Understanding And Targeting The Tph1-Serotonin-Htr3a Axis In Small Cell Lung Cancer, Yanning Hao

Theses and Dissertations--Toxicology and Cancer Biology

Small cell lung cancer (SCLC), which accounts for 10-15% of all lung cancer, is the most malignant type that tends to grow fast and spread in its early stages. The 5-year survival rate remains low at 6% overall. Thus, new therapeutic methods and pharmacological targets for SCLC patients are urgently needed. We present novel data indicating that the synthesis of serotonin is upregulated in SCLC compared to normal bronchial epithelial cells and non-small cell lung cancer. Serotonin signaling plays a critical role in various physiological and pathological processes. However, its contribution to SCLC development has not been well understood. The …

Business Meeting Report (Secretary's And Treasurer's Report), Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

5. A Chicana Pedagogy For Digital Pen Pals, Diana Noreen Rivera, Leigh Johnson

Literatures and Cultural Studies Faculty Publications

No abstract provided.

Warm Land Surface Temperatures And Eastern Asian Homo, Robert Patalano, Hong Yang

Biological and Biomedical Sciences Department Faculty Journal Articles

Climate change and hominin evolution are inextricably linked. Pleistocene climate variability, for example, is thought to have had major influences on hominin morphology, brain size, and diversity. However, clear cause-and-effect relationships between specific climatic events and major evolutionary occurrences are difficult to establish due to temporal and spatial gaps in paleoclimatic, paleoenvironmental, and archaeological records. A new branched GDGT paleotemperature record from the Lantian Basin of Central China (Lu et al., 2022), a location known for the earliest hominin presence in East Asia, illustrates warm land surface temperatures over a two-million-year period between 2.6 and 0.6 Ma, a critical time …

National Survey Of Human Epigenetic Study In Healthy Aged Population In Four Different Regions Of Thailand, Siwaporn Nilyai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Healthy ageing has become a goal to help older people maintain good-quality longevity. Researchers have found that epigenetic, environmental, and behavioural lifestyle factors influence the variation of lifespan and healthspan. This study aims to evaluate the age-associated epigenetic biomarkers among older people living in four major regions of Thailand, along with their association with lifestyle and sociodemographic characteristics. 214 participants passed the criteria and enrolled from the southern, northeastern, central, and northern areas of Thailand. Sociodemographic characteristics were recorded through interviews, and blood samples were collected to evaluate blood chemistry and epigenetic markers. SIRT1 and HMGB1 proteins in plasma were …

Molecular Survey Of Enterocytozoon Bieneusi In Bat Feces Collected From Various Areas Of Thailand, Chatuthanai Savigamin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Enterocytozoon bieneusi is a microsporidian pathogen that can cause gastrointestinal diseases such as chronic diarrhea, abdominal pain, and nausea in humans, particularly in immunocompromised individuals. This pathogen has been found in the feces of various animals, from wildlife to domestic animals, but there have been no reports of its detection in bats in Thailand. Given that bat feces are widely used as fertilizers in agriculture and that bat-infested caves are tourist destinations where people may encounter bat feces, there is a need to study the presence of Enterocytozoon bieneusi in bat feces in these areas. In this study, 16 out …

ปัจจัยบริบทแวดล้อมของการเปลี่ยนแปลงตามกาลเวลาของอัตราคลอดในวัยรุ่นอายุ 15-19 ปี ในประเทศไทย, ธัชณัท พันตรา

