Digital Commons Network^™

Does Internet Gaming Disorder Hinder Academic Performance?, Erwin Bramana Karnadi, Stevanus Pangestu

Jurnal Kajian Bimbingan dan Konseling

In 2018, the WHO has categorized gaming disorder as an official disease. One of the ways to estimate a person’s gaming disorder level or status is to use the IGD-20 Test. The purpose of our research is to determine whether or not internet gaming disorder (IGD) has a significant negative impact on academic performance using binary dependent and two-staged least squares models. We obtained data from 390 Indonesian university students, consisting of their academic performance, IGD level, gaming behavior, and several of their economic and demographic characteristics. We found that 5.13 percent of the respondents have IGD. Using both probit …

Nurse Practitioners And Community Health Workers Improve Community Health, Emmalee F. Voskuil

Theses and Graduate Projects

Addressing health disparities in primary care is essential for the advanced practice nurse practitioner(NP). Recent research demonstrates that the United States spends more money on health care than any other country of equal income but has worse outcomes, including lower life expectancy, higher infant mortality rates, and more stratified health inequities (Papanicolas, Woskie, & Jha, 2018). The NP has many opportunities to improve healthcare by partnering with diverse voices that seek to change the healthcare system. To better address health disparities among marginalized people in Minnesota, this scholarly project will determine best practices for the development and incorporation of community …

Pandemic Emotions: The Good, The Bad, And The Unconscious —Implications For Public Health, Financial Economics, Law, And Leadership, Peter H. Huang

Northwestern Journal of Law & Social Policy

Pandemics lead to emotions that can be good, bad, and unconscious. This Article offers an interdisciplinary analysis of how emotions during pandemics affect people’s responses to pandemics, public health, financial economics, law, and leadership. Pandemics are heart-breaking health crises. Crises produce emotions that impact decision-making. This Article analyzes how fear and anger over COVID-19 fueled anti-Asian and anti-Asian American hatred and racism. COVID-19 caused massive tragic economic, emotional, mental, physical, and psychological suffering. These difficulties are interconnected and lead to vicious cycles. Fear distorts people’s decision readiness, deliberation, information acquisition, risk perception, and thinking. Distortions affect people’s financial, health, and …

Does Computer-Based Classroom Instruction Impact Student Participation?, Paige Hyer

MOT Student Capstones

COVID-19 has caused a disruption of typical teaching methods forcing students to receive instruction virtually. Computer-based classroom instruction was implemented to allow for quick transition between virtual and face-to-face instruction as determined by COVID-19 cases. This research explores how computer-based classroom instruction has impacted student participation within the classroom and the role of occupational therapy to support students who utilize this method of learning. Eighteen elementary school teachers who currently utilize this method of learning were surveyed and data was collected to determine feedback on the impact of computer-based classroom instruction. Data determined that student participation is impacted by computer-based …

Representations And Narratives Of F To M Gender Dysphoric Subjects: Self, Body And Psycho-Traumatology In Comparison With M To F Transsexualism, Emanuele Maria Merlo

Journal of Mind and Medical Sciences

The present study was aimed at extending the method previously used with M to F gender dysphoric patients, to F to M individuals. In particular, the aim of the study was to highlight global and particular representations of the subjects. The study involved 10 gender dysphoric subjects in F to M transition, aged between 18 to 26 years old. Rorschach and the Thematic Apperception Test were administered with particular attention to the detection of psycho-traumatic indexes. The data reached through the extension of the method to F to M subjects revealed a continuity between the two groups. Referring to Self-representation, …

Alexithymia And Physical Outcomes In Psychosomatic Subjects: A Cross-Sectional Study, Liam Alexander Mackenzie Myles, Emanuele Maria Merlo

