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Does Probiotic Supplementation Improve Depression/Anxiety Outcome Measures?, Kathryn M. Decleene

Theses and Graduate Projects

Background: Depression and anxiety continue to be a healthcare burden worldwide. Current depression and anxiety treatments include medications and psychotherapy; however, for many patients this is not enough. Literature has recently come out detailing the gut-brain axis and its potential impact on mental health.

Purpose: This literature review sought to answer the question if probiotics could play a role in the treatment of depression and anxiety. Specifically, does supplementation with a probiotic improve clinical outcome measures of depression, anxiety, or both? Methods: A comprehensive literature review was conducted using PubMed and Google Scholar using the search terms probiotics, …

Backward Walking: A Novel Marker Of Fall Risk, Cognitive Dysfunction, And Myelin Damage In Persons With Multiple Sclerosis, Erin Edwards

Wayne State University Dissertations

Multiple sclerosis (MS) is a progressive, neurologic disease of the central nervous system that causes debilitating motor, sensory and cognitive impairments. As a result, persons with MS are at an increased risk for falls and falls represent a serious public health concern for the MS population. The current clinical measures used to assess fall risk in MS patients lack sensitivity and predictive validity for falls and are limited in their ability to capture to multiple functional domains (i.e., motor, sensory, cognitive and pathological domains) that are impaired by MS. Backward walking sensitively detects falls in the elderly and other neurologic …

An Investigation Of The Sled-Push Exercise In Older Adults: Physiological Quantification, Perceived Enjoyment And Body Discomfort, Micheal A. Baumann

Graduate Research Theses & Dissertations

Healthy aging is defined as the process of maintaining and developing functional ability that allows a state of mental and physical wellbeing. Physical activity, particularly exercise training, has been highly recommended for individuals of all ages, especially older adults, as way to maintain, improve or restore functional ability and health. Different modalities and types of exercise have been successfully tested in older adults but not much is known about the potential of the sled-push exercise in this population, a modality that has been highly used among athletes to improve cardiorespiratory fitness, muscle strength and endurance, and core stability. PURPOSE: The …

Validity And Reliability Of Fried Frailty Phenotype In Turkish Population, Hacer Doğan Varan, Olgun Deni̇z, Süheyla Çöteli̇, Rana Tuna Doğrul, Muhammet Cemal Kizilarslanoğlu, Berna Göker

Turkish Journal of Medical Sciences

Background/aim: Frailty is an important, multidimensional geriatric syndrome defined as increased vulnerability to stressors. Fried frailty phenotype (FFP) is one of the most widely used models to define physical frailty. The aim of this study is to investigate the crosscultural validity and reliability of Fried frailty phenotype (FFP) in older Turkish population. Materials and methods: A total of 450 patients, aged 59 years and over, were included. FFP translated into Turkish was used. Hand grip strength cut-off values that best predict low skeletal muscle mass index (SMI) for Turkish men and women were calculated. A modified version of FFP was …

The Effect Of Frailty On The Development Of Acute Kidney Injury In Critically-Ill Geriatric Patients With Covid-19, Murat Küçük, Bi̇şar Ergün, Mehmet Nuri̇ Yakar, Özer Ural Çakici, Erdem Yaka, Bi̇lgi̇n Cömert, Ali̇ Necati̇ Gökmen, Begüm Ergan

Turkish Journal of Medical Sciences

Background/aim: Acute kidney injury is strongly associated with mortality in critically ill patients with coronavirus disease 2019 (COVID-19); however, age-related risk factors for acute kidney injury are not clear yet. In this study, it was aimed to evaluate the effects of clinical factors on acute kidney injury development in an elderly COVID-19 patients. Materials and methods: Critically ill patients (?65years) with COVID-19 admitted to the intensive care unit were included in the study. Primary outcome of the study was the rate of acute kidney injury, and secondary outcome was to define the effect of frailty and other risk factors on …

Ic025: Transcripts Of Video Presentations, University Of Texas Health Science Center At Houston. School Of Nursing

Cizik School of Nursing 50th Anniversary

Transcripts of edited video presentations, including "Pioneers of Nursing Education, Practice and Discovery", Marianne Marcus Remembers, Janet C. Meininger Oral History, Dr. Vaunette Fay retires after 4 years at Cizik School of Nursing at UTHealth Houston and Dean Emerita Patricia Starck, PhD, RN, FAAN Shares Her Leadership History and Achievements.