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยนี้ เป็นการศึกษาแบบ Ecological study ที่ผสมผสานระหว่าง Multiple-group กับ Time-trend design โดยมีวัตถุประสงค์ เพื่ออธิบายอัตราคลอดในวัยรุ่นอายุ 15-19 ปี ระดับอำเภอในประเทศไทยทางภูมิศาสตร์ วัตถุประสงค์เฉพาะ: (ก) เพื่อระบุจุดร้อน จุดเย็น และค่าผิดปกติเชิงพื้นที่ (ข) ระบุความสัมพันธ์ระหว่างอัตราคลอดในวัยรุ่นฯ และปัจจัยบริบทเชิงพื้นที่ และ (ค) ตรวจสอบว่าความสัมพันธ์ที่ระบุแตกต่างกันไปตามพื้นที่และเวลาหรือไม่ ดำเนินการศึกษาใน 878 อำเภอทั่วประเทศ ยกเว้นในเขตกรุงเทพมหานคร และระยะเวลาการศึกษาคือช่วง 10 ปี ระหว่างปี พ.ศ. 2552-2561 ใช้ซอฟต์แวร์ Arc GIS Pro 3.0 เพื่อวิเคราะห์และสร้างแผนที่อัตราคลอดในวัยรุ่นฯ และตรวจสอบรูปแบบเชิงพื้น จุดร้อน จุดเย็น และค่าความผิดปกติ ใช้ Ordinary Least Squares (OLS) regression and Geographically Weighted Regression (GWR) เพื่อประเมินความสัมพันธ์ระหว่างอัตราคลอดในวัยรุ่นและปัจจัยบริบทแวดล้อม การวิเคราะห์ข้อมูลแบ่งเป็น 2 ช่วง คือ ช่วงปี 2552-2554 และช่วงปี 2556-2561 ผลการศึกษาพบว่า อัตราคลอดในวัยรุ่นอายุ 15-19 ปี ระดับอำเภอในประเทศไทย ทั้งสองช่วงเวลามีรูปแบบกระจายแบบไม่เป็นระเบียบหรือกระจายแบบไม่มีทิศทาง (random) และพบกลุ่มอำเภอเล็ก ๆ ที่มีนัยสำคัญของอัตราคลอดในวัยรุ่นสูง (จุดร้อน) หรือต่ำ (จุดเย็น) ในปี พ.ศ. 2552-2554 และปี พ.ศ. 2556-2561 โมเดล GWR อธิบายความสัมพันธ์ระหว่างปัจจัยบริบทเชิงพื้นที่และอัตราคลอดในวัยรุ่น ได้ดีกว่าโมเดล OLS ช่วงปี 2552-2554 โมเดล GWR อธิบายความแปรผันของอัตราคลอดในวัยรุ่นระดับอำเภอได้ร้อยละ 23.6 พื้นที่ทางภูมิศาสตร์ที่มีตัวแปรอิสระทำนายอัตราคลอดในวัยรุ่นที่แข็งแกร่งและอ่อนแอในประเทศไทย ได้แก่ ความเหลื่อมล้ำทางรายได้ ค่าใช้จ่ายเฉลี่ยต่อคนต่อเดือน วัยรุ่นได้รับการศึกษาภาคบังคับ …

“A Change Of Name During Sickness”: Surveying The Widespread Practice Of Renaming In Response To Physical Illness, Russell Fielding

Honors College Faculty Publications

This paper synthesizes and summarizes a selection of literature—largely anthropological and ethnographic, published between the early 18^th and early21^st centuries—that describes the practice of renaming gapers onwho is physically ill in order to affect their recovery. In none of these publications is this particular practice central; rather, it is often mentioned alongside myriad other cultural and naming practices. While no claim is made as to the exhaustive nature of the literature review, this analysis reveals patterns and similarities related to the reasoning behind such a practice and the special relationship between personal names and physical health in a …

Changes In Severity Of Diabetes At Diagnosis Following The Onset Of The Sars-Cov-2 Pandemic, Annelise King

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

During the SARS-CoV-2 pandemic it was seen that diabetes was a risk factor for severe COVID-19. The objective of this study is to assess the severity of diabetes at diagnosis during the COVID-19 pandemic compared to pre-pandemic to see how the pandemic and SARS-CoV-2 infection impacted the severity of diabetes. This study used University of Kentucky electronic health records of 13,794 patients who developed diabetes. The majority of patients were female, white non-Hispanic, 65+, and living in an urban area. There were differences seen between the COVID-19 positive and negative cohorts in the DKA and HbA₁c variables, with …

The Role That Diet And Lifestyle Factor Plays In An Increased Risk For Cardiovascular Disease In Asians And Pacific Islanders, Ethan Caragan