Journal of Mind and Medical Sciences

Backgrounds. Alexithymia is a relevant phenomenon, occurring transversally to healthy subjects and individuals affected by several conditions. Its role is considerable, according to current state of the art several conditions emerged as influenced, maintained and worsened by alexithymic structures and figures. The present study was aimed at highlighting the existing relations, the differences and the directions assumed by alexithymic factors and health status in patients affected by psychosomatic conditions. Methods. The sample consisted of 150 participants, 42 males (28.0%) and 108 females (72.0%), aged 26 to 78 years old with a mean of 42.24 years old (SD = 12.39). Subjects …

Effects Of News And Threat Perceptions On Americans’ Covid-19 Precautionary Behaviors, Riva Tukachinsky Forster, Megan A. Vendemia

Communication Faculty Articles and Research

Our study examines the relationship between news exposure at the onset of the COVID-19 pandemic, personal threat beliefs, beliefs about others’ threat perceptions, and participation in precautionary actions. A survey of 377 U.S . adults revealed a significant main effect of news exposure on various precautionary behaviors (e.g., facial mask wear, physical distancing). Personal threat beliefs and beliefs about others’ threat perceptions serve as unique mechanisms mediating the effect of news on specific CDC-recommended and less socially desirable actions. These findings can guide news sources covering health crises in a socially responsible manner.

Phil 201: Bioethics, Cuny School Of Professional Studies

Open Educational Resources

An exploration of complex contemporary ethical problems from healthcare, the environment, and bioethics. Issues include problems of drugs and addiction, stigma toward people with disabilities, terminal illness and chronic health needs, resource allocation in times of disaster, infectious diseases, gene editing, and humans’ relationship with their environment. Classical and contemporary ethical theories, moral theories, and the fundamentals of scientific integrity will be applied to make principled, defensible, moral judgments.

Span 110: Spanish For Health Professions, Cuny School Of Professional Studies

Open Educational Resources

Intended for students who have no background in the Spanish language, this course facilitates effective communication between patients and their healthcare providers (nurses, doctors, medical staff), through emphasis on basic, practical language needed to communicate with Spanish-speaking patients and their families in various settings. Building basic language fluency at the same time as medical terminology with cultural competency woven throughout, students will learn to gather and share basic information like greetings, goodbyes, patient intake, discussion of symptoms, location of pain and injuries, body parts, numbers, time, doses, and units of measure. Focus is on learning and becoming comfortable with basic …

Therapeutic Potential Of Trp Channels In The Targeting Of Rheumatoid Arthritis Synovial Fibroblasts, Brittany Isabella Schwam

Theses and Dissertations (ETD)

Rheumatoid arthritis is a chronic inflammatory disease primarily affecting the synovium, articular cartilage, and bone within a joint, but it is a unique form of arthritis wherein effects are systemic. The cause of this autoimmune disease remains unknown, but there are many environmental and genetic factors that play into susceptibility. Research is still far from drug-free remission despite great advancements over the past few decades. The majority of therapies developed rely on immunosuppressant or immunomodulator molecules and come with risk of infection, high costs, and toxic, uncontrolled side effects. Those diagnosed maintain a significant unmet need for targeted therapies.

There …

A Millifluidic Perfusion Cassette For Studying The Pathogenesis Of Enteric Infections Using Ex-Vivo Organoids, Reid L Wilson, Sarah A Hewes, Anubama Rajan, Shih-Ching Lin, Carolyn Bomidi, Takanori Iida, Mary K Estes, Anthony W Maresso, K Jane Grande-Allen

Faculty, Staff and Students Publications

To generate physiologically-relevant experimental models, the study of enteric diarrheal diseases is turning increasingly to advanced in vitro models that combine ex vivo, stem cell-derived "organoid" cell lines with bioengineered culture environments that expose them to mechanical stimuli, such as fluid flow. However, such approaches require considerable technical expertise with both microfabrication and organoid culture, and are, therefore, inaccessible to many researchers. For this reason, we have developed a perfusion system that is simple to fabricate, operate, and maintain. Its dimensions approximate the volume and cell culture area of traditional 96-well plates and allow the incorporation of fastidious primary, stem …

Aspiring To “Make It Work”: Defining Resilience And Agency Amongst Hispanic Youth Living In Low-Income Neighborhoods, Sara Arias-Steele

