Digital Commons Network^™

The Artificial Pancreas Today, James F. Mcmurry Jr.

Henry Ford Hospital Medical Journal

An artificial pancreas is now available in selected centers for clinical use in blood glucose control. With information derived from 24-30 hours of "closed-loop" insulin administration by means of the artificial pancreas, subcutaneous insulin doses may be determined for insulin-dependent diabetic patients. Eleven poorly controlled diabetic patients had their insulin doses reevaluated with the artificial pancreas. Ten of 11 patients showed improved glucose control when their insulin doses were modified by this method.

Hemolytic-Uremic Syndrome In A Patient Receiving Mitomycin C And 5-Fluorouracil, Glen R. Willie, Stanley M. Levy, Robert S. Michaels, Richard M. Zirkin

Henry Ford Hospital Medical Journal

Recently, an association was reported between a form of hemolytic-uremic syndrome and the use of adjuvant chemotherapy with mitomycin C and 5-fluorouracil. Our report presents the clinical course of a patient with this syndrome along with detailed renal pathological studies (including electron and immunofluorescence microscopy). This information is not available for most previous reports.

Age-Changes Of The Neuronal Component Of Meissner Corpuscles In The Mouse Digital Pad, Roger C. Mathewson

Loma Linda University Electronic Theses, Dissertations & Projects

Silver impregnated sections of mouse digital pads were studied using light microscopy to detect age-related changes of the neuronal component of Meissner corpuscles. Direct microscopic observation, photomicrographs and camera lucida tracing were utilized. From qualitative observation, the corpuscular neurites were found to undergo morphological age-related changes of diameter, tortuosity, varicosity, branching and terminal expansion size. Quantitative examination was made of the number of corpuscles, corpuscular neurites, branching neurites, cross-innervations, terminal neurite expansions, neurite intraepidermal continuations and terminal axonal processes. The number of corpuscles and neurite intraepidermal continuations decreased with age while having significant linear correlation; whereas, branching increased with age …

The Copper Status Of Vegetarian And Non-Vegetarian Men, Susan Bruce

Loma Linda University Electronic Theses, Dissertations & Projects

In this study, the copper status of 18 vegetarian and 17 non-vegetarian men were compared. Copper status was assessed by determining red blood cell superoxide dismutase (RBC-SOD) activity and plasma copper. Plasma copper levels were measured by atomic absorption spectroscopy. Plasma cholesterol, triacyclglycerols, HDL cholesterol, LDL cholesterol VLDL cholesterol were also determined. Twenty-four hour recalls and three-day food records were obtained to determine copper, zinc, energy, protein, fat, fiber, saturated fat, oleic acid, linoleic acid and cholesterol intake. Non-vegetarians had a significantly higher plasma cholesterol and LDL cholesterol than vegetarians. They also had a significantly higher cholesterol, saturated fat, percent …

Development Of A Mathematical Model Of Renal Function For Clinical Application, Barbara A. Holshouser

Loma Linda University Electronic Theses, Dissertations & Projects

This model describes the orthoiodohippurate (OIH) distribution and clearance in the renovascular system. The model is described by five compartments: the blood, left and right kidneys, bladder and the red blood cell compartment. Data for these compartments, except the RBC compartment, are collected with scintillation detectors monitoring OIH tagged with 1-131 as the radiopharmaceutical passes through each compartment. Time/ activity curves are plotted for the data and used as inputs to the model parameter estimation routine. The compartments are described by a set of first order ordinary differential equations solved using the Adam's methods. For parameter estimation, an iterative predictor-corrector …

Implementing Augmentative Communication For Aphasic Patients In Convalescent Facilities, Susan H. Mcgann

Loma Linda University Electronic Theses, Dissertations & Projects

A one-hour Blissymbol in-service training program was developed for presentation to staff members of a skilled nursing facility. The purpose was to determine whether the program would produce significant learning to justify its use in similar facilities to bridge the communication gap between nonspeaking/nonwriting aphasic patients who communicate with Blissymbols and their direct care personnel as well as family members and others who are significant in their lives.