Nursing | Student Research Posters

Cardiovascular disease is the leading global cause of mortality, often resulting in heart attacks and strokes due to obstructed blood flow to vital organs. The risk of these events is influenced by dietary choices, smoking, and physical activity. Despite preventative measures, the impact of diet and lifestyle on cardiovascular health varies across ethnic groups. This thesis aims to evaluate how variations in dietary traditions and lifestyle among Asians and Pacific Islanders contribute to increased or decreased cardiovascular disease risks compared to other racial groups. The study focuses on the dietary and lifestyle factors of Asian Americans and Pacific Islanders in …

Strengthening New Hampshire’S Primary Care Workforce Pipeline: Utilization Of Alternative Scheduling Models, Elizabeth Harrison

DNP Scholarly Projects

Abstract

BACKGROUND: Traditional clinical scheduling coupled with the current reimbursement system have created systematic barriers leading to decreased clinical education opportunities. Alternative scheduling models such as longitudinal integrated clerkships, one preceptor to two students and wave scheduling have the potential to eliminate these barriers and provide financial gains and increased access to care.

INTERVENTION: Interventions to meet this quality improvement project's objectives included (1) pre-intervention planning (2) focus groups, (3) video presentations and (4) a pilot program of alternative scheduling models in clinical practice.

RESULTS: A pilot program utilizing the alternative scheduling models increased the relative value units (RVU) of …

Facilitating Palliative Care In A Critical Access Hospital System: Implementation Of Screening And Educational Interventions, Michele Lovell

DNP Scholarly Projects

BACKGROUND: The United States health care system faces the dual challenge of an aging population with a concomitant increase in the presence of chronic and serious illness, the care of which accounts for the nation’s largest expenditure of burgeoning healthcare costs. Palliative care is specialized care for people with serious illness aimed at reducing suffering, optimizing quality of life, and enhancing medical decision making. An ample evidence base demonstrates that palliative care increases both quality of care and patient and family satisfaction while also reducing associated costs. The aim of this quality improvement project was to facilitate palliative care services …

Epidemiology Of Sars-Cov-2 Breakthrough Infections In Kentucky March 1st 2021 - December 31st, 2022, Harrison Hynes

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objective: Provide epidemiologic overview of SARS-CoV-2 breakthrough infections in Kentucky considering both demographic and geographic variables.

Background: We believe descriptive information of breakthrough cases for a defined population will provide public health practitioners with useful information relating to SARS-CoV-2 infection control and vaccination efforts.

Methods: We obtained SARS-CoV-2 case data from the Kentucky Department for Public Health COVID-19 case repository, which mirrors National Electronic Disease Surveillance System (NEDSS) data. The study sample used for analysis comprised 147,000 individuals who tested positive for SARS-CoV-2 in Kentucky between the dates of March 1^st, 2021 and December 31^st, 2022. …

Evaluating The Impact Of Mental Health Needs And Services Disruption: Covid-19 & Wisconsin Children’S Welfare Services, Gavin Rienne

Theses and Dissertations--Epidemiology and Biostatistics

Children’s traumatic experiences have lifelong impacts on their mental health and quality of life, therefore mental health services are a critical part of necessary community resources. The increased frequency and severity of natural disasters such as hurricanes, tornadoes, and pandemics reinforces the need to examine and understand the importance of mental health and child services in response to disaster events. This research assesses the relationship between disasters and subsequent health service utilization amongst children and adolescents. We investigated current research on the relationship between children’s mental health and community mental health resource efficacy and accessibility after a major disaster by …

Emergency Medicine Resident Perceptions Of A Medical Wilderness Adventure Race (Medwar), Lake Crawford

Yale Medicine Thesis Digital Library

Effective Wilderness Medicine (WM) resident education can be challenging to achieve in the traditional classroom setting. The Medical Wilderness Adventure Race (MedWAR) was developed to teach and test WM using simulated scenarios in an austere setting under physical, environmental, and psychological stress. The objective of this study was to evaluate participant perceptions of simulation-based WM training in an Emergency Medicine (EM) residency MedWAR. A 20-question descriptive survey was administered to participants of an academic EM residency program’s annual MedWAR during 2021 and 2022. The event took place during weekly scheduled didactic time at local state parks in July. The questionnaire …

