Digital Commons Network^™

Soft Tissue Mobilization Versus Hold-Relax Stretching On Wrist Extensor Tendon Stiffness In Tennis Players, Brendan Burck, Adina Taylor, Cody Pohlman, Andrew Traven, Harold Merriman, Joseph Day

University of Dayton Doctor of Physical Therapy Annual Research Symposium

No abstract provided.

Genetic Analysis Of The X-Linked Adrenoleukodystrophy Gene Abcd1 In Drosophila Uncovers A Conserved Phenotype, Joshua Manor, Sharayu V Jangam, Hyung-Lok Chung, Pranjali Bhagwat, Jonathan C Andrews, Hillary Chester, Shu Kondo, Saurabh Srivastav, Juan Botas, Ann B Moser, Suzette M Huguenin, Michael F Wangler

Duncan NRI Faculty and Staff Publications

X-linked adrenoleukodystrophy (X-ALD) is a progressive neurodegenerative disorder caused by a loss-of-function (LOF) mutation in the ATP-binding cassette subfamily D member 1 (ABCD1) gene, leading to the accumulation of very long-chain fatty acids (VLCFAs). This disorder exhibits striking heterogeneity; some male patients develop an early childhood neuroinflammatory demyelination disorder, while other patients, including adult males and most affected female carriers, experience a chronic progressive myelopathy. Adrenocortical failure is observed in almost all male patients, with the age of onset varying, sometimes being the first diagnostic finding. The gene underlying this spectrum of disease encodes an ATP-binding cassette (ABC) transporter that …

Pharmacogenomic-Guided Prescribing And Polypharmacy Across Age Groups In Obsessive-Compulsive Disorder: A Retrospective Study, Sheldon R Garrison, Matthew W Boyer, Anthony W Zoghbi, Rachel A Schwartz, Nicolette Weisensel, Martin E Franklin, Madeline M Hartig, Maharaj Singh, Sreya Vadapalli

Faculty, Staff and Students Publications

Background: This study evaluated medication utilization in children, adolescents, and adults with obsessive-compulsive disorder (OCD), a chronic psychiatric condition characterized by intrusive thoughts and repetitive behaviors. Although first-line treatments include selective serotonin reuptake inhibitors (SSRIs) and cognitive behavioral therapy (CBT), the heterogeneous biological underpinnings contribute to suboptimal outcomes, with 40-60% of individuals not responding to SSRIs. This complex phenotype often leads to psychotropic polypharmacy, which may be mitigated by incorporating combinatorial pharmacogenomic (PGx) testing into protocol-based care to identify potential gene-drug interactions.

Methods: A retrospective review was conducted of individuals with OCD aged 8 to 65 years who received either …

Targeted Skin Cancer Education Improves Agricultural Workers' Safe Sun Practices And Knowledge In South Dakota: A Farm Show Survey, Leah Naasz, Kianna Thelen, Candace Zeigler

Scholarship Pathways Program

Targeted Skin Cancer Education Improves Agricultural Workers' Safe Sun Practices and Knowledge in South Dakota: A Farm Show Survey

Leah Naasz, MD | Candace Zeigler, MD

Background: Agricultural workers are at increased risk for skin cancer due to prolonged ultraviolet (UV) exposure, yet many underutilize sun protection. Brief, community-based educational interventions may improve knowledge and preventive behaviors.

Objective: To provide a targeted skin cancer educational session to increase awareness and promote sun protection behaviors among agricultural workers in South Dakota.

Methods: Twenty agricultural workers attending the Vermillion and Sioux Falls Farm Shows participated in a pre- and post-educational survey. Inclusion …

Program Development And Implementation Of A Sensory-Based Self Regulation Curriculum For Adults With Down Syndrome At Gigi’S Playhouse, Grace Blair

OTD Capstone Projects

This doctoral capstone project was completed through partnership with Gigi’s Playhouse Nashville, a non-profit organization offering free programming and services to individuals of all ages with Down syndrome and their families. The goal of this project was to develop and implement an educational curriculum for adult education programs focused on daily life skills, money management, physical health, self confidence, and a variety of other topics. A secondary focus of this project was to support sensory regulation in individuals with Down syndrome to promote overall health and participation. The results were physical and digital materials to be used for future adult …

Patient Reported Outcome Measure Use In Heart Transplant Care, Nichole Côté

Doctoral Projects

Despite growing evidence supporting Patient-Reported Outcome Measures (PROMs) in chronic disease management, no consistent application exists within the international heart transplant community. This Doctor of Nursing Practice project implemented the Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) as a PROM within the a large volume heart transplant clinic, evaluating workflow feasibility, the association between Overall Summary Scores (OSS) and visit length, and clinician perceptions of PROM use. The KCCQ-12 was administered via a mobile health application with automated distribution. Workflow integration was assessed by calculating the percentage of scheduled visits with completed PROM documentation. Visit length was measured using electronic medical record …

