Digital Commons Network^™

Effects Of Secondhand Smoke, Rebecca Maplethorpe,, Jodi Matesi, Evelyn Nieves

RESP 1102 Intermediate Respiratory Care

The respiratory effects of secondhand smoke (SHS) are numerous throughout all populations. Studies show that patients are more likely to develop respiratory diseases if they grow up in a household with one or more smokers. SHS is linked to increased rates of many respiratory conditions such as Asthma, Tuberculosis (TB), Chronic Obstructive Pulmonary Disease (COPD), Lung Cancer, and Perioperative respiratory complications. This paper will focus on the impact of secondhand smoke on individuals, in utero to 18 years of age. However, since some conditions are not seen until later in life, adult patients will also be noted. Additionally, the issues …

Impact Of Pandemic-Driven Parental Fear On Childhood Immunization Rates: Examining Attitudes Toward Vaccination During Crisis Periods In Türkiye, Özüm Erkin, İlknur Göl

Makara Journal of Health Research

Background: This study aimed to investigate the effect of parents’ fear of coronavirus on their attitudes towards the vaccination of their children.

Methods: The study was conducted with 2,350 parents who were selected by using the snowball sampling method. The questionnaire included a personal information form, the Public Attitude towards Vaccination Scale – Health Belief Model, and the Fear of COVID-19 Scale.

Results: The scores of the study group from the sub-dimensions of the Public Attitude towards Vaccination Scale Health Belief Model were as follows: 17.39 ± 2.92 perceived susceptibility, 16.74 ± 3.19 perceived severity, 21.10 ± …

Impact Of Medication Opioid Use Disorder (Moud) Programs In Emergency Departments, Mechelle A. Zima

Nursing Capstones

The purpose of this paper is to provide a discussion of how a medication opioid use disorder (MOUD) programs integrated into the emergency department (ED) can improve patient’s outcomes compared to standard ED discharges. This study utilized a systematic literature review using PubMed, CINAHL and Google Scholar. The initial literature search identified 594 articles. After applying the predefined inclusion and exclusion criteria, 18 articles were selected. Inclusion criteria included peer reviewed articles that focused on opioid use disorder (OUD) patients treated in the ED with OUD medications while exclusion criteria involved articles with OUD patients treated in ED without OUD …

From Unrealistic To Functional Optimism In Illness Perception: A Psychometric Comparison Across 10 Countries, Elisa Kern De Castro, Oscar Lecuona, Maria João Figueiras, Cristina Quiñones, Kamlesh Singh, Shoshana Shiloh, Michaela Schippers, Ana Kinkead, Raquel Rodríguez-Carvajal

All Works

People's perceptions of illness and its risks influence health behaviors, including risk management and precautionary measures. Illness perception often involves unrealistic optimism, reducing infection risk perception. However, crises disrupt self-regulation and optimism due to uncontrollable situations. This study examines optimism's link to risk and illness perception during the first COVID-19 wave in 10 countries, with 7254 participants (48.1% women, mean age = 40, SD = 14.8). We used Bayesian structural equation modeling for psychometric stability and one-way ANOVAs for country comparisons. Multiple regression analyses examined the impact of optimism and demographic variables on illness perception. Significant cross-country variations emerged in …

Factors Related To The Incidence Of Hypertension Among People Above 18 Years At The Cibatu Public Health Center, Bekasi Regency, Verizka Azra, Yustiyani Yustiyani, Minsarnawati Minsarnawati, Catur Rosidati

Indonesian Journal of Public Health Nutrition (IJPHN)

Hypertension is a non-communicable disease that still becomes a public health issue. The percentage of hypertension cases at Cibatu Public Health Center increased from 31.7% in 2021 to 37% in 2022. Based on a preliminary study, hypertension was found to be the most common non-communicable disease at Cibatu Public Health Center. This study aimed to identify factors associated with the incidence of hypertension among individuals aged 18 years and older at Cibatu Public Health Center, Bekasi Regency, in 2024.We conducted a cross-sectional study in May involving 121 respondents. This study used standardized questionnaires that had been validated in previous research, …

