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Articles 1951 - 1980 of 104002
Full-Text Articles in Entire DC Network
Staff Education To Improve Early Identification And Management Of Clinical Deterioration In Pediatric Patients Using A Standardized Assessment Protocol, Sarabjit Chahal
Staff Education To Improve Early Identification And Management Of Clinical Deterioration In Pediatric Patients Using A Standardized Assessment Protocol, Sarabjit Chahal
Walden Dissertations and Doctoral Studies
No abstract provided.
Movement-Stabilized Three-Dimensional Optical Recordings Of Membrane Potential Changes And Calcium Dynamics In Hippocampal Ca1 Dendrites, Kevin C Gonzalez, Satoshi Terada, Asako Noguchi, George N Zakka, Cliodhna O'Toole, Giuliana Bilbao, Luke Reynolds, Anna Jász, Borbála Kertész, Zoltán Szadai, Alissa Shen, François St-Pierre, Franck Polleux, Attila Losonczy, Balázs Rózsa
Movement-Stabilized Three-Dimensional Optical Recordings Of Membrane Potential Changes And Calcium Dynamics In Hippocampal Ca1 Dendrites, Kevin C Gonzalez, Satoshi Terada, Asako Noguchi, George N Zakka, Cliodhna O'Toole, Giuliana Bilbao, Luke Reynolds, Anna Jász, Borbála Kertész, Zoltán Szadai, Alissa Shen, François St-Pierre, Franck Polleux, Attila Losonczy, Balázs Rózsa
Faculty, Staff and Students Publications
Local dendritic computations are thought to critically influence neuronal signaling and plasticity yet remain largely unexplored in vivo due to challenges in stably imaging small structures at ultrafast timescales. We developed a 3D real-time motion correction platform for movement-stabilized, ultrafast two-photon voltage imaging. By co-labeling CA1 pyramidal neurons with voltage and calcium indicators, we simultaneously measured somato-dendritic and electro-calcium coupling at multiple dendritic sites. We characterized isolated dendritic spikes and distance-dependent backpropagation of naturally occurring and photostimulation-evoked bursts and single spikes. We found that bursts backpropagated more reliably than single spikes, validated that somato-dendritic coupling decreases with distance from soma, …
Factors Associated With Vaping Frequency Among University Students, Oluwatosin Marylyn Oduneye
Factors Associated With Vaping Frequency Among University Students, Oluwatosin Marylyn Oduneye
Masters Theses
Electronic cigarette use among university students is a growing public health concern, with approximately 20-25% reporting current use. Despite extensive research on vaping initiation, factors associated with vaping frequency among established users remain understudied. This study examined stress-coping mechanisms, peer influence, and health risk perceptions as predictors of vaping frequency, guided by Bandura's Social Cognitive Theory (SCT). A quantitative cross-sectional survey was administered via Microsoft Forms to 399 university students aged 21-25 with recent vaping experience, recruited nationally through campus flyers and online platforms. Multiple linear regression was conducted in SAS OnDemand for Academics, with stress-coping, peer influence, and health …
Repurposing Semaglutide As An Adjunctive Treatment For Cocaine Use Disorder: Protocol For A Randomised Controlled Trial, Luba Yammine, Francesco Versace, Charles E Green, Heather E Webber, Jin Ho Yoon, Absalon D Gutierrez, Samuel J Leonard, Michael F Weaver, Joy Schmitz
Repurposing Semaglutide As An Adjunctive Treatment For Cocaine Use Disorder: Protocol For A Randomised Controlled Trial, Luba Yammine, Francesco Versace, Charles E Green, Heather E Webber, Jin Ho Yoon, Absalon D Gutierrez, Samuel J Leonard, Michael F Weaver, Joy Schmitz
Faculty, Staff and Student Publications
Introduction: Cocaine use disorder (CUD) is a significant public health concern in the USA, with considerable prevalence and mortality and no Food and Drug Administration (FDA)-approved pharmacotherapies. Recent advances in addiction science emphasise the need for novel, mechanism-based treatments. Glucagon-like peptide-1 receptor agonists, such as semaglutide, have shown promise in modulating reward-related behaviours and may offer therapeutic benefits for CUD. We present a study protocol evaluating semaglutide, as an adjunct to cognitive behavioural therapy (CBT), as a novel approach for treating CUD.
