Digital Commons Network^™

Evaluating Commonalities Between Different Medically Unexplained Symptoms, Dan Guo, Maria Kleinstäuber, Malcolm Henry Johnson, Frederick Sundram

Psychology Faculty Publications

This commentary presents commonalities in medically unexplained symptoms (MUS) across multiple organ systems, including symptoms, aetiological mechanisms, comorbidity with mental health disorders, symptom burden and impact on quality of life. Further, treatment outcomes and barriers in the clinician–patient relationship, and cross-cultural experiences are highlighted. This discussion is necessary in aiding an improved understanding and management of MUS due to the interconnectedness underlying MUS presentations across the spectrum of medical specialties.

Relationships Between Parent-Reported Parenting, Child-Perceived Parenting, And Children’S Mental Health In Taiwanese Children, Ching-Yu Huang, Yi-Ping Hsieh, April Chiung-Tao Shen, Hsi-Sheng Wei, Jui-Ying Feng, Hsiao-Lin Hwa, Joyce Yen Feng

Social Work Faculty Publications

The current study examines the relationship between parents’ and children’s reports of parenting and their effects on children’s mental health symptoms. Six hundred and sixty-six parent-child dyads in Taiwan participated in this study. The parents and the children filled out the parenting questionnaires, and the children also reported their general mental health. The results demonstrated that parental-reported and child-perceived parenting were positively correlated, but parents tended to report lower scores on authoritarian parenting and higher scores on Chinese parenting than did their children. There were also significant gender differences: The mothers reported higher authoritative parenting than did the fathers; and …

Early Dexamethasone Administration In Adults With Suspected Meningitis Lowers Morbidity And Mortality, Dana Siegel

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of de Gans J, van de Beek D, Investigators EDiABMS. Dexamethasone in adults with bacterial meningitis. New Eng J Med. 2002;347(20):1549-1556. doi: 10.1056/NEJMoa021334.

"Disgusted With Myself": Examining The Risk Factors And Vulnerabilities Of Hostesses At Karaoke Tv Venues In Phnom Penh, Cambodia, Glenn M. Miles, Daphne Alsiyao

Dignity: A Journal of Analysis of Exploitation and Violence

This exploratory study is one of a series of research projects interviewing survivors of sexual exploitation in southeast Asia. It assesses the risk factors and vulnerabilities of young women in Karaoke TV (KTV) venues in Phnom Penh, Cambodia. This research study assesses the risk factors and vulnerabilities of young women in these venues. A questionnaire-based survey was administered to 50 participants to gain a holistic view of the lives of young women working in Karaoke TV (KTV) venues. The survey consisted of a series of questions pertaining to demographics, family background, prejudice and discrimination, sexual risk factors, substance abuse, sexual …

Know(Ing) Thyself: Examining Complementary Practices Of Health And Wellness Through A Teacher's Standpoint, Ernest Andre Poole

Dissertations, Theses, and Capstone Projects

How do we know the nature of a thing; of a person? This is not just a compilation of skills, theories, methods, and methodologies but an examination of the various facets of a human being trying to make sense of a single human being: himself. The research presented here is an attempt to gain a better understanding of self through examination of emotions and how they are expressed, movement and how it brings forth and may hold the possibility of inner wellness, pain and its power as a common language, and the relationship between knowing and feeling. Burgeoning spirituality, self-worth, …

Neurodevelopmental Milestones And Associated Behaviours Are Similar Among Healthy Children Across Diverse Geographical Locations, José Villar, Michelle Fernandes, Manorama Purwar, Eleonora Staines-Urias, Paola Di Nicola, Leila Cheikh Ismail, Roseline Ochieng, Fernando Barros, Maria Carvalho, Elaine Albernaz

Paediatrics and Child Health, East Africa

It is unclear whether early child development is, like skeletal growth, similar across diverse regions with adequate health and nutrition. We prospectively assessed 1307 healthy, well-nourished 2-year-old children of educated mothers, enrolled in early pregnancy from urban areas without major socioeconomic or environmental constraints, in Brazil, India, Italy, Kenya and UK. We used a specially developed psychometric tool, WHO motor milestones and visual tests. Similarities across sites were measured using variance components analysis and standardised site differences (SSD). In 14 of the 16 domains, the percentage of total variance explained by between-site differences ranged from 1.3% (cognitive score) to 9.2% …