Examining The Rural Workforce: Comparing Admissions Strategies And Training Pathways In U.S. Medical And Dental Education, Charolyn A. Harris

Honors Theses

Access to healthcare in rural and underserved communities remains a significant challenge in the United States, particularly in dental care, where workforce shortages are more pronounced. This study examines how medical and dental education programs develop rural healthcare providers, focusing on admissions strategies and training pathways. Using a structured scoping review and secondary data analysis, this research compares how each field incorporates known predictors of rural practice, such as rural background and training experiences, into workforce pipeline development. Findings indicate that while both medical and dental education recognize rural background as a strong predictor of rural practice, medical education more …

Neuroprotective Effects Of Estradiol And Genistein And Interactions With Aromatase Inhibitions Post Cerebellar Lesion In Male Zebra Finches, Grace E. Thompson, Anthony P. Irovic

Honors Theses

Across vertebrates, peripheral and brain-derived estradiol (E₂) promotes neuroplasticity. After injury, E₂ can be derived locally from testosterone via aromatase (AROM), an enzyme that is upregulated in glia at the site of neural injury. E₂disrupts testicular function and elevates cancer and stroke risk, primarily via binding to estrogen receptor alpha (ER α). Genistein (GEN), a phytoestrogen, is similar to E₂ but binds preferentially to estrogen receptor beta (ER β). It may offer neuroprotection without adverse effects of E₂. We used adult male zebra finches (ZF) to model neuroprotective effects of E_{2 …}

A Transgenerational Analysis Of Factors Influencing Fertility Among Jamaican Men, Shanique Deniellia Essuman

Walden Dissertations and Doctoral Studies

No abstract provided.

Staff Education On The Phq-9 Tool And Its Use, Claudine Agwi Mbah

Walden Dissertations and Doctoral Studies

No abstract provided.

I Am God's Masterpiece: Ministry For Adults With Idd, Kerrigan J. Creech

Occupational Therapy Doctorate Capstone Posters

Executive Summary 

My capstone Accreditation Council for Occupational Therapy Education (ACOTE) focus area included program development, with additional focus on education, advocacy, and leadership. For my Applied Leadership Experience (ALE), I worked with three other occupational therapy graduate students to develop and implement an inclusive Vacation Bible School (VBS) for adults with disabilities at Parkway Ministries. The purpose and overall goal of the project was to increase opportunities for adults with disabilities to participate in an inclusive Vacation Bible School through individualized supports and activity adaptations.

A needs assessment and SWOT analysis were completed and revealed that adults with disabilities …

Systemic Α₂-Agonist Use And Lower Hazard Of Glaucoma Compared With Β-Blockers: A Cohort Study, Ibrahim Abboud, Amin Z. Khudari, Abdelaziz Abdelaal, Amr Almobayed, Subhi J. Al'aref, Jonathan S. Myers, Richard K. Lee, Abdelrahman M. Elhusseiny

Wills Eye Hospital Papers

OBJECTIVE: Systemic antihypertensive medications may influence glaucoma-related outcomes through intraocular pressure-dependent and vascular mechanisms. While topical α₂-agonists are established glaucoma therapies, the association between systemic α₂-agonists and glaucoma hazard remains unexamined; we compared their hazard with systemic β-blockers in adults with hypertension.

METHODS AND ANALYSIS: We conducted a multicentre retrospective cohort study using deidentified electronic health records. Adults aged ≥40 years with hypertension and chronic exposure to systemic α₂-agonists or β-blockers were included. Patients with pre-existing ocular hypertension (OHT), primary open-angle glaucoma (POAG), concomitant comparator use, or inadequate ophthalmic follow-up were excluded. We balanced cohorts using propensity score matching (PSM) …

Measuring Effectiveness Of A Mobility Aide On A Medical-Surgical Unit, Jamie L. Granatowicz, Laura N. Rogers, Leeza A. Struwe

Doctor of Nursing Practice Projects: College of Nursing

Purpose: To evaluate the effectiveness of a mobility aide on a medical-surgical inpatient unit to improve patients’ surgical outcomes, decrease hospital length of stay, and decrease the number of falls.

Design: A retrospective review was conducted to determine the effects of a mobility aide implemented on a medical-surgical unit. The intent was to ensure the utilization of the Enhanced Recovery After Surgery (ERAS) protocol for early mobilization before and after implementation. Two-month periods were analyzed before and after implementation.