USF Tampa Graduate Theses and Dissertations

This study explored how Hispanic youth (ages 13-21 years) living in low-income neighborhoods of Florida defined resiliency and expressed agency navigating personal challenges and neighborhood adversity in pursuit of success. From the standpoint of the participants, this study focused on how youths: 1) judge the quality of life in their neighborhoods and the opportunities available for them, 2) identify personal aspirations for themselves and 3) identify what resilient factors allowed them to face the challenges and barriers of their daily lives to pursue this aspiration. This study takes into account the structural barriers that create inequities to examine how personal …

The Mediating Role Of Pain Catastrophizing On The Association Between Depression And Pain Severity And Interference Among Elderly Asian Immigrants With Chronic Pain, Hee Jun Kim, Hyunjeong Park, Hee-Soon Juon

Department of Medical Oncology Faculty Papers

Purpose: The association between depression and chronic pain is well established. However, few studies have examined the pathways from depression to chronic pain. The present cross-cultural study aimed to test the mediating effects of pain catastrophizing on associations between depression and chronic pain (eg, pain severity, pain intensity) among Korean American elderly.

Patients and Methods: A total of 132 elderly Korean Americans with chronic pain were recruited from elderly daycare centers and Korean ethnic churches in the community. For mediation analyses, structural equation modeling with full information maximum likelihood estimation method was used. The bias-corrected bootstrap confidence interval (CI) method …

The Relationship Between Dark Triad Personality Traits And Sexting Behaviors Among Adolescents And Young Adults Across 11 Countries., Mara Morelli, Flavio Urbini, Dora Bianchi, Roberto Baiocco, Elena Cattelino, Fiorenzo Laghi, Piotr Sorokowski, Michal Misiak, Martyna Dziekan, Heather Hudson, Alexandra Marshall, Thanh Truc T Nguyen, Lauren Mark, Kamil Kopecky, René Szotkowski, Ezgi Toplu Demirtaş, Joris Van Ouytsel, Koen Ponnet, Michel Walrave, Tingshao Zhu, Ya Chen, Nan Zhao, Xiaoqian Liu, Alexander Voiskounsky, Nataliya Bogacheva, Maria Ioannou, John Synnott, Kalliopi Tzani-Pepelasi, Vimala Balakrishnan, Moses Okumu, Eusebius Small, Silviya Pavlova Nikolova, Michelle Drouin, Antonio Chirumbolo

Health Services and Informatics Research

BACKGROUND: Sexting is an increasingly common phenomenon among adolescents and young adults. Some studies have investigated the role of personality traits in different sexting behaviors within mainstream personality taxonomies like Big Five and HEXACO. However, very few studies have investigated the role of maladaptive personality factors in sexting. Therefore, the present study investigated the relationship between Dark Triad Personality Traits and experimental (i.e., sharing own sexts), risky (i.e., sexting under substance use and with strangers), and aggravated sexting (i.e., non-consensual sexting and sexting under pressure) across 11 countries.

METHODS: An online survey was completed by 6093 participants (Mage = 20.35; …

The Masochian Woman: A Fantasy Of Male Desire?, Jennifer Komorowski Ms.

Middle Voices

The Masochian woman is a figure who stages what is at stake for women when desire and the law come together. This requires an examination of the conflict that exists between the idea that women’s masochism is the fantasy of men and the truth about who wields power in the masochistic theatre. Thus, the inquiry into women’s masochism means following Jacques Lacan’s conception of women’s masochism in Anxiety, which describes it as holding a “completely different meaning, a fairly ironic meaning, and a completely different scope” from the pervert’s masochism or moral masochism (Lacan, 2016, p.190). Beginning with a critical …

Perceptions Of Health Insurers Towards Pay-For-Performance As A Cost Control Model For Hospital Services, Mandlenkosi Moyo

