Digital Commons Network^™

The Distribution And Possible Significance Of Glycoconjugates In Retinal Development, Ajit Joseph Alles

MUSC Theses and Dissertations

The neural retina is a structure that develops from a simple neuroepithelium into a complex neural organ. The histochemistry of this structure has been studied for many years by scientists using various techniques. In this study, lectin histochemistry, immunohistochemistry and experimental manipulations of retinal cell types have been used in an attempt to clarify the distribution of saccharide moieties in glycoconjugates during retinal development in the rat, the rabbit and the chick. With these methods of investigation we have demonstrated that glycoconjugate patterns vary during development and have also demonstrated the presence of several interesting glycan moieties. The distribution of …

Editor's Note, Padraig O'Malley

New England Journal of Public Policy

On occasion, the New England Journal of Public Policy will devote an entire issue to consideration of a public policy matter of major importance. The AIDS epidemic is such a matter, with a likely impact of overwhelming consequence well into the twenty-first century. The epidemic raises fundamental questions regarding the nature of individual freedom, our responsibilities to others, the always delicate balance between private rights and the public interest, and society's obligation to its "out" groups — whose members it has stigmatized, discriminated against, ridiculed, and treated as less than full and equal citizens. Indeed, it requires us to ask …

Aids In Children: An Overview Of The Medical, Epidemiological, And Public Health Problems, Ellen R. Cooper

New England Journal of Public Policy

Cases of AIDS in children under thirteen years of age have been described since 1982. Diagnosis is more difficult in children than in adults, owing to the more varied clinical presentation and the difficulty in interpretation of laboratory tests. Current diagnostic criteria of HIV infection are reviewed, as well as symptomatology, natural history, and controversies surrounding management and therapy. Without a full appreciation of the transmissibility of HIV, issues including school and day-care attendance and foster family placement remain emotionally charged. Conflicting public policies contribute to fears on the part of the general public. Because ofthe unique implications for the …

Hiv Antibody Testing: Performance And Counseling Issues, Michael Gross

New England Journal of Public Policy

This article assesses the performance of currently used tests for exposure to human immunodeficiency virus (HIV), the infectious agent associated with acquired immunodeficiency syndrome (AIDS); suggests, in view of that information, guidelines for counseling people seeking HIV antibody testing; and evaluates the claim that because antibody test results will effect behavior change in those who are infected, all members of high-risk groups should be tested.

HIV testing is likely to yield a high proportion of false-positive results in low-risk populations and infants born to infected mothers. A negative result may not establish freedom from infection in high-risk groups or the …

Outlook Magazine, Winter 1988

Outlook Magazine

No abstract provided.

The Parabrachial Nucleus In The Rat: An Immunhistochemical Study Of Its Forebrain Neural Input, Margaret M. Moga

Dissertations

No abstract provided.

Aids: An Overview, Loretta Mclaughlin

New England Journal of Public Policy

"We stand nakedly in front of a very serious pandemic, as mortal as any pandemic there ever has been," said Halfdan Mahler, director-general of the World Health Organization (WHO). "I don't know of any greater killer than AIDS, not to speak of its psychological, social and economic maiming. Everything is getting worse and worse with AIDS and all of us have been underestimating it, and I in particular. We're running scared. I cannot imagine a worse health problem in this century." When asked to compare AIDS to other epidemics, such as smallpox, that have infected and killed over the course …

The Quest For An Aids Vaccine, Robert T. Schooley

New England Journal of Public Policy

More than fifty thousand cases of AIDS have been reported in the United States since the disease wasfirst described in 1981. Many times this number of people are infected with human immunodeficiency virus (HIV), which has been identified as the agent responsible for the illness. The seriousness of the disease, coupled with the relatively rapid spread of HIV, has fueled the effort for development of an effective vaccine.

Much is now known about the life cycle of the virus, and about its structural components. This information, and information about methods of transmission of the virus, form the basis for a …

Characterization Of The K Variant Of Encephalomyocarditis Virus, Delie Roselyn Cerutis

Biomedical Sciences Theses and Dissertations

Serologically identical variants of encephalomyocarditis (EMC) virus produce different disease syndromes in mice. For instance, in ICR Swiss male mice, the B variant (EMC-B) produces no overt illness, EMC-MM produces death accompanied by eevere neurological signs, and EMC-0 destroys beta cells, thus producing a disease syndrome that resembles insulin-dependent diabetes mellitus. These apparently identical viruses provide excellent models to investigate the molecular basis of disease. Recently, we isolated a lethal variant (EMC-K) from the EMC-B virus stock and compared its characteristics to three other EMC virus variants, EMC-B, D, and MM. The present study was done to determine (i) the …