Ic025: Janet C. Meininger, Transcript, University Of Texas Health Science Center At Houston. School Of Nursing

Cizik School of Nursing 50th Anniversary

Transcipt of the oral history interview with Janet C. Meininger. See more at University of Texas School of Nursing records and its finding aid.

Ic025: Vaunette Fay, Transcript, University Of Texas Health Science Center At Houston. School Of Nursing

Cizik School of Nursing 50th Anniversary

Transcript of the oral history interview with Vaunette Fay. See more at University of Texas School of Nursing records and its finding aid.

Ic025: Patricia Starck, Transcript, University Of Texas Health Science Center At Houston. School Of Nursing

Cizik School of Nursing 50th Anniversary

Transcript of the oral history interview with Patrica Starck. See more at University of Texas School of Nursing records and its finding aid.

2022-2023 Nursing Graduate Msn-Fnp Handbook, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2022-2023 Graduate Student Handbook for the Department of Nursing at Morehead State University.

Arrow Of Time, Entropy, And Protein Folding: Holistic View On Biochirality, Victor V. Dyakin, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Chirality is a universal phenomenon, embracing the space–time domains of non-organic and organic nature. The biological time arrow, evident in the aging of proteins and organisms, should be linked to the prevalent biomolecular chirality. This hypothesis drives our exploration of protein aging, in relation to the biological aging of an organism. Recent advances in the chirality discrimination methods and theoretical considerations of the non-equilibrium thermodynamics clarify the fundamental issues, concerning the biphasic, alternative, and stepwise changes in the conformational entropy associated with protein folding. Living cells represent open, non-equilibrium, self-organizing, and dissipative systems. The non-equilibrium thermodynamics of cell biology are …

Fundamental Clock Of Biological Aging: Convergence Of Molecular, Neurodegenerative, Cognitive And Psychiatric Pathways: Non-Equilibrium Thermodynamics Meet Psychology, Victor V. Dyakin, Nuka V. Dyakina-Fagnano, Laura B. Mcintire, Vladimir N. Uversky

Molecular Medicine Faculty Publications

In humans, age-associated degrading changes, widely observed in molecular and cellular processes underly the time-dependent decline in spatial navigation, time perception, cognitive and psychological abilities, and memory. Cross-talk of biological, cognitive, and psychological clocks provides an integrative contribution to healthy and advanced aging. At the molecular level, genome, proteome, and lipidome instability are widely recognized as the primary causal factors in aging. We narrow attention to the roles of protein aging linked to prevalent amino acids chirality, enzymatic and spontaneous (non-enzymatic) post-translational modifications (PTMs SP), and non-equilibrium phase transitions. The homochirality of protein synthesis, resulting in the steady-state non-equilibrium condition …

Using The Protection Motivation Theory To Understand The Mental Health Impact Of Surviving Covid-19, Kaprea Johnson, Angel Spence, Yousef Sherif, Dana Brookover, Adrienne White

Adultspan Journal

Due to the widespread effects of COVID-19, mental health professionals need to understand the lived experiences of survivors. Data were collected from YouTube videos (N = 52), which contained firsthand perspectives from COVID-19 survivors. Survivors understood the high stakes of COVID-19, reported the dual threat to physical and mental health, entered “survival mode,” and had both positive and negative reflections on the experience. Implications for mental health professionals and future research directions are included.

Evaluating Providers’ Knowledge, Attitudes And Intentions Toward Assessing Pregnancy Desires In Women Of Childbearing Age, Sydney Hahn

DNP Projects

Abstract

Background: Unintended pregnancies account for over half of all pregnancies in the United States. Unintended pregnancies can lead to abortion, socioeconomic difficulties, medical complications, psychological issues, and political issues. Unintended pregnancies are potentially harmful to both the mother and the baby. Healthy People 2030 listed reducing the number of unintended pregnancies as one of their family planning objectives.