Exploring The Non-Communicable Disease Burden In Indonesia – Findings From The 2023 Health Survey, Akifa Laila Rusyda

Indonesian Journal of Public Health Nutrition (IJPHN)

The present study rigorously examines the correlation between obesity, high-risk dietary consumption, and unhealthy lifestyles with the prevalence of non-communicable diseases (NCDs) in Indonesia. The study employed a cross-sectional study design using secondary data from the 2023 Indonesian Health Survey, analyzing 38 units (n) representing Indonesia's provinces in 2023. The correlation analysis, conducted using Pearson's test with a significance level of 95% (α<0.05), revealed significant regional disparities in the prevalence of NCDs, dietary consumption, and lifestyle factors across Indonesia. Moreover, the findings reveal a statistically significant positive correlation between obesity, high-risk food consumption, and lifestyle risk factors with the prevalence of several NCDs, including diabetes mellitus, heart disease, hypertension, and chronic kidney disease. These results underscore the potential impact of our research on public health in Indonesia. The results highlight also the urgent need for targeted public health initiatives, such as policies promoting healthier food choices, controlling the food environment, encouraging physical activity, and supporting smoking cessation to mitigate the growing burden of NCDs in Indonesia.

Development Of A Reference Standard To Assign Bacterial Versus Viral Infection Etiology Using An All-Inclusive Methodology For Comparison Of Novel Diagnostic Tool Performance, Andrew M Fine, Todd W Lyons, Yasmin Maor, Ami Neuberger, Daniel G Ostermayer, Sharona Paz, Oded Scheuerman, Shachaf Shiber, Victoria A Statler, Michal Stein, Renata Yakubov, Shirly Yanai, Roy Navon, Lior Kellerman, Tanya M Gottlieb, Eran Eden

Faculty, Staff and Student Publications

Background: Diagnostic test evaluation requires a reference standard. We describe an approach for creating a reference standard for acute infection using unrestricted adjudication and apply it to compare biomarker tools.

Methods: Adults and children with suspected acute infection enrolled in three prospective studies at emergency departments and urgent cares were included. Adjudicators, blinded to C-reactive protein, procalcitonin, and MeMed BV (MMBV), labeled each case (bacterial/viral/non-infectious/indeterminate). Initial adjudication involved 3 adjudicators. Reference standard cohorts were defined: Microbiologically confirmed (3/3 adjudicators concur with high confidence and a concordant microbiological finding), unanimous (3/3 adjudicators concur with high confidence), suspected (3/3 adjudicators concur with …

The Effects Of Prescribed Medications On Depressive Symptoms And Neurocognitive Performance In People With Hiv, Asante R Kamkwalala, Avery Matthews, Ankita Garg, Upal Roy, Qing Ma, Erin Sundermann, Patricia K Riggs, Mattia Trunfio, Jennifer Blanchard, David J Moore, Leah H Rubin, Scott L Letendre

Faculty, Staff and Student Publications

Background: Alterations in brain function and structure, such as depression and neurocognitive impairment, continue to occur in people with human immunodeficiency virus (HIV, PWH) taking suppressive antiretroviral therapy (ART). The lifespan of PWH has improved but the healthspan remains worse than people without HIV, in part because of aging-related diseases. As a result, polypharmacy is common and increases the risk of drug-drug interactions and adverse reactions.

