Digital Commons Network^™

Long-Term Effects Of A Short-Term Study Abroad On Mindset, Madasyn Hofstedt, Heidi Harbers, Amy Yacucci

Graduate Independent Studies - Communication Sciences and Disorders

This literature review will examine 10 studies. The first section will discuss one study regarding common personality traits that practicing SLPs and SLP graduate students possess. The next section will review four studies about studying abroad. The final section will summarize four studies about the impact of mindset on life experiences and one study on how a growth mindset may potentially affect a study abroad experience.

Veru-111 Suppresses Tumor Growth And Metastatic Phenotypes Of Cervical Cancer Cells Through The Activation Of P53 Signaling Pathway, Vivek Kumar Kashyap, Nirnoy Dan, Neeraj Chauhan, Qinghai Wang, Saini Setua, Prashanth K. B. Nagesh, Shabnam Malik, Vivek Batra, Murali M. Yallapu, Duane D. Miller, Bilal B. Hafeez, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications

In this study, we investigated the therapeutic efficacy of VERU-111 in vitro and in vivo model systems of cervical cancer. VERU-111 treatment inhibited cell proliferation and, clonogenic potential, induce accumulation of p53 and down regulated the expression of HPV E6/E7 expression in cervical cancer cells. In addition, VERU-111 treatment also decreased the expression of phosphorylation of Jak2 (TyR1007/1008) and STAT3 at Tyr705 and Ser727. VERU-111 treatment arrested cell cycle in the G2/M phase and modulated cell cycle regulatory proteins (cyclin B1, p21 p34cdc2 and pcdk1). Moreover, VERU-111 treatment induced apoptosis and modulated the expression of Bid, Bcl-xl, Survivin, Bax, Bcl2 …

The Role Of Omega-3 Polyunsaturated Fatty Acids In Blood Pressure Regulation And Secondhand Smoke-Induced Vascular Dysfunction, Emily Anna Wheeler

Biomedical Sciences ETDs

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) may lower cardiovascular disease risk by reducing blood pressure (BP). We hypothesized that fat-1 transgenic mice, which convert n-6 PUFAs to n-3 PUFAs, would have improved vascular function in BP regulation and following secondhand smoke (SHS) exposure, compared to wild type (WT) mice.

BP was recorded in mice fed an n-6 PUFA, or standard chow diet. On the n-6 PUFA diet fat-1 mice had a lower mean arterial pressure and a greater decrease in diastolic BP when treated with an ACE inhibitor, compared to WT mice. No differences were observed on the chow diet. …

Academic Performance In Adolescent Students: The Role Of Parenting Styles And Socio-Demographic Factors – A Cross Sectional Study From Peshawar, Pakistan, Sarwat Masud, Syed Hamza Mufarrih, Nada Qaisar Qureshi, Fahad Khan, Saad Khan, Naseem Khan

Department of Medicine

Academic performance is among the several components of academic success. Many factors, including socioeconomic status, student temperament and motivation, peer, and parental support influence academic performance. Our study aims to investigate the determinants of academic performance with emphasis on the role of parental styles in adolescent students in Peshawar, Pakistan. A total of 456 students from 4 public and 4 private schools were interviewed. Academic performance was assessed based on self-reported grades in the latest internal examinations. Parenting styles were assessed through the administration of the Parental Bonding Instrument (PBI). Regression analysis was conducted to assess the influence of socio-demographic …

Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered To Blockade Prostate Cancer Senescence, Prashanth K.B. Nagesh, Pallabita Chowdhury, Elham Hatami, Sonam Kumari, Vivek K. Kashyap, Manish Tripathi, Santosh Wagh, Bernd Meibohm, Subhash C. Chauhan, Meena Jaggi, Murali M. Yallapu

School of Medicine Publications

Cellular senescence is one of the prevailing issues in cancer therapeutics that promotes cancer relapse, chemoresistance, and recurrence. Patients undergoing persistent chemotherapy often develop drug-induced senescence. Docetaxel, an FDA-approved treatment for prostate cancer, is known to induce cellular senescence which often limits the overall survival of patients. Strategic therapies that counter the cellular and drug-induced senescence are an unmet clinical need. Towards this an effort was made to develop a novel therapeutic strategy that targets and removes senescent cells from the tumors, we developed a nanoformulation of tannic acid−docetaxel self-assemblies (DSAs). The construction of DSAs was confirmed through particle size …

