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Clinical Case Study: The Effects Of Task Dynamics And Saltatory Pneumotactile Stimulation On Cerebral Oxygenation, Cognitive Performance, And Sensorimotor Function In An Adult Following Left Ischemic Mca Stroke, Bridget Slagle

College of Education and Human Sciences: Dissertations, Theses, and Student Research

In the chronic stage of stroke recovery, neuroplasticity is thought to require external influence, and is often considered to be experience-dependent, or “Hebbian,” plasticity. Current studies have been investigating multiple ways to induce plasticity to enhance recovery, including investigating the role of sensory stimulation in cortical priming to enhance the effects of rehabilitation interventions.

This case study of an 80-year-old female with aphasia after L-MCA ischemic stroke included 18 neurotherapeutic sessions over 10 weeks. Each session included pneumotactile somatosensory stimulation to the glabrous hand and perioral face, delivered to both the left and right side via the GALILEO, as well …

Adventitial Macrophage Accumulation Impairs Perivascular Nerve Function In Mesenteric Arteries With Inflammatory Bowel Disease, Elizabeth A. Grunz, Benjamin W. Jones, Olubodun Michael Lateef, Sidharth Sen, Katie Wilkinson, Trupti Joshi, Erika M. Boerman

Biomedical Sciences

Introduction: Inflammatory bowel disease involves aberrant immune responses and is associated with both cardiovascular disease risk and altered intestinal blood flow. However, little is known about how inflammatory bowel disease affects regulation of perivascular nerves that mediate blood flow. Previous work found perivascular nerve function is impaired in mesenteric arteries with Inflammatory bowel disease. The purpose of this study was to determine the mechanism of impaired perivascular nerve function.

Methods: RNA sequencing was performed on mesenteric arteries from IL10−/− mice treated with H. hepaticus to induce disease (inflammatory bowel disease) or left non-gavaged (Control). For all other studies, Control and …

Healthy Living For Unhoused Women, Aliya K. Jatoi

Undergraduate Honors Theses

This capstone thesis details the importance of healthcare for unhoused women. Unhoused women do not have the ability to receive women’s healthcare nor receive proper education surrounding the topic of women’s healthcare. After participating in several events with unhoused women throughout Johnson City, a lack of attention to improving the quality of women’s healthcare was noticed. To address this issue, I began by surveying unhoused women, talking with unhoused women, and collecting online data and statistics regarding homelessness, prevelant diseases, and infection rates among unhoused women. After collecting data, educational materials, such as flyers with information about local resources and …

Electromyography (Emg) Of Lower Extremity Muscles During The Spanish Squat In Varied Foot Positions, Matthew Feddema, Jake Graf, Jenna Hildebrant, Allison Jepson, Jake Marciniak, Benjamin Oie

Physical Therapy Scholarly Projects

Background: Knee injuries are among the most common sports-related injuries, often linked to weakness or imbalance in the quadriceps and gluteal muscles. Squat variations are frequently prescribed in rehabilitation to strengthen these muscle groups and enhance knee and hip stability. The Spanish squat (SS) has shown to be effective for increasing quadriceps activation while reducing joint stress. However, limited research has examined how different stance widths during Spanish squats may effect lower extremity muscle activation.

Purpose: This study aimed to compare surface electromyography (EMG) activity of selected lower extremity muscles during Spanish squat variations (narrow, shoulder-width, and wide stances) and …

Establishing The Inter-Rater Reliability Of The Titleist Performance Institute (Tpi) Movement Screen, Ian Henry Dahners, Matthew Fetner, Carlan Haugrud, Hunter Johnson, Braeden Lee Knutson, Erica Jo Peters, Dana Jayde Zarn

Physical Therapy Scholarly Projects

Background: The Titleist Performance Institute (TPI) Movement Screen is a golf-specific physical assessment widely used by professionals to identify physical limitations that may influence swing mechanics and injury risk. Despite its popularity, there is limited peer-reviewed evidence regarding the screen’s inter-rater reliability. Without established reliability, clinical and performance decisions based on TPI scores may be questionable. Prior research on similar tools, such as the Functional Movement Screen (FMS) and Selective Functional Movement Assessment (SFMA), shows that reliability varies based on evaluator experience, scoring objectivity, and standardization—all relevant concerns for the TPI Movement Screen.