Corticosteroid Effects And Senescence In Cultured Endothelium, Stephen A. Gudas

Theses and Dissertations

Cultures of human umbilical vein endothelial cells were treated with heparin-corticosteroid combinations to determine effects on cellular growth. Standard proliferation assays, colony formation assays, and cytoflourometric analysis were the methods employed. Dexamethasone (DEX) and hydrocortisone (HC) were inhibitory to growth of HUVEC when EtOH was used as a solvent and fully supplemented medium (20% serum) was employed. When DMSO was the solvent, growth enhancement sometimes occurred when (DEX) was the test steroid; growth inhibition occurred with this steroid when a reduced (1%) serum component was used. Since significant inhibition of cell colony formation in response to DEX administration was observed, …

Enhanced Effect Of Liposome-Encapsulated Amikacin On Mycobacterium Avium-M. Intracellulare Complex Infection In Beige Mice, Nejat Düzgüneş, Veluchamy K. Perumal, L. Kesavalu, Jayne A. Goldstein, Robert J. Debs, Pattisapu R.J. Gangadharam

All Dugoni School of Dentistry Faculty Articles

We examined the therapeutic effects of free and liposome-encapsulated amikacin on Mycobacterium avium-M. intracellulare complex infection by using the beige-mouse model of the disease. In the first series of studies, intravenous administration of four weekly doses of 5 mg of amikacin per kg encapsulated in large (approximately 0.4-μm diameter), unilamellar liposomes arrested the growth of M. avium-M. intracellulare complex organisms in the liver, as measured by CFU counts. M. avium-M. intracellulare complex levels in untreated animals and in those treated with the same dose of free amikacin increased by several orders of magnitude over 8 weeks. Liposome-encapsulated amikacin was also …

Sensitivity To Ingested Sulfites, Steve L. Taylor, Julie A. Nordlee

Department of Food Science and Technology: Faculty Publications

Sulfiting agents, including sodium and potassium bisulfite, sodium and potassium metabisulfite, sodium sulfite, and sulfur dioxide, have enjoyed widespread use as food and drug ingredients. The oral ingestion of these sulfiting agents is now known to trigger asthma in a small subset of the asthmatic population. The best evidence suggests that perhaps 150,000 to 200,000 individuals in the United States may be sulfite sensitive. Although the mechanism of sulfite-induced asthma remains unknown, several possibilities have been considered, including inhalation of sulfur dioxide (SO₂) while swallowing, an IgE-mediated reaction, and a deficiency of sulfite oxidase leading to impaired sulfite …

Evaluating Cholesterol Screening In A Community Pharmacy, Osama Mohamed Ibrahim

University of the Pacific Theses and Dissertations

The purpose of this research project was to evaluate the role of the community pharmacist in screening, identifying, and referring ambulatory patients with high total blood cholesterol (TBC) in a community pharmacy. Fifty seven patients, out of 241 initially screened individuals, met the study inclusion criteria and were accepted into this study. Of these 57 patients, 51 patients completed the six month study period. The normal population group consisted of 164 participants with TBC < 200 mgjdL at the initial cholesterol testing (visit 1). The drop out group represented six patients who failed to continue attending the two follow up tests (visit 2 and 3). For screening purposes, a non-fasting whole blood sample was used to measure TBC using the Boehringer Mannheim Reflotron analyzer.

The project was evaluated based on mean TBC levels obtained during the initial screening and the two follow up tests, pre-test and post-test scores, behavior and …

Polyamine And Acetylpolyamine Levels During Phenylhydrazine-Induced Erythropoiesis In Mouse Spleen, Othman A. Alshabanah

University of the Pacific Theses and Dissertations

The phenylhydrazine-induced erythropoietic mouse spleen is used as a model system to demonstrate the relationship between tissue growth and polyamine metabolism. Phenylhydrazine produced significant changes in spleen weights, hematocrits and reticulocyte counts in Swiss-Webster mice. The average spleen weight went up from a control of 155 mg to 875 mg at 96 hours after phenylhydrazine administration, while a 49% reduction in the value of hematocrit was observed at 72 hours. Reticulocyte counts in peripheral blood went from 0.8 to 58% at 168 hours after treatment with phenylhydrazine. Phenylhydrazine at a dose of 40 mg/kg produced significant increases in the levels …

Being Aware: The Meaning Of The Relationship Between Social Support And Health Among Independent Older Women., Susan Elaine Trippet

All ETDs from UAB

No abstract provided.