Purpose: The purpose of this DNP project was to evaluate providers’ knowledge, attitudes, and intentions toward assessing pregnancy desires in women of childbearing age. Methods: The study was a one-group pre/post intervention design. The data was gathered via a convivence sample …

Characterizing Cellular Stress, Hippocampal Function, And Behavior In A Novel Rat Model Of Alzheimer's Disease, Anne A. Schulman

Honors Theses

Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder that affects over 5 million individuals in the United States alone. While AD is primarily thought of as a disease that destroys neural networks required for memory recall and formation, AD also cause impairment in emotional regulation, cognitive flexibility, and executive function pathways. The cause of AD is unknown; however, the allele ApoE4 has been identified as a risk factor for the onset of AD. ApoE4 provides a valuable opportunity to study AD through animal models. This thesis utilized a human ApoE4 transgenic rat model (hApoE4) to investigate the biological and behavioral …

Effect Of Living Arrangements On Cognitive Function In Chinese Elders: A Longitudinal Observational Study, Yanwei Lin, Qi Zhang, Tingxian Wang, Zhirong Zeng

Community & Environmental Health Faculty Publications

Objective To examine how living arrangement as a social contextual factor can affect Chinese elders’ cognitive function.

Setting and participants Our sample consists of 2486 Chinese elders from two waves (2014 and 2018) of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) that was administered in 22 of China’s 31 provinces using a multi-stage, disproportionate, purposive random sampling method. The CLHLS aims to better understand the determinants of healthy longevity in China and collects extensive data on a large population of fragile elders aged 80–112 in China.

Outcome measures Cognitive function was measured by the Mini-Mental State Examination (MMSE). Living arrangement …

Mennonite College Of Nursing Annual Report, Fiscal Year 2022, Judy Neubrander

Annual Reports - Mennonite College of Nursing

Annual report of the Mennonite College of Nursing at Illinois State University

Telehealth Simulation And Education Impact On Student Knowledge, Leah Schmitt

Schultz-Werth Award Papers

Background: One of the most recent improvements to the everchanging healthcare is telehealth. Telehealth is used by about 70% of healthcare providers across the United States. It is used to reach patient populations such as those in rural locations or with limited resources. Telehealth can improve patient outcomes and encourage quality patient care. However, many nursing schools include programs to educate students on the utilization of telehealth. Purpose: In undergraduate and graduate nursing school, do telehealth simulations and education improve student knowledge? Methods: A review of literature was completed using the databases: EBSCOhost, PubMed, and CINAHL. Key words searched included …

Gait Characteristics And Cognitive Function In Middle-Aged Adults With And Without Type 2 Diabetes Mellitus: Data From Enbind, Pieter M.R. Herings, Adam H. Dyer, Sean P. Kennelly, Sean Reid, Isabelle Killane, Louise Mckenna, Nollaig M. Bourke, Conor P. Woods, Desmond O'Neill, James Gibney, Richard B. Reilly

Articles

Type 2 Diabetes Mellitus (T2DM) in midlife is associated with a greater risk of dementia in later life. Both gait speed and spatiotemporal gait characteristics have been associated with later cognitive decline in community-dwelling older adults. Thus, the assessment of gait characteristics in uncomplicated midlife T2DM may be important in selecting-out those with T2DM at greatest risk of later cognitive decline. We assessed the relationship between Inertial Motion Unit (IMUs)- derived gait characteristics and cognitive function assessed via Montreal Cognitive Assessment (MOCA)/detailed neuropsychological assessment battery (CANTAB) in middle-aged adults with and without uncomplicated T2DM using both multivariate linear regression and …

Alzheimer's Disease Research Progress In Australia: The Alzheimer's Association International Conference Satellite Symposium In Sydney, Claire E. Sexton, Kaarin J. Anstey, Filippo Baldacci, C. J. Barnum, Anna M. Barron, Kaj Blennow, Henry Brodaty, Samantha Burnham, Fanny M. Elahi, Jürgen Götz, Yun-Hee Jeon, Maya Koronyo-Hamaoui, Susan M. Landau, Nicola T. Lautenschlager, Simon M. Laws, Darren M. Lipnicki, Hanzhang Lu, Colin L. Masters, Wendy Moyle, Akinori Nakamura, Giulio Maria Pasinetti, Naren Rao, Christopher Rowe, Perminder S. Sachdev, Peter R. Schofield, Einar M. Sigurdsson