The Complex Relationship Between Celebrity-Driven Magazines And Depictions Of Fertility At Advanced Reproductive Ages, Brennan Peterson

Marriage and Family Therapy Faculty Articles and Research

"In this issue of the Journal of Women’s Health, Willson and colleagues explore how age and fertility are portrayed in celebrity-driven magazines.¹ Specifically, they examine if popular media depictions of celebrity pregnancies present accurate information related to age and fertility, the use of assisted reproductive technology (ARTs), and pregnancy-related risks associated with advanced maternal age (AMA >35 years). Their study provides an important viewpoint related to the impact of media on reproductive perceptions, and its potential intersection with delayed childbearing, fertility awareness, and reproductive decision making."

Personality And Phobias In Adolescence: Age And Gender In Psychopathological Expressions, Salvatore Settineri, Emanuele Maria Merlo, Angela Alibrandi, Federica Sicari, Irene Pagano Dritto, Fiorella Strangis, Fabio Frisone

Journal of Mind and Medical Sciences

Background: Although the understanding of adolescent phobias is important, this phenomenon has thus far not been adequately researched. This report, based on clinical experience, highlights prevalent phobic phenomena linked to personality characteristics. Methods: A sample of 241 adolescents from High School and the University of Messina, Italy was evaluated for phobic responses using the SAFA Scales. Personality types and aspects were assessed by the Myers-Briggs Type Indicator F Form. Results: The results were consistent with the reported literature and revealed that psychopathological phenomena such as anxiety, obsession, eating disorders and phobias decreased with aging; however, depression remained constant over time. …

Forgetting Fallujah: Covert Silence, Digital Public Memory And The Civilian Consequences Of Operation Phantom Fury In Iraq, Jason L. Jarvis

Journal of Vincentian Social Action

“Forgetting Fallujah” challenges the institutional memory of Fallujah advanced in “US Marines.” For most people, the understanding of war is based entirely on media images (Schwalbe, 2006; Sontag, 2003). This essay, like the work of Jackie Orr (2016) is a salvo in an ideological struggle to re-signify the meaning of Fallujah. The invasion of Fallujah was more severe for civilians than the torture of prisoners at Abu Ghraib, yet Fallujah caused almost no public outcry because it lacked visual evidence and went uncovered by mainstream American media (Entman, 2006). Covert silence in “US Marines” demonstrates that digital memory is easily …

Daily Technology Interruptions And Emotional And Relational Well-Being., Brandon T. Mcdaniel Phd, Michelle Drouin

Health Services and Informatics Research

The current abundance of technology in daily life creates opportunities for interruptions in couple interactions, termed technoference or phubbing. The current study examined reports from both partners in 173 romantic relationships who completed daily surveys on technoference and relational well-being measures across 14 days. By using daily diary data, we were able to examine within-person associations and more closely approximate everyday life. Utilizing multilevel modeling, we found that on days when participants rated more technoference than usual, they felt worse about their relationship, perceived more conflict over technology use, rated their face-toface interactions as less positive, and experienced more negative …

Influence Of Gut Microbiome On Obesity In Western-Style Dietary Practices Versus Other Diets: A Systematic Review, Keely A. Niemeyer, Doris I. Buezo, Loren Landeros, Karina Corral

OSRI Journal of Student Research and Innovation

BACKGROUND: The human gut is home to a microbiome that has a complex relationship to human health. Like the human genome project, microbiome is catching the attention of researchers who seek new methods to combat obesity and negative health outcomes associated with it.

OBJECTIVES: This systematic review aims to distinguish the impact of a Western diet on gut health verses a plant-based diet.

DATA SOURCES: EBSCOHost library databases inclusive of CINAHL plus, ScienceDirect, and PubMed using keywords to better understand the correlation of dietary practices and microbiome balance.

