Digital Commons Network^™

Cognitive Impairment And Depression In Hispanic And Non-Hispanic White Low-Income Older Adults A Cross-Sectional Study, Cecil Latta

Honors Undergraduate Theses

Hispanic older adults represent a growing population in the United States and may be disproportionately affected by cognitive impairment and depression. We theorize that cognitive impairment would be more prevalent in the older Hispanic community and would affect the levels of depression in both Hispanic and non-Hispanic Whites older adults. This cross-sectional study examined the association between cognitive impairment and depression in 157 older adults, including Hispanic (n = 91, 57.96%, age: M = 76.4, SD = 6.8) and non-Hispanic White (n = 66, 42.04%, age: M = 76.2, SD = 6.5). We used the Memory Impairment Screen to assess …

Cultural Competence In Pre-Medical Education: Examining Preparedness For Cross-Cultural Care, Fiza N. Khan

Honors Undergraduate Theses

As the U.S. population continues to grow more diverse, there is an urgent need for future healthcare providers to develop strong cultural competence. This study investigates undergraduate pre-medical students’ knowledge, attitudes, and comfort levels toward caring for diverse patient populations, including immigrants, refugees, and individuals from varied cultural backgrounds. The goal was to assess how well students are prepared to provide culturally responsive care before entering medical school. Recognizing that the foundation for medical training begins at the undergraduate level, this study aims to identify specific gaps in readiness that may hinder equitable patient care in the future.

A modified …

Barriers And Facilitators Of A Sense Of Belonging Among Occupational Therapy Students And Faculty: A Qualitative Study Using The Ecology Of Human Performance Framework, Sabina Khan, Elizabeth Deluca-Berg, Kersten Laughlin, Jacqueline Achon, Khalil Mrabe, Christianah Edema

Journal of Occupational Therapy Education

A sense of belonging significantly influences both student engagement and faculty motivation. The objective of this study was to identify the barriers and facilitators of a sense of belonging among students and faculty of an occupational therapy department. A qualitative descriptive study was conducted with fifty-one students and ten faculty recruited via non-random purposeful sampling. Data were collected through focus group discussions with students and semi-structured interviews with faculty. Both the focus group discussions and interviews were audio-recorded and transcribed by a professional transcription service. Inductive coding was used to identify initial themes, which were then deductively mapped to the …

Disparities Between Reported And Actual Study Habits And Perceptions Among First Year Occupational Therapy Graduate Students, Melisa P. Kaye, Marcella Mccollum, Sydney Hanzalik

Journal of Occupational Therapy Education

Studying for exams forms a significant part of the occupational therapy graduate school experience. While successful completion of exams is a central focus for students, little time is devoted to explicitly teaching new graduate students how to most effectively study. Instead, when they enter their occupational therapy programs, students experience a steep learning curve, and often rely on previous habits or trial and error to discover the most efficacious study strategies. The purpose of this study was to examine the study behaviors, habits, and beliefs of new graduate students to gain insight into the prevalence of use of various study …

Small Molecule Screening Identifies Hsp90 As A Modifier Of Rna Foci In Myotonic Dystrophy Type 1, Sara J Johnson, Hannah L Johnson, Reid T Powell, Clifford Stephan, Fabio Stossi, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic dystrophy type 1 (DM1) is a multisystemic disorder caused by a CTG triplet repeat expansion within the 3' untranslated region of the DMPK gene. Expression of the expanded allele generates RNA containing long tracts of CUG repeats (CUGexp RNA) that form hairpin structures and accumulate in nuclear RNA foci; however, the factors that control DMPK expression and the formation of CUGexp RNA foci remain largely unknown. We performed an unbiased small molecule screen in an immortalized human DM1 skeletal muscle myoblast cell line and identified HSP90 as a modifier of endogenous RNA foci. Small molecule inhibition of HSP90 leads …

Therapy-Induced Senescence In Cancer: Developing Senolytic-Based Combination Strategies To Delay Re-Emergence Of Triple-Negative Breast Cancer, Eesha Chakraborty

