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What's Happening: November 26, 1986, Maine Medical Center

What's Happening

No abstract provided.

David Baltimore Oral History, David Baltimore

Oral History Collection

Susan Mehrtens' Note:

We met in Dr. Baltimore's office at the Whitehead Institute, and our meeting was short (less than 45 minutes) but direct and to the point: Baltimore credits The Jackson Laboratory for setting him on his course as a biologist, but beyond that, he sees Jax as a dated, low-key place. One speaking engagement at Jax that left him astonished to see an empty parking lot at 5PM made an indelible impression on him and he echoes the attitudes of others outside Jax--like Law and Sprott--that Jax is not a dynamic, hotshot institution on the cutting edge of …

What's Happening: November 12, 1986, Maine Medical Center

What's Happening

No abstract provided.

Barbara Sanford Oral History, Barbara Sanford

Oral History Collection

Susan Mehrtens' Note:

Barbara Sanford's interview echoes most of what I have heard from many of the staff regarding the Lab's mission and goals. The Lab's ideal size, geographical location--with its pluses and minuses--and the environment in which to do science in the current period--all find echoes on other tapes. There is little of candor, consequence or calculation here. Sanford clearly recognizes the stressful nature of scientific life in these times of federal cutbacks, and, as well, the frustrations of directing a laboratory whose size, complexity and needs preclude personal scientific work by the Director. In the face of such …

Donald Bailey Oral History, Donald Bailey

Oral History Collection

Susan Metrhens' Note:

Regarded by many of his peers at Jax as one of the most intuitive, prescient and creative scientists at the Lab, Bailey was a very reflective narrator. While he provides one anecdote of c.c. Little1s sartorial habits, this tape is largely devoid of anecdotal material, and is more a reminiscence by a scientist who was at Jax in the early '50's, who left and returned in 1967. I tried, through a variety of questions, to probe the synergy between Bailey and the Lab, the degree to which his prescience and creativity might be due to the freedom …

Priscilla "Skippy" Lane Oral History, Skippy Lane

Oral History Collection

Susan Mehrtens' Note:

We have in this tape the recollections of one of the most prolific authors in the field of mouse mutants, an indefatigable co-worker of Margaret Dickey, Margaret Green and currently, Muriel Davison. Full of scientific terms, this tape reveals clearly Lane's thorough absorption in the field to which she has devoted nearly the last forty years of her life. Toward the end of this tape, Lane alludes to Earl Green's sexist attitude, which other women have also mentioned to me on and off tape. Lane also waxes eloquently here about her efforts to establish a hiera'rchy within …

Aryl Substituted 1h-4,5-Dihydro-1,2,3-Triazoles As Anticonvulsants, Pankaja K. Kadaba

Pharmaceutical Sciences Faculty Patents

Anticonvulsant compositions comprise as the active ingredient a compound . . .

To see the remainder of this abstract, please download this patent.

The Case For The Use Of Animals In Biomedical Research, Carl Cohen

Morality and Ethics of Animal Experimentation Collection

No abstract provided.

Digest Of The Philadelphia College Of Osteopathic Medicine (Fall 1986), Philadelphia College Of Osteopathic Medicine

Digest

The Fall 1986 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Making Them Comfortable
• John J. Fernandes, DO
• Pathology Department to be Computerized
• O.J. Snyder Award Recipient
• In the Land of Shoo-fly Pie
• Class Acts
• In Memorium
• How Sweet It Is
• On Campus
• Calendar

Vital Signs, Fall 1986, Boonshoft School Of Medicine

Vital Signs

A thirty four page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Water-Cover Influences On Diatom Ingestion Rates By Meiobenthic Copepods, Alan W. Decho

