Digital Commons Network^™

The Role Of Tgfβ-Activated Kinase 1 In Fibroblast Differentiation And Cardiac Remodeling After Injury., Daniel Chien Nguyen

Electronic Theses and Dissertations

Immediately following myocardial injury, a robust reparative response is orchestrated through intercellular communication. While various cell populations play critical roles in this process, cardiac fibroblasts have long been recognized as essential mediators of collagen synthesis and scar maturation; however, recent investigations have uncovered significant heterogeneity within the cardiac fibroblast population, revealing distinct subpopulations with roles that extend beyond their traditional functions. Notably, after tissue injury, fibroblasts exposed to damage signals can transition to an inflammatory phenotype, utilizing paracrine and autocrine signaling to coordinate immune cell recruitment and activation. Yet, the mechanisms underlying inflammatory cardiac fibroblast differentiation and their influence on …

Hypoxia Induced Ribosomal Rna Fragmentation Mediated By Rnase L, Vanessa Kristina Pizutelli, Dimitri G Pestov

Rowan-Virtua Research Day

Ischemic injury contributes to a range of global pathologies. Ischemia/Reperfusion Injury (IRI) is a paradoxical phenomenon that involves an initial restriction of blood flow followed by a sudden restoration of perfusion. This type of injury takes place in conditions such as myocardial infarction, acute kidney disease, and ischemic stroke and often leads to cellular death. Additionally, IRI exacerbates post-surgical outcomes and plays a role in graft dysfunction and transplant rejection. Despite efforts to develop therapies targeting known IRI pathways, clinical trials have largely been unsuccessful, underscoring the need for alternative mechanisms and biomarkers associated with IRI-induced apoptosis. Reactive oxygen species …

Navigating Insulin Access For Pediatric Type 1 Diabetes: Caregivers' Experiences And Challenges, Ella Anderson

Doctoral Dissertations

Between 2012 and 2018, the annual 14% increase in insulin prices made Type 1 Diabetes (T1D) the most expensive chronic health condition, significantly raising out-of-pocket costs for uninsured or underinsured individuals in the United States (Hayes & Farmer, 2020; Willner et al., 2020). This study utilized a qualitative content analysis methodology to explore the challenges and experiences of parents with children diagnosed with T1D with accessing insulin for their child. Five participants from various areas of the United States responded to open-ended questions both in person and via Zoom. The analysis revealed three main themes: pragmatics of managing diabetic care, …

Kansas City, Kansas, Vida Davidović

Department of English: Dissertations, Theses, and Student Research

KANSAS CITY, KANSAS is a thesis that operates in the tradition of expressionist dramaturgy and playwriting, taking up themes of abuse, imperialism, war, trauma, womanhood, Balkan identities, history of the Balkans, as well as the discourses of psychoanalysis and postcolonial theory. The use of different theoretical frameworks related to both international and personal politics, which are shown to be intertwined, suggests a strong relationship between political processes in the Second World Countries that had experienced many occupations throughout their history and the way women in those countries relate to the questions of body, authority, feminity, and interpersonal relationships. The play …

#Genderaffirminghormonetherapy And Health Information On Tiktok: Thematic Content Analysis, Julia Beatini, Nora Yanyi Sun, Julianna K. Coleman, Maetal E. Haas-Kogan, Andrea Pelletier, Deborah Bartz, Alex Sogomon Keuroghlian

Student Papers, Posters & Projects

BACKGROUND: Transgender and gender diverse people often turn to online platforms for information and support regarding gender-affirming hormone therapy (GAHT); however, analysis of this social media content remains scarce.

OBJECTIVE: We characterized GAHT-related videos on TikTok to highlight the implications relevant to GAHT prescribers.

METHODS: We used a web scraper to identify TikTok videos posted under the hashtags #genderaffirminghormonetherapy and #genderaffirminghormones as of November 2023. We identified recurrent themes via qualitative content analysis and assessed health education videos with the Patient Education Materials Assessment Tool for Audiovisual Materials (PEMAT-A/V) scale and a modified Currency, Relevance, Authority, Accuracy, and Purpose (CRAAP) …

Unveiling The Potential Of Urolithin A In Cancer Therapy: Mechanistic Insights To Future Perspectives Of Nanomedicine, Vinita Karumuru, Anupam Dhasmana, Narsimha Mamidi, Subhash Chauhan, Murali Yallapu

School of Medicine Publications

Cancer remains a leading global health challenge, with high mortality rates persisting despite significant advancements in therapeutic interventions. Major obstacles, including systemic toxicity, therapy resistance, metastasis, and relapses, emphasize the urgent need for safer, more effective, and readily accessible treatment strategies. Among emerging alternatives, natural bioactive compounds have gained considerable attention because of their diverse therapeutic potential and lower toxicity profiles. Urolithin A (UA), a metabolite derived from ellagic acid through gut microbiota metabolism, has emerged as a compelling anticancer agent. UA has multiple mechanisms of action, including the regulation of autophagy, enhancement of mitochondrial function, and inhibition of tumor …

Bryant University Research And Engagement Day Program

Bryant REDay (Research and Engagement Day)

No abstract provided.