Purpose: To determine the inter-rater reliability of …

Pedagogical Strategies In Medical Laboratory Science Student Learning Outcomes: A Comparative Study Of Learner-Centered And Lecture-Based Instruction, Kasey Kuker

Medical Laboratory Science Independent Study Projects

Learner centered teaching (LCT) has gained prominence across the health sciences, yet its specific impact on Medical Laboratory Science (MLS) education remains underexamined. This comparative literature review synthesizes findings from various empirical studies to evaluate how active, learner centered pedagogies - such as flipped classrooms, blended learning, team based learning, simulation, gamification, and structured feedback - perform relative to traditional lecture based instruction. Across diverse MLS and allied health contexts, LCT consistently improved cognitive outcomes including examination performance, laboratory skill proficiency, and long term retention. Equally significant were gains in affective outcomes: heightened self efficacy, motivation, engagement, teamwork, and professional …

Clinical Pathway For Rhogam Administration In The Emergency Department, Lauren Kyzar, Amy Bigham

Appalachian Student Healthcare Research Review

Background: Clinical pathways in emergency departments (ED) are designed to standardize patient care and reduce variability in clinical practice. In a rural hospital setting, the ED management of RhoGAM administration in pregnant patients with vaginal bleeding varied by provider with no standard of care achieved. This approach raised concerns about potential patient safety issues.

Methods: In response, the local emergency department medical director, in conjunction with local perinatal providers developed a clinical pathway to standardize care and optimize RhoGAM administration. The clinical pathway was implemented to the local ED providers over a three-month period. Retrospective chart review for Type and …

A Meta-Analysis Of Endometrial Cancer Metabolites As Potential Non-Invasive Biomarkers, Makenna K. Johnson

Honors Theses

Endometrial Cancer (EC) is the most prevalent gynecological cancer in the United States and causes tens of thousands of deaths. Despite its massive negative impact in developed countries, there currently is no reliable screening tool used to diagnose women. Due to this urgent need for minimally invasive and precise techniques to diagnose this malignancy, the metabolomics field has been at the forefront of current research. An untargeted mass-spectrometry approach is used by many researchers to form an initial hypothesis as to which metabolites are key in identifying EC cases. However, there are sometimes inconsistencies between studies. A meta-analysis approach examines …

Systemic Barriers To Educational And Employment Attainment Among Individuals With Substance Use Disorders, Mollie B. Mccann Poblocki

Creativity and Change Leadership Graduate Student Master's Projects

Substance use disorders (SUDs) and opioid use disorder (OUD) represent one of the most pressing yet poorly understood public health crises in the United States. Despite decades of clinical intervention, recovery outcomes remain deeply unequal, not because individuals lack motivation, but because the structural systems surrounding them are fundamentally broken. This project explored that reality through a comprehensive literature review examining how systemic barriers across educational systems, labor markets, poverty dynamics, and healthcare infrastructure shape vulnerability, treatment access, and recovery outcomes for individuals with SUDs. Major findings revealed a consistent socioeconomic gradient of harm: individuals with lower educational attainment, unstable …

An Investigation Of The Roles Aging, Gender And Age-Related Hearing Loss Play In Emotional Prosody Recognition, Giavanna Yowell

Undergraduate Honors Thesis Collection

Emotional prosody recognition is crucial for social interactions but is influenced by aging, gender, and age-related hearing loss (Lambrecht et al., 2012; Oerlemans et al., 2014; Palermo et al., 2013). No past studies have looked at all of these factors collectively. To address this shortcoming, the current study explored the relationships between aging, hearing loss and gender differences in emotional prosody recognition. The ability to recognize emotions through facial expressions was also included as a comparative measure. One hundred fifteen individuals (42 men and 73 women), ages 50 and older (M = 60.39, SD = 8.12), completed a hearing handicap …