Methods: This cross-sectional project investigated the relationship between 7 medication-related metrics (including anticholinergic burden), depressive symptoms, and neurocognitive performance in 491 PWH at a single center in the United States. All participants were taking …

Bibliometric Analysis Of Research Trends Related To Human Immunodeficiency Virus., Madyson E. Johnson, Kaitlyn R. Coffman, Valerie Rivas, Elizabeth Barrett

ATU Scholars Symposium

Human immunodeficiency virus poses major health burden across the globe including the United States of America and has its zoonotic origin from the Simian Immunodeficiency viruses of sooty mangabey monkey and chimpanzee in Africa. Epidemiological trends indicate that even though the mortality rates for HIV are falling globally, the rates of new cases have been rising since 2010 in several countries including the USA. An estimated 0.5% of the human population is currently infected with the virus with countries like USA, India, Nigeria and South Africa carrying the highest burden of the disease. Host receptors such as CD4 and coreceptors …

A Bivalent Self-Amplifying Rna Vaccine Against Yellow Fever And Zika Viruses, Peter Battisti, Matthew R. Ykema, Darshan N. Kasal, Madeleine F. Jennewein, Samuel Beaver, Abbie E. Weight, Derek Hanson, Jasneet Singh, Julie Bakken, Noah Cross, Pauline Fusco, Jacob Archer, Sierra Reed, Alana Gerhardt, Justin G. Julander, Corey Casper, Emily A. Voigt

Animal, Dairy, and Veterinary Science Student Research

Introduction: Yellow fever (YFV) and Zika (ZIKV) viruses cause significant morbidity and mortality, despite the existence of an approved YFV vaccine and the development of multiple ZIKV vaccine candidates to date. New technologies may improve access to vaccines against these pathogens. We previously described a nanostructured lipid carrier (NLC)-delivered self-amplifying RNA (saRNA) vaccine platform with excellent thermostability and immunogenicity, appropriate for prevention of tropical infectious diseases.

Methods: YFV and ZIKV prM-E antigen-expressing saRNA constructs were created using a TC-83 strain Venezuelan equine encephalitis virus-based replicon and complexed with NLC by simple mixing. Monovalent and bivalent vaccine formulations were injected intramuscularly …

An Intranasally Administered Igm Protects Against Antigenically Distinct Subtypes Of Influenza A Viruses, Hailong Guo, William R Strohl, Yan Xu, Haijuan Du, Tongqing Zhou, Ningyan Zhang, Kai Xu, Xinli Liu, Tong-Ming Fu, Zhiqiang An

Faculty, Staff and Student Publications

Engineering broadly neutralizing monoclonal antibodies (mAbs) targeting the hemagglutinin (HA) of Influenza A virus (IAV) is a promising approach for intervention of seasonal flu. However, HA plasticity often leads to resistant strains that compromise mAb potency as bivalent IgGs. Here we hypothesize that multimerization of anti-IAV antibodies as IgMs can enhance coverage and neutralization potency. Here, we construct 18 IgM antibodies from known broadly neutralizing IgGs targeting different IAV HA epitopes and evaluate their breadth and potency of neutralization against distinct H1N1 and H3N2 IAVs. The IgM version of receptor binding site-specific IgG F045-092 shows increased breadth and antiviral potency …

The Attitudes And Perspectives Of Laboratory Professionals On The Use Of Machine Learning Combined With Maldi For Viral Identification: A Qualitative Study, Grace Johnson

Honors Projects

The use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) with machine learning (ML) has been proposed by numerous studies as a novel approach for viral identification. However, the development and implementation of this instrumentation is still in its early stages, and laboratory professionals' perspectives on its feasibility, accuracy, implementation, and effect on current laboratory operating procedures remain underexplored.

This study aimed to investigate laboratory professionals’ attitudes and opinions regarding the use of MALDI-TOF-MS coupled with machine learning for viral identification, focusing on perceived benefits, barriers, and factors that would affect participants’ opinions on implementation.