Doctoral Dissertations and Projects

Hospital costs are the most significant portion of health-related costs incurred by non-profit health insurers registered as medical schemes in South Africa. Medical schemes continue to use retrospective reimbursement models for hospitals despite general acknowledgment that these models do not limit hospital costs and utilization. Although medical schemes are interested in implementing alternative reimbursement models, such as pay-for-performance (P4P), they are uncertain about which P4P models they can use to reduce hospital costs, resulting in their inability to make critical changes to their costs from traditional fee-for-service models. This qualitative exploratory multiple case study used 17 open-ended case interviews to …

Pirnas As Modulators Of Disease Pathogenesis, Kayla J. Rayford, Ayorinde Cooley, Jelonia T. Rumph, Ashutosh Arun, Girish Rachakonda, Fernando Villalta, Maria F. Lima, Siddharth Pratap, Smita Misra, Pius N. Nde

Publications and Research

Advances in understanding disease pathogenesis correlates to modifications in gene expression within different tissues and organ systems. In depth knowledge about the dysregulation of gene expression profiles is fundamental to fully uncover mechanisms in disease development and changes in host homeostasis. The body of knowledge surrounding mammalian regulatory elements, specifically regulators of chromatin structure, transcriptional and translational activation, has considerably surged within the past decade. A set of key regulators whose function still needs to be fully elucidated are small non-coding RNAs (sncRNAs). Due to their broad range of unfolding functions in the regulation of gene expression during transcription and …

Experiences Of Shame, Exclusion, & Appropriation In Mindfulness-Based Wellness Culture, Charlotte Grace Starling

University Honors Theses

Yoga, meditation, and other mindfulness practices provide numerous benefits both physical and mental health to their practitioners. There is less research exploring the role mindfulness-based wellness programs and practices fit within the cultural environment of the United States and how the mindfulness movement influences wellness culture and practices. These practices and spaces have been accused of harming folks who don't fit the dominant social narrative of thin, white, upper-middle-class participants. This paper aims to explore how the United State’s commodification of mindfulness practices contributes to experiences of shame, exclusion, and appropriation in wellness culture. This is done by a literature …

Parameters Affecting Continuous In Vitro Culture Of Treponema Pallidum Strains, Diane G Edmondson, Bridget D Delay, Lindsay E Kowis, Steven J Norris

Faculty, Staff and Student Publications

The bacterium that causes syphilis, Treponema pallidum subsp. pallidum, has now been cultured in vitro continuously for periods exceeding 3 years using a system consisting of coculture with Sf1Ep rabbit epithelial cells in TpCM-2 medium and a low-oxygen environment. In addition, long-term culture of several other syphilis isolates (SS14, Mexico A, UW231B, and UW249B) and the T. pallidum subsp. endemicum Bosnia A strain has been achieved. During in vitro passage, T. pallidum subsp. pallidum exhibited a typical bacterial growth curve with logarithmic and stationary phases. Sf1Ep cells are required for sustained growth and motility; however, high initial Sf1Ep cell …

Mapk4 Promotes Prostate Cancer By Concerted Activation Of Androgen Receptor And Akt, Tao Shen, Wei Wang, Wolong Zhou, Ilsa Coleman, Qinbo Cai, Bingning Dong, Michael M Ittmann, Chad J Creighton, Yingnan Bian, Yanling Meng, David R Rowley, Peter S Nelson, David D Moore, Feng Yang

Faculty, Staff and Students Publications

Prostate cancer (PCa) is the second leading cause of cancer death in American men. Androgen receptor (AR) signaling is essential for PCa cell growth/survival and remains a key therapeutic target for lethal castration-resistant PCa (CRPC). GATA2 is a pioneer transcription factor crucial for inducing AR expression/activation. We recently reported that MAPK4, an atypical MAPK, promotes tumor progression via noncanonical activation of AKT. Here, we demonstrated that MAPK4 activated AR by enhancing GATA2 transcriptional expression and stabilizing GATA2 protein through repression of GATA2 ubiquitination/degradation. MAPK4 expression correlated with AR activation in human CRPC. Concerted activation of both GATA2/AR and AKT by …