Acute Effects Of Tempering On Biomechanical Tissue Characteristics In The Lower Back, Danielle Rae Marie Alley

Undergraduate Honors Thesis Collection

Body tempering (BT) is a novel, myofascial release technique that is growing in popularity among sports medicine and performance practitioners. No studies have explored its effects on biomechanical tissue characteristics or its influence on perceived disablement within the thoracolumbar spine region. The aim of this study was to examine the acute effects of BT on soft-tissue characteristics and perceived disablement in the thoracolumbar spine region. A randomized controlled trial was used to study 22 young adults (10 males, 12 females, age=21.1±0.68 years, height=170.6±11.8 cm, mass=65.2±14.2 kg). Treatment group participants received a 1-minute BT treatment to the soft tissues of their …

Synthetic Explorations Towards Phenyl Benzazepine-Inspired Scaffolds And Synthesis Of Minor Cannabinoid Derivatives, Vishwashiv Kumar Emogaje

Theses and Dissertations

D1R is a compelling therapeutic target for correcting dopaminergic imbalances. However, existing ligands exhibit suboptimal pharmacokinetic properties. As such, we synthetically explored untouched structural modifications to the phenyl benzazepine scaffold. Cannabinoid-based molecules also display potential to treat neurological maladies and cancer. We synthesized Cannabichromene derivatives and uncovered enhanced anticancer activities.

Neuroprotective Effects Of Prophylactic Brivaracetam On Memory And Anxiety Following Traumatic Brain Injury, Sofia Dumic

Theses and Dissertations

Prophylactic brivaracetam (BRV) was evaluated in a rat TBI model for effects on behavior and serum tau. BRV reduced anxiety-like behavior with optimal dose-dependent effects at 2.1mg/kg, but did not affect working memory. Serum tau was detectable early post-injury, supporting its use as a biomarker.

Newly Registered Nurses With Neurodiversities: A Qualitative Study Of Their Experiences During Transition To Professional Practice, Heather Wallace

Dissertations and Theses (Open Access)

Abstract Introduction: Transition-to-practice (TTP) programs play a crucial role in bridging the academic-to-practice gap for newly licensed Registered Nurses (NLRNs) and improving first-year retention rates. However, these programs may fall short in addressing the specific needs of NLRNs with neurodiversities (NLRN-ND). Neurodiversity (ND) encompasses Autistic Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD), Tourette Syndrome, and the 3 Ds – Dyslexia, Dyscalculia, and Dysgraphia. Unsupportive environments for disclosing neurodiversity and requesting accommodations may contribute to the 10-25% NLRNs leaving their jobs within the first year, with 1-3% exiting the nursing profession altogether. Objectives: This study aimed to (1) explore NLRN-ND …

The Impact Of Palm Cooling On The Physiological And Cognitive Function Of Aerobically Trained Individuals, Katherine L. Tibbs

Honors Theses

Background: Cooling strategies have been shown to combat the harmful effects that an increase in body temperature can potentially cause, and palm cooling in particular has been adopted due to its effectiveness in mitigating muscle fatigue during exercise. While there is clear support that this improves muscular strength and endurance, there is a lack of research on the impact palm cooling has on the mental aspect of physical activity. The purpose of this study was to investigate the cognitive and physiological effects of palm cooling on aerobic exercise performance. Methods: Ten aerobically trained participants between the ages of 18-35 were …

Exploring Stem Cell-Based Approaches To Ameloblast-Like Cell Development: Progress And Limitations In Enamel Formation, Ava L. Abruzzese

Honors Scholar Theses

Enamel is one of the most critical structural components of the tooth. As the outermost layer, it serves as a protective barrier, shielding the underlying dentin and dental pulp from physical trauma and mechanical forces. The formation and mineralization of enamel are regulated by specialized cells known as ameloblasts. Once enamel maturation is complete, these cells undergo apoptosis. Consequently, enamel lacks the capacity for natural regeneration after damage or erosion, which can result from various environmental factors. When enamel is compromised, current clinical interventions focus on preventing further deterioration rather than true regeneration. These approaches include the use of remineralizing …