Research outputs 2014 to 2021

The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias. This leadership includes the Australian Imaging, Biomarker, and Lifestyle Flagship Study of Ageing (AIBL), which has fueled the identification and development of many biomarkers and novel therapeutics. Two multimodal lifestyle intervention studies have been launched in Australia; and Australian researchers have played leadership roles in other global studies in diverse populations. Australian researchers have also played an instrumental role in efforts to understand mechanisms …

Bio-Clinical Evaluation Of Collateral Score In Acute Middle Cerebral Artery Occlusion, Esra Demi̇r, Hesna Bektaş, Hasan Bayindir, Oğuzhan Kurşun

Turkish Journal of Medical Sciences

Background/aim: Acute ischemic stroke (AIS) is characterized as a neurological deficit owing to an acute focal damage to the brain by cerebral infarction. A collateral score is the most significant factor evaluating the prognosis of AIS, its relationship with demographic data, serum biochemical parameters, and clinical disability in this field. Materials and methods: We conducted a single-center retrospective study with 100 patients with AIS within the first 6 h of ischemic stroke. Data for consecutive AIS patients were collected from February 2019 to May 2020. The collateral score was assessed by using developed scoring systems defined by Maas et al. …

The Evaluation Of Disease Awareness, Caregiver Burden, And Workday Loss In Caregivers Ofcopd Patients, Ayşe Baha, Nurdan Köktürk, Burcu Öztürk Şahi̇n, Eli̇f Yildirim, İpek Özmen, Alev Gürgün, Ayşe Füsun Topçu, Evri̇m Eylem Akpinar, Funda Elmas Uysal, Hadi̇ce Seli̇moğlu Şen, Nalan Ogan, Yeşi̇m Önder, Ömer Tamer Doğan, Mehmet Polatli, Züleyha Bi̇ngöl

Turkish Journal of Medical Sciences

Background/aim: Our aim is to determine the caregiver burden of chronic obstructive lung disease (COPD) patient's caregivers, and to determine whether there is a workday loss. Materials and methods: 252 COPD patients and their caregivers were included. Disease information of the patients were recorded and a questionnaire was applied. Socio-demographic characteristics of the caregivers were recorded and a questionnaire consisting of 24 questions including COPD disease, treatment and loss of working days, and the Zarit Scale were used. Results: 128(50.8%) of the patients according to GOLD were group-D, 97(38.5%) of the patient's relatives were working, 62(24.7%) were not able to …

The Validity And Reliability Study Of The Turkish Version Of Engagement In Healthy Ageing, Ramazan Kiraç, Seda Uyar, Mehmet Aki̇f Eri̇şen, Nur Feyzal Kesen

Turkish Journal of Medical Sciences

No abstract provided.

Association Between Depression Scores And Comprehensive Geriatric Assessment And Frailty In Geriatric Outpatients With Somatic Complaints: An Observational Cross-Sectional Study, Hande Selvi̇ Öztorun, Bi̇lge Gözükara, Remzi̇ Bahşi̇, Tuğba Turgut, Deni̇z Mut Sürmeli̇, Çağlar Coşardereli̇oğlu Seçer, Volkan Atmiş, Ahmet Yalçin, Sevgi̇ Aras, Murat Varli

Turkish Journal of Medical Sciences

No abstract provided.

Classical Heart Rate Variability And Non-Linear Heart Rate Analysis In Mice Under Na-Pentobarbital And Ketamine/Xylazine Anesthesia., Hasan Kazdağli, Hasan Fehmi̇ Özel, Mustafa Özbek, Şüheda Alpay, Mürüvvet Alenbey

Turkish Journal of Medical Sciences

No abstract provided.

