Digital Commons Network^™

A Framework For Aligning 5-Year And Lifetime Breast Cancer Risk In Women Without High-Penetrance Mutations, Graham A Colditz, Debbie L Bennett, Kala Visvanathan, Bernie A Rosner, Shu Jiang

2020-Current year OA Pubs

OBJECTIVE: Reconciling cutoff thresholds for short-term (5-year) and long-term (lifetime) breast cancer risk could support tailored and evidence-based approaches to supplemental screening and risk management most relevant to short-term clinical actions. This study aims to consistently classify women at increased risk and provide 5-year risk cutoff that corresponds to a 20% lifetime risk.

METHODS: Using U.S. Surveillance, Epidemiology and End Results (SEER) program population incidence data for women 40 to 74 years of age, this study reports both lifetime and 5-year population-based risk estimates controlling for competing risk and age varying breast cancer incidence. A cut point for 5-year risk …

Demographic And Socioeconomic Factors Influence Perceived Community Needs And Risk Factors For Firearm Violence In Mississippi, Masoumeh Karimi, Matthew Morris, Xiaoshan Gordy, Matthew Kutcher, Leila Seidfaraji, Michelle Brassfield, Erin Dehon, Alyscia Severance, Rukia Lumumba, Fredrick Womack, Lei Zhang

Journal of Public Health in the Deep South

Background: The burden of firearm-related injuries and deaths is not borne equally across sociodemographic groups. The present study investigated the perceived needs and risk factors of firearm related injuries and mortality across gender, education, and income levels through a quantitative needs assessment completed by community members and firearm injury survivors living in the greater Jackson, Mississippi, metropolitan area.

Methods: A total of 93 participants including gunshot wound patients, survivors and community members who have been recruited through community organizations completed the needs assessment survey collecting data on demographic information, firearm exposure, substance use, community exposure to crime and …

Pilot Evaluation Of A Cross-Disciplinary Training Addressing Substance Use Among Mississippi Mothers, Saijun Zhang, Catherine Poehling, Xiaoshan Gordy, Chinedu P. Chukwu, Jerome R. Kolbo, Masoumeh Karimi, Matthew Morris, Andrew Voluse, Erin Dehon, Michelle Brassfield, Danielle Lahn, Lisa Slade, Deanna Howington, Kathleen Rhodes, Tearsenee Davis, Sonja Fuqua, Lei Zhang

Journal of Public Health in the Deep South

Background: Intimate partner violence (IPV) and substance use co-occurring is often managed in siloed systems. Training IPV and related service providers on substance use topics may strengthen screening, response, and referral.

Purpose: To assess whether a pilot training program on substance use disorders (SUDs) in Mississippi improved service providers’ knowledge, preparedness, and attitudes around substance use and satisfaction with the training.

Methods: Pre–post surveys were administered to healthcare and community service providers who completed the training, assessing substance use service-related knowledge, preparedness, and attitudes.  Descriptive statistics and t-tests were used to analyze the data.

Results: Fifty-nine providers completed a …

Informal Caregiving In Sporadic Creutzfeldt-Jakob Disease: A Constructivist Grounded Theory Study And Its Implications For Clinical Translation, Lauren Pourghaderi

Doctor of Philosophy in Translational Health Sciences Dissertations

Background: Sporadic Creutzfeldt-Jakob Disease (sCJD) is a rare, fatal, rapidly progressive neurodegenerative dementia that occurs in the absence of a known cause. Due to the rapid neurodegeneration in sCJD, informal caregivers take a sudden leading role in caregiving and decision-making. sCJD differs from other dementias in ways that shape caregiving and increase burden, but support interventions aimed to address caregiver burden in dementia overlook these distinctions, limiting their effectiveness. The scope of sCJD-specific informal caregiving research is limited, and no foundational theory describing the sCJD informal caregiving experience in its entirety exists. A theoretical foundation would provide the basis for …