Methods and analysis: This is a randomised, double-blind, placebo-controlled trial enrolling 75 treatment-seeking adults with CUD. Participants will …
Beyond Crisis: Patient Access And Sustainability, Miguel A. Mendoza
Beyond Crisis: Patient Access And Sustainability, Miguel A. Mendoza
Doctoral Dissertations and Projects
Critical systems underwent drastic workflow adaptations during the COVID-19 pandemic. Many of these operational alterations persist today, while others have been reduced or eliminated. This is a qualitative study on the operational, technological, and human-centered challenges experienced by healthcare organizations providing primary care services in Southwest Ohio during and immediately after the pandemic. This flexible research design implements in-depth, semi-structured interviews with healthcare professionals leading primary care operations to capture a longitudinal perspective on pandemic-era service delivery, and the legacy systems still in place today. Thematic analysis revealed seven themes that determine the effectiveness of care delivery models. Social Determinants …
Exploring The Impact Of Cultural Beliefs On Death Anxiety: A Qualitative Study To Inform Healthcare Education And Practices, Sharon Sonnilal
Exploring The Impact Of Cultural Beliefs On Death Anxiety: A Qualitative Study To Inform Healthcare Education And Practices, Sharon Sonnilal
Doctoral Dissertations and Projects
A hermeneutic phenomenological approach framed this qualitative study, examining how cultural beliefs, spiritual traditions, and relational contexts shape death anxiety and meaning-making among adults from diverse backgrounds. Terror Management Theory and Culturally Sensitive Grief Treatment guided the conceptualization of death anxiety as a culturally mediated and relational phenomenon rather than an isolated psychological response. A purposive sample of 13 adults aged 18 and older represented diverse cultural, racial, gender, and spiritual identities. Recruitment occurred via Instagram, and participants completed an open-ended demographic and narrative survey. Participants who provided rich survey narratives received invitations to complete semi-structured Zoom interviews to deepen …
Implementing A Standardized Social Determinants Of Health Screening Process To Improve Care Coordination In Primary Care, Catherine A. Addison
Implementing A Standardized Social Determinants Of Health Screening Process To Improve Care Coordination In Primary Care, Catherine A. Addison
Walden Dissertations and Doctoral Studies
No abstract provided.
Exploring The Role Of Self-Efficacy In Undergraduate Nursing Students: A Transcendental Phenomenological Study, Dorothy Elaine Rolling
Exploring The Role Of Self-Efficacy In Undergraduate Nursing Students: A Transcendental Phenomenological Study, Dorothy Elaine Rolling
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to explore the role of self-efficacy for nursing students whose primary language was not English and who were enrolled in higher education in the northeastern area of the United States. The theory guiding this study was Bandura’s theory on self-efficacy. The major tenets of the self-efficacy theory aligned with the metaparadigm of nursing (person, health, environment, nursing) and with the study’s focus, which was to explore how English as a second language (ESL) nursing students could successfully complete the registered nursing program at an institution of higher learning. The central research question was: …
Evaluation Of The Effectiveness Of The Guardian Protective Cap In Reducing The Incidence And Recovery Duration Of Concussions Among Division Ii Collegiate Football Players In The State Of West Virginia, Dave Mcentire
Doctoral Dissertations and Projects
This study focuses on a retrospective quasi-experimental design to evaluate the effectiveness of the Guardian protective cap in reducing the incidence and recovery duration of concussions among Division II football players in the state of West Virginia. The study will evaluate the medical records, obtained from the NCAA certified athletic trainers, of four seasons worth of data from two separate football teams. The study will examine two seasons worth of data of the teams prior to mandating the usage of the protective caps during practice, and two seasons of data following their implementation. The study will compare the overall incidence …
Psychological Impact Of Career Roles On African American Women: A Qualitative Study On The Long-Term Effects On Behavioral Health Providers' Field, Yolanda Seals-Stewart
Psychological Impact Of Career Roles On African American Women: A Qualitative Study On The Long-Term Effects On Behavioral Health Providers' Field, Yolanda Seals-Stewart
Doctoral Dissertations and Projects
There is an untold narrative regarding the levels of stress, anxiety, and depression. This leaves a gap in researchers understanding systemic, cultural, and social factors that shape mental health outcomes in a unique way. There is also a deeper need for exploration of resiliency and coping skills strategies utilized by African American women in the behavioral health field, as well as how behaviors such as discrimination, workplace dynamics, and microaggression impact the overall psyche. By addressing these gaps, a more thorough understanding of the long-term psychological effect can be addressed, and these women can receive support mechanisms and interventions that …