After development, the in-service program was given two "dry-runs" in skilled nursing facilities similar to the "study facility". It was then revised to improve clarity and to make it fit within time …

Nasal Dosage Forms Containing Natural Female Sex Horomones, Anwar A. Hussain, Shinichiro Hirai, Rima Bawarshi

Pharmaceutical Sciences Faculty Patents

The invention relates to a novel method of administering the natural female sex hormones, 17 β-estradiol and progesterone, to achieve enhanced bioavailability thereof. The invention further relates to novel dosage forms of 17 β-estradiol and/or progesterone which are adapted for nasal administration, such as solutions, suspensions, gels and ointments. The dosage forms containing a combination of 17 β-estradiol and progesterone are particularly useful as contraceptives, while the dosage forms containing only one of the hormonal components find utility in the treatment of conditions such as menopause, menstrual disorders, etc., which are known to respond to administration of a natural or …

อิทธิพลของประสาทซิมพาเธติดต่อต่อมน้ำลาย สับแมนดิบูล่าร์และเมเจอร์สับลิงกวล : ตอนที่ 1 ปริมาตรและน้ำหนักของต่อม, นวลน้อย เวชบรรจง, มาโนช ชัยวัฒน์, จุติศรี แสงวิเชียร, ดอลลี่ เมธาธราธิป, สิริมา สุตรา, วันดี อภิณหสมิต, วิวัฒน์ ศิริกุล

Chulalongkorn University Dental Journal

ทําการทดลองโดยตัด superior cervical ganglion ด้านขวาในหนู (Swiss Webster mice) เพศเมีย อายุ 8 สัปดาห์ ต่อมาอีก 3 เดือนจึงตัดเอา submandibular และ major sublingual salivary glands ออกมาศึกษา ผลปรากฏว่าปริมาตรและน้ำหนักของ submandibular gland ข้างซ้ายในกลุ่มทดลอง (experimental animals) เพิ่มขึ้นอย่างเห็นได้ชัดเจนเมื่อนําไปเปรียบเทียบกับต่อมข้างเดียวกันในกลุ่มเปรียบเทียบ (sham-operated animals) โดย P-value ของปริมาตร <0.001 และ P-value ของน้ำหนัก (0.003 และเมื่อเปรียบเทียบปริมาตรของ submandibular gland ใน experimental animals พบว่าต่อมด้านขวามีปริมาตรน้อยกว่าต่อมด้านซ้ายอย่างมีนัยสําคัญทาง สถิติ (P <0.005) ส่วนปริมาตรและน้ำหนักของ major sublingual gland ด้านซ้ายและขวาในทั้ง experimental และ sham-operated animals แตกต่างกัน แต่ไม่มีนัยสําคัญทางสถิติ

Food Habits And The Utilization Of Drift Organisms By Larval Fishes In The Middle Fork Of Drake's Creek, Kentucky, Shirley Timbrook

Masters Theses & Specialist Projects

Food habits of larvae of the northern hog sucker, common shiner, rosyface shiner, and Micropterus sp. from the Middle Fork of Drake's Creek, Kentucky were identified from 18 March to 12 August 1982. Eighteen taxa of animals were observed in the stream drift and a total of seventeen taxa, including larval fish, were identified in the stomach analysis. Eggs, rotifers, hydracarina, and diptera represented the greatest component of the drift comprising 34%, 32%, 8%, and 6%, respectively. The major organisms observed in the gut analysis included eggs (fish, rotifer, and copepod species), rotifers (Euchlanis sp.), diptera (Chironomidae), annelida (Naididae), copepoda …

Iron And The Liver: Acute Effects Of Iron-Loading On Hepatic Heme Synthesis Of Rats. Role Of Decreased Activity Of 5-Aminolevulinate Dehydrase., H L. Bonkowsky, J F. Healey, P R. Sinclair, J F. Sinclair, S I. Shedlofsky, G H. Elder

Dartmouth Scholarship

Acute iron loading of rats, by intraperitoneal administration of iron-dextran (500 mg Fe/kg body wt 18-20 h before killing) decreased by 30% the rate of conversion of 5-amino-[14C]levulinate ([14C]ALA) into heme as measured with a recently described procedure for liver homogenates (1981. Biochem. J. 198: 595-604). The decrease in conversion of labeled ALA into heme caused by iron loading was shown to be due to a 70-80% decrease in activity of ALA dehydrase. The decrease in activity of ALA dehydrase caused by iron loading was not associated with a decrease in hepatic concentrations of GSH, nor could it be reversed …

A Comparison Of Three Approaches And The Effect On Observable Maternal Behaviors In Adolescent-Infant Bonding, Joreen Buttner

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract Not Included]

Longitudinal Pantothenic Acid Status Of Pregnant And Lactating Women, Won Oack Song

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Pantothenic acid nutritional status was evaluated in a cohort of twenty-nine Caucasian pregnant women, aged 20-35, during their third trimester of pregnancy, at two-weeks postpartum and at three months postpartum. Seventeen non-pregnant, non-lactating women who had similar demographic backgrounds as the pregnant women were selected as a control group and followed the same experimental schedule as the pregnant women. A fasting blood sample, two days 24-h urine specimens and diet record were obtained for each of two days from each subject at each period.

