Digital Commons Network^™

Decoding Spatial Transcriptomics Across Multicellular And Subcellular Resolutions, Chongyue Zhao, Hanqiu Zhao, Zhiyu Dai, Et Al.

2020-Current year OA Pubs

Current whole-genome spatial transcriptomics (ST) platforms, which range from multicellular (e.g., Visium) to subcellular resolution (e.g., Visium HD, Stereo-seq), face significant challenges in accurately decomposing or aggregating spots into single cells-the fundamental units of biological activity. To date, most existing computational methods operate at the spot level, and no method has effectively reconstructed transcriptomes at single-cell resolution. In this study, we present STARS (Spatial Transcriptomics across Resolutions for Single Cells). Leveraging Vision Transformer model and contrastive learning, STARS combines high-resolution histology images with spot-level transcriptomics data to reconstruct single-cell-level gene expression from multicellular and subcellular platforms. We demonstrate the advantage …

Increasing Near-Miss Reporting: An Evidence-Based Approach, Rosalud H. Sanchez-Lozada

Doctoral Projects

Near-miss events, defined as errors intercepted before reaching the patient, offer valuable opportunities for learning and prevention, particularly in high-acuity intensive care units (ICUs). Despite the availability of electronic reporting systems and national emphasis on patient safety, near-miss reporting remains inconsistent in many critical care settings. This Doctor of Nursing Practice (DNP) quality improvement project evaluated the impact of a structured educational intervention on near-miss reporting within a cardiovascular intensive care unit (CVICU) at a large academic medical center. A single-group pre–post design was used to examine changes in reporting trends following a three-week intervention that included staff education, leadership …

The Impact Of Tgfβ Conditioning And Socs3 Expression On Cytokine Signal Transduction And Inflammatory Gene Expression In Fibroblasts, Morgan Anderson-Crannage

NYMC Student Theses and Dissertations

Inflammation is a major driver in many aspects of recessive dystrophic epidermolysis bullosa (RDEB) pathology, including impaired wound healing, fibrosis, and potentially cutaneous squamous cell carcinoma development. Fibroblasts, as key stromal cells in the dermis, are responsible for orchestrating inflammatory responses through the secretion of cytokines and chemokines upon stimulation with IL-1α or IL-6. Suppressor of Cytokine Signaling 3 (SOCS3) functions as a negative feedback regulator of cytokine signaling and has emerged as a key modulator of inflammatory responses in immune cells and fibroblasts. Transforming Growth Factor Beta (TGFβ), a known driver of fibrosis in RDEB, has been implicated in …

Global Health Financing Of Diagonal Interventions: Building Resilient And Sustainable Health Systems In Sub-Saharan Africa, Lucy Kim

Master in Public Policy Theses

Background: Global health financing has historically prioritized disease-specific “vertical” programs over broader “horizontal” strengthening of general health systems. Vertical programs in HIV have led to unprecedented reductions in mortality worldwide, but HIV remains a significant public health threat in sub-Saharan Africa, where vertical strategies have long been criticized for creating fragmented health systems. In response, global health strategies have shifted towards combining vertical investments with broader horizontal activities, commonly referred to as “diagonal” programming. While evidence suggests that diagonal programming has the potential to create more resilient and sustainable health systems, evaluating its value for money is challenging due to …

Beyond The Ban: Chhaupadi Abolition And The Governance Of Menstrual Autonomy In Western Nepal, Nikita Paudel

Master in Public Policy Theses

This thesis examines how two decades of efforts to abolish chhaupadi have shaped the everyday conditions under which women and girls experience menstruation in western Nepal. Chhaupadi, commonly understood as menstrual seclusion, has been addressed through Supreme Court directives, national policy, criminal law, municipal implementation instruments, hut demolition campaigns, public health programming, and rights-based advocacy. Yet the practice has persisted, adapted, and in some cases moved into less visible spaces. Rather than treating this as a simple gap between law and practice, this thesis asks how abolition efforts themselves have become part of the regulatory regime through which menstruation is …

Early Neurodevelopmental Outcomes In A Child With Tuberous Sclerosis Complex Treated With Everolimus And Vigabatrin, Sarah Ml Wilson, Megan Samuels, Luana Pimentel, Shelley Varnado, Claire Sartwell, Rosleen Mansour, Deborah Pearson, Hope Northrup, Mary Kay Koenig

Faculty, Staff and Student Publications

Objectives: To report early neurodevelopmental outcomes in a child with Tuberous Sclerosis Complex (TSC) treated with everolimus and vigabatrin.