A qualitative descriptive research …

The Dialogue Dilemma: The Role Of Patient-Clinician Communication For Low-Income People Who Smoke And Manage Multiple Conditions, Monique T. Cano, Michael R. Lindstrom, Ricardo F. Muñoz

School of Mathematical & Statistical Sciences Faculty Publications

Introduction: Adults from low-income backgrounds who smoke face significant health disparities related to tobacco use, often at disproportionately high rates. These individuals are more likely to endure multiple mental and physical (MP) health conditions, which can negatively influence their self-rated health (SRH). The quality and effectiveness of patient-clinician communication (PCC) can influence how patients perceive their own health. Understanding how PCC influences SRH among low-income adults who smoke and suffer from multiple MP conditions is essential for clinical care as multimorbidity is on the rise. This study examines how PCC may influence the health perceptions of low-income adults who smoke …

The Impact Of Epac2-Associated Junction Plakoglobin On Respiratory Syncytial Virus Infection, Devang Deepak, Kashish Khatkar, Jong Min Choi, Ke Zhang, Sung Yun Jung, Tian Wang, Wenzhe Wu, Xiaoyong Bao

Faculty, Staff and Students Publications

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants, young children, and immunocompromised individuals. Currently, FDA-approved monoclonal antibody therapies are limited to infants and young children with severe RSV disease. As a result, there is an urgent need for comprehensive studies of RSV pathogenesis to support the development of new therapeutic strategies. Exchange proteins directly activated by cAMP (EPAC) have recently emerged as key regulators in various viral infections. Our previous work identified EPAC isoform 2 (EPAC2) as a critical factor in RSV replication and host innate immune responses. However, …

Low Serum Alkaline Phosphatase Concentrations At Hospital Admission As Markers For Severe Pediatric Sars-Cov-2-Related Acute Illnesses, Sneha Jayadeep, Julie A. George, Bishara J. Freij

Conference Presentation Abstracts

Background: Alkaline phosphatase (ALP) is composed of several isoenzymes. The measured serum (total) ALP is mostly of bone and liver origin. ALP activity changes with growth and puberty, and its level is affected by age and sex. Abnormal ALP levels have been noted in COVID19 patients but its use as a marker of severity has not been assessed to our knowledge.

Objective: Assess if low serum ALP is a marker of disease severity in acute Pediatric SARS-CoV-2-related illnesses.

Design/Methods: Retrospective observational study of children 0-18 years of age hospitalized at Beaumont Children’s Hospital from 3/1/2020-3/31/2022 with positive PCR for SARS-CoV-2 …

Optimization Of Reaction Conditions For Synthesizing Kasa-Targeting Drug Candidates For Tuberculosis Treatment, Megan A. Baxter

Research and Creativity Symposium

Tuberculosis (TB) remains a global health challenge, with increasing drug resistance pressing for the development of novel treatments. KasA, a key enzyme in mycobacterial fatty acid biosynthesis, is a promising drug target for TB treatment. This research focuses on the design and synthesis of potential KasA inhibitors, specifically optimizing reaction conditions to efficiently produce 1-methyl-6-aminoindazole. This molecule is an intermediate in the synthesis of drugs targeting TB. Characterization of synthesized compounds is performed using NMR, mass spectrometry, and gas chromatography to confirm structure and purity. The first step involved optimizing the solvent and base for the methylation of nitroindazole. We …

Factors Associated With Quality Of Intrapartum Care In Kenya: A Complex Samples Analysis Of The 2022 Kenya Demographic And Health Survey, Lilian Nuwabaine, Earnest Amwiine, Quraish Sserwanja, Joseph Kawuki, Mathius Amperiize, Angella Namulema, Ahmed Sarki, John Baptist Asiimwe

School of Nursing & Midwifery, East Africa

Background

The provision of quality intrapartum care increases women’s utilization of skilled birth attendants in health facilities and improves maternal and newborn health. This study aimed to investigate the factors associated with the quality of intrapartum care using the 2022 Kenya Demographic and Health Survey (KDHS).

