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Neuroprotective Effects Of Sorghum Polyphenol In Alzheimer’S Disease: In Vitro And In Silico Analyses, Rasheed A. Abdulraheem, Ralph N. Martins, Rajapandiyan Krishnamoorthy, Mohammad A. Alshuniaber, Prashant Bharadwaj, Zhaoyu Li, Ranil Coorey, Vijay Jayasena, Stuart K. Johnson, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Background/Objective: Accumulation of amyloid-beta (Aβ) senile plaques in the human brain is a major hallmark of Alzheimer’s disease (AD), which manifests as progressive decline in memory and cognitive functions and currently lacks effective disease-modifying therapies. Emerging evidence demonstrates that polyphenol-rich plant foods are potential complementary therapies for AD. Methods: In this study, we investigated crude polyphenol extracts (CPEs) and purified polyphenol extracts (PPEs) from three sorghum genotypes for their ability to inhibit Aβ42-induced toxicity in MC-65 cells. Thioflavin T fluorescence, cell viability, mitochondrial function, oxidative stress assays, and Western blotting, along with RNA sequencing and computational analyses, were used to …

The Effect Of Cyp1a2 Gene Polymorphisms On Caffeine Pharmacokinetics And Exercise Performance In Male Recreational Athletes, Chloe Masters, Ajmol Ali, Claire Badenhorst, Martin Dickens, Kay Rutherfurd-Markwick

Research outputs 2022 to 2026

This study examined the effects of caffeine consumption on endurance exercise performance, and the influence of CYP1A2 gene polymorphisms in caffeine pharmacokinetics and exercise performance. The data sets of two randomised, double blind, placebo-controlled crossover study design experiments have been merged. Thirty-eight recreationally active male participants provided saliva samples for CYP1A2 genotyping (AA homozygotes n = 19; AC heterozygotes n = 19) and completed either a 10-km run or 40-km cycling time trial of 60-min following a single dose of 6 mg·kg⁻¹ caffeine (CAF) or placebo (maltodextrin; PLA) throughout which heart rate (HR) and time to completion (TTC) were …

Improving Body Protocoling To Reduce Patient Dose And Optimize Patient Care, Rafael Herrera

Graduate Medical Education Research Journal

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From Visual Field To Visual Field: 10-2 Visual Field Map Prediction From 24-2 Visual Field Using Machine Learning And Detection Of Central Visual Field Progression, Golnoush Mahmoudinezhad

Graduate Medical Education Research Journal

NA

Primary Tracheal Small Cell Carcinoma: A Systematized Review, Tony Satroplus

Graduate Medical Education Research Journal

NA

Associations Of Insurance Status, Frailty, And American Society Of Anesthesiologists On Endoscopic Transnasal Transsphenoidal Surgery, Steven Goicoechea

Graduate Medical Education Research Journal

NA

A Rare Case Of Haemophilus Influenzae Shoulder Septic Arthritis In An Elderly Patient, Annemarie Leonard

Graduate Medical Education Research Journal

NA

Effects Of Cross-Curricular Instruction On Clinical Education Outcomes For Speech-Language Pathology Graduate Students, Michele Dacy, Kimberly Smith

Journal on Empowering Teaching Excellence

Access the online Pressbooks version of this article here.

Cross-curricular instruction is the process of combining information from two or more subjects within a single discipline in order to help students integrate the knowledge and skills they learn from separate courses. The purpose of this study was to examine how cross-curricular instruction impacted speech-language pathology (SLP) graduate students' knowledge, confidence, and clinical skills related to the assessment of patients with co-occurring diagnoses of dementia and dysphagia. Twenty-three SLP master's students completed a questionnaire before and after receiving cross-curricular instruction on how to assess dysphagia in persons with dementia. The questionnaire …

The Effects Of Ballistic Resistance Training On Upper-Limb Power And Reaction Time In Youth Épée Fencers, Mahmoud Sallam, Mazin Hasan Alhasany, Hachin Chani, Ghofran Bashir, Bushra Al-Hammashi, Gaffar Saad, Hussein Hashos, Amr Hamza, Mariola Gepfert

Baltic Journal of Health and Physical Activity

Background: Explosive power and rapid reaction time are crucial in fencing. Ballistic resistance training (BRT) may improve these qualities but is rarely applied in fencing. Materials and methods: To assess the effects of an eight-week BRT program on upper-limb power and reaction time in youth Egyptian épée fencers, nineteen male fencers (aged 16.6 ± 1.5) were randomly divided into a BRT group (n = 10) and a control group (n = 9). The BRT group added three weekly 30-minute sessions of "Ballistic Six" exercises to regular fencing training. Tests before and after included: tennis ball throw (power), armed …