Methods: The authors report a five-year-old girl with Tuberous Sclerosis Complex who was initiated on vigabatrin at seven weeks old to treat infantile spasms and on everolimus at two months of age to treat a subependymal giant cell astrocytoma. Neuropsychological assessments were conducted in this patient at 12, 24, and 36 months using the Bayley-III and Vineland-II.

Results: On the Bayley-III, the patient had a high average cognitive composite score at 12 months and a high average language composite score at …

Caregiving Experiences And Challenges Among Caregivers Of Children With Epilepsy In Thailand: A Qualitative Study, Arthittaya Kaenkrai, Pramote Thangkratok, Pawanrat Panjatharakul, Apasri Lusawat, Moritz Tacke

Journal of Health Research

Background: Childhood epilepsy requires long-term management and places substantial responsibilities on caregivers. In Thailand, limited public awareness and persistent stigma surrounding epilepsy may intensify caregivers’ psychosocial and practical burdens. This study aimed to explore the lived experiences of caregivers of children with epilepsy in Thailand.

Methods: A qualitative study using two semi-structured focus group discussions (FGDs; 5 participants per group) and 15 in-depth interviews (IDIs) was conducted with primary caregivers of children with epilepsy receiving care at a neurological referral institute in Thailand. Participants were purposively selected to capture a diverse range of caregiving experiences. Data were audio-recorded, transcribed verbatim, …

Comparison Of Selected Supply Chain Management Practices Of Three Major Regional/Metropolitan Hospitals, Alan D. Smith

Atlantic Marketing Association Proceedings

No abstract provided.

Implementation Of A Nurse-Driven Early Mobility Algorithm In Critically Ill Adults, Andrea Saito

Doctoral Projects

Background: Early mobilization of critically ill patients is recommended in clinical practice guidelines to mitigate ICU-acquired weakness, delirium, and improve recovery. This intervention is inconsistently implemented in many health systems due to a variety of barriers. One frequent barrier is uncertainty regarding whether patients meet safety criteria for mobilization. Purpose: The purpose of this quality improvement project was to implement a nurse-driven early-mobility algorithm with a clinical safety screen in an adult medical-surgical ICU and evaluate its impact on patient mobility scores, delirium rates, and ICU length of stay.​ Methods: The intervention was evaluated using a quasi-experimental before and after …

Demystifying Longitudinal Melanonychia: Low-Cost 3d-Printed Nail Models For Patient Education, Nuran C. Golbasi, Zachary J.K. Neubauer, Nataliedeana Badillo, Shari R. Lipner

Student Papers, Posters & Projects

No abstract provided.

Rehabilitation Belief And Engagement Transformation (Rbet) Model: A Grounded Theory Approach, Jade Ibhar V. Cuambot, Marc Eric S. Reyes, Karen Katrina V. Trinidad

Makara Human Behavior Studies in Asia

Competitive sports injuries have significant physiological and psychological consequences for athletes. While rehabilitation medicine effectively addresses the physical aspects of injury recovery, the psychological and emotional journey of injured athletes remains neglected. Thus, the current study addresses this gap by examining athletes’ transforming belief systems and emotional experiences during injury rehabilitation. A qualitative research design grounded in grounded theory principles was conducted with professional athletes to understand how their beliefs toward rehabilitation evolved over time. Findings revealed a dynamic process of belief transformation consisting of seven interconnected stages, captured in the Rehabilitation Belief and Engagement Transformation (RBET) Model: (1) Pre-rehabilitation …

Postoperative Pain After Dental Procedures: The National Dental Practice-Based Research Network Observational Study Using An Mobile Health Platform, Muhammad F Walji, Alfa-Ibrahim Yansane, Sayali Tungare, Rahma Mungia, David Holmes, Kim Funkhouser, Celeste Machen, Janelle Urata, Christoffer Redlund, Gautam Shirodkar, Hans Malmstrom, David H Yu, Oluwabunmi Tokede, D Brad Rindal, Gregg H Gilbert, Heiko Spallek, Joel White, Elsbeth Kalenderian

Faculty, Staff and Student Publications

Background: Managing postoperative dental pain is essential, but patient-reported data on pain and medication practices are scarce. The authors examined patient-reported pain, functional interference, and medication use after common dental procedures.

Methods: In this prospective observational cohort study, 2,674 adults in a multicenter US practice-based network reported pain intensity and interference via a mobile application. Outcomes were collected on days 0, 1, 3, 5, and 7 to assess trajectories across endodontics, periodontal surgery, oral surgery, and implant dentistry as well as multiple procedures within these 4 categories.