Successfully Transitioning Executives During Times Of Multidimensional Change: A Delphi Study Examining Organizational Practices In Large Hospital Systems, Lilicia Bailey

Theses and Dissertations

Healthcare is the fastest growing industry in the United States and globally. Economists forecast that as the population grows and life expectancy increases, the healthcare sector will continue expanding to meet consumer needs domestically and globally. Population aging and the emergence of global pandemics has substantially increased the demand for healthcare services and has created volatile, complex, uncertain, and ambiguous conditions that ignite social, economic, and workforce shifts within and outside the organization. While these factors require growth and agility within healthcare organizations, high turnover in the healthcare workforce threatens these organizations’ ability to effectively fulfill their mission. The high …

Association Of Diabetes Prevalence With Labor Force Participation Rates In Kentucky Counties, Ryan Montgomery

MPA/MPP/MPFM Capstone Projects

Compared to other states in the USA, Kentucky has one of the highest rates of diagnosed diabetes and one of the lowest levels of labor force participation. This project employs a multivariable linear regression model to estimate the correlation between county-level diabetes prevalence and county-level labor force participation rates in Kentucky counties from 2015-2019, using publicly available data from the Centers for Disease Control’s Behavioral Risk Factor Surveillance System (BRFSS) and the U.S. Census Bureau’s American Community Survey (ACS). Labor force participation rates serve as the dependent variable and diabetes prevalence rates serve as the primary independent variable, alongside nine …

Campus Sexual Violence In The Time Of Covid-L9, Hannah Holt

Master’s Theses

Campus sexual assault (CSA) was likely on the rise in the United States (Koss et al., 2022) even prior to the COVID-19 pandemic, during which there was a global increase in violence against women. The present study is a needed addition to the limited rigorous scientific studies on the impact of the COVID-19 pandemic on campus sexual assault (CSA). A mixed-methods, ecological, and critical feminist approach was used to investigate CSA during the mitigation period. The present study specifically utilized the Sexual Experiences Survey (Koss et al., 2007) to assess changes in frequency of victimization within two representative samples of …

Africa Guidelines For Hepatocellular Carcinoma Buildup Process, Ghassan Abou-Alfa, Mary Afihene, Marinela Capanu, Joanne Chou, Akwi Asombang, Olusegun Alatise, Adda Bounedjar, Lina Cunha, Hailemichael Mekonnen, Papa Diop, Reda Elwakil, Mahamat Ali, Ntokozo Ndlovu, Jerry Ndumbalo, Precious Makondi, Christian Tzeuton, Tiago Castria, Adwoa Afrakoma Agyei-Nkansah, Fiyinfolu Balogun, Alain Bougouma, Blaise Ibara, Eduard Jonas, Stephen Kimani, Peter Kingham, Reshad Kurrimbukus, Nazik Hammad, Mona Fouad, Noha S. El Baghdady, Eloumou Fiacre, Vikash Sewram, C. Wendy Spearman, Ju Yang, Lewis Roberts, Ashraf Abdelaziz

Pharmacy

Abstract

Purpose

Hepatocellular carcinoma (HCC), the fourth most common cancer in Africa, has a dismal overall survival of only 3 months like in sub-Saharan Africa. This is affected by the low gross domestic product and human development index, absence of coherent guidelines, and other factors.

Methods

An open forum for HCC-experienced health care workers from Africa and the rest of the world was held in October 2021. Participants completed a survey to help assess the real-life access to screening, diagnoses, and treatment in the North and Southern Africa (NS), East and West Africa (EW), Central Africa (C), and the rest …

Self-Assessed Personality Traits And Adherence To The Covid-19 Lockdown, Jakub Jan Rojek, Przemysław Waszak, Ilona Bidzan-Bluma, Aleksandra Sanewska, Joanna Stępień, Tomasz Michalski, Liliana Lorettu, Roberta Meloni, Che Sheng Chu, Myriam Abboud, Jakub Grabowski