A Rational Approach For Creating Peptides Mimicking Antibody Binding, Sameer Sachdeva, Hyun Joo, Jerry Tsai, Bhaskara Jasti, Xiaoling Li

School of Pharmacy Faculty Articles

This study reports a novel method to design peptides that mimic antibody binding. Using the Knob-Socket model for protein-protein interaction, the interaction surface between Cetuximab and EGFR was mapped. EGFR binding peptides were designed based on geometry and the probability of the mapped knob-sockets pairs. Designed peptides were synthesized and then characterized for binding specificity, affinity, cytotoxicity of drug-peptide conjugate and inhibition of phosphorylation. In cell culture studies, designed peptides specifically bind and internalize to EGFR overexpressing cells with three to four-fold higher uptake compared to control cells that do not overexpress EGFR. The designed peptide, Pep11, bound to EGFR …

B.S. In Speech, Language And Communication Disorders_2019-2020, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Tolle Lege Works Published In 2019, Mcquade Library

Bibliographies

Compiled Tolle Lege bibliography of works published by members of the Merrimack College Community in 2019. Works include journal articles, books, book chapters, conference presentations and posters, and more.

Metabolism Reprogramming In Hexavalent Chromium-Induced Human Lung Carcinogenesis, James Tate Fortin Wise

Theses and Dissertations--Pharmacology and Nutritional Sciences

Hexavalent chromium, Cr(VI), is an established human carcinogen that is a worldwide environmental health concern. It is well understood that reactive oxygen species, genomic instability, and DNA damage repair deficiency are important contributors to Cr(VI)-induced carcinogenesis. After decades of research some cancer hallmarks remain understudied for the mechanism of Cr(VI) carcinogenesis. Dysregulated cellular energetics have been established as a hallmark of cancer. Energy pathways that become dysregulated in cancer include mitochondrial respiration, lipogenesis, pentose phosphate pathway, one carbon metabolism, and increased anaerobic glycolysis in the presence of oxygen or ‘Warburg effect’.

To investigate metabolism changes in Cr(VI) carcinogenesis, we exposed …

Effects Of Rhinacanthin-C In Multidrug-Resistance Breast Cancer Cells, Suwichak Chaisit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Rhinacanthin-C (RN-C) is a major bioactive naphthoquinone ester found in Rhinacanthus nasutus Kurz (Acanthaceae). This compound has potential therapeutic value as an anticancer agent. Rhinacanthin-C was reported to enhance doxorubicin cytotoxicity in breast cancer cells through direct inhibition of P-gp activity. However, its ability in reversing multidrug resistance (MDR) in cancer cells through the down-regulation of P-gp expression, alteration of detoxification system, and increase in apoptosis proteins remains unreported. Thus, this study was to investigate the potential MDR reversal effect of rhinacanthin-C and its underlying mechanisms in MCF-7/DOX. In this study, rhinacanthin-C (1 µM, 48 h) significantly enhanced cytotoxicity of …

Evaluation Of The Effect Of Carvedilol On The Thioredoxin Pathway In H9c2 Rat Cardiomyocytes, Metab Alharbi

Electronic Theses and Dissertations

The thioredoxin (Trx) system is an endogenous antioxidant system that affects cell function and survival through controlling cellular redox status. Trx and TrxR are the main enzymes in this system while thioredoxin interacting protein (TXNIP) is a negative regulator. This study’s goal was to better understand the Trx system’s involvement in the cardiovascular disease and modulate the pathway through drug treatment. Carvedilol is a non-selective β-blocker that also exhibits antioxidant properties, but the exact mechanism of the antioxidant effect is still unclear. H9c2 rat cardiomyocytes were used to examine the effect of carvedilol on the Trx system under normal conditions. …

Development Of Tissue-Derived Biomaterial ‘Cornea-Ecmix’: Its Utility In The Management Of Corneal Diseases, Somshuvra Bhattacharya

Electronic Theses and Dissertations

Transparent cornea, at the front of the eye, mediates vision by refracting incoming light. Due to its anatomical position, cornea is susceptible to a variety of physical and chemical insults. Severe damage caused to cornea due to trauma or disease conditions can impair vision. While the cornea’s inherent repair mechanism restores partial vision loss, transplantation is the only viable treatment option if its transparency is completely lost. A global shortage of transplantable donor tissues necessitates the need for the development of functional corneal prosthetics. As cornea mostly is made up of extracellular matrix (ECM), several studies have explored the utility …