Implementation Of A Standardized Short Stay Pain Protocol To Reduce Pain In Short Term Care Facility, Maggie O'Brien, Kenzie Reuter, Holly Hansen, Elle Wichmann

Celebrating Scholarship and Creativity Day (2018-)

Pain is a common symptom across all areas of nursing care, yet it is often undertreated in skilled nursing facilities, particularly among residents receiving rehabilitation services. Pain in this population may result from a variety of causes, including musculoskeletal conditions, wounds and pressure injuries, neuropathic pain, and chronic illnesses. A review of Minimum Data Set (MDS) reports and resident pain reports from the short-term rehabilitation unit revealed a concern of disparity. Long-term care residents demonstrated strong quality indicator scores (9.21 out of 10), while short-term stay residents scored significantly lower (2.76 out of 10). This discrepancy raised concerns about pain …

Dental Rehabilitation Of Pediatric Patient With Ellis-Van Creveld Syndrome: Case Report, Emma Kojima Dds, Robin Onikul, Neena Patel, Jenna Sparks, Amy Burleson

Posters

Ellis-van Creveld Syndrome, also known as Chondroectodermal dysplasia, is a rare autosomal recessive disorder caused by mutations in the EVC and EVC2 genes4. This syndrome is characterized by polydactyly of the hands, short limbs, ectodermal dysplasia, and congenital heart defects. Because Ellis–van Creveld syndrome affects all three embryonic layers, it presents with a range of oral manifestations, including absence of the mucobuccal fold, a serrated alveolar ridge, multiple labial frenula, abnormalities in tooth morphology, and congenitally missing teeth1. This report details a 20-month-old female who presented to the Children’s Mercy Dental Clinic in May 2019 for comprehensive dental care. The …

Hidden Word Treasure Hunt: Design Of Dyslexia Game-Based Intervention, Olivia N. Epp

Honors Program: Senior Projects (Public)

For this creative project, a literacy intervention board game entitled Hidden Word Treasure Hunt was designed for elementary students with dyslexia. Developmental Dyslexia is a neurodevelopmental learning disability which causes reading and writing difficulties. The goal of the intervention is to provide a fun and engaging way for students with dyslexia to practice skills like spelling, phonemic awareness, rhyming, and more. The game includes multiple choice question cards (treasure cards) and challenge spelling cards (key cards), and the student also has the opportunity to practice spelling the words with a whiteboard and marker. The student and SLP can play their …

Probing The Roles Of Connexin 43 Hemichannels In A Mouse Model Of Alzheimer's Disease, Madison Treasure-Areno

All Graduate Theses and Dissertations, Fall 2023 to Present

Alzheimer’s disease is a progressive disorder involving neuronal death and cognitive decline, such as memory loss and changes in personality. One feature of the disease is buildup of abnormal protein called amyloid-beta in the brain. Amyloid-beta may activate support cells called astrocytes, triggering them to release large amounts of chemicals, possibly harming nearby cells. This study set out to examine the roles of the channels on astrocytes involved in releasing these chemicals, called connexin 43 hemichannels. Using a mouse model of Alzheimer’s disease, this study blocked the hemichannels using the drug Tonabersat, and measured spatial learning and memory in a …

The Camus Initiative: A Multiphase, Multicentre International Collaboration To Redefine Risk Stratification, Reporting, And Grading Of Surgical Complications In Urology., Christopher Soliman, Niranjan J. Sathianathen, Niall M. Corcoran, Nathan Lawrentschuk, Patrick Y. Wuethrich, Marc A. Furrer, Paul Chung, Camus Study Group Collaborators