Implementation Of A Standardized Protocol To Improve Provider Documentation And Initiation Of Guideline-Concordant Hypertension Follow-Up Within 14 Days In Primary Care, Stella Williams

Doctor of Nursing Practice Projects

Hypertension is a major modifiable risk factor for cardiovascular morbidity and mortality, yet timely follow-up after elevated blood pressure (BP) readings is not consistently documented in primary care. This Doctor of Nursing Practice (DNP) quality improvement project evaluated whether a standardized hypertension screening follow-up protocol improved provider initiation or documentation of guideline-concordant follow-up within 14 days. The faculty-approved PICOT population was primary care providers in a primary care clinic; we used eligible electronic health record (EHR) encounters as the analytic records to observe provider performance. We used a quantitative pre/post design and retrospectively reviewed 30 eligible EHR encounters: 15 pre-implementation …

Financial Recovery Capital: Exploring The Role Of Extension Education In Promoting Substance Use Recovery, Alex Elswick, Nichole L Huff, Omolola A. Adedokun, Leslie Workman

Journal of Extension

Substance use is a widespread and complex public health challenge. Financial stress (e.g., unemployment, inadequate housing, transportation access, poor financial literacy) is pervasive among people with substance use disorder (SUD). However, few educational interventions exist to address financial stress for this group. Through the theoretical lens of recovery capital (an asset-based approach that describes the totality of resources that support SUD recovery), we summarize the association between financial stress and substance use, offering implications for Extension educators by highlighting PROFIT, an exemplary program that leverages Extension education as a tool to promote financial recovery capital among people with SUD.

Effects Of Hydrogen-Infused Water On Endurance Performance, Body Hydration Biomarkers, And Health-Related Quality Of Life In Collegiate Athletes (Hydro2eau): A Randomized-Controlled Clinical Trial, Jovan Kuzmanovic, Nikola Todorovic, Marijana Ranisavljev, David Nedeljkovic, Sergej M. Ostojic

Baltic Journal of Health and Physical Activity

Background: Hydrogen-infused water (HIW) has attracted considerable interest over the past two decades due to its potential health benefits. However, its effects on exercise performance and hydration biomarkers remain inadequately explored, particularly in physically active populations such as collegiate athletes. This study aimed to investigate the impact of medium-term HIW supplementation on running performance, hydration biomarkers, and health-related quality of life in collegiate athletes. Methods: A randomized, double-blind, placebo-controlled, crossover trial was conducted with twelve collegiate athletes (age: 25.1 ± 3.5 years, six female). Participants consumed 660 mL daily of either HIW (300 µmol/L dihydrogen) or control water (0 µmol/L …

Pentosan Polysulfate Sodium (Pps, Elmiron) Maculopathy Demonstrates The Importance Of Coordinated Care From A Low Vision Perspective, Charlotte I. Spada Od, Stephanie Schmiedecke Barbieri Od, Patricia Sanchez Diaz Dvm, Phd, Jeffrey Rabin Od, Phd

Optometric Clinical Practice

Background: Pentosan polysulfate sodium (PPS, Elmiron®) is a widely used medication to reduce pain caused by interstitial cystitis, a bladder disorder most often affecting females. PPS maculopathy is a novel form of toxic retinal disease often not recognized or mistaken for other retinal conditions such as macular degeneration due to the initial similarities on fundus exam. However, when visualized using fundus autofluorescence, affected eyes show characteristic hyper/hypo-autofluorescent patterns.