Bet You Can’T Eat Just One: Binge Eating Disorder Promotion In American Food Advertising, Debbie Danowski

Communication, Media & The Arts Faculty Publications

"Eat Like Andy“; "What Would You Do For A Klondike Bar?“ For well over a century, American food manufacturers have been competing for consumers’ attention through the use of catchy jingles, iconic characters and celebrities. At the same time, the products being advertised contain greater amounts of addictive ingredients, which encourage binge eating resulting in an unprecedented obesity epidemic. Combine this with the full-scale commercialization of the culture today“. Jhally identifies and the powerful impact of food advertisements becomes clear as does the need to evaluate these ads. As Kilbourne noted nearly a quarter of a century ago, the majority …

Neutrophil To Lymphocyte Ratio As A Predictor Of Treatment Response And Mortality In Septic Shock Patients In The Intensive Care Unit, Rabi̇a Sari, Zühal Karakurt, Mustafa Ay, Muhammed Emi̇n Çeli̇k, Ülgen Yalaz Tekan, Fulya Çi̇yi̇ltepe, Feyza Kargin, Cüneyt Saltürk, Özlem Yazicioğlu Moçi̇n, Gökay Güngör, Nalan Adigüzel

Turkish Journal of Medical Sciences

Background/aim: While C-reactive protein (CRP) is a well-studied marker for predicting treatment response and mortality in sepsis, it was aimed to assess the efficacy of the neutrophil lymphocyte ratio (NLR) as a predictor of mortality and treatment response in sepsis patients in the intensive care unit (ICU). Materials and methods: In this retrospective cross-sectional study, sepsis patients were divided according to the presence of septic shock on the 1st day of ICU stay, and then subgrouped according to mortality. Patient demographics, acute physiologic and chronic health evaluation II and sequential organ failure assessment scores, NLR and CRP (on the 1st, …

Validity And Reliability Of The Amsterdam Preoperative Anxiety And Information Scale In The Turkish Population, Funda Çeti̇nkaya, Esi̇n Kavuran, Kevser Sevgi̇ Ünal Aslan

Turkish Journal of Medical Sciences

This study aimed to adapt the Amsterdam Preoperative Anxiety and Information Scale (APAIS) to measure the preoperative anxiety of adult Turkish patients undergoing surgery.Materials and methods: The sample of this methodological study included 210 patients. Data were collected by using personal information forms, the APAIS, and the State Anxiety Scale (STAI). Cronbach's ∝-coefficient was calculated, and test-retest reliability was tested. Results: Cronbach's ∝-coefficients of the APAIS anxiety and information requirement subscales were 0.897 and 0.786, respectively. The mean test and retest scores of the APAIS were not different. The test and retest scores of the patients were significantly, positively, and …

The Effect Of A Multigenerational Workforce On Workplace Bullying, Supaporn Walton-Robertson

Department of Conflict Resolution Studies Theses and Dissertations

Workplace bullying has become increasingly prevalent in the workplace, and as such has led to instances of job dissatisfaction, and in extreme cases, workplace violence. It is important to understand workplace bullying as an organization, a manager, and particularly in the role of human resources in order to best address such situations. Current studies have evaluated the effects of workplace bullying, along with possible suggested causes – however with the vast differences in the four generations now working together in the workplace – this is an area that also needs to be addressed as the problem of workplace bullying continues …

Role Of Tnfα Antagonists And Genetic Polymorphisms In Modulating Susceptibility To Mycobacterial Infection Among Patients With Crohn's Disease, Ahmad Qasem

Electronic Theses and Dissertations

Tumor Necrosis Factor alpha antagonists (anti-TNFα) have been extensively used for Crohn's disease (CD) treatment. Even though they may control CD symptoms initially, treatment response varies among patients, which seems to depend on single nucleotide polymorphisms (SNPs) in TNFα receptors superfamily 1A and 1B (TNFRSF1A/B). Most importantly, M. tuberculosis infection has been strongly associated with these medications, but no studies have elucidated the effects of anti-TNFα on CD associated with MAP (Mycobacterium avium subspecies paratuberculosis; a possible causative agent of CD, and closely related to M. tuberculosis). Here, we investigated the effects of recombinant inflammatory cytokines and anti-TNFα therapeutics on …