Department of Neurology Faculty Papers

Surgical complications remain a major source of preventable morbidity, mortality, and health care expenditure, but existing frameworks such as the Clavien-Dindo classification and Comprehensive Complication Index are clinician-centred and intervention-focused and fail to capture cumulative patient-centred outcomes. This protocol outlines the Complications After Major and Minor Urological Surgery (CAMUS) initiative, a global, multiphase effort to redefine complication reporting, risk stratification, and outcome measurement in urological surgery. CAMUS aims to address these limitations via an integrated, seven-arm programme combining retrospective and prospective data analysis, consensus development, and digital infrastructure design. Arm 1 has assembled a retrospective data set of 130 034 …

Evidence-Based Practice In Speech-Language Pathology: Creating Effective Therapy Materials, Avalee Dunkley

Undergraduate Honors Capstone Projects

Evidence-based practice is a fairly new topic in speech-language pathology, gaining traction among professionals in the field in the last twenty years. Evidence-based practice is the integration of high-quality research, patient cultural and social values, and clinician expertise to treat a patient. Patients are more likely to progress when these three factors are combined. This paper explores four areas of speech-language pathology that are commonly treated in school-aged children: speech sound disorders, language disorders, social communication disorders, and the use of augmentative and alternative communication. Each section gives a summary of the disorder and how the disorder can be treated …

Fragile Patients, Intentional Care: Nonpharmacological Pain Management Treatment Approaches In The Neonatal Intensive Care Unit (Nicu), Kristie A. Moeller

Occupational Therapy Capstone Presentations

The aim of this project was to increase clinical skills in a level III neonatal intensive care unit (NICU) and explore how nonpharmacological occupational therapy (OT) interventions impact pain management in the NICU for a variety of patients. Due to the increasing rates of admissions to the NICU and the impact that pain has on child development there was a clear need to gain skills to create interventions that would minimize the effect on infant development (Martin & Osterman, 2025; Pineda et al., 2025). The needs assessment revealed the need for occupational therapists (OTs) role in nonpharmacological pain management to …

Public Health Responsible Ai Capability (Ph-Raic) Framework: A Conceptual Model For Integrating Ai Into Public Health Agencies, Arnob Zahid, Ravishankar Sharma, Rezwan Ahmed

All Works

Background: Artificial intelligence (AI) is transitioning from experimental pilots to core public health functions such as disease surveillance, resource planning, and analysis of social and structural determinants of health. Yet, health data collection and stewardship remain fragmented across the globe; some jurisdictions still rely on paper-based systems, while others operate noninteroperable digital systems that can exacerbate inequities. Treating health data as a global good therefore requires governance that enables innovation while protecting rights, safety, and trust. This study aims to develop a conceptual meso-level capability framework that translates responsible AI principles into organizational practices for public health agencies. Methods: We …

Population Pharmacokinetics And Dosing Simulations Of Pentobarbital In The Pediatric Population, Victoria Etges Helfer, Lorena Medina-Aymerich, William J. Muller, Marisa Meyer, Amira Al-Uzri, Russell Mcculloh, Chi D. Hornik, Stephen J. Balevic, Rachel G. Greenberg, Daniel K. Benjamin, Sarah G. Anderson, Daniel Gonzalez

Department of Pediatrics Faculty Papers

Pentobarbital is a barbiturate with sedative and anticonvulsant properties, occasionally used in pediatric patients for preoperative sedation, deep sedation during mechanical ventilation, and seizure control. Despite its long-standing clinical use, age-appropriate dosing remains challenging due to variability across studies and limited pediatric pharmacokinetic (PK) data. This study (NCT01431326) aimed to characterize the population pharmacokinetics of pentobarbital in pediatric patients (birth to 21 years) and evaluate dosing strategies using model-based simulations. A two-compartment population PK model, allometrically scaled to total body weight, adequately described pentobarbital plasma concentrations, with no additional covariates identified as significant. Simulations were conducted across four age groups: …

The Impact Of Glucose Exposure On Organic Cation Transporters (Oct) Function In A Corneal Epithelial Cell Line, David A. Garza