The mean dietary pantothenic acid intakes of the women during pregnancy (5.30±1.74 mg/day) and during lactation …

The Effect Of A Cardiac Education Program On The Knowledge, Stress, And State Anxiety Levels Of First Time Post Myocardial Infarction Patients In A Post Coronary Care Unit, Jeanine L. Johns

Ellmer School of Nursing Theses & Dissertations

The effect of a cardiac education program in terms of changes in knowledge, state anxiety and stress were examined for persons suffering a myocardial infarction for the first time. In addition, the relationship between stress and trait anxiety and changes in knowledge and state anxiety were examined. A sample of 20 patients were selected from two medium sized hospitals in Southeastern Virginia. Statistically significant differences at the .01 level were found between the means of the pretest and posttest scores of the experimental group for knowledge and state anxiety using the t test for dependent groups. The same test showed …

What's Happening: April 20, 1983, Maine Medical Center

What's Happening

No abstract provided.

Ua12/2/1 College Heights Herald, Vol. 58, No. 53 Magazine, Wku Student Affairs

WKU Administration Documents

Magazine published by the WKU campus newspaper. This issue contains articles:

• Collins, Michael. Helping Hands - Student Therapists Work Under Highly Emotional Conditions - Jennie Edlin, Jodie Oliver, Frank Kersting, Debbie Watson, Belinda Morris, Terri McClure
• Wright, Sharon. Something Like Best Friends - Charles Pearson, boa constrictor

What's Happening: April 6, 1983, Maine Medical Center

What's Happening

No abstract provided.

Vital Signs, Spring 1983, Boonshoft School Of Medicine

Vital Signs

A twenty five page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

The Effects Of Insulin On Hepatic Glucocorticoid Receptor Content In The Diabetic Rat, Jeffrey John Yourick

Masters Theses

The streptozotocin-induced diabetic rat liver was analyzed for glucocorticoid receptor (GCR) content by a saturation and Scatchard analysis. A preliminary study was performed on the stabilization of the cytoplasmic GCR in a frozen cytosol preparation. The addition of 10% glycerol (V/V), 10 mM sodium molybdate, and 0.2 mg/ml trypsin inhibitor resulted in an approximate 20% sparing of GCR content upon freezing.

The hepatic GCR content of diabetic rats was significantly decreased from a control level of 0.1667 ± 0.0142 pmol/mg protein to 0.1094 ± 0.007 pmol/mg protein. Insulin replacement therapy to the diabetic rat dramatically increased the hepatic GCR content. …

Cerebrovascular Lesions, Emotional Behavior And Changes In Reinforcement Density, George Kahle Henry

Masters Theses

Two adult stroke patients, one left hemisphere and one right hemisphere, reported weekly levels of depression, anxiety, and hostility following discharge to the home environment. Spouses reported weekly levels of perceived changes in emotional behavior. Data on changes in emotional behavior were recorded using the Multiple Affect Adjective Checklist. Weekly rates of positive reinforcement were recorded throughout the study for both patients. Following an eight week baseline period the rate of positive reinforcement was increased via manipulation of homework assignments to involve the patients in previously enjoyed activities. Results revealed a moderately high negative correlation between patient*s reported level of …

Otopathology In Two Lines Of The Diabetic Chinese Hamster, Cricetulus Griseus, Jo A. Oostveen

Masters Theses

Recent evidence suggests that a bilateral, progressive sensorineural hearing loss is associated with diabetes mellitus in humans. The microangiopathy presumedly leading to this loss seems to be similar to microvascular changes leading to this loss seems to be similar to microvascular changes leading to renal and retinal deterioration. A total of twenty-four pairs of temporal bones from two diabetic, and one non-diabetic lines of the Chinese hamster were processed and evaluated for their total auditory histopathology. Hematoxylin and eosin serial sections demonstrated a mean otopathological involvement 5.6 times greater for diabetic animals compared to non-diabetic animals. Capillary basement membrane thickening …

A Hearing Assessment Using Operant Audiological Testing With A Severely Retarded Deaf-Blind Child, Patricia Timpson

Masters Theses

This study assessed the feasibility of teaching a 7-year-old severely retarded, hearing and vision impaired girl to respond consistently to a pure tone stimulus using operant audiometric techniques. The experimenter first shaped a head turn response using the opportunity to rock on a rocking horse as reinforcement. Following response shaping, the experimenter used a bone conduction transducer (BCT) as a tactile stimulus in training the subject to turn her head to the left in a similar fashion to a 500 Hz, 65 dB tone/vibration. After 15 days of transfer training, designed to bring the left head turn response under control …

The Effects Of Prostaglandin E2 On The Healing Processes Of Rat Perforated Tympanic Membranes, Diane Sue Saylor

Masters Theses

Prostaglandin E₂ (PGE₂) was topically administered to perforated rat tympanic membranes in an attempt to facilitate regrowth of the membranes. Every 24 hours for the first four postperforation days, two groups of tympanic membranes were processed and examined histologically for differences between PGE₂ treated and control animals.