What Is The Protective Effect Of Preischemic Kisspeptin-10 Administration Against Ischemia/Reperfusion Injury Of Striatum On Mice?, Hati̇ce Akkaya, Engi̇n Sümer, Seli̇m Kutlu, Hati̇ce Solak, Bayram Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Kisspeptin is a neuropeptide with a primary role on the onset of puberty and has beneficial effects on ischemia/ reperfusion (I/R) injury. In this study, we aimed to investigate the effect of kisspeptin administration on striatal I/R injury in mice. Material and methods: Forty adult C57/BL6 mice were randomly divided into four groups: Sham, Kisspeptin, I/R, and I/R + Kisspeptin groups. The groups were administered with either physiological saline (Sham and I/R groups) or kisspeptin (Kisspeptin and I/R + Kisspeptin groups) intraperitoneally 40 min before the operation. A microdialysis probe was placed in the right striatum according to stereotaxic …

Ultrasonographic/Regional Muscle Measurements For Diagnosing Sarcopenia In Older Adults With And Without Dementia, Zekeri̇ya Ülger, Gözde Şengül Ayçi̇çek, Özgür Kara, Murat Kara

Turkish Journal of Medical Sciences

Background/aim: Sarcopenia and dementia are growing concerns among older adults that muscle and brain atrophy may cooccur. We aimed to compare the age-related loss of muscle mass by using ultrasound (US), and skeletal muscle mass index (SMI) by bioelectrical impedance analysis in older adults with and without dementia. Materials and methods: A total of 221 older adults aged ≥65 years were included in the study. The diagnosis of sarcopenia was established if low muscle mass according to either SMI or sonographic gastrocnemius (GC) muscle thickness was combined with low grip strength. The diagnosis of dementia was based on the National …

Frailty In Community-Dwelling Older Adults: Reliability And Validity Of The Turkish Version Of The Gérontopôle Frailty Screening Tool, Serdar Ceylan, Merve Güner Oytun, Arzu Okyar Baş, Meltem Koca, Burcu Balam Doğu, Meltem Gülhan Hali̇l, Mustafa Cankurtaran, Cafer Balci

Turkish Journal of Medical Sciences

Background/aim: Recognizing frailty had a great importance in countries with an increasing geriatric population. The study aims to evaluate the reliability and validation of the Gérontopôle frailty screening tool (GFST), which was developed to screen frailty in the community-dwelling older adults, for the Turkish population. Materials and methods: In this crosssectional study, participants who applied to the geriatrics outpatient clinic of a university hospital were included. Comprehensive geriatric assessments of all patients were performed. The validity of the GFST was tested by its concordance with the FRAIL scale. Test-retest and interrater reliability analyses were made. Results: Ninety-six patients were included …

Cohort Analysis Of Four Graduating Classes Of Occupational Therapy Students' Knowledge Of Aging, Lavona Traywick, Brittany N. Saviers, Terry Wayne Griffin, Teressa Brown

Journal of Occupational Therapy Education

At the same time that the number of senior adults in the United States is steadily rising, there is also a rising shortage of allied health care professionals, including occupational therapists, to meet the current and expected needs of the senior adult population. There are national standards that all occupational therapy programs must meet; however, there is not a set national curriculum. It is assumed that students will enter their respective occupational therapy programs with a base knowledge of aging due to prerequisite requirements. To test that assumption, with Institutional Review Board approval, over four consecutive years 192 first-year, first-semester …

Exploration Of A Short-Term Learning Community Focused On Evidence-Based Occupational Therapy Interventions For Children And Youth With Autism, Christine T. Myers, Sandra Brown, Ashley Parigian

Journal of Occupational Therapy Education

Continuing education (CE) for occupational therapists typically takes place in workshops, seminars, or webinars with little support for practice change after the event concludes. Continuing education that occurs over an extended time with opportunities for social learning and competence assessment may improve knowledge translation. This study explored how pediatric occupational therapists who participated in a short-term, online learning community acquired new knowledge about evidence-based interventions from learning activities and how they applied this new knowledge to practice. Weekly modules with facilitated discussions, competency self-assessment, and peer-reviewed journal article readings occurred over a six-week period. An exploratory design included content analysis …