Functional Mushrooms Supplementation As A Prebiotic Fibre Impacting Microbiome Composition, The Gut Metabolome And Impact On The Intestinal Epithelial Barrier Integrity, Julie Daoust

Oxford ICSB

This study aimed to determine if functional mushroom preparation supplementation with Cordyceps militaris mycelium and fruiting body, Ganoderma lucidum mycelium and fruiting body, and a blend of ten species of functional mushrooms could impact gut health. The Ex Vivo model Simulator of Human Intestinal Microbial Ecosystem (SHIME®) has been used to study the behaviour of a human microbiome in response to various factors. The aim of this study was to demonstrate changes in the microbiome after supplementation with functional mushroom preparation and the resulting neuroactive metabolome using the SHIME® model. The endpoints measured were microbial fermentation activity, metabolic fingerprinting, microbial …

De Novo Variants In Cdkl1 And Cdkl2 Are Associated With Neurodevelopmental Symptoms, Ali H Bereshneh, Jonathan C Andrews, Daniel F Eberl, Guney Bademci, Nicholas A Borja, Stephanie Bivona, Wendy K Chung, Shinya Yamamoto, Michael F Wangler, Shane Mckee, Mustafa Tekin, Hugo J Bellen, Oguz Kanca

Duncan NRI Faculty and Staff Publications

The CDKL (cyclin-dependent kinase-like) family consists of five members in humans, CDKL1-5, that encode serine-threonine kinases. The only member that has been associated with a Mendelian disorder is CDKL5, and variants in CDKL5 cause developmental and epileptic encephalopathy type 2 (DEE2). Here, we study four de novo variants in CDKL2 identified in five individuals, including three unrelated probands and monozygotic twins. These individuals present with overlapping symptoms, including global developmental delay, intellectual disability, childhood-onset epilepsy, dyspraxia, and speech deficits. We also identified two individuals with de novo missense variants in CDKL1 in the published Deciphering Developmental Disorders (DDD) and GeneDx …

Resilience And Its Association With Hopelessness, Depression, Loneliness, Post-Traumatic Stress Disorder (Ptsd) And Suicidal Ideations And Behavior In A Cohort In The Nairobi Metropolitan, David M Ndetei, Victoria Mutiso, Christine Musyimi, Eric Jeremiah, Pascalyne Nyamai, Samuel Walusaka, Veronica Onyango, Kamaldeep Bhui, Daniel Mamah

2020-Current year OA Pubs

Comprehending resilience in the face of mental health issues is important, especially for young people who deal with a variety of psychological pressures. This study aims to investigate the co-occurrence of several mental health conditions and the role of resilience as a potential intervention in youth 14-25 years in the Nairobi metropolitan area. We recruited 1,972 youths. The following self-administered instruments were used: resilience (ARM-R), hopelessness (BHS), depression (BDI, PHQ-9), PTSD (HTQ), loneliness (UCLA Loneliness Scale) and suicidality (C-SSRS). Descriptive statistics, Pearson correlation and hierarchical multiple regression analyses were conducted on the data. The key findings are that depression and …

Narcissistic Personality Indicators As Predictors Of Narcissistic Personality Disorder: A Cross-Cultural Study, Wael M. F. Abuhassan, Brigid Unim, Zulfiqar Ullah Siddiqui, Shaheen Falki, Karavadi Vidusha, Fayez Mahamid, Fakher Nabeel Mohammad Khalili, Kamel H. Katalo

An-Najah University Journal for Research - B (Humanities)

Background: Individuals affected by narcissistic personality disorder (NPD) are characterized by lack of empathy, grandiosity, low self-esteem, and a need for attention and special treatment that leads to unstable interpersonal relationships, occupational problems, and significant psychosocial distress. Objectives: The study aims to evaluate which Narcissistic Personality (NP) dimensions are the strongest and most significant predictors of NPD. Methods: The present study followed a cross-cultural research design aimed at determining the strongest and most significant predictors of NPD, therefore the shortened version of the Narcissistic Personality Indicators (NPI) questionnaire (NPI-40) developed by Raskin and Terry (1988) was administered online to those …