Reading Burney’S Mastectomy Letter: Presentist Thinking And Personal Responses In The Classroom, Heather Meek

ABO: Interactive Journal for Women in the Arts, 1640–1830

Frances Burney’s mastectomy letter, in its graphic and detailed depiction of the operation she underwent without anesthetic in 1811, does not always lend itself immediately to standard, scholarly classroom discussion. It tends, rather, to incite unusually intimate responses, as well as conversations about medicine and health today. In my teaching of the letter in literature courses at Université de Montréal over the course of the past 13 years, I have found that students are inclined to seize upon the subject of breast cancer as especially contemporary in its relevance and to share their own anecdotal knowledge of the disease. I …

Enhancing Clinical Care Quality Through 1-On-1 Quality Improvement Education In Family Medicine, Jude K A Des Bordes, Shira K. Goldstein, Nahid J. Rianon

HCA Healthcare Journal of Medicine

Background

Ongoing improvement and evaluation of clinical care are essential to maintaining high standards. The Accreditation Council for Graduate Medical Education (ACGME) requires all accredited family medicine programs to provide quality improvement (QI) education. Given competing educational demands, residency programs must adopt innovative approaches to teaching QI. This article describes an individualized approach to QI education that we implemented in our family medicine residency program and the outcome of its evaluation.

Methods

Guided by a logic model and evaluated using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework, this quasi-experimental 1-group pre-test-post-test study (July 2022-June 2023) involved all second-year …

Does Staff Education Increase Sequential Compression Device Utilization: A Retrospective Study, Devin Q. John, Vincent Lee, Akshay V. Daji, Hans Lapica, Connor Donley, Matthew J. Mccrosson, Nino Coutelle, Carlos Fernandez, Diego Lima

HCA Healthcare Journal of Medicine

Background

Venous thromboembolism (VTE) is a significant perioperative safety concern among orthopedic patients, with an incidence of 0.4%-1.0% and a substantial risk of chronic complications. Sequential compression devices (SCDs) are recommended for VTE prophylaxis, yet compliance remains suboptimal due to staff misconceptions. This study evaluates the impact of a resident-led educational intervention on SCD utilization among nursing staff in orthopedic postoperative care.

Methods

This retrospective study was conducted at 2 hospitals (HCA Florida JFK Hospital and HCA Florida Palms West Hospital). Nursing staff participated in a single educational session addressing SCD benefits, application techniques, and operational protocols. Data on SCD …

Are Combat Athletes Different Sleepers? A Pittsburgh Sleep Quality Index-Based Comparative Survey Across Athletic Populations, Zofia Tkocz, Małgorzata Hołda Dr, Michał Spieszny, Adam Zając, Robert Trybulski, Aleksandra Filip-Stachnik

Baltic Journal of Health and Physical Activity

Background: Sleep plays an important role in athletic performance, recovery, and cognitive function. The aim of this study was to compare sleep quality and selected sleep-related  variables in combat sports athletes and athletes from other sport disciplines . Materials and Methods: Ninety-eight competitive athletes participated in the study, including 52 combat sports athletes and 46 athletes  representing other sport disciplines. Sleep quality was assessed using the modified Pittsburgh Sleep Quality Index (PSQI) with a weekly recall period, global PSQI score and additional  variables, such as sleep duration, sleep latency, and habitual sleep-wake times, were analyzed using general linear models adjusted …

Detection And Diagnostic Screening Of Breast Cancer: A Systematic Review And Future Frontiers, Lama Yassine, Amira J. Zaylaa

BAU Journal - Science and Technology

A comprehensive evaluation of current and novel diagnostic techniques is necessary since the diagnosis of breast cancer is essential for improving treatment efficacy and raising long-term survival. Evidence from conventional imaging methods including mammography, ultrasonography, and magnetic resonance imaging is combined in this systematic review with advancements in liquid biopsies and current AI-based diagnostic tools. Using specific keywords related to breast cancer, early detection, imaging, biomarkers, and artificial intelligence, a thorough search was conducted in PubMed, Scopus, Web of Science, and IEEE Xplore. Reviews, case reports, and studies unrelated to breast cancer were excluded; only clinical, experimental, and computational research …