Relations Among Maternal And Paternal Behavior And Children's Stress Biology, S.K. Jiaming Lin, Stacey N. Doan, John Milton

Scripps Senior Theses

Parenting behavior has been shown to have a wide range of effects, influencing children’s psychological and biological stress outcomes. Most research focuses on maternal parenting behaviors, with few studies observing the effects of paternal behaviors or the influence of both parents on their children. In this study, the relationship between maternal and paternal parenting behaviors was examined in its association to predict children’s cortisol levels. Cultural differences in parenting styles was also observed. American (N=86) and Chinese (N=97) families participated in the study, with parents reporting their behaviors. Children’s cortisol was collected during a stressor task and correlational analysis was …

Embodied Transitions In Michel De Montaigne, Nora Martin Peterson, Peter Martin

Department of Modern Languages and Literatures: Faculty Publications

Sixteenth-century French philosopher Michel de Montaigne was one of the first writers to reflect on embodiment. “I am myself the matter of my book,” he proclaims in the introduction to his Essays. Montaigne writes about various moments of embodied transitions: a near-death experience, reflections on aging and cognitive decline, and a lengthy discussion of how to cope in the face of devastating loss. Taking an interdisciplinary perspective by analyzing the relationship between embodiment, health representations, and geropsychological themes, this chapter analyzes Montaigne’s in-between moments, arguing that Montaigne’s essays—innovative in their own time—remain important in discussing embodied transitions today.

Characterization Of The Tgfb Pathway And Its Role In Prostaglandin Metabolism In C. Elegans, Muhan Hu

All ETDs from UAB

Cell to cell communication is fundamental to all life processes, from fertilization to death. The TGFߟ superfamily is a large family of proteins that is involved in a wide array of physiological and pathological processes, including development, wound healing, immune system function, cancer, and reproduction. This group of signaling peptides is well conserved across many organisms, from basic nematode to humans. While many studies have aimed to delineate the functions of TGFߟ, they have also unveiled the complexity of this multifunctional family of ligands. In this thesis, I take advantage of the simple C. elegans model system to study the …

Descriptive Phenomenological Analysis Of Influences To Death Anxiety, Michelle M. Ehle

Antioch University Dissertations & Theses

There are two certainties in life: we are born, and we will die. Everything in between birth and death is our life. This truth leads many individuals to existential questions: What is the meaning of life? How do we become satisfied with life, knowing that death is impending? Does awareness of death motivate how we live? Death anxiety is a well-studied subject; well over 500 studies provide information on who is the most fearful of death among a variety of groups (women versus men, religious verses secular, youth verses elderly, et cetera). These studies also use presuppositions to explain fear …

The Effects Of Eicosapentaenoic Acid (Epa) And Docosahexaenoic Acid (Dha) On Brown Adipogenesis In Stem Cell Culture, Darynne A. Dahlem, Yan Huang

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are major maternal dietary supplements due to their positive benefits on neurological tissue growth during the first 12 weeks of gestation. Previous studies show that EPA and DHA inhibit muscle formation but promote adipogenesis. However, no research has addressed the question whether high intake of EPA and DHA affects brown fat development during gestation. The objective of this study was to measure the effect of EPA and DHA supplement on brown adipogenesis and potential pathways related to mitochondrial biosynthesis using fibroblasts as in vitro model. Using Oil-Red-O staining …

Evaluating The Effects Of Antibody-Conjugated Multi-Walled Carbon Nanotubes In Combination With Microwave Irradiation, Amy Chall

College of Graduate Studies: Theses & Dissertations

Cancer remains one of the largest public health concerns of our day, particularly in developed countries where technological advances have allowed populations to live well into their eighth decade. In America, those in their 80’s have a 1 in 2 chance of developing cancer in their lifetime. Prostate cancer, specifically is the second leading cause of cancer deaths in males. Traditional cancer therapies cause high levels of toxicity to the patient due to mechanisms of action that often attack cancer cells and healthy cells alike. The holy grail of cancer research is to find a treatment that targets the cancer …

Leptin Supplementation In Embryo Culture Medium Increases In Vivo Implantation Rates In Mice, Ali̇ Ci̇han Taşkin, Ahmet Kocabay