Nursing News & Views - March 2025, Brenda Rocha Rn, Cno

Nursing Newsletters

Nursing News & Views Newsletter - March 2025

Qsp Modeling Shows Pathological Synergism Between Insulin Resistance And Amyloid-Beta Exposure In Upregulating Vcam1 Expression At The Bbb Endothelium, Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J Thompson, Sunil Krishnan, Krishna R Kalari, Karunya K Kandimalla

Faculty, Staff and Student Publications

Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases. Insulin signaling regulates critical functions of the blood-brain barrier (BBB), and endothelial insulin resistance could lead to BBB dysfunction, aggravating AD pathology. However, insulin signaling is intrinsically dynamic and involves interactions among numerous molecular mediators. Hence, a mechanistic systems biology model is needed to understand how insulin regulates BBB physiology and the consequences of its impairment in T2DM and AD. In this study, …

In Vitro Anticancer, Antioxidant And Chelating Activities Of Natural Organosulfur Compounds Originated From Türkiye: An Investigation On Breast And Colorectal Cancer Cells, Ümmügülsüm Polat Korkunç, Hi̇lal Çalik, Leyla Polat Köse, Rabi̇a Çakir Koç, Emi̇ne Karakuş

Turkish Journal of Medical Sciences

Background/aim:Taşköprü garlic, cultivated in the Taşköprü region of Kastamonu province, is a very famous in Türkiye.This study aimed to determine the anticancer and antioxidant effects of extracts from Kastamonu Taşköprü garlic on human breast cancer and colorectal cancer cells.Materials and methods:Taşköprü garlic, which contains natural organosulfur compounds, has a geographical registration. Taşköprü garlic, which contains natural organosulfur compounds (OSCs), has a geographical registration.Garlic contains oil- and water-soluble OSCs known to exhibit anticancer activity by interfering with MCF-7 and Caco-2 proliferation and tumor metastasis. In this study, the antiproliferative activity of oil- and water-soluble garlic extracts with and without glutathione at …

Are Cinnamon Derivatives Effective And Safe For Diabetes?, Methi̇ye Mancak, Ufuk Koca Çalişkan

Turkish Journal of Medical Sciences

Background/aimCinnamon spice is obtained by drying the tree bark of the Cinnamomum Schaeff genus. Cinnamomum genus belongs to the Lauraceae family and there are approximately 250 different species around the world. The most common species in the market are Cinnamomum verum J. S. Presl, C. cassia (L.) J. Presl, C. burmannii (Nees & T. Nees) Blume and C. loureiroi Nees. Cinnamon and its by-products are used for many years for their antidiabetic effect. In this research, the major chemical content and in vitro antidiabetic activities of different commercially available cinnamon samples were evaluated to conclude whether they are safe to …

Oral Health-Related Quality Of Life: A Cross-Sectional Comparison Between Dental And Non-Dental Students At Newgiza University, Fayrouz Sayed Saber, Mohamed Sabry, Alaa Nawar, Mayar El Weik

Future Dental Journal

Introduction: Evaluating oral health-related quality of life (OHRQoL) among Egyptian dental students can broaden the traditional focus on dental criteria to include social, emotional, and functional aspects. This perspective shift is vital as background knowledge influences both perceptions and behaviors regarding oral health. Comparing OHRQoL between dental and non-dental students is crucial for understanding these differences.

Aim: This study aims to compare the oral health related quality of life and oral hygiene measures between a group of dental and non-dental students at Newgiza University.

Methods: During the Oral Health Day at Newgiza University, the short form of the Oral …

Antidiabetic Properties Of Prickly Pear (Opuntia Ficus-Indica) Fruit Extract, Kenzy Aidan Joseph Mckay

The Undergraduate Research Journal

Diabetes mellitus is a metabolic disorder that claims 1.5 million lives annually. Opuntia ficus-indica, commonly known as the prickly pear, has been commonly used in traditional folk medicine for its hypoglycemic properties. It has been claimed that it has antimicrobial and antioxidant properties as well. The plant is native to Mexico and is commonly found in the middle east and India and folk medicine from all of these areas have been using prickly pear medicinally for years. To test these claims an extract of locally sourced Opuntia ficus-indica was prepared using the flesh and seeds of the fruit. The …

What Women Intercollegiate Coaches Say: Decision-Making Factors When Navigating Career Choices, Courtney Boucher, Nicole M. Lavoi