Theses & Dissertations

Organic cation transporters (OCT) facilitate the movement of neurochemicals and medications, contribute to the removal of cellular waste, and facilitate neuronal communication. Three subtypes of these high-capacity, low-affinity transporters (OCT1, OCT2, and OCT3) are differently expressed in peripheral tissues such as the liver, kidneys, as well as the central nervous system. OCTs are also expressed in ocular tissues. Chronic hyperglycemia is a complication commonly associated with diabetes that can lead to ocular diseases such as diabetic keratopathy, which affects the cornea. In this project, we expose immortalized human corneal epithelial cells (HCE-S) to various glucose concentrations to study their impact …

Prefrontal Engagement In Cognitive Flexibility Across Paradigms, Katarina Kalajzic

Honors Scholar Theses

Cognitive flexibility is an executive function that involves dynamically adapting behavior in the face of changing environmental circumstances to achieve a particular goal. Disrupted in numerous psychiatric disorders such as Alzheimer’s disease, schizophrenia, OCD, and depression, the neural correlates of cognitive flexibility are not well understood. However, the prefrontal cortex (PFC) is strongly implicated in executive function and attentional control processes. Thus, we sought to examine the neural circuitry involved in distinct cognitive flexibility tasks – the attentional set-shifting task and the probabilistic 2-armed bandit task. Through optogenetic suppression, we targeted pyramidal neurons of the rodent medial prefrontal cortex, an …

Factors Affecting Pedestrian-Vehicle Conflicts: An Empirical Analysis, Christo D. Jamo

Honors Scholar Theses

The number of pedestrian deaths increased by 78% between 2009 and 2023, while other motor vehicle crash deaths increased by 13% in the same period [1]. To identify potential pedestrian safety measures, this study analyzed the effects of location-based demographics, pedestrian phasing type, and other physical infrastructure and behavior variables on the probability of pedestrian-vehicle conflicts at signalized intersections, which is a surrogate measure of crash risk. Data were collected from 55 intersections in Connecticut, and the pedestrian-vehicle interactions were classified by severity based on the Swedish Traffic Conflict Technique: undisturbed passage, potential conflict, minor conflict, or serious conflict. Because …

Diagnostic Ability Of Rate Of Torque Development For Patellofemoral Pain, Arun Loganathan, Neal R. Glaviano Phd, Sungwan Kim Phd

Honors Scholar Theses

Context: Patellofemoral pain (PFP) is a highly prevalent condition (22.7% in general population) that significantly impacts the quality of life of those who suffer from it. However, there is no gold standard test to diagnose it yet, leading to inconsistencies with treatment as well as delayed intervention. Rate of torque development (RTD) is a neuromuscular measure that has shown strong connections to PFP.

Objective: The purpose of this study is to determine the diagnostic ability of RTD for PFP.

Design: Cross-sectional.

Setting: Laboratory.

Participants: Thirty-five individuals with PFP (24 males and 11 females, 22.7 ± 3.7 years, 1.67 ± 0.1 …

Validation Of A Real-Time Pcr Laboratory Developed Test For The Detection Of Pneumocystis Jirovecii In Bronchoalveolar Lavage Samples, Caitlyn Moon

Honors Scholar Theses

Pneumocystis jirovecii is an opportunistic, host-obligate fungal pathogen responsible for causing P. jirovecii pneumonia (PJP) in humans. PJP is treated with trimethoprim-sulfamethoxazole (TMP-SMX), a strong broad-spectrum antibiotic that carries risk of renal and hepatotoxicity. Therefore, rapid diagnosis or exclusion of PJP is crucial to ensure PJP-positive patients receive effective treatment and PJP-negative patients avoid unnecessary antibiotics. Unlike most microorganisms, P. jirovecii cannot be cultured, presenting complications for the typical methods of diagnosing fungal pathogens. Historically, the gold standard for diagnosis was direct microscopic examination with stains such as methenamine silver and calcofluor white, but this diagnostic technique requires highly skilled …