Perceptions Of The Effects Of Launch Control Center Environmental Exposures And Alert Schedules Among Missile Operations Officers: A Mixed Methods Phenomenological Study, Dawnie Rae Ramie
Doctoral Dissertations and Projects
This mixed methods hermeneutic phenomenological study focused on an investigation of the perceptions of missile operations alert duty and the effects on health and sleep hygiene among Air Force missile operations officers. Questionnaires, interviews, and surveys were all used to gather data on subjects’ experiences and perspectives, including methods to mitigate the effects of poor sleep. Driving questions of research included how missile alert schedules affect sleep habits, as well as how missileers perceived alert duties may impact their health. Data was collected through a web-based Qualtrics Likert questionnaire (N=139), open-ended interviews with purposively selected subjects (N=17), and web-based Qualtrics …
Temporomandibular Joint Ganglion Cyst Causing Dynamic External Auditory Canal Obstruction And Position-Dependent Hearing Loss: A Case Report And Literature Review, Ali Akbar, Abdulrahman Meerza, Craig Pearl
Temporomandibular Joint Ganglion Cyst Causing Dynamic External Auditory Canal Obstruction And Position-Dependent Hearing Loss: A Case Report And Literature Review, Ali Akbar, Abdulrahman Meerza, Craig Pearl
Faculty, Staff and Student Publications
Purpose: Ganglion cysts of the temporomandibular joint (TMJ) are uncommon periarticular lesions and may be diagnostically challenging because symptoms are often nonspecific. When these lesions arise posterior to the joint, they can produce otologic complaints through dynamic narrowing of the external auditory canal (EAC). Herein, we report on a histologically confirmed TMJ ganglion cyst causing position-dependent hearing loss and review the relevant literature.
Case description: A 72-year-old woman presented with a 3-year history of bilateral preauricular pain, left-sided tinnitus, left aural fullness, and near-complete hearing loss in the left ear when the mandible was closed in occlusion. Clinical examination showed …
Target Ii Data Portal: A Multi-Omics Resource For Environmental Toxicant Studies In Mice, Prashant K Kuntala, Benpeng Miao, Deepak Purushotham, Bo Zhang, Daofeng Li, Ting Wang
Target Ii Data Portal: A Multi-Omics Resource For Environmental Toxicant Studies In Mice, Prashant K Kuntala, Benpeng Miao, Deepak Purushotham, Bo Zhang, Daofeng Li, Ting Wang
2020-Current year OA Pubs
The Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET) program is a multiphase program that aims to understand how environmental factors contribute to disease susceptibility using toxicant-exposed mouse models. Here, we present the TaRGET II Data Portal ( https://data.targetepigenomics.org/ ), a comprehensive repository of multi-omics datasets generated from mice exposed to a range of environmental toxicants, including arsenic (As), lead (Pb), bisphenol A (BPA), tributyltin (TBT), di(2-ethylhexyl) phthalate (DEHP), tetrachlorodibenzo-p-dioxin (TCDD), and ambient air pollution (PM2.5). Epigenomic profiling assays capturing alterations in chromatin accessibility, DNA methylation, gene expression, and histone modifications were produced across multiple research …
Disney Princess Films Representation Of Food And Their Effects On Teenage Girls' Eating Norms, Addison Benninghoff
Disney Princess Films Representation Of Food And Their Effects On Teenage Girls' Eating Norms, Addison Benninghoff
InnovateHER Meeting 2026
Media portrayal obviously have some profound impacts on our society. The problem at hand is that there have been and will continue to be body image and eating habits linked to the media in teenage girls' lives. A mainstream example of this can be seen early on in young girls' lives when they are first exposed to princess films, which have representations of both femininity and the idealized female form. Disney maintains these body ideals whether the heroine is Asian, Scottish, African-American, or Native American. How are these body ideals broadcast through eating habits? What messages about normative eating might …
Building Resilience: Empowering Baccalaureate Nursing Students For Enhanced Well-Being And Success, Jessica Imrie Dnp, Emily Nowak Phd, Roxanne Wilson Phd
Building Resilience: Empowering Baccalaureate Nursing Students For Enhanced Well-Being And Success, Jessica Imrie Dnp, Emily Nowak Phd, Roxanne Wilson Phd
InnovateHER Meeting 2026
Providing baccalaureate students with resilience-building modules such as stress management, mindfulness, optimism, socialization, and reflection can increase psychological well-being and success through a nursing program. It can also decrease the number of meetings faculty have with students regarding psychological concerns
Approval Motivations In Sharing Humorous Tiktok's, Mariam Al-Areedy
Approval Motivations In Sharing Humorous Tiktok's, Mariam Al-Areedy
InnovateHER Meeting 2026