International Journal of Physical Activity and Health

To address misconceptions about the lack of women in sport coaching, factors influencing intercollegiate women coaches' career decisions, including their choices to leave positions, apply for new ones, and accept or deny job offers were explored. Utilizing a multi-level analysis underpinned by critical feminist theory, a comprehensive understanding of the systemic and structural barriers women coaches faced, as well as the strategies they employed to navigate their careers were illuminated. Key findings revealed that unequal pay, lack of administrative support, insufficient resources, and pervasive gender biases significantly impacted women's career choices. The importance of supportive workplace environments, flexible working conditions, …

Unitlessness: Highlighting The Trans-Discursive Qualities Of Nondualism And Implications For Psychological Terminology, Christian U. Krägeloh

International Journal of Transpersonal Studies Advance Publication Archive

Nondual awareness has recently gained increased interest in broader psychological research. In meditation contexts, it reflects the dissolution of subject and object, while in Maha_ya_na Buddhism, practitioners aim to develop insight that leads to awareness of nonduality in everyday-life situations. Traditionally, teaching of nondualism employed paradoxes to prompt nonconceptual inquiry into reconciling dualistic contradictions. To offer an approach to communicate nondualism to a modern audience of psychology researchers, the framework of unitlessness is introduced here, which differentiates between linguistic characteristics (units) and experiential phenomena (unity), both within an enveloping ineffability (unitlessness). This type of nondualism is trans-discursive, as it acknowledges …

Building Place-Based Experiential Learning Into The Honors Curriculum At Ohio University, Geoffrey L. Buckley, Nicole Finnicum, Michelle O'Malley, Jennifer Bowie, Yolonda Youngs

Honors in Practice Online Archive

Observing the demand for interdisciplinary experiential learning opportunities post-COVID, authors present a place-based curriculum in honors. Workshop-style special topics classes provide students with an immersive and flexible learning environment, energize faculty, and engage alumni and community partners. Coursework, fieldwork, internships, and study abroad opportunities all contribute to the development of an informed and engaged citizenry. Authors address challenges in funding, access, and equity, and they suggest ways these challenges might be met.

Resilience And Reality: Exploring The Lived Experiences Of People Living With Hiv In Texas During The Covid-19 Pandemic – A Qualitative Study., Ahmed F. Alanazi

Social Work Dissertations - Archive

This study investigated the lived experiences of individuals living with HIV (PLWH) in the Dallas-Fort Worth (DFW) area of Texas during the COVID-19 pandemic, using an Interpretative Phenomenological Analysis (IPA) framework. The research examined the intersection of health, social dynamics, and psychological resilience among PLWH, who faced compounded vulnerabilities due to systemic inequities and the dual public health crises of HIV and COVID-19. Through semi-structured interviews with ten participants from diverse backgrounds, the study captured the profound impacts of disrupted healthcare systems, heightened stigma, and social isolation on this marginalized population. The findings reveal that the pandemic exacerbated existing inequities …

Navigating Barriers: Challenges And Strategies For Adopting Artificial Intelligence In Qualitative Research In Low-Income African Contexts, Kahabi Isangula

School of Nursing & Midwifery, East Africa

Introduction:

 AI is transforming qualitative research. It enhances efficiency, accuracy, and depth in studies. Technologies like machine learning (ML), natural language processing (NLP), and large language models (LLMs) simplify tasks like transcription, coding, and thematic analysis. However, in low-income African settings, there are barriers to AI adoption. These include ethical concerns, infrastructure limitations, financial constraints, and technical skill gaps. Issues around data privacy and the dehumanization of research also add challenges.

Methods: 

This paper explores the challenges and opportunities of AI in qualitative research in low-income African contexts. It uses a descriptive approach, reviewing literature and personal experiences from rural …

40 Years Passing By In (A) “Heartbeat”, Christopher Janney

Monsoon: South Asian Studies Association Journal

This article outlines the forty-year history go Christopher Janney’s iconic performance work “HeartBeat.” Trained as an architect and jazz musician, Janney combines these two disciplines to create large interactive light/sound installations and performances. On the one hand, he attempts to make architecture more like music, more “alive” using real-time sensing devices as on his “Harmonic Convergence” installation on the Miami International Airport. On the other hand, he attempts to make music more like architecture, more physical more visual. In his “HeartBeat” performance, a dancer wears a heartbeat device that amplifies his/her heartbeat in “real time.” Over this pulse, live musicians …

Yoga Sūtra Book Four And The Yogabindu, Christopher Key Chapple

Monsoon: South Asian Studies Association Journal

Four themes from the fourth pāda of Patañjali’s Yoga Sūtra are examined here: karma (IV:2-13), individuality (IV:16), humility (IV:20-22), and freedom (IV:29-34). Affirmations and variant interpretations of these four are provided from Haribhadra Virahāṅka’s Yogabindu, most likely composed a century or two later.