Takikardia Ventrikel Berulang Pasca Coronary Artery Bypass Grafting (Cabg): Laporan Kasus Berbasis Bukti, Ika Prasetya Wijaya, Simon Salim, Audina Dhiya Nabila

Jurnal Penyakit Dalam Indonesia

Coronary artery bypass grafting (CABG) remains the treatment of choice for patients with complex multivessel coronary artery disease but carries a risk of serious perioperative complications, including ventricular arrhythmias such as ventricular tachycardia (VT). Although VT following CABG is rare, it is potentially life-threatening and often results from multiple interrelated factors. This report presents a case of recurrent ventricular tachycardia after CABG and to highlight the underlying mechanisms, risk factors, and evidence-based management strategies aimed at preventing adverse outcomes.We report a 54-year-old woman with diabetes, hypertension, prior myocardial infarction, and severe left ventricular dysfunction who underwent urgent CABG for three-vessel …

Gagal Jantung Kanan Pada Hipertiroid Tidak Terkontrol: Laporan Kasus, Kevin Lazuardy, Leonard Nainggolan, Nadim Marchian Tedyanto

Jurnal Penyakit Dalam Indonesia

Right heart failure is a clinical syndrome that is influenced by various factors. The incidence of heart failure reaches 5/1,000 population, while the prevalence of heart failure reaches 1-2% of the adult population. Management of the main etiology of heart failure is the main therapy. In some cases, hyperthyroidism is an indirect cause of heart failure, especially in right heart failure. Hyperthyroidism can cause reversible pulmonary hypertension which causes right heart failure, although the underlying mechanism is uncertain at the moment. This study reports a 46-year-old woman who was diagnosed with right heart failure and also had hyperthyroidism. In this …

Patterns Recognized In Ayres Sensory Integration®: A Scoping Review, Marica Botha, Janine Van Der Linde, Zoe Mailloux

Department of Occupational Therapy Faculty Papers

Background/Objectives: Associations between scores on tests of sensory integration functions demonstrated in numerous studies over six decades have contributed to the development of Ayres Sensory Integration® (ASI) theory and practice. Understanding these "patterns" aids therapists in their interpretation of assessment results, ensuring appropriate and effective intervention. This study aimed to describe and discuss published research on identified patterns related to constructs in the Ayres Sensory Integration® approach. Methods: Arksey and O'Malley's framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews Checklist were used. The literature review search was guided by the following …

Factors Affecting The Incidence Of Stunting In Sawangan Subdistrict, Depok City, In 2023, Amanda Salsabila, Shaumi Maghfira Lamakampali, Erin Shafa Jasmine, Vera Putri Pranoto, Ratu Ayu Dewi Sartika, Primasti Nuryandari Putri

Jurnal Nasional Kesehatan Lingkungan Global

Stunting remains a major problem in Indonesia, particularly in Depok City, West Java. This study aims to analyze the factors influencing stunting in Sawangan District. The study design used is a cross-sectional study, analyzing test variables such as stunting incidence, maternal characteristics (age, education, maternal nutritional status during pregnancy, and personal hygiene), and toddler factors (exclusive breastfeeding status and LBW incidence) using univariate, bivariate (chi-square test), and multivariate (binary logistic regression) analyses. The analysis shows that maternal personal hygiene and LBW incidence in toddlers significantly influence stunting incidence. Other factors, such as age, education, and maternal nutritional status during pregnancy, …

Predictors Of Culture-Positive Urinary Tract Infections And Antibiotic Resistance Among Pregnant Females In Al-Hilla City: A Cross-Sectional Study, Zainab Salim Husein, Ishraq Ahmed Chiad, Zeena Jamal Alkhazraji

Al-Esraa University College Journal for Medical Sciences

Background: Urinary tract infection (UTI) is a frequent health problem in women. Patients often present with significant pyuria, and sometimes with no bacterial growth. Objective: The purpose of this study was to investigate the correlations between demographic, clinical, and behavioral factors and urine culture findings and to analyze the antibiotic sensitivity patterns of the isolated uropathogens. Methods: A cross-sectional study was done among pregnant women presenting with elevated pus cells (> 20 cells/HPF). Data on demographic characteristics, pregnancy complications, and hygiene habits were analyzed. Urine culture and comparative antibiotic sensitivity tests were performed for the isolated pathogens (Escherichia coli …