Macrophage And Adipocyte Interaction As A Source Of Inflammation In Kidney Disease, Cristina Martos-Rus, Goni Katz-Greenberg, Zhao Lin, Eurico Serrano, Diana Whitaker Menezes, Marina Domingo-Vidal, Megan Roche, Kavitha Ramaswamy, D. Craig Hooper, Bonita Falkner, Maria P Martinez Cantarin

Kimmel Cancer Center Faculty Papers

In obesity, adipose tissue derived inflammation is associated with unfavorable metabolic consequences. Uremic inflammation is prevalent and contributes to detrimental outcomes. However, the contribution of adipose tissue inflammation in uremia has not been characterized. We studied the contribution of adipose tissue to uremic inflammation in-vitro, in-vivo and in human samples. Exposure to uremic serum resulted in activation of inflammatory pathways including NFκB and HIF1, upregulation of inflammatory cytokines/chemokines and catabolism with lipolysis, and lactate production. Also, co-culture of adipocytes with macrophages primed by uremic serum resulted in higher inflammatory cytokine expression than adipocytes exposed only to uremic serum. Adipose tissue …

[(Wr)8Wkβa]-Doxorubicin Conjugate: A Delivery System To Overcome Multi-Drug Resistance Against Doxorubicin, Khalid Zoghebi, Hamidreza Montazeri Aliabadi, Rakesh Kumar Tiwari, Keykavous Parang

Pharmacy Faculty Articles and Research

Doxorubicin (Dox) is an anthracycline chemotherapeutic agent used to treat breast, leukemia, and lymphoma malignancies. However, cardiotoxicity and inherent acquired resistance are major drawbacks, limiting its clinical application. We have previously shown that cyclic peptide [WR]₉ containing alternate tryptophan (W) and arginine (R) residues acts as an efficient molecular transporter. An amphiphilic cyclic peptide containing a lysine (K) residue and alternative W and R was conjugated through a free side chain amino group with Dox via a glutarate linker to afford [(WR)₈WKβA]-Dox conjugate. Antiproliferative assays were performed in different cancer cell lines using the conjugate and the …

Counselors-In-Training Reactions To Clients Living With And Without Hiv, Melissa Zeligman, J. Richelle Joe

Journal of Counseling Sexology & Sexual Wellness: Research, Practice, and Education

An estimated one million people are currently living with HIV in the United States. Therefore, an important question remains pertaining to professional helpers’ preparedness in working with people living with HIV/AIDS (PLWHA). This study (N = 165) utilized an analogue design, with participants receiving one of four possible clinical case vignettes, to determine the relationship of client HIV status and race with counselor-in-training self-efficacy, multicultural competency, and empathy. Results revealed that client HIV status was predictive of counselor self-efficacy, and that self-efficacy held relationships with multicultural counseling competency and empathy. Findings suggest multicultural skills training may be particularly important to …

Specification Of The Patterning Of A Ductal Tree During Branching Morphogenesis Of The Submandibular Gland., Janice L Walker, Weihao Wang, Edith Lin, Alison Romisher, Meghan P Bouchie, Brigid Bleaken, A Sue Menko, Maria A Kukuruzinska

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The development of ductal structures during branching morphogenesis relies on signals that specify ductal progenitors to set up a pattern for the ductal network. Here, we identify cellular asymmetries defined by the F-actin cytoskeleton and the cell adhesion protein ZO-1 as the earliest determinants of duct specification in the embryonic submandibular gland (SMG). Apical polarity protein aPKCζ is then recruited to the sites of asymmetry in a ZO-1-dependent manner and collaborates with ROCK signaling to set up apical-basal polarity of ductal progenitors and further define the path of duct specification. Moreover, the motor protein myosin IIB, a mediator of mechanical …

2022-01-04_Michiganoverview_Covidschooloutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The School Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102480---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

K-12 School-Related Outbreak Reporting: In accordance with the Council of State and Territorial Epidemiologists' outbreak definition, a K-12 school-associated COVID-19 case (confirmed or probable) is defined as a student, teacher, or staff member physically present in the school setting or participated in a school sanctioned extracurricular activity within 14 days prior to illness onset (or a positive test result) OR …