Theses and Dissertations

Therapy-induce senescence (TIS) represents a major biological outcome of many anticancer treatments and is increasingly recognized as a strategic vulnerability in triple negative breast cancer, which is a highly aggressive subtype with limited therapeutic options and frequent relapse. Here, we probed TIS as a primary cellular response that may ultimately compromise long-term outcomes using standard chemotherapeutic agents in TNBC as well as the antibody-drug conjugate sacituzumab govitecan (SG). Both chemotherapy and SG reliably induced pronounced senescence across TNBC models, yielding durable growth arrest, however, also generating a persistent reservoir of viable tumor cells capable of eventual proliferative recovery, a hallmark …

The Relationship Between Mindfulness, Emotion Regulation, And Anxiety Levels Among College Students In Saudi Arabia, Tahani Aljuaid

Dissertations

Problem

Anxiety is one of the most common psychological issues affecting youth globally and is particularly prevalent among Saudi adolescents and college students. Studies in Saudi Arabia have reported anxiety rates ranging from 48.9% to 66.2% among adolescents and high levels of generalized anxiety among university students, especially females (Aldosary et al., 2023; Alhabeeb et al., 2023). Poor emotion regulation has been identified as a key factor associated with anxiety and other mental health difficulties. In recent years, mindfulness has gained attention as a protective factor that promotes better emotion regulation and reduces anxiety symptoms. Despite this growing recognition, there …

Safety Of Indocyanine Green Microdosing For Clinical Imaging Of Csf Ventricular Dynamics And Extracranial Outflow, Miriam Zamorano, Banghe Zhu, Ahmed T Massoud, Jonathan Hendricks, H Alex Choi, Pedram Peesh, Brandon A Miller, Xinhai Robert Zhang, Manish N Shah, Eva M Sevick-Muraca

Faculty, Staff and Student Publications

Background and purpose: Intravenous administration of indocyanine green (ICG) has been approved in brain surgeries for decades, yet concerns about neurotoxicity prevent its direct administration into the cerebrospinal fluid (CSF). Armed with prior animal studies demonstrating the feasibility of using ICG microdosing into the CSF, we sought to evaluate its nonclinical safety profile and obtain surrogate measures in adults prior to its use in human neonates.

Methods: Evaluation of ICG toxicity was conducted in mixed primary CNS cell cultures and in an extended safety study of juvenile rat pups deploying intraventricular injections of saline (as control) or ICG. Analysis of …

Navigating Ethical Complexities In Health Education: Exploring Challenges In Teaching Food And Health, E. Oljans, M. Quennerstedt, D. Barker, A. Caldeborg, V. Varea

Research outputs 2022 to 2026

Teaching food and health may be challenging, especially in classrooms where young people from different cultures, ethnicities, and religions meet. This article explores teachers’ navigation of ethical complexities when teaching food and health in classrooms with immigrant students. Five didactical strategies were identified: (1) The educare strategy, (2) The tiptoeing strategy, (3) The collegial support strategy, (4) The intercultural strategy, and (5) The pluralistic strategy. These didactical strategies are embedded in various educational settings. Our results demonstrate that a further focus on ethical and intercultural competence should be carefully supported and implemented in teacher education and continual professional development programmes …

Vaccines And Publics: A Variety Of Engagement Experiences, David H. Lee

Publications and Research

This chapter is about some of the sites and scenes where members of the public are exposed to (and engage in) vaccination discourse. To preview, after a brief introduction, we begin with messaging models of communication, followed by the move from messaging to engagement. Next, case examples of public engagement with vaccines are introduced, from pandemic influenza preparedness in the U.S., to polio eradication initiatives in India, and then to COVID-19 public engagement events in England. Settings of public engagement are noted, including online, in churches and museums. Then, there’s a section about communication and public participation, seen as either …

Minds, Made Up Or Malleable? Covert Commands At The Eclipse Of Vaccine Communications, David H. Lee

Publications and Research

Abstract: Although millions have died from SARS-CoV-2 illness, COVID vaccines are credited with stemming the tide. Vaccinations and boosters significantly decrease the incidence of severe illness and death (even if they don’t usually prevent COVID-19 infection). Despite the success of global vaccination efforts, frequent reports of vaccine hesitance and refusal suggest that public health communications need improvement.