STUDY ELIGIBILITY: Criteria that include diet, current research, and scholarly peer reviewed …

A Challenging Case Of Spontaneous Bacterial Empyema In A Cirrhotic Patient, Saad Emhmed Ali, Olalekan Akanbi, Macy Godman, Mohanad Soliman, Wesam M. Frandah, Karim Benrajab

Internal Medicine

Spontaneous Bacterial Empyema (SBEM) is distinguished as a primary infection of pre-existing hepatic hydrothorax in the absence of cardiopulmonary or pleural disease. It is an under-recognized complication of cirrhosis and is associated with high morbidity and mortality. The diagnosis requires chest imaging to rule out underlying pneumonia as an etiology; a diagnostic thoracentesis is crucial to make the diagnosis and should be obtained in any patient with pleural effusion and evidence of infection. Expeditious administration of antibiotics is essential to ameliorate the outcome. We present an interesting case of spontaneous bacterial empyema in a cirrhotic patient with hepatic hydrothorax.

Recent Trends, Current Research In Cyberpsychology: A Literature Review, Amarjit Kumar Singh, Pawan Kumar Singh

Library Philosophy and Practice (e-journal)

Cyberpsychology refers to the study of the mind and behavior in the context of interactions with technology. It is an emerging branch, which has focused on the psychological aspects connected to the increasing presence and usages of technology in modern lives. This paper traces recent advancement and trends of Cyberpsychology is an emerging domain of knowledge and goes on the give a literature review of the same. An analysis of the recent research and literature covering 300 most relevant research papers from the period of 2012 to 15, August 2019 was conducted to determine and shape the research pattern based …

Exploring Informal Caregivers’ Roles In Medical Tourism Through Qualitative Data Triangulation, Rebecca Whitmore, Valorie A. Crooks, Jeremy Snyder

The Qualitative Report

When Canadian medical tourists go abroad, they are often accompanied by friends and family, referred to as caregiver-companions, who provide informal care. These individuals play a role in patient decision-making and are stakeholders in medical tourism, yet little is known about their participation in this consumer health practice. To examine the roles that Canadian caregiver-companions play while accompanying medical tourists abroad, and to identify how multi-perspective qualitative data can augment our understanding of these roles, primary and secondary analysis was undertaken on datasets generated from multiple qualitative studies: semi-structured interviews with medical tourists, caregiver-companions, and international patient coordinators, and a …

A Flavor Perception Game Designed To Introduce Basic Chemical Sensation Of Taste Modalities To Undergraduate Nursing And Exercise Sciences Students, Angela L. Mahaffey

Nursing: School of Nursing Faculty Publications and Other Works

The Flavor Perception Game was designed with the goals of developing an interactive and hands-on activity, providing a platform to review chemical senses of the five tastes, promoting student investment in the course material, and providing a basis for discussion on chemical senses of the five tastes. Knowledge of taste sensation is useful for nursing and exercise sciences students, as human physiology is integral to both baccalaureate curricula. The game is inexpensive, easy to incorporate into a 50-minute lecture period, and free of chocolate allergens. Student participants (N=34) tasted three candies and completed a voluntary anonymous poll regarding their detection …

Characterizing The Role Of Extracellular Matrix In Non-Small Cell Lung Carcinoma Metastasis Using A 3d Microenvironment Mimetic In-Vitro Culture System., Douglas John Owulaku Saforo

Electronic Theses and Dissertations

Lung cancer is the leading cause of cancer related death in the United States and worldwide. Five-year survival rates for non-small cell lung carcinoma patients have not improved in decades, and a majority of patients succumb to metastasis. Identification of therapeutic targets for metastatic disease is essential for the development of novel therapies. However, current 2-dimensional (2D) in vitro models are not reflective of the tumor microenvironment (TME) and are inadequate in identifying therapeutic targets. We adapted a 3-dimensional (3D) extracellular matrix (ECM) in vitro model to a hypoxic incubator to approximate physiological hypoxia of the TME in a microenvironment …