Case report: A patient taking PPS for 10 years presented with macular changes and complaints of blurry vision and nyctalopia. Clinical, electrodiagnostic, and genetic testing were performed including fundus autofluorescence and …

Implementation Of A Six-Month Produce Prescription Program For A Rural Medicaid Population Increased Vegetable Consumption And Reduced Food Security In Washington State, Nicole Stendell Hollis, Tafere Belay, Alyssa Castillo, Lupita Silva, Deborah Guack

All Faculty Scholarship for the College of Education and Professional Studies

Objective

Methods

Pacific Rxtracts - October 2026, Pacific Rxtracts

Pacific RxTracts

• Tackling Tremors with Tavapadon (featured as the Breaking News article)
• Dupilumab Efficacy and Safety in Patients With Allergic Bronchopulmonary Aspergillosis
• Gefurulimab in Generalized Myasthenia Gravis: Results From the PREVAIL Trial
• Inebilizumab Proves Efficacy in Managing Exacerbations and Rescue Therapy in Phase 3 Myasthenia Gravis Trial
• Coincidence or Carelessness: An Investigation into Potentially Inappropriate Prescribing Cascades
• Nipocalimab Shows Promise for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)
• Comparing Intravenous Iron Therapies in the Pediatric Population
• Oseltamivir and Outcomes in Children Hospitalized With Influenza
• Valiltramiprosate’s Impact on Early Alzheimer’s Biomarkers and Outcomes
• Blinatumomab as a Chemotherapy Alternative in Pediatric Acute …

Early Prediction Of The Breast Cancer Response To Neoadjuvant Chemotherapy Based On Intratumoral Interstitial Fluid Pressure Using 3-D Subharmonic-Aided Pressure Estimation, Sung In Choi, Basak Dogan, Corinne E. Wessner, Jessica H. Porembka, Priscilla Machado, B. Bersu Ozcan, Nisha Unni, Maysa Abu-Khalaf, Kenneth Hoyt, Flemming Forsberg, Kibo Nam

Department of Radiology Faculty Papers

Elevated intratumoral interstitial fluid pressure (IFP) may negatively impact the efficacy of neoadjuvant chemotherapy (NAC). This study aimed to predict the breast cancer response to NAC based on intratumoral IFP using 3D contrast-enhanced ultrasound (CEUS) with subharmonic-aided pressure estimation (SHAPE). This prospective study enrolled breast cancer patients undergoing NAC from two clinical sites. 3D CEUS was performed at 0%, 10%, and 30% of NAC completion using a GE Logiq E9 with Definity. The pressure gradients between the tumor and adjacent normal tissue were estimated by SHAPE, utilizing the inverse linear relationship between the ultrasound contrast agent’s subharmonic signal amplitude and …

Program Evaluation Of Hospital Initiative To Reduce Nulliparous Term Singleton Vertex Cesarean-Section Rate, Denise Hopkins

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Cesarean birth among nulliparous, term, singleton, vertex (NTSV) patients is an important maternal health quality indicator, as potentially unnecessary cesarean births can increase maternal morbidity and affect subsequent pregnancies. Healthy People 2030 established an NTSV cesarean birth rate target of 23.6%. At the participating hospital, rates demonstrated variability and frequently exceeded this benchmark, supporting evaluation of an existing initiative promoting safe vaginal birth. Aim of the Project: The project aimed to evaluate the effectiveness of the Supporting Vaginal Delivery for Low-Risk Mothers (SOAR) initiative in reducing NTSV cesarean birth rates while maintaining neonatal safety and assessing program adherence. Review …

Baby-Friendly Implementation For Decreased Skin-To-Skin Care Initiation Delays, Brianna Grace

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Immediate skin-to-skin care (SSC) remains inconsistently implemented, despite evidence linking it to improved neonatal outcomes. At the project site, baseline SSC rates were 64% for vaginal births and 19% for Cesarean births, below the 80% standard established by the Baby-Friendly Hospital Initiative.

Aim of the Project: This QI project aimed to improve outcomes by implementing evidence-based SSC practice and first-hour breastfeeding initiation to align with Baby-Friendly standards.