The chapter begins by acknowledging adverse events associated with COVID vaccination, including rare cases of anaphylaxis, GBS, and myocarditis. An inoculation-theoretic rationale is offered for this admission of vaccine risks: just as immune defenses mount when organisms are exposed to pathogens, so too …

Building Boundary-Crossers In Clinical-Translational Research: An Exploratory Study Of A Novel Communication Intervention, Carrie Cameron, Irene Rull-Garcia, Laura G Meyer, Jose-Armando Fernandez-Guerrero, Erin K Dahlstrom, Christine Bell, Christine Pribbenow

Faculty, Staff and Student Publications

INTRODUCTION: Integrating scientific research across multiple disciplines to advance breakthroughs is at the heart of clinical-translational science (CTS); among competencies that have been identified as essential for progress, skillful communication is critical. Few tools are available to address the social dynamics of the multidimensional diversity characteristics of CTS. We created the "Building a Diverse Biomedical Workforce Through Communication Across Difference (CAD)" workshop intervention. Based on principles of intercultural communication, CAD taught novel situationally-based communication skills to dyads of near-peer mentors and their undergraduate mentees. This study reports on the effectiveness of the operative mechanisms employed in CAD workshops for helping …

Weight Stigma Amongst Nurses And Nursing Students: A Scoping Review Of Direct And Comparative Evidence, Mahshid Fonoudi, Beverley Ewens, Amanda Towell-Barnard

Research outputs 2022 to 2026

Aim: To map both direct and comparative research on weight stigma amongst nurses and nursing students by identifying the extent, range and nature of studies and identify the gaps in this area. Design: Scoping review, following the Joanna Briggs Institute (JBI) guidelines. Data Sources: Seven databases including MEDLINE, Web of Science, CINAHL, Embase, Scopus, PsycINFO and Cochrane Library, in addition to Google Scholar and Open Access Theses and Dissertations were systematically searched in August 2023. Methods: Inclusion criteria comprised nurses or nursing students as participants, weight stigma as the concept and any context. After uploading all search results into EndNote …

Understanding Widowhood Cultural Practices, Values, And Beliefs, Of Nigerian American Women: An Ethnonursing Study, Prisca Anuforo

Electronic Theses and Dissertations

Introduction: Many widowhood cultural practices are detrimental to the health and well-being of widows in Nigeria. Little is known about the experiences of widowhood for Nigerian American women, their cultural practices, and how it affects their health.

Purpose: Understand widowhood cultural practices among Nigerian Americans and how these experiences may affect health and wellbeing.

Methods: The qualitative ethnonursing method was used to collect data from 25 Nigerian American widows. Data were analyzed using NVivo qualitative data manager software guided by Leininger’s four phases of qualitative analysis.

Results: Widowhood cultural practices are modified and undertaken to preserve health and honor the …

Learning To Be An Autistic Therapist: Personal Steps Towards An Autism-Affirming Psychotherapy, Sasha D. Strong

Ought: The Journal of Autistic Culture

How can Autistic therapists understand and support themselves, and how can this help them support their clients? In this paper, I recount my personal journey of healing and growth as an Autistic psychotherapist, 16 months after self-identification. Here is an overview of conceptual frameworks from #actuallyautistic authors, critical theory, queer theory, and social justice that I have found helpful. I also share some of the therapeutic and wellness approaches that have been important to me, including mindfulness and bodyfulness. Organic knowing has been pivotal for me in discerning between masking and aliveness, and regaining a choice around masking behaviors. This …

