Student Publications

OBJECTIVES: To determine the characteristics of popular breast cancer related websites and whether more popular sites are of higher quality.

DESIGN: The search engine Google was used to generate a list of websites about breast cancer. Google ranks search results by measures of link popularity---the number of links to a site from other sites. The top 200 sites returned in response to the query "breast cancer" were divided into "more popular" and "less popular" subgroups by three different measures of link popularity: Google rank and number of links reported independently by Google and by AltaVista (another search engine).

MAIN OUTCOME …

Bse: Risk, Uncertainty, And Policy Change, Enda Cummins, Pat Grace, Kevin Mcdonnell, Shane Ward

RISK: Health, Safety & Environment (1990-2002)

The authors discuss how, in our "risk society," a range of potential risks and uncertainties are associated with new technologies and new diseases, such as BSE. These risks bring with them worries about human health, while the ability to assess and manage new health scares is an essential skill for government and related industries.

Inside Unlv, Diane Russell, Betty Blodgett, Kevin Force, Jennifer Vaughan, Cate Weeks, Jonathan Paver

Inside UNLV

No abstract provided.

Comparing Bottled Water And Tap Water: Experiments In Risk Communication, Branden B. Johnson

RISK: Health, Safety & Environment (1990-2002)

The author discusses results of experiments in risk communication comparing bottled water and tap water.

Prevalence Of Various Upper Extremity Disorders In Patients With Carpal Tunnel Syndrome Versus Patients Without Carpal Tunnel Syndrome, Daniel C. Buda

Loma Linda University Electronic Theses, Dissertations & Projects

Background and Purpose: Increasingly larger numbers of patients present with repetitive strain injuries of the upper extremities, especially carpal tunnel syndrome (CTS). A large number of these patients appear to have more than one upper extremity condition. The purpose of this study was to determine the probability that a patient diagnosed with carpal tunnel syndrome will also be diagnosed with other upper extremity and/or cervical spine disorders.

Subjects: A group of 188 subjects diagnosed with carpal tunnel syndrome and a group of 203 subjects without carpal tunnel syndrome were selected through a chart review of patients at Loma Linda …

A Novel Electrocardiogram Segmentation Algorithm Using A Multiple Model Adaptive Estimator, Gregory S. Hoffman

Theses and Dissertations

This thesis presents a novel electrocardiogram (ECG) processing algorithm design based on a Multiple Model Adaptive Estimator (MMAE) for a physiological monitoring system. Twenty ECG signals from the MIT ECG database were used to develop system models for the MMAE. The P-wave, QRS complex, and T-wave segments from the characteristic ECG waveform were used to develop hypothesis filter banks. By adding a threshold filter-switching algorithm to the conventional MMAE implementation, the device mimics the way a human analyzer searches the complex ECG signal for a useable temporal landmark and then branches out to find the other key wave components and …

The Hoop Of Learning: A Holistic, Multisystemic Model For Facilitating Educational Resilience Among Indigenous Students, Margaret A. Waller, Scott K. Okamoto, Ted Hibbeler, Patricia Hibbeler, Patricia Mcintyre, Roland Mcallen-Walker, Audrey A. Hankerson

The Journal of Sociology & Social Welfare

Indigenous communities in the United States have a wealth of cultural and social resources that can facilitate educational resilience among Native students. This article reviews the historical context, contemporary trends, and current challenges related to education of Indigenous students. The authors present an innovative middle school-to-high school-to-college bridge program as one example of many positive educational initiatives currently developing across the country.

Estimating Causal Parameters In Marginal Structural Models With Unmeasured Confounders Using Instrumental Variables, Tanya A. Henneman, Mark Johannes Van Der Laan, Alan E. Hubbard

U.C. Berkeley Division of Biostatistics Working Paper Series

For statisticians analyzing medical data, a significant problem in determining the causal effect of a treatment on a particular outcome of interest, is how to control for unmeasured confounders. Techniques using instrumental variables (IV) have been developed to estimate causal parameters in the presence of unmeasured confounders. In this paper we apply IV methods to both linear and non-linear marginal structural models. We study a specific class of generalized estimating equations that is appropriate to these data, and compare the performance of the resulting estimator to the standard IV method, a two-stage least squares procedure. Our results are applied to …

Santa Clara Magazine, Volume 44 Number 3, Winter 2002, Santa Clara University

Santa Clara Magazine

10 - GLOBALIZATION EMPOWERS GOOD AND EVIL By Rob Elder. Thomas Friedman, Pulitzer Prizewinning author and international affairs columnist for The New York Times, discusses this complex issue during a visit to campus.

14 - ON THE COLLISION OF WORLDS By Fred White. Corny science fiction movies inspire an SCU English professor to ponder deeply cosmic questions.

18 - THE CAMPAIGN FOR SANTA CLARA By Elizabeth Kelley Gillogly '93. SCU launches the largest campaign in its history, with plans for endowed scholarships, a new library, a new building for the Leavey School of Business, and much more.