Covidistress Global Survey Dataset On Psychological And Behavioural Consequences Of The Covid-19 Outbreak, Austin Horng-En Wang, Over 50 Other International Authors

Political Science Faculty Research

This N=173,426 social science dataset was collected through the collaborative COVIDiSTRESS Global Survey – an open science effort to improve understanding of the human experiences of the 2020 COVID-19 pandemic between 30th March and 30th May, 2020. The dataset allows a cross-cultural study of psychological and behavioural responses to the Coronavirus pandemic and associated government measures like cancellation of public functions and stay at home orders implemented in many countries. The dataset contains demographic background variables as well as measures of Asian Disease Problem, perceived stress (PSS-10), availability of social provisions (SPS-10), trust in various authorities, trust in governmental measures …

Maternal Hpa Axis Function During Parenting Is Associated With Reduced Brain Activation To Infant Cry And More Intrusive Parenting Behavior, Andrew Erhart

Electronic Theses and Dissertations

Previous research indicated that maternal cortisol function and maternal brain response to infant stimuli are separately related to differences in parenting behavior. Evidence from animal models have demonstrated that chronically high cortisol concentration alters brain structure and function, suggesting that studying these two mechanisms together may further improve understanding of parental behavior in human mothers. First time mothers of infants aged 1-7 months old (M age = 3 months) were recruited to participate. Mother’s cortisol concentration was measured during a naturalistic interaction with their infant and their behavior was coded for maternal sensitivity and nonintrusiveness. In a separate session using …

Targeting Epigenetic Mechanisms In Endometriosis, Sarah Elizabeth Brunty

Theses, Dissertations and Capstones

Endometriosis is a complex and elusive gynecological disease in which the inner lining of the uterus grows in locations outside of the uterus and forms lesions. It is known to affect 1 in 9 women of reproductive age worldwide. Symptoms of endometriosis include severe pain, heavy periods, and infertility. While multiple theories of origin exist, none fully encompass all aspects of the disease, although all theories agree that this is an inflammation-driven disease. Due to this, many researchers are turning towards epigenetics to explain the initiation and progression of endometriosis. However, what is causing these epigenetic changes is still a …

Exploring Efficacy Of An Anti-Malarial Nanomedicine In Non-Small Cell Lung Cancer Treatment, Vineela Parvathaneni

Theses and Dissertations

New drug and dosage form development faces significant challenges, especially in oncology, due to longer development cycle and associated scale-up complexities. Repurposing of existing drugs with potential anti-cancer activity into new therapeutic regimens provides a feasible alternative. In this project, amodiaquine (AQ), an anti-malarial drug, has been explored for its anti-cancer efficacy through formulating inhalable nanoparticulate systems using high-pressure homogenization (HPH) with scale-up feasibility and high reproducibility. A 32 multifactorial design was employed to better understand critical processes and formulation parameters so as to ensure product quality with improved anticancer efficacy in non-small cell lung cancer (NSCLC). Optimized AQ loaded …

Double-Coated Biodegradable Poly (Butyl Cyanoacrylate) Nanoparticulate Delivery Systems For Brain Targeting Of Doxorubicin Via Oral Administration, Neeraj Kaushal

Theses and Dissertations

Primary brain cancer cells grow within the brain or cancer cells can metastasis from different site of the body into brain. The major hurdle in the treatment of brain cancer is the presence of blood-brain barrier (BBB). Additionally, acquired multidrug-resistant (MDR) impedes the success of long-term chemotherapy. Therefore, the objective of this investigation is to evaluate the brain targeting potential of orally administered poly(butyl cyanoacrylate) nanoparticulate delivery systems (PBCA-NPDS), double-coated with Tween 80 and polyethylene glycol (PEG) 20000 for brain delivery of doxorubicin, that does not cross the BBB by itself. And, evaluate the MDR reversal potential of PBCA-NPDS. Doxorubicin-loaded …