Collective Karma: From The Yogasūtra To Taylor Swift, Zoë Slatoff

Monsoon: South Asian Studies Association Journal

The Indian knowledge traditions speak at length about karma, which is divided into three categories—accumulated (saṃcita), ripe (prārabdha), and future (kriyamāṇa). While much is said about our individual karma and how it affects our repeated reincarnation in cyclic existence, how does this affect others and how do others affect us? In other words, as this paper explores, what is our reciprocal and collective karma?

Painting Liberation: A Visual Ontology Of The Interplay Of Mind And Consciousness In Book Four Of The Yoga Sūtras, Melissa Townsend

Monsoon: South Asian Studies Association Journal

This presentation explores how artistic practice can illuminate philosophical questions about the nature of mind, consciousness, and liberation as articulated in Book Four of the Yoga Sūtras of Patañjali. Through a series of paintings that visually translate these sūtras, I propose that art offers a unique, experiential means of engaging with the complex relationship between citta (mind) and puruṣa (consciousness).

The paintings function as a form of “visual ontology,” inviting viewers to engage with abstract philosophical concepts in a sensory, tangible way. By depicting the interplay between the mutable processes of the mind and the unchanging awareness of consciousness, these …

New Graduate Nurse Professional Perseverance Strategies In A Time Of Crisis, Jennifer E. Smith Edd

Dissertations of Practice

This qualitative grounded theory study examined how new graduate nurses who entered practice just prior to and during the COVID-19 pandemic developed and sustained resilience while navigating extraordinary professional and personal challenges. The study focused on associate degree nurses who graduated between December 2018 and May 2022 and were employed in acute and sub-acute care settings with direct patient care responsibilities, including the care of patients with COVID-19. Data were collected through semi-structured interviews and reflective journal entries and analyzed using open, axial, and selective coding.

Findings revealed that resilience was not a static characteristic but an evolving process influenced …

Patterns Of Self-Harm Presentations At A Tertiary Urban Hospital In Kenya: A Retrospective 5-Year Study (2018–2022), Willie Njoroge, Catherine Gitau, Everline Onchari, Linnet Ongeri, Linda Khakali, Murad Khan, Zul Merali, Lukoye Atwoli, Jasmit Shah

Brain and Mind Institute

Introduction Self-harm represents a complex and multifaceted public health issue of global significance, exerting profound effects on individuals and communities alike. It involves intentional self-poisoning or self-injury with or without the motivation to die. Although self-harm is highly prevalent, limited research has focused on the patterns and trends of self-harm among hospital populations in low- and middle-income countries, particularly within Africa. This study aims to explore the socio-demographic and clinical profile of patients presenting with self-harm and determine the common self-harm patterns at a tertiary facility in Kenya.

Methodology We carried out a descriptive retrospective study and included patients from …

Examining The Association Between Perceived Stigma And Mental Health Help-Seeking Behavior Among Racial/Ethnic Minority Students In Health Professions Education, Camila A. Agurto

Honors Undergraduate Theses

Racial and ethnic minority (REM) students in health professions programs in the U.S. have considerable mental health issues. Still, they are less likely to access mental health services when compared to their White peers. The stigma they face, such as —public stigma, self-stigma, or intersectional stigma, may serve as a barrier to help-seeking. Although there is increasing recognition of the barriers to mental health care experienced by these students, there is no systematic understanding of how perceived stigma associated with mental health issues affects mental health help-seeking by REM students enrolled in health professions education. This systematic literature review aims …

Femtech In Context: A Critical Conceptual (Re)View, Danica Facca, Jodi Hall, Gail Teachman, Joanna Redden, Lorie Donelle Phd, Rn, Fcan

Publications

Emerging as a commercial category in 2016, ‘femtech’ has been publicly celebrated as a category of consumer-based digital health technologies designed to support the unmet and systemically marginalized health needs of women in areas such as menstruation, fertility, pregnancy, postpartum, and menopause, through data-driven apps, wearables, and self-diagnostic tools. Since its emergence, the term femtech has become culturally significant and has taken on a life of its own across commercial, public, and healthcare discourses. Despite the growth of femtech scholarship, clarity is lacking on how different disciplines have challenged the assumptions about sex, gender, health, technology, and innovation that shape …