Results: Among 2,674 participants (mean age, 49.8 years; 55.6% were female), mean (SD) …

Tiktok And The Brain: Neuropsychological Correlates Of Short-Form Video Consumption, Caty Enders

Psychology ETDs

Short-form video platforms like TikTok have quickly become the fastest growing segment of social media, thanks to powerful algorithms serving up personalized content driven by large quantities of user data. This study investigates the neuropsychological correlates of digital media use, with a particular focus on TikTok and smartphone screen time among young adults. Combining correlational analyses and an experimental design (n = 49; n = 44 included in final sample), we examined the relationship between digital media use and cognitive and emotional functioning across multiple domains. Objective measures of digital media consumption (daily average screen time and time on TikTok) …

Healthcare Professional Knowledge About Food Insecurity And Treatment Options, Amberlyn Jarman

Doctor of Nursing Practice Scholarly Project

Food insecurity is a significant social determinant of health associated with obesity, chronic disease, increased healthcare utilization, and higher mortality, particularly in rural and underserved populations. Healthcare providers are uniquely positioned to identity and address food insecurity; however, gaps in provider knowledge and awareness of available community resources persist. This scholarly project evaluated whether an educational intervention could improve healthcare providers' knowledge and awareness of food insecurity and local treatment options. A mixed-methods approach of quantitative and qualitative measure was utilized for research. Pre- and post-test design was used with healthcare providers from a four-state rural region, including Kansas, Missouri, …

Thoughts From The Pit: Can Raving Change The World? A Literature Review Exploring Rave Culture As Expressive Arts Healing, Marissa Rose Renella

Expressive Therapies Theses

This literature review examines the structural and philosophical commonalities between expressive arts therapy (EXA) and rave culture. Drawing on scholarship from anthropology, cultural studies, health sciences, transpersonal psychology, neuroscience, and expressive arts therapy, this review identifies five core principles shared between the two fields: transformational experiences, multimodality, entrainment and flow, containment and ritual, and community and social action values. Across each principle, the literature reveals not surface-level similarity but deep convergence — two fields that have, independently and through different lineages, arrived at the same understanding of what human beings need in order to heal, grow, and connect. To the …

Re-Painting Motherhood: A Community-Based Expressive Arts Project Exploring Motherhood’S Myths, Realities, And Hopes Through A Narrative Therapy Lens, Lauren Grignaffini-Morris

Expressive Therapies Theses

This thesis examines how socially constructed ideals of motherhood shape maternal identity, distress, and isolation, and explores the potential of addressing these experiences through a community-based expressive arts project. Drawing on motherhood studies, expressive arts therapy, and narrative therapy, the project highlights the potential benefits of utilizing expressive arts in a community setting to ease the tension between romanticized cultural narratives and the lived realities of mothers. Conducted with a support group for mothers in rural Vermont, the project used visual art, movement, creative writing, and collaborative mixed-media painting to examine problem-saturated motherhood stories, connect through embodied experience, and explore …

Playfulness And Awe: How Ecodramatherapy Can Facilitate The Experience Of Positive Emotional States To Reduce Perceived Stress, Corey Jennifer Maier

Expressive Therapies Theses

This paper investigates the question, “can a play and awe-based Ecodramatherapy intervention help to reduce levels of perceived stress in a group of food forest volunteers?” Methods for investigation and subsequent discussion of results draw from the Biophilia Hypothesis, Stress Reduction Theory, and Trait Activation Theory to guide conceptualization. Based on a review of the literature suggesting that playfulness and awe have an effect on both perceived and physiological stress, the author created an Ecodramatherapy intervention designed to evoke playfulness and awe for a group of 4 stressed food forest volunteers. The volunteer group was of mixed ethnicities and genders …

Embodied Identity In Dementia: Art Therapy As A Pathway To Selfhood, Sarah E. Southwick

Expressive Therapies Theses

Older adults living with dementia have often been erroneously perceived as inhabiting a singular lived experience marked by degeneration in cognitive functioning and considerable losses in self-identity. There is substantial literature to suggest that multisensory stimulation and art therapy are well-positioned as conduits for self-expression. However, a gap exists related to artistic media and how they may be implemented and tailored for people with dementia. This capstone explores the paradigm of selfhood as a subjective essence of being that may be accessed through creative expression and sensory engagement. Arts-based directives were implemented through a person-centered expressive arts therapy framework. Two …