Turkish Journal of Veterinary & Animal Sciences

Leptin is a hormone-like protein consisting of 167 amino acids. The aim of this study is to compare the effects of different leptin concentrations on in vitro and in vivo embryo development rates. In vitro development rates were investigated by embryo culture studies, and in vivo implantation rates and the quality of embryos were assessed by embryo transfers to the recipient mice. The results showed that addition of leptin into the embryo culture medium at 10 and 100 ng/mL doses supported the in vitro development of mouse embryo. Moreover, leptin increased the total cell number of blastocyst, particularly the trophectoderm …

Toward An Understanding Of The Clinical Relevance Of Nitric Oxide (No) Measurements In In Vitro Cell Culture Studies, Maria Paula Kwesiga

Dissertations, Master's Theses and Master's Reports

Diabetic foot ulcers (DFU) are one of the most challenging complications associated with diabetes mellitus (DM). Every 1 in 4 patients with DM are expected to develop an ulcer in their life time. The time course of healing is on average 90 to 120 days which increases the risks of infection, amputations and death. Nitric oxide (NO) is a signaling molecule produced in the body that has been established in the literature to serve many roles in the body, including as a vasodilator, neurotransmitter immune modulator and antimicrobial agent. Emerging evidence has shown that NO is indispensable in every stage …

In Vitro Safety And Permeation Assessments Of Lidocaine Loaded In Dissolving Microneedle Patch For Ocular Administration, Sirikool Thamnium

Chulalongkorn University Theses and Dissertations (Chula ETD)

The challenge in ocular drug delivery have brought much attention in pharmaceutical research. Efforts have been made to improve the low bioavailability causing by physiological limitations of ophthalmic drug administration. Topical lidocaine solution is a popular choice for ocular treatment, but less than 5% of topically applied dose reached to the target site. Lidocaine loaded in dissolving microneedle patch was considered a good alternative approach to treating eyes. The study aimed to investigate the cytotoxicity of the lidocaine loaded in dissolving microneedle administration against human corneal epithelial cells (HCECs) as well as ex vivo drug target localization with tissue penetration. …

A Comparison Of Microrna Profiles Between Rat Incisors And Molars, Sirawit Nipakasem

Chulalongkorn University Theses and Dissertations (Chula ETD)

Unlike the molar, rodent incisor is a distinct organ that have continuously growth at distal end of tooth throughout its lifetime to compensate for abrasion. The key of continuous growth is the result of delayed root formation and prolonged crown formation that possibly made by stem cell niche, so-called cervical loop, which involve various genes and signaling pathways. MicroRNAs (miRNAs) are small non-coding single stranded RNAs that involved in biological mechanisms of dental development. To study the role of miRNA, we extracted total RNA from the dental pulp tissue collected from the apical part, coronal part of incisors and molars, …

Effects Of Rhinacanthin-C In Multidrug-Resistance Breast Cancer Cells, Suwichak Chaisit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Rhinacanthin-C (RN-C) is a major bioactive naphthoquinone ester found in Rhinacanthus nasutus Kurz (Acanthaceae). This compound has potential therapeutic value as an anticancer agent. Rhinacanthin-C was reported to enhance doxorubicin cytotoxicity in breast cancer cells through direct inhibition of P-gp activity. However, its ability in reversing multidrug resistance (MDR) in cancer cells through the down-regulation of P-gp expression, alteration of detoxification system, and increase in apoptosis proteins remains unreported. Thus, this study was to investigate the potential MDR reversal effect of rhinacanthin-C and its underlying mechanisms in MCF-7/DOX. In this study, rhinacanthin-C (1 µM, 48 h) significantly enhanced cytotoxicity of …

Examination Of Potential Factors To Predict Fieldwork Performance: A Program Evaluation Project, Sandra M. Whisner, Matthew Geddie, Dawndra Sechrist, Eugene Wang

Journal of Occupational Therapy Education

This program evaluation project evaluated the validity of a hypothesized model for predicting fieldwork performance using data of 121 occupational therapy students from a single university. The first aim was to evaluate the hypothesized relationships between observed measures (e.g., admission GPAs) and proposed latent factors (e.g., academic achievement) for predictor and outcome variables. Factor analysis of the outcome variable revealed a three-factor structure, measured by 13 items from the Fieldwork Performance Evaluation for the Occupational Therapy Student. However, factor analyses of the predictor variables did not support the proposed latent factors: Academic Achievement and Professional Potential. The second aim was …