College Of Pharmacy Program Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

College Of Pharmacy Overview In Ponce, Puerto Rico, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Filling Preposition-Based Templates To Capture Information From Medical Abstracts, Gondy Leroy, Hsinchun Chen

CGU Faculty Publications and Research

Due to the recent explosion of information in the biomedical field, it is hard for a single researcher to review the complex network involving genes, proteins, and interactions. We are currently building GeneScene, a toolkit that will assist researchers in reviewing existing literature, and report on the first phase in our development effort: extracting the relevant information from medical abstracts. We are developing a medical parser that extracts information, fills basic prepositional-based templates, and combines the templates to capture the underlying sentence logic. We tested our parser on 50 unseen abstracts and found that it extracted 246 templates with a …

Providers Choices In Web-Medical Records: An Analysis Of Trade-Offs Made By Physicians In San Bernardino County, Jay Eriah Shankar

Theses Digitization Project

This thesis concluded that offering physicians an appropriate Web-based transcription service should be well received and improve their medical record management and patient care.

Cognitive Rehab Solutions: A Computer-Assisted Cognitive Training Program, Avani Rajnikant Patel

Theses Digitization Project

The purpose of this project is to offer a functionally comprehensive application, Cognitive Rehab Solutions (CRS), that is designed for neuropsychologists to deliver restorative cognitive training in areas of attention and memory of persons with brain impairment.

Actiononaias Ligamentina As A Biomonitor In The Green River: An Unique Approach For Analysis Of Environmental Impacts, Robert Kirkland

Masters Theses & Specialist Projects

Biomonitoring has become an important component in bioassessment programs. It is used to maintain high water quality standards, and determine contaminant levels and biological affects in areas that have been heavily disturbed. The objectives of this research were 1) to improve and apply certain modern biomonitoring techniques and 2) to locate possible contaminant sources affecting the flora and fauna of the Green River and of Mammoth Cave. Actinonaias ligamentina (Lamarck, 1819), a freshwater mussel, was used for interpretation of these impacts as well as refinement of biomonitoring techniques. The mussels were collected in the Lawler Bend region of the Green …

A History Of Quality Of Life Measurements, Jordan Matthew Prutkin, Alvan R. Feinstein

Yale Medicine Thesis Digital Library

Purpose: To review the origins and early development of quality of life measurements in the medical literature. Methods: A comprehensive literature review of Medline from 1966-1986 examining articles with quality of life as a subject heading. Studies were included if they were the original article describing a scales development or used scales developed in the social science literature. Results: The measurements have been derived from two separate sources: a transfer and expansion of medical appraisals for health status, and an application of sociometric and psychometric methods for populational assessment of happiness, well-being, and other affects. Neither source of measurements used …

Predicting The Spatial Dynamics Of Rabies Epidemics On Heterogeneous Landscapes, David L. Smith, Brendan Lucey, Lance A. Waller, James E. Childs, Leslie A. Real

Zoonotics and Wildlife Disease: Publications

Often as an epidemic spreads, the leading front is irregular, reflecting spatial variation in local transmission rates. We developed a methodology for quantifying spatial variation in rates of disease spread across heterogeneous landscapes. Based on data for epidemic raccoon rabies in Connecticut, we developed a stochastic spatial model of rabies spread through the state’s 169 townships. We quantified spatial variation in transmission rates associated with human demography and key habitat features. We found that large rivers act as semipermeable barriers, leading to a 7-fold reduction in the local rates of propagation. By combining the spatial distribution of major rivers with …

Medtextus: An Ontology-Enhanced Medical Portal, Gondy Leroy, Hsinchun Chen

CGU Faculty Publications and Research

In this paper we describe MedTextus, an online medical search portal with dynamic search and browse tools. To search for information, MedTextus lets users request synonyms and related terms specifically tailored to their query. A mapping algorithm dynamically builds the query context based on the UMLS ontology and then selects thesaurus terms that fit this context. Users can add these terms to their query and meta-search five medical databases. To facilitate browsing, the search results can be reviewed as a list of documents per database, as a set of folders into which all the documents are automatically categorized based on …

College Of Optometry Program Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Accuracy Of Predictive Methods To Estimate Resting Energy Expenditure Of Thermally-Injured Patients, Roland N. Dickerson, Jane M. Gervasio, Marti L. Riley, James E. Murrell, William L. Hickerson, Kenneth A. Kudsk, Rex O. Brown

Scholarship and Professional Work – COPHS

Background

The purpose of this study was to evaluate the bias and precision of 46 methods published from 1953 to 2000 for estimating resting energy expenditure (REE) of thermally injured patients.

Methods

Twenty-four adult patients with ≥20% body surface area burn admitted to a burn center who required specialized nutrition support and who had their REE measured via indirect calorimetry (IC) were evaluated. Patients with morbid obesity, human immunovirus, malignancy, pregnancy, hepatic or renal failure, neuromuscular paralysis, or those requiring a FiO2 >50% or positive end expiratory pressure (PEEP) ≥10 cm H2O were excluded. One steady-state measured REE measurement (MEE) …