Findings: The results demonstrated clinical significance for patients when implementing a mobility aide. The mean length of stay was 1.044 days …

Reducing Emergency Department Overuse Through Patient Education, Maddie Pieper, Joshua Heuertz

Doctor of Nursing Practice Projects: College of Nursing

Background/Introduction

Emergency departments (EDs) are designed to provide rapid evaluation and management of acute, life-threatening, and time-sensitive conditions. However, EDs are frequently used for nonemergent or low-acuity concerns that could be managed in primary care or urgent care settings. This overuse contributes to rising healthcare costs, resource strain, longer wait times, and overcrowding. Underserved populations may rely more heavily on ED services because of barriers such as limited primary care access, language differences, low health literacy, restrictive work schedules, transportation challenges, and difficulty navigating the healthcare system. These factors can make the ED seem the most accessible source of care. …

Colorectal Cancer Screening: Implementation And Evaluation Of A Screening Algorithm In A Rural Family Practice Clinic, Mollie M. Tate, Whitney Dubas

Doctor of Nursing Practice Projects: College of Nursing

Background: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in the United States and disproportionately affects rural populations. Although more than 90% of cases occur in adults older than 50 years, increasing incidence among younger adults prompted an update to national guidelines recommending screening beginning at age 45. Rural residents face multiple barriers to colorectal cancer screening (CRCS), including limited access to care, transportation challenges, lack of insurance, and absence of standardized screening processes in primary care. These barriers contribute to lower screening rates, delayed diagnosis, and poorer outcomes. Evidence demonstrates that CRCS reduces CRC morbidity and …

Rational Design And Efficacy Evaluation Of A Novel Solid Dispersion-Based Bempedoic Acid–Ezetimibe Fixed-Dose Combination Tablet Versus Nexlizet®, Mohamed A. Heikal, Wael Ali, Mahmoud A. Mahdy, Eman Gomaa

Nanotechnology Research Centre

Background/Objectives: For hyperlipidemic patients with statin resistance, a fixed-dose combination of a non-statin drug such as ezetimibe (EZT) and bempedoic acid (BA) provides a significant benefit. Although both drugs exhibit poor aqueous solubility, the oral bioavailability of EZT is more critically limited by dissolution, whereas BA maintains adequate absorption due to its high intestinal permeability. With regard to the reference product, Nexlizet® (180/10 mg), our study focused on developing a novel tablet with superior in vitro performance without incorporating sodium lauryl sulfate (SLS), as it may potentially alter BA absorption. Methods: The solid dispersion technique (co-precipitation) was applied using the …

Determining The Relatedness Of Simian Varicella Virus Strains Using Polymerase Chain Reactions And Delta Herpesvirus-Dervied Primers, Ellyn M. Waits

Honors Theses

This study examines genetic variation among strains of Simian Varicella Virus (SVV) using genomic analysis. The primary goal of this experiment was to observe potential genomic differences among the Liverpool vervet virus (LVV), the Tsukuba herpesvirus, and the Delta herpesvirus (DHV) strains using primer sets developed from the fully sequenced DHV strain. SVV strains were initially cultivated in Vero cell cultures to begin viral propagation. Viral proliferation in these cell cultures enables DNA isolation via standard purification methods. The extracted viral DNA is subjected to polymerase chain reaction (PCR) amplification targeting specific regions of open reading frames (ORFs) in the …

Tale Of Two Pharmacies, Katie R. Jadin

Honors Theses

Community pharmacists are among the most accessible healthcare providers in the United States and play an increasingly important role in improving patient outcomes. This study observes whether geographical distance and demographic differences influence patient healthcare needs within community pharmacy settings. Communities in Wisconsin and Mississippi, approximately 800 miles apart, were compared due to differences in population demographics, socioeconomic factors, and disease burden.

A survey was distributed to community pharmacy employees, including pharmacists, pharmacy interns, and pharmacy technicians, to assess common disease states, medication patterns, pharmacy workload, and patients' barriers to care. Twelve responses were collected from pharmacy employees.