A Mini Review Of Plant Tissue Culture: The Role Of Media Optimization, Growth Regulators In Modern Agriculture, Callus Induction And The Applications, Norrizah Jafaar Sidik, Hasan M. Agha, Abdulmutalib Alabeed Alkamil, Muneer Mohammed Saleh Alsayadi, Amjad Abdulhadi Mohammed

AUIQ Complementary Biological System

Plant tissue culture is an innovative biotechnological approach developed to meet the escalating global demand for agricultural production with enhanced nutritional value. This aseptic, in vitro technique allows for the cultivation of plant cells, tissues, or entire plants under controlled environmental and nutritional conditions, facilitating the generation of genetically identical clones. The method is indispensable in preserving endangered plant species, boosting crop yield and quality, and enabling year-round production of disease-free plants. Central to plant tissue culture is the composition of the growth medium, which must include a precise balance of macronutrients, micronutrients, amino acids, vitamins, and plant growth regulators …

The Living Document: Medical Records As A Malleable Presence, Camilla Lyckblad

Proceedings from the Document Academy

Understanding why individuals might safeguard information or keep secrets in working documents such as medical records is essential for the development of good quality care, fostering an environment where both patients and staff feel secure to part with sensitive information, encouraging more honest and open communication as well as improved quality of care. This ongoing research aims to deepen comprehension of information behavior in clinical contexts, where the contemporary medical record, with its increasing properties such as open record access for patients, can be viewed as an entity that both listens and influences. This examination sheds light on the complex …

Citation Bias, Diversity, And Ethics, Keisha S Ray, Perry Zurn, Jordan D Dworkin, Dani S Bassett, David B Resnik

Faculty and Staff Publications

How often a researcher is cited usually plays a decisive role in that person's career advancement, because academic institutions often use citation metrics, either explicitly or implicitly, to estimate research impact and productivity. Research has shown, however, that citation patterns and practices are affected by various biases, including the prestige of the authors being cited and their gender, race, and nationality, whether self-attested or perceived. Some commentators have proposed that researchers can address biases related to social identity or position by including a Citation Diversity Statement in a manuscript submitted for publication. A Citation Diversity Statement is a paragraph placed …

Addressing The Teen Mom Situation In Thailand: A Systematic Review On Challenges, Initiatives And Recommendations For Improvement, Junkkrit Wunggrath, Phinphot Phrommasen, Wanchalerm Ritthimon

Jurnal Keperawatan Indonesia

Teenage pregnancy in Thailand poses significant public health challenges with implications for societal welfare and economic development. This systematic review analyzed the challenges faced by teenage mothers in Thailand, evaluated existing initiatives, and proposed evidence-based recommendations. A comprehensive literature search was conducted using the Scopus and Web of Science databases and others focusing on literature from 2016 to 2023. Keywords included “teenage pregnancy,” “teen mom,” “unwanted pregnancy,” and “unintended pregnancy” resulting in the selection of 36 studies. The PRISMA framework was followed to ensure a systematic approach. Data extraction focused on societal, educational, economic, and health-related challenges as well as …

Insights Into Human Norovirus Cultivation In Human Intestinal Enteroids, Khalil Ettayebi, Gurpreet Kaur, Ketki Patil, Janam Dave, B Vijayalakshmi Ayyar, Victoria R Tenge, Frederick H Neill, Xi-Lei Zeng, Allison L Speer, Sara C Di Rienzi, Robert A Britton, Sarah E Blutt, Sue E Crawford, Sasirekha Ramani, Robert L Atmar, Mary K Estes

Faculty, Staff and Students Publications

Human noroviruses (HuNoVs) are a significant cause of epidemic and sporadic acute gastroenteritis worldwide. The lack of a reproducible culture system hindered the study of HuNoV replication and pathogenesis for almost a half-century. This barrier was overcome with our successful cultivation of multiple HuNoV strains in human intestinal enteroids (HIEs), which has significantly advanced HuNoV research. We optimized culture media conditions and generated genetically modified HIE cultures to enhance HuNoV replication in HIEs. Building upon these achievements, we now present new insights into this culture system, which involve testing different media, unique HIE lines, and additional virus strains. HuNoV infectivity …

Best Integrated Writing Fall 2024 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Kristie Mckiernan, Tracy Smith

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University.