Faculty Publications

Laboratory experiments on meiobenthic copepods using ¹⁴C-diatoms were conducted to investigate whether: (1) feeding rates or (2) food sources (planktonically-suspended foods or benthic sediment-associated foods) vary in response to the presence or absence of water-cover (i.e. simulated Higher-water vs Low-water conditions). Three diatom-feeding harpacticoids were examined. Scottolana canadensis feeds at significantly higher rates (2x) during Higher-water (HW) conditions (P<0.001), at which time it consumes planktonic foods; during Low-water (LW), feeding is greatly reduced. These feeding patterns are related to its burrow-dwelling and to its subtidal habitat. Cletocamptus deitersi remains virtually unaffected by changes in ambient water-cover, feeding at nearly equal rates during HW and LW conditions but always tending to consume more benthic diatoms. Microarthridion littorale consumes food at nearly equal rates during HW and LW …

1986 Fall No. 11, School Of Medicine Office Of Alumni Affairs

Medicinews

LSU Medicinews Number 11 Fall 1986 was edited by Russell C. Klein, and published by the LSU School of Medicine Office of Alumni and Continuing Education Services.

This issue consists of 24 pages.

The Synthesis And Evaluation Of The Cardiovascular Activity Of Novel Imidazole Ring Systems, Joseph E. De Los Angeles

Chemistry & Biochemistry Theses & Dissertations

An investigation was undertaken to synthesize and evaluate the cardiovascular activity of two imidazole ring systems. Imidazoles with hypotensive activity would provide novel potential antihypertensive drugs. These novel structures may also find use as chemical probes in the study of the cardiovascular system and as prototypes for other potential cardiovascular agents.

The histamine derivative, 7,7-dipyridyl-4,5,6,7-tetrahydroimidazo-[4,5-c]pyridine (ligand l), was demonstrated to possess significant hypotensive activity in laboratory rats. A 15 mg/Kg dose of ligand 1 produces a statistically significant decrease in blood pressure when injected IP. This hypotensive effect is also associated with marked increase in heart rate. Although compound 1 …

The Flame, Fall-Winter 1986, Mennonite College Of Nursing

The Flame (1985-present)

The Flame is a newsletter of Illinois State University's Mennonite College of Nursing

Thomas Roderick Oral History, Thomas Roderick

Oral History Collection

Susan Metrhens' Note:

Roderick has been a scientist at Jax for thirty years, working in no other place. He was hired just as Earl Green replaced C.C. Little and Roderick worked with and for Green for some dozen years before moving into his own lab, on his own grants. Roderick is both perceptive and analytical and this tape is valuable for his willingness to reflect on trends and personalities. He also has a philosopher's willingness to consider the values that drive the lab. Roderick was forthcoming with anecdotes, including a most telling one of Rich Prehn showing the courage of …

1,2,3,-Triazole Anticonvulsant Drugs, Pankaja K. Kadaba

Pharmaceutical Sciences Faculty Patents

Anticonvulsant compositions comprise as the active ingredient a compound . . .

To see the remainder of this abstract, please download this patent.

Beta-Adrenergic Blocking Agents In Congestive Heart Failure, Sidney Goldstein

Henry Ford Hospital Medical Journal

Although recent physiologic studies suggest that increased catecholamine release in humans may in the long run represent an adverse homeostatic mechanism, this catecholamine release is acutely important in permitting human response to stress. Clinical interventions with beta-adrenergic blocking agents have showed a salutary effect on cardiac function in patients with severe heart failure: in patients with heart failure associated with myocardial infarction, these agents may help improve mortality rates. These studies indicate that the drugs are well tolerated when used carefully in these high-risk patients.

New Positive Inotropic Agents, Syed M. Jafri, James A. Bristol

Henry Ford Hospital Medical Journal

Current therapy for heart failure remains inadequate. New positive inotropic agents that augment myocardial contractility have been introduced. The positive inotropic effects of these nonglycoside, nonsympathomimetic agents are due, at least in part, to inhibition of cardiac phosphodiesterase activity and hence to an increase in myocardial cyclic AMP levels. These agents also have vasodilator properties through their effects on the enzyme phosphodiesterase in the vascular smooth muscle. Recent developments in the preclinical pharmacology, mechanism of action, and clinical experience with these new inotrope vasodilators are presented in this review. The role these drugs will play in revising our therapeutic strategy …