All Works

Introduction: The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, has forced all countries affected by it to introduce quarantine and isolation to prevent the spread of the virus, as well as masking and distancing. Not everyone is equally willing to follow the rules related to limit the extent of the coronavirus epidemic. This might be connected with personality traits, especially openness, positive attitude, and optimism. Materials and Methods: An online survey was created and completed by participants in April–May 2020. Self-assessment of personality traits and adherence to lockdown recommendations were assessed. A total of 7404 participants took part in the …

The Shortfalls Of Vulnerability Indexes For Public Health Decision-Making In The Face Of Emergent Crises: The Case Of Covid-19 Vaccine Uptake In Virginia, Lydia Cleveland Sa, Erika Frydenlund

VMASC Publications

Equitable and effective vaccine uptake is a key issue in addressing COVID-19. To achieve this, we must comprehensively characterize the context-specific socio-behavioral and structural determinants of vaccine uptake. However, to quickly focus public health interventions, state agencies and planners often rely on already existing indexes of "vulnerability." Many such "vulnerability indexes" exist and become benchmarks for targeting interventions in wide ranging scenarios, but they vary considerably in the factors and themes that they cover. Some are even uncritical of the use of the word "vulnerable," which should take on different meanings in different contexts. The objective of this study is …

The Wennberg Anthology, John E. Wennberg

Dartmouth Scholarship

In 1967, after finishing my postgraduate training at Johns Hopkins in internal medicine and epidemiology, I took a job at the University of Vermont in Burlington as Director of the Northern New England Regional Medical Program (RMP). The Vermont program was one of some fifty RMPs that blanketed the country as part of President Johnson’s Great Society program. The idea behind the RMP was that advances in biomedicine had so improved the outcomes of major killer diseases that it was critical to ensure that all Americans, not just those fortunate enough to live near an academic medical center, had access …

Conspiracy Theories Are Not Religions: Scrutinizing Religious Exemptions To The Covid-19 Vaccine, Shirley B. Luk

University of San Francisco Law Review

No abstract provided.

For The Good Of The People: An Interpretive Analysis Of Chinese Volunteerism In The Critical Matter Of Care At The Start Of The Pandemic, Fan Li, Chunyun Gu, Yanqun Hu, Roxanne Vandermause, Anne F. Fish, Zehui Zhou, Xiaodan Yuan, Qianqian Zhou, Junya Zhu, Qingqing Lou

Nursing Faculty Works

Purpose: China employed a unique volunteerism system where health care providers outside of Hubei Province, the epicentre, travelled to reverse the devastation wrought by coronavirus disease 2019 (COVID-19) at its global onset. The aim is to study the unique circumstances of Chinese volunteerism in the context of continuing pandemic threats, specifically exploring the experiences of 20 Chinese nurse and physician volunteers fighting COVID-19 during the outbreak. Methods: Interviews were done through video calling. Results: Using content analysis with a hermeneutic perspective, emerging patterns showed the ways in which China’s particular manifestation of volunteerism teaches us how to engage global threats …

Deriving Spatially Explicit Direct And Indirect Interaction Networks From Animal Movement Data, Anni Yang, Mark Q. Wilber, Kezia R. Manlove, Ryan S. Miller, Raoul Boughton, James Beasley, Joseph Northrup, Kurt C. Vercauteren, George Wittemyer, Kim Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

Quantifying spatiotemporally explicit interactions within animal populations facilitates the understanding of social structure and its relationship with ecological processes. Data from animal tracking technologies (Global Positioning Systems [“GPS”]) can circumvent longstanding challenges in the estimation of spatiotemporally explicit interactions, but the discrete nature and coarse temporal resolution of data mean that ephemeral interactions that occur between consecutive GPS locations go undetected. Here, we developed a method to quantify individual and spatial patterns of interaction using continuous-time movement models (CTMMs) fit to GPS tracking data. We first applied CTMMs to infer the full movement trajectories at an arbitrarily fine temporal scale …

Gpcrs And Fibroblast Heterogeneity In Fibroblast-Associated Diseases, Nidhi V. Dwivedi, Souvik Datta, Karim El-Kersh, Ruxana Sadikot Md, Mrcp, Apar Kishor Ganti, Surinder K. Batra, Maneesh Jain