TikTok is a short-form video platform where users create and share content that is often centered around humor, trends, and everyday social experiences. In face-to-face interactions, people typically rely on immediate feedback to navigate conversations, often using approval seeking behaviors to gain positive reactions and rejection-avoidant behaviors to reduce the risk of negative judgement. While these motivations are well-established in in-person settings, less is known about how they function in digital environments like TikTok, where teens privately share humorous content without immediate social cues to guide their interactions. My general hypothesis was that both rejection avoidance and approval-seeking behaviors will …
Health-Seeking Behaviors Of Ethiopian Women In The United States: A Pilot Qualitative Study, Hanna Belay, Felicia Leammuda, Ahmed Ugbad, Beamlak Kebede
Health-Seeking Behaviors Of Ethiopian Women In The United States: A Pilot Qualitative Study, Hanna Belay, Felicia Leammuda, Ahmed Ugbad, Beamlak Kebede
InnovateHER Meeting 2026
This study explores how Ethiopian immigrant women understand health and navigate healthcare in the United States. Using qualitative interviews with two participants, findings show that health is viewed holistically, with strong reliance on traditional remedies. Participants engage with the U.S. healthcare system selectively, often seeking care only when symptoms become severe. Barriers such as system complexity, fear, and time delays influence healthcare decisions.
Empowering Women: Understanding Neurological Changes In The Aging Brain, Joy Mckenzie
Empowering Women: Understanding Neurological Changes In The Aging Brain, Joy Mckenzie
InnovateHER Meeting 2026
Women tend to have more neurological changes than men as they age starting in their mid-30s (Mosconi, 2024). While aging is a natural process, the neurological changes can impact a woman’s personal and professional quality of life (Faubion et al., 2023; Gravini, 2023). For years, women’s neurological symptoms have been ignored by being told that their experiences are normal and just a part of life (Haver, 2025). That narrative is starting to shift with the increased awareness of changes specific to women. There are resources to assess cognitive changes such as memory, processing speed, and word finding and strategies to …
The Influence Of Social Media On Body Image, Self-Esteem, And Eating Disorder Risk In Adolescent Females, Nestanet A. Molla
The Influence Of Social Media On Body Image, Self-Esteem, And Eating Disorder Risk In Adolescent Females, Nestanet A. Molla
InnovateHER Meeting 2026
- This literature review explored how appearance-focused social media affects adolescent girls. The studies showed that social media is linked to body dissatisfaction, comparison behaviors, lower self-esteem, and unhealthy eating behaviors, especially when use is intensive, problematic, or strongly appearance-focused1–4
- At the same time, protective factors such as media literacy, family support, and body-positive interventions may help reduce these negative effects4,5
Headset To Reset: Virtual Reality Therapy In Postoperative Heart And Lung Transplant Patients, Michaela Sanchez
Headset To Reset: Virtual Reality Therapy In Postoperative Heart And Lung Transplant Patients, Michaela Sanchez
Doctoral Projects
Postoperative heart, lung, and heart-lung transplant recipients are at increased risk for anxiety and depression, both of which have been associated with increased risk of complications and higher mortality rates. The purpose of this quality improvement project was to implement a mindfulness-based virtual reality (VR) therapy intervention for postoperative transplant recipients at a Northern California academic medical center and to evaluate its feasibility, tolerability, and acceptability during the index hospitalization. Over a 15-week period, five participants completed a total of eight VR sessions. Participants selected from immersive mindfulness-based environments, including guided meditation and other relaxation experiences. Anxiety and depression were …
Human Papillomavirus Vaccine Discourse And Sentiment On Reddit Before And After Covid-19: Mixed Methods Retrospective Cross-Sectional Study, Marcin Marciniak, Sean A Setzen, Deeya Bhattacharya, Jamie Masliah, Robin Powszok, Erich M Sturgis, Vanessa C Stubbs, Mihir K Bhayani
Human Papillomavirus Vaccine Discourse And Sentiment On Reddit Before And After Covid-19: Mixed Methods Retrospective Cross-Sectional Study, Marcin Marciniak, Sean A Setzen, Deeya Bhattacharya, Jamie Masliah, Robin Powszok, Erich M Sturgis, Vanessa C Stubbs, Mihir K Bhayani
Faculty, Staff and Students Publications
Background: Human papillomavirus (HPV) is a sexually transmitted virus that causes various oropharyngeal and anogenital cancers. The HPV vaccine provides protection against several strains of HPV and is a key preventative tool against HPV-related cancers; however, vaccination rates remain suboptimal in the United States due to variable state mandates and misperceptions of vaccine efficacy and risks. As social media becomes an increasingly popular avenue for health discussions, platforms such as Reddit offer opportunities to understand public vaccine discourse, particularly among underrepresented groups. Furthermore, vaccine hesitancy and mistrust generally increased during the COVID-19 pandemic, potentially impacting HPV vaccination rates.