Despite the …

The Impact Of Hearts For The Homeless On Students At The University Of Mississippi, Ellie Menszer

Honors Theses

Hearts for Homeless (H4H) is an international organization that works to help one of the most vulnerable populations for cardiac disease, the homeless, due to the lack of access to health care and information. At the University of Mississippi, H4H is a registered student organization that volunteers weekly at the Oxford Community Market (OXCM) to provide free blood pressure screenings and heart health information. H4H helps the community while also providing students with hands-on patient care experience. The goal of this research is to determine how volunteering with H4H impacts students at the University of Mississippi. A literature review informed …

Synthesis Of Novel Tetrafluorinated Alcohols Through The Dimerization Of Difluoromethyl Ketones For Use In Drug Development, Abigail A. Ryan

Honors Theses

As the most electronegative element, fluorine has unique applications and properties. The carbon-fluorine bond is known to be one of the strongest bonds in organic chemistry. As a result of fluorine’s high C–F bond strength, fluorine chemistry has become an interdisciplinary field of chemistry, pharmacy, physics, geology, and ecology. In pharmaceuticals for example, current estimates indicate that about 15–20% of FDA approved small-molecule drugs include at least one fluorine atom. The incorporation of fluorine atoms into organic molecules has become a powerful strategy in modern drug development, as fluorination can enhance metabolic stability, lipophilicity, and biological activity. Despite these advantages, …

Illness Perception, Depression, And Anxiety Among Middle-Aged Adults With End-Stage Chronic Kidney Disease, Zioleyda Soto

Walden Dissertations and Doctoral Studies

No abstract provided.

Staff Education To Improve Gad-7 Screening For Generalized Anxiety Disorder In Outpatient Behavioral Health Settings, Senami Olubunmi Edalere-Lukula

Walden Dissertations and Doctoral Studies

No abstract provided.

Staff Education To Improve Fall Prevention In A Behavioral-Health Urgent Care Setting, May Nnenna Akalemeaku

Walden Dissertations and Doctoral Studies

No abstract provided.

Kern National Network At Ouwb: Helping Medical Student Ideas Come To Life While Promoting Student Wellness And Academic Success, Shivapriya Chandu, Ahmad Abu-Mahfouz, Rohit Ray, Riya Chhabra, Berkley Browne-Holtz

Posters

Poster Winner - Medical students experience evolving stressors and wellness needs throughout training. From preclinical coursework to board preparation and clinical rotations, priorities may shift over time. This project addresses the following research question: How can we effectively improve student wellness initiatives through student engagement during the M1- M3 medical school years?

The Cadaver As The First Patient: Early Integration Of Pathology In The Preclinical Anatomy Laboratory, Sruthi Shriram, Lauren Desantis, Tulika Singhal, Kevin Ta, Courtney Shields, Muhammad Jawwad Arshad, Varna Taranikanti, Madison Konja

Posters

No abstract provided.

Optimizing Patient-Facing Ai Chatbot Questions To Improve Readability And Actionability In Anesthesia Education, Sarah Kadado, Bianca Elias, Roy Soto

Posters

In anesthesia, high patient anxiety and limited counseling time increase the need for clear, usable information. Artificial intelligence (AI) chatbots (e.g., ChatGPT) are increasingly used for patient anesthesia education. Many AI-generated responses exceed the recommended 6th-8th grade reading level for patient education information. Responses also often lack actionable guidance for patients. This study quantifies how optimizing patient-facing prompts improves readability, understandability, and actionability.

Implementation Of Self-Directed Learning In Preclinical Respiratory Course, Tai Metzger, Kaycee L. Fillmore, Inaya Hajj-Hussein, Dwayne Baxa, Kyeorda Kemp, Virginia Uhley, Claudio Cortes

Posters

Self-directed learning (SDL) is essential to incorporate into the medical curriculum to develop lifelong learning skills. The Liaison Committee on Medical Education (LCME) defines four specific components of SDL that must be incorporated into medical education. We created an team-based SDL activity and evaluated whether this format aligned with the SDL components defined by the LCME, using students’ evaluations and reflections.

Perceptions Of Radiology Residency Staffing Models Across Years Of Training, Alex Zhang, Alexander Swantek, Adela Pouzar, Sayf Al-Katib

Posters

Case staffing is the primary method by which radiology residencies teach at the workstation. Despite this, the styles and methods for how staffing is performed have not yet been comprehensively described. Understanding these models and evaluating resident perspectives can inform best practices and enhance radiology education.

Do Preclinical Assessment Strategies Matter? Nbme Usage And Student Outcomes Across U.S. Medical Schools, Reem Fawaz, Aaryan Patel, David Thomas

Posters

Preclinical assessment strategies vary widely across U.S. medical schools. Limited data exist on how these strategies relate to student success outcomes. Our study examines whether exam usage patterns are associated with Step 1 performance, Step 2 performance, and overall match rate.

Equitable Exposure, Unequal Outcomes Summative Performance Following Clinical Integration Anatomy Laboratories, Christopher Ramus, Stefanie Attardi

Posters

Cadaver-based anatomy education remains essential but faces high content demands, limited physical and personnel resources, and a continually condensed timeline. These challenges necessitate efficient instructional efficient instructional strategies. Pedagogical research supports active learning strategies for better retention, engagement, and application.