Cleft Lip And Palate: From Genetic Foundations To Psychological Impact – A Multidisciplinary Review, Farah Abdulwahab Al-Saadi, Teeba Fares Hadi, Sura Saleem Albermani

Al-Esraa University College Journal for Medical Sciences

Cleft lip and/or cleft palate consider one of the most known and common congenital disorders of the head causing clear disruption of the normal face structure. Despite being the most seen birth defects, the clefts genetic basis is still not fully comprehended. Clefts have sporadic genetic nature, it can occur duo to rare mutations as part of syndromic disease or it can be isolated, non-syndromic cleft. The contemporary advances in genomic technology have enabled a deeper comprehension of the complex architecture of cleft lip/palate, of these technologies are genome-wide association studies, whole genome sequencing, transcriptome-wide association studies and others. Furthermore, …

Mpox Preparedness And Pandemic Memory: An Exploratory Study Among Young And Highly Educated Populations In Iraq, Israa M. Ali Alameen

Al-Esraa University College Journal for Medical Sciences

No abstract provided.

The Association Between Osteoporosis In Females Following Menopause And Vitamin D Deficiency, Hadel Kareem Al-Rubaiawi, Noor Adel Hussein, Dunia Abdul Jabbar Star, Amer Hasan Abdullah, Salma Abdul-Ridha Abbas, Hawazin Aziz Hamim

Al-Esraa University College Journal for Medical Sciences

The intricate relationship among osteoporosis, vitamin D deficiency, and hormonal changes. Growth hormone, cortisol, parathyroid hormone, estrogen, testosterone, thyroid hormones, and thyroid hormones are a few of the hormones that affect bone turnover and density. Alterations in their concentrations, whether brought on by healthy aging or illnesses, can interfere with bone remodelling and increase the risk of osteoporosis. Moreover, inadequate levels of vitamin D increase the risk by decreasing the absorption of calcium and the mineralization of bone. Estrogen and vitamin D deficits increase bone loss, especially in postmenopausal women. Proactive treatment techniques, including hormone replacement therapy, vitamin D supplements, …

Organic Coumarin Derivatives As Laser-Active Materials: A Review Of Synthesis, Optical Behaviour, And Applications, Aya H. Mohammed, Mohammed Hasan Al-Dahlaki

Al-Esraa University College Journal for Medical Sciences

Coumarin derivatives have settled into a position of unusual prominence among organic laser-active materials. Few other chromophore families combine such favourable photophysics with synthetic chemistry that is at once long-established and still actively evolving. The aim of this review is to draw together what is now known about coumarin-based laser dyes — their preparation, their optical behaviour, the laser performance that has been achieved with them, and the broader applications that have followed — with particular attention to work published between 2019 and 2026. Considerable space is given to the structural origin of the strong intramolecular charge transfer (ICT) character …

A Mathematical Model For Managing Diphtheria Outbreaks In Nigeria Via Vaccination, Enhanced Surveillance, Effective Quarantine, And Social Distancing Measures, Hycienth Ortser Orapine, Nyiutya Cephas Ine, Dekera Jacob Washachi, Ali Audu Baidu, Lubem Matthew Kwaghkor

Mathematical Modelling and Numerical Simulation with Applications

Diphtheria is a highly infectious respiratory and skin disease that poses a significant threat to global public health. In Nigeria, children and adults with low immunity remain at high risk due to recurring annual outbreaks in the last decade, with a death rate of as high as 68.8\%. This paper presents a deterministic compartmental model to evaluate the effectiveness of interventions implemented by the Nigerian government. The model's mathematical and epidemiological validity is established through proofs of non-negativity and boundedness. The basic reproduction number ($R_0$) is derived, and stability analysis confirms that the diphtheria-free equilibrium is locally and globally asymptotically …

The Prevalence Of Oral Diseases In Heredity Bleeding Disorders In Iraq, Warkaa M. Al-Wattar

Al-Esraa University College Journal for Medical Sciences

Aim: To investigate the effect of bleeding disorder on oral condition in Iraqi patients. Patient and methods: 153 patients were included in this study attending dental unit in Iraqi center of hematology. They were diagnosed and treated for ordinary oral diseases like dental caries and periodontal diseases mainly. While treatment vary from only diagnosis and checkup to more complicated surgical extraction. The patients data include sex, blood group, cheife complain and type of treatment. Results: The main chief complain was dental caries and less periodontal diseases while main treatment management was only checkup. The blood group O was the most …