Examining Adolescence And Agency In The Midst Of International Crisis: Pandemics, Pandemonium, And Zombie Young Adult Literature, T. Hunter Strickland

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

The COVID-19 pandemic of 2020-22 brought an abundance of changes to secondary education as students transitioned across the country to virtual and hybrid learning contexts. Teachers flexed quickly and frequently to support the learning that students acquired in these new, digital spaces even as school, district, and state demands on teaching increased. The English/Language Arts classroom pivoted along with others as teachers sought out digital reading and writing resources for students to engage in. In the midst of a national crisis, a metaphorical monster that sought to destroy, much like Beowulf ’s dragon did, adolescent readers, despite the discourses of …

Conceptions Of Latinos And Latinas About The Grieving Process And Associate Concepts Of Dying, Death, Bereavement, And Loss: A Covid-19-Post-Pandemic Case Study, Rosario Garcia Ortiz

Dissertations

The purpose of this study was to recognize the grieving process and the related concepts of Latinos who lost a loved one to the COVID-19 pandemic. Death and dying have been studied in the United States, with limited studies focusing on the Latino culture. The COVID-19 pandemic was a devastating experience for the world and continues to be studied for understanding and lessons in the aftermath. This research included four participants from the Latino culture who lost a loved one during the COVID-19 pandemic. An inductive approach and data analysis were used to form theoretical constructs. Three main categories were …

Effects Of Tranexamic Acid On Human Osteoblasts As Proxy For Fracture Healing, Alexander Abraham, D Nicole Meyers, William D Rieger, Ryan Anthony, Humberto Aparicio, Adam Y Park, James F Kellam, Catherine G Ambrose

Faculty, Staff and Student Publications

Objectives: To investigate the effect of tranexamic acid (TXA) through in vitro culture of primary human osteoblasts (HOB) and in vivo using an operative rat femur fracture model. It was hypothesized that there would not be any effect on fracture healing in both studies.

Methods: Primary HOBs were exposed to varying concentrations of TXA over different time periods. Cells were assessed for viability, metabolism, and mineralization. For the in vivo model, fractures were created in the femora of adult rats, exposed to either TXA or saline, and then assessed for healing at different time points. A modified radiographic union score …

Interleukin-1 Receptor-Associated Kinase 1 In Cancer Metastasis And Therapeutic Resistance: Mechanistic Insights And Translational Advances., Mariana K Najjar, Munazza S Khan, Chuling Zhuang, Ankush Chandra, Hui-Wen Lo

Faculty, Staff and Student Publications

Interleukin-1 Receptor Associated Kinase 1 (IRAK1) is a serine/threonine kinase that plays a critical role as a signaling transducer of the activated Toll-like receptor (TLR)/Interleukin-1 receptor (IL-1R) signaling pathway in both immune cells and cancer cells. Upon hyperphosphorylation by IRAK4, IRAK1 forms a complex with TRAF6, which results in the eventual activation of the NF-κB and MAPK pathways. IRAK1 can translocate to the nucleus where it phosphorylates STAT3 transcription factor, leading to enhanced IL-10 gene expression. In immune cells, activated IRAK1 coordinates innate immunity against pathogens and mediates inflammatory responses. In cancer cells, IRAK1 is frequently activated, and the activation …

The Role Of Lymph-Adipose Crosstalk In Alcohol-Induced Perilymphatic Adipose Tissue Dysfunction, Kourtney D. Weaver, Liz Simon, Patricia E. Molina, Flavia Souza-Smith