Opening Space For Joy: Play As A Pathway In Dance/Movement Therapy With Adults In Addiction Recovery, Brittany M. Walsh

Expressive Therapies Theses

This literature review examines the cultivation of joy through play in dance/movement therapy (DMT) for adults in addiction treatment. Substance use disorders (SUDs) and addictive behaviors are complex, multifaceted conditions influenced by biological, psychological, social, and systemic factors; however, treatment approaches often prioritize symptom reduction and traditional talk-based models. Although necessary, these approaches often fail to honor the whole person, and can inadvertently reinforce shame, stigma, isolation, and dehumanization. Drawing on trauma-informed, neurobiological, relational, and decolonizing frameworks, this review positions joy as a fundamental aspect of human experience and an affirmation of dignity. Playful processes in DMT have the potential …

From Worry To Invention: Developing The Lunch Bunch As A Multimodal Expressive Arts Model For Regulation, Collaboration, And Peer Connection In Elementary Schools, Pascale Lauren Mimran-Ugbabe

Expressive Therapies Theses

This thesis documents the development of the Multimodal Expressive Arts Lunch Bunch, a small group intervention for elementary students delivered during the school lunch period at a public elementary school in Boston, Massachusetts. Grounded in multimodal expressive arts therapy, intermodal transfer theory, polyvagal-informed co-regulation, and principles of externalization, the intervention was designed as a low-barrier creative support group accessible regardless of diagnosis, referral status, or family pursuit of clinical services. Two cohorts of teacher-nominated students, one group of fourth-grade girls and one mixed-gender third-grade group, participated in a sequenced arc moving from worry externalization through collaborative invention, prototype construction, and …

Rhythms Of Hippocampal Function And Memory After Moderate Prenatal Alcohol Exposure, Lilliana May Sanchez

Psychology ETDs

Fetal Alcohol Spectrum Disorders involve morphologic and neurobiological abnormalities in offspring subjected to prenatal alcohol exposure. Although not as well studied as high exposure, moderate prenatal alcohol exposure represents the most common and undetected form in humans. While learning and memory deficits have been well characterized at the behavioral level in humans with Fetal Alcohol Spectrum Disorders and in animal models of moderate prenatal alcohol exposure, few studies have determined the circuit or systems level mechanisms of the behavioral deficits. A complete understanding of the neural bases of memory deficits after moderate prenatal alcohol exposure is needed to ultimately identify …

Improving Health Literacy And Self-Management In Adults With Heart Failure: A Nurse-Led Virtual Intervention In Outpatient Support Groups, Vivian Efosa Osunde

Doctoral Projects

Heart failure is a leading cause of morbidity and hospital readmissions, with limited health literacy contributing to poor self‑management and adherence challenges. The purpose of this Doctor of Nursing Practice project was to evaluate the feasibility and preliminary outcomes of a nurse‑led, virtual education-intervention designed to improve health literacy, self‑care behaviors, and medication adherence among adults with chronic heart failure who participate in an outpatient support group. A quality improvement design was used. Convenience sampling yielded nine adult participants with a documented diagnosis of chronic heart failure who attended at least one virtual support group session. The intervention consisted of …

Whiny Women: How Medical Gaslighting Becomes Medical Trauma, Neena Marcus

Honors Projects

Background: The idea of “medical gaslighting” has been present since 1969, but it has increased in popularity in the recent century. Women in particular are at increased risk of being dismissed by their healthcare providers, as throughout history they have been deemed “hysterical” or untrustworthy when recounting their symptoms.

Methods: Articles were compiled from CINAHL Complete, Google Scholar, and the University of Washington library. A total of 33 articles were chosen and reviewed.

Results: Medical gaslighting results in lasting medical trauma, a decreased quality of life and detachment from standard healthcare. Six themes were recurrent in the papers utilized: sexism, …

Impact Of Third Trimester Alcohol Exposure (Ttae) On Oligodendrocyte Development And Behavior In Mice, Estrella Villicana

Biomedical Sciences ETDs

Prenatal alcohol exposure (PAE) during late gestation can cause cognitive, behavioral, and motor impairments associated with fetal alcohol spectrum disorders (FASDs). The third trimester corresponds to a critical period of brain growth and maturation. This study examined the effects of Third Trimester-equivalent Alcohol Exposure (TTAE) on oligodendrocyte development and adult behavior. Neonatal mice were exposed to ethanol or air vapor from postnatal day (P) 4–8. Immunohistochemical analyses were performed at P8 and P30 to assess myelination, apoptosis, and oligodendrocyte lineage progression. TTAE significantly reduced myelin basic protein (MBP) expression at P8, which was recovered by P30, indicating delayed developmental myelination. …