Methods

Secondary data from the 2022 KDHS of 11,863 participants, who were selected by multistage stratified sampling, was used. Based on literature and the availability of indicators within the 2022 KDHS, the quality of intrapartum care was operationalized as receiving all the three clinical components of intrapartum care including a mother having a facility-based …

Reducing Antibiotic Duration For Pneumonia And Sinusitis In The Emergency Department: A Quality Improvement Approach, Joshua Saucedo, Leslie Hueschen, Amanda Nedved, Marsha Dannenburg, Patricia Phillips, Jennifer Floyd, Alaina N. Burns, Rana El Feghaly

Presentations

Background: Limiting antibiotic duration is one of the pillars of antimicrobial stewardship programs (ASP) as it reduces unnecessary antibiotic exposure. In our emergency department (ED), >90% of respiratory infections are treated with first-line guideline-recommended antibiotics; however, duration continues to be prolonged especially for community acquired pneumonia (CAP) and acute bacterial rhinosinusitis (ABRS). Institutional guidance recommends shortening antibiotic durations to 3-5 days for CAP and 5-7 days for ABRS, however only 13% of discharged ED patients receive the recommended duration. Objective: Our aim is to increase the percentage of children discharged home from the ED with a diagnosis of CAP or …

Spectrum Of Congenital Anomalies Detected Through Anatomy Ultrasound At A Referral Hospital In Ghana, Alim Swarray-Deen, Morgan Yapundich, Sarah Boudova, Kwaku Doffour-Dapaah, Jeff Osei-Agyapong, Perez Sepenu, Alex K. Boateng, Teresa A. Mensah, Patrick Anum, Nana Essuman Oduro, Theophilus Adu-Bredu, Promise E. Sefogah, Jerry Coleman, Samuel A. Oppong

Department of Obstetrics and Gynecology Faculty Papers

BACKGROUND: Africa has a high burden of congenital anomalies due in part to limited preconception care, infections, and environmental exposures. However, the true prevalence of congenital anomalies is unclear because of insufficient access to prenatal diagnostic services. We aimed to determine the rate of congenital anomalies, and characterize the anomalies detected prenatally at a referral hospital in Ghana.

METHODS: We performed a four-year retrospective review of all fetal anomaly ultrasounds performed and congenital anomalies detected from January 1st, 2020, to December 31st, 2023, at Korle Bu Teaching Hospital, Accra, Ghana. Data were extracted from the electronic database on maternal age, …

Evaluating The Causal Effect Of Receiving Transthoracic Echocardiography On 28-Day Mortality In Mimic-Iii Intensive Care Unit Patients With Sepsis, Monserrath Velez, Jack O'Connor, Nicholas Della Pesca, Rio Baliga

Research & Creative Achievement Day

❏ Sepsis (an infection associated with vital organ dysfunction) is an emergent

medical condition estimated to occur in about 30% of intensive care unit

(ICU) patients[1] and is responsible for 20% of all deaths worldwide[2]

❏ Transthoracic echocardiography (TTE; an imaging modality that uses

ultrasound technology to record heart structure and function) is widely used in

medical treatment [3]

❏ 28-day mortality (whether or not a patient dies within 28 days after receiving a

treatment) is a measure considered to closely approximate ICU mortality[4]

Objectives

❏ Assess and quantify the causal effect of receiving a TTE on …

Investigating Genetic Regulators Of Crystal Cell Development In Drosophila Melanogaster, Andrea Feria, Nyla Walbrook, Anisa Turaeva, Rebecca Spokony

Publications and Research

Crystal cells, a subset of Drosophila melanogaster hemocytes, are important for melanization, a crucial immune response. While the genetic regulation of crystal cell develop remains incompletely understood, this study investigates the functions of five candidate genes: ACXB, ACXA, Gp210, CG4390, and Cyp4s3; identidied through previous genome-wide association studies. Using the Gal4/UAS system along with RNA interference (RNAi), we exclusively knocked down each gene in third instar larvae and quantified crystal cell populations following heat shock-induced melanization. Our results imply that the knockdown of ACXB and ACXA significantly increased crystal cell counts in both sexes, suggesting these genes either act as …

Use Of Procalcitonin In Therapeutic Decisions In The Pediatric Intensive Care Unit, Pierre Tissières, Elisabeth Esteban Torné, Johannes Hübner, Adrienne Randolph, Corsino Rey Galán, Scott Weiss