Targeting Pathogenic Lafora Bodies In Lafora Disease Using An Antibody-Enzyme Fusion, M. Kathryn Brewer, Annette M. Uittenbogaard, Grant L. Austin, Dyann M. Segvich, Anna Depaoli-Roach, Peter J. Roach, John J. Mccarthy, Zoe R. Simmons, Jason A. Brandon, Zhengqiu Zhou, Jill Zeller, Lyndsay E. A. Young, Ramon C. Sun, James R. Pauly, Nadine M. Aziz, Bradley L. Hodges, Tracy R. Mcknight, Dustin D. Armstrong, Matthew S. Gentry

Molecular and Cellular Biochemistry Faculty Publications

Lafora disease (LD) is a fatal childhood epilepsy caused by recessive mutations in either the EPM2A or EPM2B gene. A hallmark of LD is the intracellular accumulation of insoluble polysaccharide deposits known as Lafora bodies (LBs) in the brain and other tissues. In LD mouse models, genetic reduction of glycogen synthesis eliminates LB formation and rescues the neurological phenotype. Therefore, LBs have become a therapeutic target for ameliorating LD. Herein, we demonstrate that human pancreatic α-amylase degrades LBs. We fused this amylase to a cell-penetrating antibody fragment, and this antibody-enzyme fusion (VAL-0417) degrades LBs in vitro and dramatically reduces LB …

Disrupting The Intergenerational Transmission Of Trauma Among Alaska Native People: A Conceptual Model For The Family Wellness Warriors Initiative, Lily Ray, Bobbi Outten, Polly Andrews, Katherine Gottlieb

Journal of Health Disparities Research and Practice

Background: Increasing evidence demonstrates the life-long physical, emotional, and social effects of traumatic experiences. In recognition that many health disparities are driven by high rates of traumatic experiences, Alaska Native and American Indian people have created wellness programs that build health by first healing historical and lifetime trauma. Yet, many of these promising community-based interventions are not described in the health sciences literature. Southcentral Foundation’s Family Wellness Warriors Initiative (FWWI) was created by Alaska Native people, addresses traumatic experiences as the root cause of family violence, and builds on cultural strengths. The goal of this study was to build a …

Postpartum Psychosis In A Non-Native Language-Speaking Patient: A Perspective On Language Barriers And Cultural Competency., Tatsuhiko Naito, Justin Chin, Jun Lin, Pritesh J Shah, Christine M. Lomiguen

Touro College of Osteopathic Medicine (New York) Publications and Research

Postpartum psychosis is a condition characterised by rapid onset of psychotic symptoms several weeks after childbirth. Outside of its timing and descriptions of psychotic features, minimal research exists due to its relative rarity (1 to 2 per 1000 births in the USA), with greater emphasis on postpartum sadness and depression. With the existing literature, cultural differences and language barriers previously have not been taken into consideration as there are no documented cases of postpartum psychosis in a non-English-speaking patient. Correctly differentiating postpartum psychosis from other postpartum psychiatric disorders requires adeptly evaluating for the presence of psychotic symptoms with in-depth history …

Enhancing Cell Seeding And Osteogenesis Of Mscs On 3d Printed Scaffolds Through Injectable Bmp2 Immobilized Ecm-Mimetic Gel, Farahnaz Fahimipour, Erfan Dashtimoghadam, Mohammad Mahdi Hasani-Sadrabadi, Jessica Vargas, Daryoosh Vashaee, Doug Lobner, Tahereh S. Jafarzadeh Kashi, Behnam Ghasemzadeh, Lobat Tayebi

Biomedical Sciences Faculty Research and Publications

Objective

Design of bioactive scaffolds with osteogenic capacity is a central challenge in cell-based patient-specific bone tissue engineering. Efficient and spatially uniform seeding of (stem) cells onto such constructs is vital to attain functional tissues. Herein we developed heparin functionalized collagen gels supported by 3D printed bioceramic scaffolds, as bone extracellular matrix (ECM)-mimetic matrices. These matrices were designed to enhance cell seeding efficiency of mesenchymal stem cells (MSCs) as well as improve their osteogenic differentiation through immobilized bone morphogenic protein 2 (BMP2) to be used for personalized bone regeneration.