School of Graduate Studies Faculty Publications

Chronic alcohol use leads to metabolic dysfunction in adipose tissue. The underlying mechanisms and the contribution of alcohol-induced adipose tissue dysfunction to systemic metabolic dysregulation are not well understood. In our previous studies, we found that chronic alcohol feeding induces mesenteric lymphatic leakage, perilymphatic adipose tissue (PLAT) inflammation, and local insulin resistance in rats. The goal of this study was to further explore the link between alcohol-induced lymphatic leakage and PLAT immunometabolic dysregulation, locally and systemically, using in vivo and ex vivo approaches. Male rats received a Lieber–DeCarli liquid diet, of which 36% of the calories were from alcohol, for …

The History And Development Of Doctor Of Health Science (Dhsc) Programs In The United States - Past, Present, And Future Part I - Past, Helen Ewing, Richard Davis, Randy D. Danielsen, Eric Sauers, Robin Reesal

Internet Journal of Allied Health Sciences and Practice

Purpose: This three-part article series will elucidate how the Doctor of Health Science (DHSc) programs in the United States were envisioned and introduced. Method: Part I discusses relevant historical information about Higher Education and the traditional Doctor of Philosophy (PhD) degree to reach this goal. It describes the transition of PhD philosophies to professional doctorates by following the historical postgraduate program paths in education, nursing, and public health. Included is a brief discussion about the rapid growth of professional doctorates. Part I ends by identifying the origins of DHSc programs within the United States system of higher education. Part …

The Well-Being Of Honors College Students Compared To Non-Honors College Students Accounting For Prior Gifted Experience, Hannah C. Dewald, Allyson S. Graf

Journal of the National Collegiate Honors Council Online Archive

Student wellness is a growing concern among educators. Previous studies on the well-being of honors students as compared to other undergraduates result in mixed findings. This study examines the trajectory of gifted programming in education and specific challenges to the collegiate experience, presenting differences between honors students (N = 49) and non-honors peers (N = 138) using two well-being indicators (academic anxiety and academic self-efficacy) and three related factors (perceived past school competitiveness, maladaptive perfectionism, and pressure due to labeling). While authors posit that honors students may have higher academic anxiety and lower self-efficacy than those not enrolled …

Tau Is Required For Glial Lipid Droplet Formation And Resistance To Neuronal Oxidative Stress, Lindsey D Goodman, Isha Ralhan, Xin Li, Shenzhao Lu, Matthew J Moulton, Ye-Jin Park, Pinghan Zhao, Oguz Kanca, Ziyaneh S Ghaderpour Taleghani, Julie Jacquemyn, Joshua M Shulman, Kanae Ando, Kai Sun, Maria S Ioannou, Hugo J Bellen

Duncan NRI Faculty and Staff Publications

The accumulation of reactive oxygen species (ROS) is a common feature of tauopathies, defined by Tau accumulations in neurons and glia. High ROS in neurons causes lipid production and the export of toxic peroxidated lipids (LPOs). Glia uptake these LPOs and incorporate them into lipid droplets (LDs) for storage and catabolism. We found that overexpressing Tau in glia disrupts LDs in flies and rat neuron-astrocyte co-cultures, sensitizing the glia to toxic, neuronal LPOs. Using a new fly tau loss-of-function allele and RNA-mediated interference, we found that endogenous Tau is required for glial LD formation and protection against neuronal LPOs. Similarly, …

Intercellular Mitochondrial Transfer Contributes To Microenvironmental Fate Redirection Of Mammary Cancer Cells, Julie Sofie Bjerring

Biomedical Sciences Theses & Dissertations

The dynamic cellular microenvironment, made up of resident cells and various macromolecules, differs markedly across tissues in the body. The multidirectional signals that cells receive from this microenvironment, along with the signaling they send back, heavily influence their physiology and behavior. Recent important findings have further validated this notion as the mammary microenvironment has been shown to suppress tumor progression by redirecting cancer cells to adopt a normal mammary epithelial progenitor fate in vivo. However, the mechanism(s) driving changes in metabolic reprogramming and cancer fate redirection is understudied. The work presented in this dissertation focuses on exploring the impact of …