Objective: This …
Latest In Resuscitation Research: Highlights From The 2025 American Heart Association's Resuscitation Science Symposium, Caleb T Suh, Clark G Owyang, Lindsay Shepard, Betty Yang, Ryan W Morgan, Daniel M Rolston, Catherine R Counts, Tommaso Scquizzato, James Horowitz, Tatyana Shvilkina, Katherine Berg, Sam Parnia, Sanam Alilou, Catherine Swarts, Ryan A Coute, Lama A Ammar, William C Herring, Thomas Lederer, Joaquin Araos, Benjamin S Abella, Cameron Dezfulian, Sarah M Perman, Felipe Teran
Latest In Resuscitation Research: Highlights From The 2025 American Heart Association's Resuscitation Science Symposium, Caleb T Suh, Clark G Owyang, Lindsay Shepard, Betty Yang, Ryan W Morgan, Daniel M Rolston, Catherine R Counts, Tommaso Scquizzato, James Horowitz, Tatyana Shvilkina, Katherine Berg, Sam Parnia, Sanam Alilou, Catherine Swarts, Ryan A Coute, Lama A Ammar, William C Herring, Thomas Lederer, Joaquin Araos, Benjamin S Abella, Cameron Dezfulian, Sarah M Perman, Felipe Teran
Faculty, Staff and Students Publications
No abstract provided.
Learning How To Walk Like A Secretary: To Lead Or To Be Led, Timon T. C. Hogenaar
Learning How To Walk Like A Secretary: To Lead Or To Be Led, Timon T. C. Hogenaar
Middle Voices
Commentary
Learner-Centered Education As A Model For Promoting Client-Centered Care In Communication Sciences And Disorders, Shanna R. Callewaert, Sarah M. Ginsberg
Learner-Centered Education As A Model For Promoting Client-Centered Care In Communication Sciences And Disorders, Shanna R. Callewaert, Sarah M. Ginsberg
Teaching and Learning in Communication Sciences & Disorders
As the student voice is increasingly valued in teaching and learning within higher education, learner-centered education (LCE) has gained traction as a method of creating classrooms that are unique to students’ desires and expectations (Barr & Tagg, 1995; Weimer, 2002). Similarly, client-centered care can be employed as a way for clinicians to shape treatment based on clients’ individual goals (Barry & Edgman-Levitan, 2012; Epstein & Street, 2011). This paper explores the relationships between LCE and client-centered care, noting the importance of engaging communication sciences and disorders students in LCE as it can promote the use of client-centered care in their …
Faculty And Student Perspectives On Course Collaborations Within Communication Sciences And Disorders, Shanna R. Callewaert, Sarah M. Ginsberg
Faculty And Student Perspectives On Course Collaborations Within Communication Sciences And Disorders, Shanna R. Callewaert, Sarah M. Ginsberg
Teaching and Learning in Communication Sciences & Disorders
The collaborative course (re)design (CCRD) process provides faculty and students with an opportunity to collaborate in partnership to redesign a course that the faculty teaches and that the student has previously taken. This process amplifies student voices and allows faculty to increase their understanding of students’ learning and experiences. However, barriers of CCRD, such as faculty members’ desires to retain decision-making control, students’ hesitations to share feedback, and logistical concerns, prevent many faculty and students from taking part in the process. This qualitative study sought to gain insight into the perspectives held by students and faculty in the communication sciences …
A Qualitative Job Posting Analysis From Missouri To Guide Competency-Based Curriculum In Slp Education, Megan Batzer
A Qualitative Job Posting Analysis From Missouri To Guide Competency-Based Curriculum In Slp Education, Megan Batzer
Teaching and Learning in Communication Sciences & Disorders
Competency-based education is a major trend for health professions education and one of the topics the Ad Hoc Committee to Plan Next Steps to Redesign Entry-Level Education for Speech-Language Pathologists (SLPs) recently explored. Competency-based education is an outcomes-based educational model where the focus is on development and mastery of specific knowledge and skills through instruction, assessment, and feedback. Competency-based education encompasses multiple educational theories including the self-determination theory, self-directed learning, self-assessment, and self-efficacy. Understanding the perspectives of key constituents, such as employers, on the setting-specific and across-setting knowledge, skills, and attributes required for the clinical fellowship (CF) experience could guide …