Review of the Evidence: The applied interventions align with the seminal guidance from the World Health Organization and the United Nations Children’s Fund, which represents the global standard for maternity and newborn …

Hidden Patterns: Revealing The Noise Exposure Habits Of College Musicians Throughout The Year, Maya Vallejo

Holster Scholar Projects

College musicians face elevated risk for noise-induced hearing loss (NIHL) due to extensive rehearsal, headphone use, and performance activity, yet most objective sound-exposure studies rely on personal dosimeters that capture only brief windows (1–3 weeks) during the academic year, and overlook headphone-specific exposure. This study leveraged historical Apple Watch and AirPods sound data from participants in the ongoing AMI study (Skoe lab, University of Connecticut) to compare environmental and headphone noise exposure between academic-year and academic-break periods in college-age lifelong, former, and non-musicians. Sound levels (dBA) were calculated using duration-weighted, log-power averaging to account for the logarithmic nature of decibels. …

A Word From The Writing Team (October 2026), Pam Walter, Mfa, Laura Deloretta, Phd

A Word From the Writing Team (Newsletter)

No abstract provided.

Ceftaroline Pharmacokinetics On Ecmo, A Pediatric Case Report., Kathryn Pavia, Ashton Bellamy, Alaina Burns, Allison Scott, Ethan A. Poweleit

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: In-vitro studies suggest that patients on extracorporeal membrane oxygenation (ECMO) may struggle to achieve therapeutic ceftaroline exposure to treat infections due to antibiotic sequestration within the ECMO oxygenator; however, there are no published data regarding ceftaroline concentrations from patients supported by ECMO.

PATIENT PRESENTATION: Here we present an analysis of ceftaroline pharmacokinetics in a 5-y-old patient supported on ECMO due to influenza-associated necrotizing pneumonia.

RESULTS: A total of nine concentrations were analyzed, including three concentrations prior to cannulation and six on ECMO. ECMO cannulation was associated with a relatively small change in the volume of distribution (0.17 L/kg to …

Considering Access And Methodological Rigor In Framing Results Of The Bergen 4 Day Treatment Program For Obsessive-Compulsive Disorder

Faculty, Staff and Students Publications

No abstract provided.

A Rare Recurring Gain-Of-Function Variant In Bmpr2 Causes Neurodevelopmental Phenotypes In Humans And Flies, Zhi Tan, Ariel Brautbar, Maria Descartes, Erica T Gray, Alejandro Iglesias, Scott D Mclean, Morgan Nutter, Olivia Daugherty, Amber Begtrup, Ingrid M Wentzensen, Yufeng Shen, Damian W Young, Martin M Matzuk, Oguz Kanca, Michael F Wangler, Hugo J Bellen, Wendy K Chung, Shinya Yamamoto

Faculty, Staff and Students Publications

Bone morphogenetic protein receptor type 2 (BMPR2) encodes an evolutionarily conserved serine/threonine kinase that phosphorylates type-1 BMP receptors to mediate intercellular communication upon ligand binding. Loss-of-function variants in BMPR2 are known to cause pulmonary arterial hypertension and other cardiovascular disorders. Here, we report a rare recurrent missense variant in BMPR2 (c.1126G>A [GenBank: NM_001204] [p.Glu376Lys]) identified in six individuals, who all present with neurodevelopmental phenotypes including autism spectrum disorder and global developmental delay. Trio analysis demonstrates de novo occurrence of this variant in at least five of the individuals. Using the fruit fly Drosophila melanogaster, we show that this variant …

Pooled Proportion And Associated Factors Of Postoperative Pain During The Recovery Time Among Adult Surgical Patients In An Ethiopian Setting With Limited Resources: A Systematic Review And Meta-Analysis, Sintayehu Samuel Lorato, Mitiku Desalegn, Kelemu Abebe Gelaw, Yohannes Godie Ashebir, Olyad Kuma Getahun, Gebeyehu Lakew, Mathewos Mekonnen Gemmechu, Tiruye Menshaw Tiruneh, Yibeltal Assefa Atalay, Amlaku Nigusie Yirsaw, Eyob Ketema Bogale, Natnael Atnafu Gebeyehu, Tewodros Shitemaw Tekoye, Genanew Kassie Getahun, Kedir Seid, Abel Tibebu Goshu

Research outputs 2022 to 2026

No abstract provided.