Methotrexate Adherence In Rheumatoid Arthritis Patients Using The Cqr-19 Scale And Its Relationship With Behavioral Factors At Marjan Teaching Hospital, Fatima Abbas Abed, Ali Hussein Al-Hafidh, Adnan Hussein Mahmoud

Al-Nisour Journal for Medical Sciences

Background: Methotrexate (MTX) and other disease-modifying antirheumatic medications are necessary for the long-term management of rheumatoid arthritis (RA), a chronic autoimmune illness. Nonetheless, a significant obstacle in the treatment of RA continues to be non-adherence to MTX. Comprehending the behavioral elements linked to adherence could potentially enhance therapy results.
Objective: To assess MTX adherence using the CQR-19 and examine its association with behavioral factors among RA patients at Marjan Teaching Hospital.
Methods: A cross-sectional study was conducted in the Rheumatology Unit of Marjan Teaching Hospital, Babylon, Iraq, from December 18, 2025, to April 18, 2026. A total of 220 RA …

Ai-Driven Arabic Linguistics For Autism Spectrum Disorder: A Systematic Review And Conceptual Framework, Jamal K. Abbas, Israa Abed Jawad, Qamar Ali Abdulridha, Haytham Falih Hassan, Dena Qusay Alrawi, Ula Kamal Abdulkadir, Amal Hassan J. Al-Bazzaz, Riyam Zaid Alameri

Al-Nisour Journal for Medical Sciences

ASD is a complicated neurodevelopmental condition where diagnosis and intervention still depend on subjective behavioral observation. These challenges, however, are greater in Arabic-speaking contexts with scant, standardized diagnostic tools, limited linguistic resources, and a broad application of AI solutions developed primarily for English language data. This paper implements a systematic review of a conceptual framework that uses computational linguistics, NLP, and AI to support ASD early screening and speech-language intervention within the Arabic-speaking population. Rather than reporting empirical findings, the paper synthesizes recent peer-reviewed literature to identify linguistically-anchored ASD-related markers suitable for computational analysis, encompassing echolalia, atypical pronoun usage, pragmatic …

Oxidative Stress And Recurrent Miscarriage: Exploring The Underlying Mechanisms, Hawraa Hazim, Alaa Al-Qaisi, Muataz Ali

Al-Nisour Journal for Medical Sciences

Despite a significant number of anatomical, genetic and chromosomal studies, the problem of recurrent miscarriage (RM) is still one of the challenges in reproductive medicine, as in almost 50% of the cases no clear cause is found. These are unexplained cases that are frequently called idiopathic RM and indicate that there might be an underlying molecular and biochemical mechanism that is not routinely checked during clinical practice. This review focuses on the key role of oxidative stress and redox imbalance in the pathogenesis of idiopathic RM. A special focus is placed on mitochondrial dysfunction, which results in increased electron leakage …

Evaluation Of Maternal Health Awareness And Its Influence On Child Vaccination Coverage In Rural Areas, Enass Razzaq Hamza

Al-Nisour Journal for Medical Sciences

Purpose: The objective of the study was to measure maternal health awareness and its effects on the coverage of child vaccination among rural Al-Mada’in district mothers in Iraq.

Design: A cross-sectional study with a community-based design was employed.

Subject: A total of 400 mothers aged 18 to 45 years with at least one child under five years of age participated in the study.

Setting: Rural areas of Al-Mada’in district, southeastern Baghdad, Iraq.

Measures: Structured interviewer-administered questionnaires were used to collect data on maternal awareness of nutrition, hygiene, antenatal care and immunization. Check Vaccinations cards of 392 children (98.0 percent) were …

Assessment Of Nurses' Knowledge, Attitudes And Practice Toward Breast Self-Examination In Al-Najaf City Hospitals, Aseel Shalaan Kareem, Iman Qasim Kteo Al-Hussein, Zainab Neamat Jumaah

Al-Nisour Journal for Medical Sciences

One of the main causes of mortality for women worldwide is breast cancer. Therefore, it is essential to enhance awareness and information about breast cancer and breast cancer screening in order to diagnose the disease early. The study aimed to assess nurses' knowledge, attitude, and practice regarding breast self-examination before implementing nurse led educational program. A descriptive cross-sectional design was conduct among nurses works in hospitals, the data were collected by A systematic questionnaire including sociodemographic characteristics and three domains to assessing Knowledge, Attitudes and Practice related to BSE. Descriptive statistical analysis used to summarize the findings. The finding showed …