Improving Speech-Language Pathology Graduate Student Confidence In Evidence-Based Practice, Courtney Olson, Carla Tierney-Hendricks
Improving Speech-Language Pathology Graduate Student Confidence In Evidence-Based Practice, Courtney Olson, Carla Tierney-Hendricks
Teaching and Learning in Communication Sciences & Disorders
Evidence-based practice (EBP) is widely acknowledged to be beneficial and necessary for the treatment of patients. However, a gap between evidence-based practice research and use is present. One way to improve EBP implementation is by focusing on incorporating explicit EBP instruction at the graduate student level. This study describes the development of a series of learning modules based on key EBP principles in order to increase graduate student confidence in EBP. Twenty-four first-semester graduate students were followed over the course of 8-weeks, with one group of twelve students receiving structured supplemental learning and the other group receiving only their traditional …
Decoding Spatial Transcriptomics Across Multicellular And Subcellular Resolutions, Chongyue Zhao, Hanqiu Zhao, Zhiyu Dai, Et Al.
Decoding Spatial Transcriptomics Across Multicellular And Subcellular Resolutions, Chongyue Zhao, Hanqiu Zhao, Zhiyu Dai, Et Al.
2020-Current year OA Pubs
Current whole-genome spatial transcriptomics (ST) platforms, which range from multicellular (e.g., Visium) to subcellular resolution (e.g., Visium HD, Stereo-seq), face significant challenges in accurately decomposing or aggregating spots into single cells-the fundamental units of biological activity. To date, most existing computational methods operate at the spot level, and no method has effectively reconstructed transcriptomes at single-cell resolution. In this study, we present STARS (Spatial Transcriptomics across Resolutions for Single Cells). Leveraging Vision Transformer model and contrastive learning, STARS combines high-resolution histology images with spot-level transcriptomics data to reconstruct single-cell-level gene expression from multicellular and subcellular platforms. We demonstrate the advantage …
Increasing Near-Miss Reporting: An Evidence-Based Approach, Rosalud H. Sanchez-Lozada
Increasing Near-Miss Reporting: An Evidence-Based Approach, Rosalud H. Sanchez-Lozada
Doctoral Projects
Near-miss events, defined as errors intercepted before reaching the patient, offer valuable opportunities for learning and prevention, particularly in high-acuity intensive care units (ICUs). Despite the availability of electronic reporting systems and national emphasis on patient safety, near-miss reporting remains inconsistent in many critical care settings. This Doctor of Nursing Practice (DNP) quality improvement project evaluated the impact of a structured educational intervention on near-miss reporting within a cardiovascular intensive care unit (CVICU) at a large academic medical center. A single-group pre–post design was used to examine changes in reporting trends following a three-week intervention that included staff education, leadership …
The Impact Of Tgfβ Conditioning And Socs3 Expression On Cytokine Signal Transduction And Inflammatory Gene Expression In Fibroblasts, Morgan Anderson-Crannage
The Impact Of Tgfβ Conditioning And Socs3 Expression On Cytokine Signal Transduction And Inflammatory Gene Expression In Fibroblasts, Morgan Anderson-Crannage
NYMC Student Theses and Dissertations
Inflammation is a major driver in many aspects of recessive dystrophic epidermolysis bullosa (RDEB) pathology, including impaired wound healing, fibrosis, and potentially cutaneous squamous cell carcinoma development. Fibroblasts, as key stromal cells in the dermis, are responsible for orchestrating inflammatory responses through the secretion of cytokines and chemokines upon stimulation with IL-1α or IL-6. Suppressor of Cytokine Signaling 3 (SOCS3) functions as a negative feedback regulator of cytokine signaling and has emerged as a key modulator of inflammatory responses in immune cells and fibroblasts. Transforming Growth Factor Beta (TGFβ), a known driver of fibrosis in RDEB, has been implicated in …