Examining The Impact Of Supramaximal Eccentric And Long-Lever Isometric Training Protocols On Isometric Hamstring Strength, Nordic Hamstring Performance, And Sprint Speed, Adam E. Sundh, Devin S. Vervoort, Nicholas J. Ripley, A. J. Lamb, Paul Comfort

Research outputs 2022 to 2026

The aim of this study was to compare the effects of a 6-week higher-volume eccentric training protocol with a combined lower-volume eccentric and long-lever isometric protocol on posterior chain strength and sprint performance. Thirty-three NCAA Division II soccer players (men: n = 17, age = 19.7 ± 1.2 years, height = 178.9 ± 6.6 cm, body mass 79.8 ± 8.1 kg; women: n = 16, age = 20.1 ± 0.9 years, height = 166.7 ± 5.2 cm, body mass = 67.0 ± 12.1 kg) were allocated to either group via exhaustive minimization. Nordic hamstring exercise break-point angle (NBPA), rapid isometric …

Engagement And Weight Change In An Online Weight Management Program In Clinical Settings: An Implementation Project, Caroline M Apovian, Ashley C Mccarthy, Alexander J Blood, Lipika Samal, Naomi D L Fisher, E John Orav, Matthew Wien, Jorge Plutzky, Jason P Block, David W Bates, Ronen Rozenblum, Michela Tucci, Marian Mcpartlin, Michael Oates, Katherine D Mcmanus, Benjamin M Scirica

Faculty, Staff and Students Publications

Background: There is an urgent need for scalable strategies for treatment of overweight and obesity that can be implemented in clinical settings.

Objective: To implement and evaluate an online weight management program in a large, diverse population of patients.

Design: Clinical implementation project in primary care and specialty clinics.

Participants: Eligible patients were ≥ 20 years old, spoke English or Spanish, and had a body mass index (BMI) of ≥ 30 kg/m2 or a BMI of 25-29.9 kg/m2 plus ≥ 1 cardiovascular risk factor or obesity-related condition.

Intervention: Enrolled patients were encouraged to register for a 12-month digital health program …

A Genetic Risk Variant Associated With The Risk Of Primary Biliary Cholangitis Is Inherited From Neanderthals, Heather J Cordell, George F Mells, Richard N Sandford, David E Jones, Gideon Hirschfield, Katherine A Siminovitch, M Eric Gershwin, Brian D Juran, Elizabeth J Atkinson, Angela Cheung, Mariza De Andrade, Aris Baras, Konstantinos N Lazaridis, Rosanna Asselta, Pietro Invernizzi, Manuela Sironi, Sriram Sankararaman, Canadian‐Us Pbc Consortium, Uk‐Pbc Consortium, Italian Pbc Genetics Study Group

Faculty, Staff and Students Publications

Background: Primary Biliary Cholangitis (PBC) is an autoimmune cholangiopathy with polygenic architecture and unknown aetiology. Evidence links Neanderthal-derived genetic variants to autoimmune conditions; however, their contribution to PBC susceptibility remains unexplored.

Objective: We investigate whether archaic alleles influence PBC risk.

Design: Genotype data from four PBC cohorts were analysed: CANUK (4615 cases, 9233 controls), OLD IT (444 cases, 901 controls), NEW IT (255 cases, 579 controls) and MAYO (891 cases, 621 controls). Association testing with 235 592 Neanderthal Informative Markers (NIMs) was performed, adjusting for population stratification. Heritability was estimated using RHE-mc and temporal haplotype dynamics were assessed using ancient …

Growing South Dakota (Fall 2026), College Of Agriculture, Food And, Environmental Sciences

Growing South Dakota (Publication of the College of Agriculture, Food and Environmental Sciences)

[Page] 2 Support from donors helping set SDSU dairy graduates above the rest
[Page] 4 A decade of impact: Celebrating 10 years of cow-calf, swine education and research facilitates
[Page] 8 98-year-old donor keeps decades-long scholarship going in honor of late husband
[Page] 11 Looking back at Michele Dudash's tenure in academia
[Page] 12Giving students opportunities, experience to build their futures
[Page] 16 A Jackrabbit's journey in growing agricultural leadership
[Page] 18 Building South Dakota's next generation of rural veterinarians
[Page] 19 Conservation: A family affair
[Page] 20 South Dakota Water Resources Institute finds solutions to South Dakota's water challenges …

Bare Bones Medicine: A Young Physician Adapts To An Island Medical Practice, Chuck Radis

Faculty Publications

This is the story of Dr. Radis's introduction to his new job as an island physician in Maine.