Methods

A 3D gel based on heparin-conjugated collagen matrix capable of …

An Investigation Of Problem Gambling And Young Sports Players In An Irish Amateur Sporting Organisation., Maurice Murphy

Dept. of Management & Enterprise Conference Material

The gambling industry is huge in Ireland. The betting firm Paddy Power alone had an operating profit of €163.8million in 2014. The activity has become more popular and accessible in recent years due to its move online. In fact, anybody with a smartphone can gamble wherever they may be. While research within Ireland has been limited, there are some startling statistics related to gambling addiction in Ireland with roughly 7% of gamblers at risk of developing a gambling problem and approximately 30-35% of the gambling industry’s revenues coming from those who have gambling issues. According to the Institute of Public …

Failure Of Oxysterols Such As Lanosterol To Restore Lens Clarity From Cataracts, Damian M. Daszynski, Puttur Santhoshkumar, Ashutosh S. Phadte, K. Krishna Sharma, Haizhen A. Zhong, Marjorie F. Lou, Peter F. Kador

School of Veterinary and Biomedical Sciences: Faculty Publications

The paradigm that cataracts are irreversible and that vision from cataracts can only be restored through surgery has recently been challenged by reports that oxysterols such as lanosterol and 25-hydroxycholesterol can restore vision by binding to αB-crystallin chaperone protein to dissolve or disaggregate lenticular opacities. To confirm this premise, in vitro rat lens studies along with human lens protein solubilization studies were conducted. Cataracts were induced in viable rat lenses cultured for 48 hours in TC-199 bicarbonate media through physical trauma, 10 mM ouabain as Na+/K+ ATPase ion transport inhibitor, or 1 mM of an experimental compound that induces water …

Orthorexia Nervosa Among Collegiate Female Student-Athletes, Maryse Bard-Martel

Graduate Theses/Dissertations

Orthorexia nervosa (ON) is a specific style of disordered eating defined as an unhealthy obsession with eating healthy food, or going to extremes in the pursuit of a diet that is supposed to be good for you. The purpose of this study was to explore the prevalence of orthorexia nervosa tendencies in college female soccer players in the NCAA Division 1. Purposive sampling was used, and participants were current student-athletes from the Missouri State women’s soccer team (n=18). Survey research was utilized to assess athletes’ attitudes and behaviors related to various aspects of diet and training, and the control it …

Health Care In The Caribbean: A Comparative Analysis Between Cuba And Puerto Rico, Matheus Moreira Sanches Peraci

Honors Projects

The paper at hand focuses on comparing the differences of the Cuban and Puerto Rican health care (HC) system and conditions. As this is a comparative research analysis, this was done by reviewing many different reliable sources and compiling the relevant information from Cuba and Puerto Rico. The factors that were taken into account are: (a) Political and Health Care Systems, (b) Natural and Artificial Disaster and (c) Country’s Demographics and Health Statistics.

Collegiate Program Safety Culture Survey – A Comparison Of Disciplines, Wendy Beckman, Daniel Siao, Carlos Smith, Kevin Corns

International Symposium on Aviation Psychology - 2019

The use of safety culture surveys to determine constituent perception of an organization’s efforts toward safety is widely accepted. However, the use of such surveys to compare disciplines within a collegiate aviation department has infrequently been employed. Students enrolled in flight, maintenance, and UAS programs participated in a safety culture survey, providing data on the safety culture within each program as well as the ability to compare programs. Subscales for safety values, safety fundamentals, and risk assessment were included. There were statistically significant differences in safety values between the maintenance group and both the flight and UAS groups, and between …

Notch Inhibitors And The Bet Inhibitor Jq-1 Decrease The Growth Of Primary Tumor Cells Derived From A Novel Mouse Model Of C11orf95-Rela Induced Brain Tumor, Ericka Randazzo, Jesse Dunnack, Justin Fang, Joseph Loturco Phd