Status Of Cardiac Transplantation With A Report Of The First Year's Experience At Henry Ford Hospital, Fraser M. Keith, Donald J. Magilligan Jr., Jeffrey B. Lakier, Conrad Drost

Henry Ford Hospital Medical Journal

Cardiac transplantation is now widely accepted as effective treatment for selected patients with end-stage heart disease. Improvements in immunosuppressive treatment and monitoring in the past 15 years have resulted in impressive one-year and five-year survival rates of 80% and 60%. In general, survivors have enjoyed a considerably improved quality of life. A cardiac transplantation program was initiated at Henry Ford Hospital in 1985, and a total of 15 patients received heart transplants in the first 12 months. Fourteen patients are currently alive and well at various stages posttransplant. This early clinical success has prompted the consideration of both combined heart-lung …

The Effects Of Certain Oral Bacteria On The In Vitro Growth Of Bacteroides Gingivalis, Steven G. Morrow

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of nine gram positive and grain negative cocci and bacilli, which are indigenous to the oral cavity, on the in vitro growth of Bacteroides gingivalis was examined in this study. A pure culture of B. gingivalis is was obtained from the American Type Culture Collection. The nine oral test organisms were Streptococcus mitis, Streptococcus mutans, Streptococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus, Corynebacteriurn hofmanii, Lactobacillus acidophilus, Branhamella catarrhalis, and Escherichia coli. The effect on the growth of B. gingivalis of the nine test organisms was evaluated on a solid medium by use of …

The Effect Of Dietary Fat Level On Tumor Development And Immunity In Balb/C Mice Fed Casein Of Wheat Gluten As Protein And Challenged With Herpes Type 2-Transformed Cells, Helen Drakou

Loma Linda University Electronic Theses, Dissertations & Projects

A high percentage of fat in the diet has been implicated through epidemiological studies in several human cancers. Studies in experimental animals have produced evidence that increasing the fat in the diet decreases the animal’s ability to restrict tumor development and growth. In previous work done in this laboratory with BALB/c mice injected with herpes simplex Type 2-transformed mouse cells (H238), the effects of a diet which greatly enhanced tumor growth was compared with one which restricted tumor growth. The latter, a low (5%) fat, low protein diet, in which the protein was casein, was also found to produce a …

Sprague-Dawley Rats Fed Milk Or Beef Protein : Differences In Response To 1,2-Dimethylhydrazine Carcinogenesis, Stanley W. L. Ng

Loma Linda University Electronic Theses, Dissertations & Projects

Colon cancer is responsible for a high percentage of cancer deaths in developing countries, and there is convincing epidemiological evidence that meat protein and fat in the diet increase the incidence of this form of cancer. An animal tumor model which has been used by many investigators interested in colon cancer is the 1,2-dimethylhydrazine (DMH)-rat or DMH-mouse tumor model. In previous work done in this laboratory the DMH-BALB/c mouse tumor model was used to compare the production of colon tumors in mice fed a diet using non-fat powdered milk as a source of protein with those in mice fed beef …

Relationship Between Dietary Intake And Reproductive Hormones In Premenopausal Vegetarian And Nonvegetarian Seventh-Day Adventist Women, Joan M. Spuehler

Loma Linda University Electronic Theses, Dissertations & Projects

There is evidence that specific nutrients may modify hormonal balance and contribute to breast cancer etiology. To investigate the relationship between dietary nutrients and plasma reproductive hormones and to determine hormone-nutrient interrelationships, we measured plasma estrogens, androgens. progesterone and prolactin levels in 10 premenopausal Seventh-day Adventist (SDA) vegetarian and 10 premenopausal SDA nonvegetarian women. Over three days in each of three consecutive months. diet records and fasting midluteal blood samples were collected. The nonvegetarians consumed significantly more protein, total and saturated fats, oleic and linoleic acids, and cholesterol than did the vegetarians. Hormonal status of the two groups did not …

Response Of Plasma Lh To Gonadotropin Releasing Hormone (Lrh) Treatment In Yong Swamp Buffalo Bulls, Peerasak Chantaraprateep, Maneewan Kamonpatana, Chainarong Lohachit, Annop Kunavongkrit, Prachin Virakul