The Effects Of Behavior Skills Training To Teach A Clinician To Implement A Structured Work System, Megan E. Bowling

Masters Theses, 2020-current

Many children with autism spectrum disorder present with deficits in completing daily living tasks, which may be due to the sequencing of information required to complete these skills. Structured work systems present a support for children to visually organize and sequence events, though they are most used in the classroom setting. The study tested the effectiveness of behavior skills training to teach a behavior support clinician to implement a structured work system via least-to-most prompting. Data was collected on the clinician’s percent of accurate implementation, which was then analyzed across three daily living behaviors in a multiple probe design. Results …

Brain-Based Mechanisms Of Behavioral Impairment In Fetal Alcohol Spectrum Disorder (Fasd): The Neuroimaging Biomarkers Of Inhibitory Control, Zinia Pervin

Biomedical Engineering ETDs

The developing brain is highly susceptible to alcohol-induced toxicity, often resulting in long-term deficits in executive function and behavioral regulation. Inhibitory control impairments are among the most prominent deficits observed in Fetal Alcohol Spectrum Disorder (FASD). This study investigated the neural mechanisms of inhibitory dysfunction using a multimodal MEG–DTI approach in 67 children aged 6–8 years (34 with FASD, 33 controls) who performed a Go/No-Go task. Source-level MEG analyses revealed reduced stimulus-locked cortical activation in the anterior cingulate cortex and significant group-by-hemisphere interactions in the superior parietal cortex and cuneus. Time–frequency analyses showed diminished response-locked beta power in the sensory-motor …

Ai Tools For Research Teams, Sandra Desjardins

Library Class: Lunch & Learn

Join us for a fast-paced, practical session on using free and low-cost AI tools to save hours on your research workflow, from initial discovery to final synthesis. We'll have an overview of tools like Rayyan, ResearchRabbit, and Elicit.

The Academic Workplace Climate Measure: A New Instrument To Measure Counselor Education Faculty Climate, Ryan Holliman, Ryan D. Foster, Pedro Blanco

Journal of Counselor Preparation and Supervision

Research indicates that between 32% and 62% of faculty in higher education have experienced some form of incivility (Cassell, 2011; Fox, 2010; Heffernan & Bosetti, 2020; Hollis, 2012; Keashly & Neuman, 2008; McKay et al., 2008). Incivility among faculty can be associated with declining health, decreased faculty retention, diminished self-esteem, and lowered psychological well-being (McClendon et al., 2021; Miner et al., 2012; Raskauskas & Skrabec, 2011). Although counselor educators are presumably experts in effective communication and conflict negotiation, anecdotal reports of conflict in counselor education departments are frequent. This study developed an instrument called the Academic Workplace Climate Measure. In …

Understanding Counselor Burnout From An Ecological Systems Perspective, Stephanie Thorson-Olesen, Lisa Belknap, Emily Velidow, Jessica Gaul, Phoenix Rosewood, Nayara Aparecida Da Costa Silva Beall

Journal of Counselor Preparation and Supervision

Using Bronfenbrenner’s Ecological Systems Theory as a guiding framework, this study explored the experiences of licensed counselors who self-identified as having recovered from burnout. Burnout was conceptualized as a prolonged response to chronic occupational stress, while participants were invited to describe their experiences based on their own lived understandings of the phenomenon. A qualitative thematic analysis was conducted using data collected through an anonymous online survey featuring open-ended prompts. Participants included 32 licensed counselors who graduated from CACREP-accredited programs and reported previously experiencing burnout and no longer identifying as currently burned out. Thematic analysis yielded nine interrelated themes encompassing contributors, …

Predicting Counseling Student Well-Being: The Role Of Faculty And Stress, Kendall G. Woods, Elizabeth K. N. Harper, Michell L. Temple

Journal of Counselor Preparation and Supervision

Approximately one-third of Americans live in areas with limited access to mental health services, with only one mental health provider for every 350 people (Health Resources and Services Administration [HRSA], 2024; Reinert & Nguyen, 2022). The shortage of mental health providers persists as the need for services grows, a challenge compounded by the 40-60% attrition rate among counseling trainees (Chrzanowski, 2018). Improving counseling program completion is essential to address the mental health workforce shortage. While previous research has emphasized the importance of faculty support for graduate students (Estrada et al, 2019), little research has examined how faculty-student interactions and academic …