University Scholar Projects

Brain tumors are the most common childhood solid malignancy, and because of remarkable advances in treating many cancers outside of the brain, they have become the leading cause of cancer mortality in children. Ependymomas are a class of brain tumors which can be further subdivided into three groups based upon their location and genetic features. Of the three classes, supratentorial ependymomas are the only subgroup known to be marked by an oncogenic driver gene, which consists of a fusion mutation between the C11orf95 and RELA genes. C11orf95-RELA positive tumors are the most aggressive and lethal of …

Effect Of Tyrosine On The Productivity Of Pc12 Cells By Measuring Extracellular Atp Release, Sabrina Burkholder, Mary Rapmund, David Fogel, Jon Flees

Student Scholar Symposium Abstracts and Posters

Given the challenge to “reverse-engineer the brain”, our group tried to address the problems of a lack of long term focus and attention span. Tyrosine was determined to aid in mental focus and brain productivity as it is a precursor to the neurotransmitter Dopamine. Given that Tyrosine is naturally occurring in the body, it is preferable to add to the body, whereas a substance like Adderall has negative effects, including increased heart rate that, over time, can cause cardiovascular damage. Drawing connections between in increase ATP and an increased ability to focus and perform under stress, extracellular ATP secretion of …

Quantifying Expression Of Interneuron Subtype Markers For Dlx-2 Transfected Ng2 Cells, Timothy Nolan

Honors Scholar Theses

Neurons are a post-mitotic cell population, and therefore, they are not able to regenerate in vivo after a traumatic injury. Because inhibitory GABAergic interneurons and oligodendrocyte precursor cells (OPCs) are derived from the same precursor, recent studies have focused on transforming these OPCs into GABAergic neurons. However, there are different types of GABAergic interneurons that have different electrophysiological responses, which can lead to functional differences. The Nishiyama laboratory had already used a key gene in GABAergic interneuron and OPC differentiation, Distal-less homeobox 2 (Dlx-2), to transfect OPCs; early electrophysiology tests showed most of these transfected cells behaved like immature neurons, …

When Process Becomes Processing: Managing Instructor Response To Student Disclosure Of Trauma In The Composition Classroom, Kelci Barton

Electronic Theses and Dissertations

In first-year composition courses, there are three aspects of teaching that are researched well so far: disclosure of trauma in student writing, instructor feedback, and emotional labor. The disclosure of trauma is almost completely unavoidable in first-year composition. We encounter an issue with instructor feedback; how do we provide feedback to student writing, like grammar and mechanics, when the student has disclosed trauma in the writing? Additionally, we can build off this with emotional labor, which already occurs consistently in teaching but is heightened in this instance. When providing feedback to a student who has disclosed trauma, this can be …

The "Fat Acceptance And Fat Pride Movements" And Consumer Culture: A Critical Intervention On Popular Obesity Discourses, Gabriella Josephine Papas

Cultural Studies Capstone Papers

This project is presented as a critical intervention into the larger debates surrounding the U.S. fat acceptance and fat pride political ‘movements,’ at a historical moment when the country is suffering from a deep obesity epidemic and crisis. At a time of deep concern about increasing healthcare costs and overall societal health, the fact that the dominant discourse among fat activists tends to contradict prevalent positions and findings of contemporary medical research calls for a critical ideological critique of the movements and an interrogation of their rhetoric. In this project Gabriella Papas’ critique combines concepts from both cultural studies and …

Vulnerability And Physical Well-Being Of Caregivers: What Relationship?, Salvatore Settineri, Fabio Frisone, Angela Alibrandi, Emanuele Maria Merlo

Journal of Mind and Medical Sciences

Objectives. To assess relationships among burden, compassion, and well-being and health among an active group of caregivers.

Methods. 301 caregivers with female prevalence (F = 61.1%, M = 38.9%) and ages between 18 and 84 years old (average = 38.72; SD 13.36) participated. Evaluation was carried using standardized instruments to assess: Burdens (CBI), dimensions related to Compassion and Burnout (ProQOL-5), State of Well-being (Who-5) and particular health-related domains (Emotional state, Physical health, Depressive Polarity, Dysphoric Polarity-SF-36). Correlational analyses and multivariate linear regressions were performed.

Results. Positive correlations emerged between Burdens and Compassion Fatigue, Well-being and Satisfaction; inverse correlations emerged among …