Department of Medicine Faculty Papers

Procalcitonin (PCT) is frequently used by clinicians in children with suspected bacterial infections and sepsis. However interpretation in the critically ill child may be challenging due to the complexity of underlying conditions and its impact on PCT values. Herein, we propose a guidance for the use of procalcitonin in critically ill children, supported by a comprehensive analysis of the literature, to help the clinician for interpreting PCT in the various clinical conditions encountered in pediatric intensive care units. We describe the importance of the clinical context, timing of measurement and evidence on PCT values in diagnosing sepsis and to guide …

Intervention To Increase Uptake Of Cervical Screening In Norfolk City, Frederick Kankam Adu

Graduate Student Government Association Research Conference

The Objective is to determine the impact free screening and education to females between the ages 21 to 64 years, or under 21 years who are sexually active and unvaccinated against HPV virus have on uptake of cervical screening. In this study we use Before and After study design. The Outcomes for cervical screening are categorized as negative, atypical squamous cells undetermined significance( ASCUS), low-grade squamous intraepithelial lesion( LGSIL), high-grade squamous intraepithelial lesion(HGSIL), unsatisfactory samples, and HPV positive. Colposcopy will be performed if abnormal pap-smear is found. And outcomes of colposcopies, after abnormal Pap tests will be classified as negative( …

Bridging The Gap Between Knowledge And Practices Pertaining To Naloxone Use: A Single-Institution Experience In North Carolina, Michael S. Argenyi, Gisele Bailey, Christopher J. Mclouth, Erin Barnes, Candice J. Mcneil

Journal of Patient-Centered Research and Reviews

Naloxone is a life-saving medication for opioid overdose, which claims many lives annually. This study investigated provider attitudes about, beliefs about, and barriers to naloxone use to inform an increase in provider prescription of naloxone. The survey took place at a large Southern tertiary health center. An adapted REDCap survey utilizing validated questions was distributed via institutional e-mail listservs. The results (N = 181) were analyzed using descriptive and chi-square statistics. While 90.9% of the providers had heard of the strategy of prescribing naloxone to prevent overdose, only 72.1% of providers would have considered prescribing naloxone. Providers reported implementing treatment …

Sars-Cov-2 N Protein And Anti-Spike Serologies: Insights Into Covid-19 Disease Severity And Mortality-A Secondary Analysis Of The Activ-1 Trial, Alfredo J Mena Lora, Kimi Enders, Huimin Wu, Luis Parra-Rodriguez, Christopher Palma, Katy Saliba, Sylvain Laverdurre, P Brian Smith, Kevin J Anstrom, Samuel A Bozzette, William G Powderly

2020-Current year OA Pubs

BACKGROUND: Understanding factors that predict progression to severe COVID-19 is critical. Antibodies targeting SARS-CoV-2 spike protein confer protection, while the N protein of SARS-CoV-2 plays roles in viral replication and immune dysfunction. This study explores the significance of N protein and anti-spike antibodies on disease severity, progression, and mortality.

OBJECTIVES: To evaluate the relationship between SARS-CoV-2 N protein and anti-spike antibody levels with disease severity, clinical outcomes, and mortality in hospitalized patients with COVID-19.

DESIGN: A secondary analysis of serologic data from participants in the ACTIV-1 randomized clinical trial, which evaluated immunomodulators for the treatment of hospitalized patients with COVID-19. …

The Havcr1-Centric Host Factor Network Drives Zika Virus Vertical Transmission, Wenzhe Yu, Jun Tao, Hongmin Cao, Wanshan Zheng, Beiang Zhang, Yue Zhang, Peiqun Xu, Yiwei Zhang, Xuan Liu, Yinan Wang, Han Cai, Gang Liu, Fan Liu, Haibin Wang, Haiyan Zhao, Indira U Mysorekar, Xiaoqian Hu, Bin Cao