Journal Articles: Biochemistry & Molecular Biology

G protein-coupled receptors (GPCRs) are the largest and most diverse class of signaling receptors. GPCRs regulate many functions in the human body and have earned the title of "most targeted receptors". About one-third of the commercially available drugs for various diseases target the GPCRs. Fibroblasts lay the architectural skeleton of the body, and play a key role in supporting the growth, maintenance, and repair of almost all tissues by responding to the cellular cues via diverse and intricate GPCR signaling pathways. This review discusses the dynamic architecture of the GPCRs and their intertwined signaling in pathological conditions such as idiopathic …

An Investigation Of Media Reports Of Digital Surveillance Within The First Year Of The Covid-19 Pandemic, Leigha Comer, Lorie Donelle Phd, Rn, Fcan, Marionette Ngole, Jacob J. Shelley, Anita Kothari, Maxwell Smith, James M. Shelley, Saverio Stranges, Brad Hiebert, Jason Gilliland, Tommy Cooke, Jodi Hall, Jed Long

Publications

INTRODUCTION: The COVID-19 pandemic prompted a surge in digital public health surveillance worldwide, with limited opportunities to consider the effectiveness or impact of digital surveillance. The news media shape public understanding of topics of importance, contributing to our perception of priority issues. This study investigated news media reports published during the first year of the pandemic to understand how the use and consequences of digital surveillance technologies were reported on. METHODS: A media content analysis of 34 high- to low-income countries was completed. The terms "COVID-19," "surveillance," "technologies," and "public health" were used to retrieve and inductively code media reports. …

Use Of Digital Technologies For Public Health Surveillance During The Covid-19 Pandemic: A Scoping Review, Lorie Donelle Phd, Rn, Fcan, Leigha Comer, Brad Hiebert, Jodi Hall, Jacob J. Shelley, Maxwell J. Smith, Anita Kothari, Jacquelyn Burkell, Saverio Stranges, Tommy Cooke, James M. Shelley, Jason Gilliland, Marionette Ngole, Danica Facca

Publications

Throughout the COVID-19 pandemic, a variety of digital technologies have been leveraged for public health surveillance worldwide. However, concerns remain around the rapid development and deployment of digital technologies, how these technologies have been used, and their efficacy in supporting public health goals. Following the five-stage scoping review framework, we conducted a scoping review of the peer-reviewed and grey literature to identify the types and nature of digital technologies used for surveillance during the COVID-19 pandemic and the success of these measures. We conducted a search of the peer-reviewed and grey literature published between 1 December 2019 and 31 December …

Successes And Barriers Of Health Information Exchange Participation Across Hospitals In South Carolina From 2014 To 2020: Longitudinal Observational Study, Kausik Lakkaraju, Aniket Gupta, Biplav Srivastava, Marco Valtorta, Dezhi Wu

Publications

Sentiment Analysis Systems (SASs) are data-driven Artificial Intelligence (AI) systems that output polarity and emotional intensity when given a piece of text as input. Like other AIs, SASs are also known to have unstable behavior when subjected to changes in data which can make them problematic to trust out of concerns like bias when AI works with humans and data has protected attributes like gender, race, and age. Recently, an approach was introduced to assess SASs in a blackbox setting without training data or code, and rating them for bias using synthetic English data. We augment it by introducing two …

Kenyan Healthcare Professionals’ Perceptions Of Global Health Engagements In Relation To The Covid-19 Pandemic, Erick Amick

Graduate Research Theses & Dissertations

Over the past 30 years, there has been a significant increase in opportunities available for individuals living in high-income countries (HICs) to participate in programs that provide health services in low- and middle-income countries (LMICs). These global health engagements (GHEs) have become common in many LMICs around the world, including Kenya. Prior to the advent of the COVID-19 pandemic, much of the research exploring individuals’ perspectives of GHEs were situated from the viewpoint of participants traveling from HICs to participate in global health programs. Few studies have examined perspectives of constituent groups in LMICs, such as healthcare professionals (i.e., healthcare …