The Thai Journal of Veterinary Medicine

Investigation on response of LH to gonadotropin releasing hormone (LRH) treatment in 3 young swamp buffalo bulls was carried out every second month for 4 occasions. The animals were 16, 17 and 19 months old at the beginning of the trial. Response of plasma LH to LRH treatment was described in term of "total response" calculated from the area under the curve during 150 mn. It was shown that magnitude of LH response of the animals at the age group of 16-18 no. was higher than those in the older age groups (19-21 mo and 22-25 mo). Mean plasma LH …

Rabies In Swine : Natural Infection In Three Case, Songkram Luangtongkun, Boonmee Sayasoothjaree, Thongchai Chalermchaikit, Kumphee Kortheerakul

The Thai Journal of Veterinary Medicine

Natural infection of rabies in three cases of swine were observed. The affected pigs were bitten by rabid dogs at various sites on the body. The incubation period in these three cases varied between 8-16 days. The sudden onset of fever, dilatation of the pupil and nervous signs were the consistent findings with short course of not more than 3 days, except one had a prolonged course of seven days. Ninety two percent of the reported case of rebies in Thailand were found in dogs. Cats come second to dog but share only around five percent of total. Only a …

A Canine Mammary Gland Neoplasia : A Chinico-Pathologic Study, Wichan Pavaranggoon, Nipon Sukulmaeka, Noppamas Napombejra, Chainarong Lohachit, Peersak Chantaraprateep, Ted Tesaprateep, Archariya Kanchanadeb

The Thai Journal of Veterinary Medicine

Twenty cases of canine mammary gland neoplasia were clinico pathologically investigated at the Obstetrics, Gynaecology & Reproduction and Pathology units, small animal hospital, Faculty of Veterinary Science, Chulalongkorn University from November 1983 through October 1984. The diagnosis was based on a combination of history, clinical signs, radiographic and histological findings. Neoplasm were histologically classified according to Hampe and Misdorp (1974). All cases were treated by mastectomy, 14 in 17 (82.4%) cases had completely recovered and 3 in 17 (17.6%) cases died within 6 months after the operation. In addition, details of etiology, incidence and characteristics of neoplasm were also discussed.

John Paul Scott Oral History, John Paul Scott

Oral History Collection

Susan Mehrtens' Note:

Dr. J.P. Scott was the head of animal behavioral research at Hamilton Station. He carne to our meeting with a thoughtful outline, and spoke to it for most of our interview. His tape, as a result, is mostly a monologue. This tape is extremely valuable because Jax threw away all the records of Hamilton Station, so only the accounts of Scott, Fuller and Fox (in this project) can provide a record of this aspect of the Lab's past. Scott indicates how pervasive was the network in which his work was conducted, and how many noteworthy figures or …

Interview With Princess O'Flynn Bareis Regarding Her Life (Fa 154), Manuscripts & Folklife Archives

Folklife Archives Oral Histories

Transcription of an interview with Princess O'Flynn Bareis conducted by Cathy Behan for an oral history project titled "A Generation Remembers, 1900-1949." Bareis discusses her life and times, including information about growing up in Utica, Daviess County, Kentucky, education, religion, the general store her grandfather owned, African Americans, and her experience with mental illness and spouse abuse.

Alternatives Sought To Save Lab Animals, Jim Detjen

Popular Press Items

No abstract provided.

Dale Foley Oral History, Dale Foley

Oral History Collection

Susan Mehrtens' Note:

Dale Foley was the administrative "right arm" of both Little and Green, and, as such, was in a position to comment on the Lab's financial and administrative activities from the perspective of a key participant. As we began, he brought out several pages of notes, which formed the basis of the monologue that followed. To my surprise, his tape consists almost totally of accounts of the acquisition of property and building of the major Jax buildings. Aside from references to several valued Jax volunteers--several of them wealthy Trustees--Foley stuck to the physical plant in his interview. Intuitively, …