Center on Aging Staff Publications

Zika virus (ZIKV) vertical transmission results in devastating congenital malformations and pregnancy complications; however, the specific receptor and host factors facilitating ZIKV maternal-fetal transmission remain elusive. Here, we employ a genome-wide CRISPR screening and identify multiple placenta-intrinsic factors modulating ZIKV infection. Our study unveils that hepatitis A virus cellular receptor 1 (HAVCR1) serves as a primary receptor governing ZIKV entry in placental trophoblasts. The GATA3-HAVCR1 axis regulates heterogeneous cell tropism in the placenta. Notably, placenta-specific Havcr1 deletion in mice significantly impairs ZIKV transplacental transmission and associated adverse pregnancy outcomes. Mechanistically, the immunoglobulin variable-like domain of HAVCR1 binds to ZIKV via …

Parapneumonic Empyema Complicating Community-Acquired Pneumonia: Etiology In The Era Of Pneumococcal Vaccination And Role Of Molecular Diagnosis, Bradford D Gessner, Anne J Blaschke, Kristina G Hulten, Delma J Nieves, Ashley Miller, Cody Bender, Raul Isturiz, Ronika Alexander, Shannon M Nielsen, Linda B Lamberth, Alejandro Cane, Adriano Arguedas

Faculty, Staff and Students Publications

Background: Impact of pneumococcal conjugate vaccines (PCVs) on pneumococcal disease is well described; pneumococcus is infrequently identified by culture in pneumonia. Yield is higher when pleural fluid is cultured. Polymerase chain reaction (PCR) in pleural fluid samples improves pathogen identification, particularly in the case of S. pneumoniae.

Methods: Healthy children with empyema who underwent pleural fluid drainage were eligible. Demographics and PCV immunization status were collected. Blood/pleural fluid cultures were obtained. Pleural fluid samples were sent for PCR for pathogen. Serotyping was done by Neufeld-Quellung reaction on pneumococcus isolates, and PCR in culture negative cases.

Results: From December 2018 to …

Air Temperature And Gastroenteritis Among Rohingya Populations In Bangladesh Refugee Camps, Takuya Takata, Xerxes Seposo, Nasif Hossain, Kayo Ueda

Ateneo School of Medicine and Public Health Publications

Importance

The Rohingya displaced population in Bangladesh is the largest stateless population in the world. Infectious diseases, such as gastroenteritis, respiratory infections, and fever, are among the major health problems the Rohingya population has faced. Although associations between gastroenteritis and air temperature have been reported in various regions, no study has yet been carried out among the displaced populations.

Objectives

To evaluate the association between air temperature and risk of gastroenteritis among the forcibly displaced Rohingya population in refugee camps in Bangladesh.

Design, Setting, and Participants

In this cross-sectional study, daily time series data derived from facility-based case reports were …

2025 North Texas Gme Research Forum Program, Hca Healthcare

North Texas Research Forum 2025

No abstract provided.

Enriched Pathways In Gut Microbiome Predict Response To Immune Checkpoint Inhibitor Treatment Across Demographic Regions And Various Cancer Types, Xunhui Cai, Jennifer Y Cho, Lijun Chen, Yufeng Liu, Fenghu Ji, Siyi Ge, Hui Yu, Jianbo Shao, P Andrew Futreal, Boris Sepesi, Don Gibbons, Yaobing Chen, Guoping Wang, Chao Cheng, Meng Wu, Jianjun Zhang, Ansel Hsiao, Tian Xia

Faculty, Staff and Student Publications

Understanding the effect of gut microbiota function on immune checkpoint inhibitor (ICI) responses is urgently needed. Here, we integrated 821 fecal metagenomes from 12 datasets to identify differentially abundant genes and construct random forest models to predict ICI response. Gene markers demonstrated excellent predictive performance, with an average area under the curve (AUC) of 0.810. Pathway analyses revealed that quorum sensing (QS), ABC transporters, flagellar assembly, and amino acid biosynthesis pathways were enriched between responders (R) and non-responders (NRs) across 12 datasets. Furthermore,