At 24 hours postperforation granulocyte infiltration at the perforation site was greater in the test animals. By 48 hours blood clots were larger in PGE₂ treated animals. Finally, the epithelium was thinner in test animals than in control animals at 96 hours.

Slight tendencies for the test animals …

Evidence For Hydrated Spermidine-Calf Thymus Dna Toruses Organized By Circumferential Dna Wrapping, Kenneth A. Marx, George C. Ruben

Dartmouth Scholarship

In spermidine-condensed calf thymus DNA preparations, torus–shaped condensates were shown by transmission electron microscopy to exist under the hydrated conditions of the freeze fracture experiment. Using extremely low Pt metal deposition levels (9 A Pt/C) high–contrast replicas of the spermidine–DNA toruses were obtained that showed circumferential wrapping of single DNA double helix–size surface fibres. Stereoscopic analysis of high magnification stereomicrographs established some details of the three-dimensional organization of two DNA double helix sections winding circumferentially on the inner surface of one such torus. These measurements demonstrate the usefulness of stereoscopic analysis of these high macromolecular organization magnification. Measurements on a …

The Regional Acceleratory Phenomenon: A Review, Harold M. Frost

Henry Ford Hospital Medical Journal

The regional acceleratory phenomenon (RAP) is a complex reaction of mammalian tissues to diverse noxious stimuli. The phenomenon occurs regionally in the anatomical sense, involves both soft and hard tissues, and is characterized by an acceleration and domination of most ongoing normal vital tissue processes. It may represent an "SOS" mechanism which evolved to potentiate tissue healing and local tissue defensive reactions. When a RAP is obtunded, retarded healing and lowered resistance to infection and mechanical abuse may ensue. When ignored in experimental design, the phenomenon can seriously perturb studies of metabolic bone disease and of the effects of mechanical, …

Current Concepts In Otitis Media, Michael M. Paparella

Henry Ford Hospital Medical Journal

Otitis media continues to be a common and disabling problem which has become, in recent years, a fertile area for research. Based on studies in animals and humans, otitis media is classified into four groups: acute purulent otitis media (POM), serous otitis media (SOM), and mucoid or secretory otitis media (MOM). Together, these are referred to as otitis media with effusion (OME). The types can overlap and evolve into another type to become chronic otitis media and mastoiditis, characterized by the presence of granulation tissue or cholesteatoma. The biochemistry, microbiology, and pathology as well as clinical features of the disease …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Effect Of Tinnitus Maskers On Speech Discrimination Among Those Wearing Tinnitus Maskers, John Alexander Chonka

Dissertations and Theses

The purpose of this study was to determine the effect(s) of tinnitus maskers and tinnitus instruments on speech discrimination utilizing a population of subjects who currently have tinnitus and are presently wearing these devices. The hypothesis which guided this investigation states that there is no difference between discrimination scores with and without tinnitus maskers. In an attempt to test this hypothesis, speech discrimination scores were obtained from 26 listeners both in quiet and in the presence of cafeteria noise, with and without use of their tinnitus maskers.

What's Happening: February 9, 1983, Maine Medical Center

What's Happening

No abstract provided.

Life History Of The Lahontan Cutthroat Trout, Salmo Clarki Henshawi, In Pyramid Lake, Nevada, William F. Sigler, William T. Helm, Paul A. Kucera, Steven Vigg, Gar W. Workman

Great Basin Naturalist

The Pyramid Lake Lahontan cutthroat trout (Salmo clarki henshawi) population was sampled on a monthly basis from November 1975 through December 1977. A subsample of 676 trout, stratified by fish size and lake habitat, provided biological data. The entire population is presently derived from hatchery production, stocked at lengths of approximately 75 to 300 mm. Peak annulus formation occurs in March and April, followed by the period of maximum growth. Scale patterns illustrate a variable growing season. Maximum growth in length is in the first three years of life; after that males begin to grow faster than females. …

What's Happening: January 19, 1983, Maine Medical Center

What's Happening

No abstract provided.