Evaluating Large-Scale Propensity Score Adjustment When Sample Size Is Small, Fleur Vereijken, Jenna M Reps, Marc A Suchard, Linying Zhang, George Hripcsak, Peter R Rijnbeek, Ross D Williams, Martijn J Schuemie

2020-Current year OA Pubs

BACKGROUND: Large-scale propensity score (LSPS) models are increasingly used to control confounding in observational studies, but their reliability in small-sample settings is unclear. Small samples can limit a study's ability to estimate propensity scores accurately and achieve adequate covariate balance, raising concerns about insufficient confounding adjustment. Resulting in small datasets being excluded, despite potentially containing valid information.

METHODS: We evaluated the balancing and bias reduction performance of LSPS models using six target-comparator pairs. To emulate a distributed data network analysis setting, we partitioned two large real-world data sources into smaller subsets. Within each subset, LSPS models were fit locally and …

A Nurse-Driven Port-A-Cath Access Protocol To Improve Timeliness Of Vascular Access, Enisa Mehmeti

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Delayed Port-a-Cath (PAC) access limited timely care on a medical-surgical unit that relied on the vascular access team for routine access. Baseline median PAC access time was 45 minutes, and the vascular access team received an average of 15 PAC-related pages per week.

Aim of the Project: This quality improvement project implemented an evidence-based, nurse-driven PAC access protocol to reduce median access time to 30 minutes or less, achieve competency validation among at least 80% of eligible charge registered nurses, reduce vascular access team paging by at least 50%, and maintain the central line-associated bloodstream infection (CLABSI) rate at …

Letter To The Editor: “Tackling Large Periapical Cysts With Precision”, Kainaz Tehemton Zarolia, Varun B. Irani

International Arab Journal of Dentistry

On reviewing the article "Surgical Symphony : Tackling large periapical cysts with precision" we came across a few points to be highlighted in otherwise an extremely descriptive and informative article.

Sharksrx Newsletter Fall 2026, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Implementing An Evidence-Based Checklist To Improve Hypertension Clinical Performance, Angelica Wilson

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Hypertension is a significant chronic disease management challenge at an urban Federally Qualified Health Center (FQHC), where about 26% of adults aged 18 to 85 years have uncontrolled blood pressure (BP). Despite the organization achieving a hypertension control rate of 74%, which exceeds the national FQHC average of 57.6% and approaches the goal of 80%, there remains inconsistent implementation of evidence-based hypertension management. The lack of standardized workflow has led to variances in BP reassessment, treatment management, lifestyle counseling, documentation, and follow-up, resulting in missed opportunities for guideline-directed care.

Aim of the Project: The quality improvement (QI) project aimed …

Enhancing Care Coordination: Nurse-Physician Bedside Communication To Improve Outcomes, Harriet Chinakwe

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Inconsistent nurse-physician bedside communication on a 28-bed hybrid intermediate stepdown unit contributed to gaps in care coordination, patient engagement, and discharge readiness. Baseline Centers for Medicare & Medicaid Services (CMS) Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) (2026), Press Ganey (2022) communication scores were below the national 90th-percentile benchmark; nurse communication at 58% and doctor communication at 46%, indicating the need for a structured communication process.

Aim of the Project: The quality improvement project aimed to improve nurse-physician communication during daily bedside rounds by implementing a TeamSTEPPS-informed, structured bedside rounding process using the PATIENT tool over 12 …