Maternal Reactions To The Knowledge Of Fetal Sex Based On Sex Preference., Molly Kay Walker

All ETDs from UAB

No abstract provided.

Maternal, Environmental, And Temperamental Characteristics Of Toddlers With And Toddlers Without Sleep Problems., Kathryn Redwood Wood

All ETDs from UAB

No abstract provided.

1988 Winter No. 18, School Of Medicine Office Of Alumni Affairs

Medicinews

LSU Medicinews Number 18 Winter1988-89 was edited by Russell C. Klein, and published by the LSU School of Medicine Office of Alumni and Continuing Education Services.

This issue consists of 28 pages.

Jefferson Alumni Bulletin – Volume Xxxvii, Number 2, Winter 1988

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XXXVII, Number 2, Winter 1988

A lively component, Page 2

Jefferson scene, Page 8

The role of Chinese principles in modern medicine, Page 12

Class notes, Page 19

Clinical Use Of A Standard Kit-Preparation Of Radiolabeled Monoclonal Antibody 96.5 In The Diagnostic Imaging Of Metastatic Melanoma., Mansoor Saleh, D M. Miller, L Peterson, C D. Russell, M W. Unger

Haematology and Oncology, East Africa

We studied the efficiency of a standard-kit preparation using 1 mg 111In-labeled 96.5 monoclonal antibody in combination with 19 mg of unlabeled antibody in the diagnostic imaging of 27 patients with documented metastatic melanoma. Twenty-three of 26 patients (88%) demonstrated immunoscintigraphic localization of tumor. Of 104 metastatic sites previously documented by conventional studies, 62 (60%) were identified by immunoscintigraphy. A total of 77 sites demonstrated localization of radiolabeled antibody. Fifty-four (70%) corresponded to known sites of disease; eight sites (10%) were "discovered" by immunoscintigraphy and subsequently confirmed by conventional studies; 15 imaged sites (20%) could not be confirmed by conventional …

Nursing And Health Care In Jacksonville, Florida, 1900-1930, Linda Emerson Sabin

UNF Graduate Theses and Dissertations

This study examines the development of nursing as a vocation, in the early twentieth century, within the context of a growing southern city and an evolving health care system. Nursing advanced from a domestic service to a recognized vocation during this era. An extensive survey of historical and nursing literature revealed few studies which focus on nursing and health care in an urban context. Those studies identified gave only brief glimpses of nurses and focus on northern cities. This investigation aims to add a southern chapter to the history of nursing and health care in urban settings.

A community systems …

An Anatomical And Physiological Investigation Of Hippocampal Connections Involved In Cardiovascular Control, Kenneth Gary Ruit

Dissertations

No abstract provided.

Pulpotomies Utilizing Povidone-Iodine In Primary Teeth, Ramon Marti

Master's Theses

No abstract provided.

The Effects Of Relaxation Training On Anxiety Levels, Absenteeism, And Academic Performance In First, Second And Third Grade Children: Implications For Coping With Stress, So Hee Jon

Master's Theses

No abstract provided.

Glucocorticoid-Responsive Hepatic Cytochromes P-450 In The Rat: Multiplicity And Differential Regulation, Keith Alan Hostetler

Theses and Dissertations

The multiplicity of glucocorticoid-responsive hepatic cytochromes P-450 in the rat was investigated by developing a series of monoclonal antibody probes directed against purified steroid-inducible isozymes from the rat (P-450p) and man (HLp). Two antibodies, termed 1G8 and 13-7-10, showed unique specificity for purified cytochromes P-450 upon immunoblot analyses. These antibodies were further characterized in terms of their reactivity toward proteins in liver microsomes from untreated and xenobiotic-treated rats. Three P-450p-related proteins were identified using 1G8 and 13-7-10 to monitor the expression of P-450p family subtypes. In untreated rats, members of this family exhibited sex-specific expression. Treatment with various chemicals resulted …

An Identified Histaminergic Neuron Can Modulate The Outputs Of Buccal-Cerebral Interneurons In Aplysia Via Presynaptic Inhibition, Hillel J. Chiel

Faculty Scholarship

We have identified 2 buccal-cerebral interneurons (BCIs), B17 and B18, that appear to be involved in the coordination of feeding behavior in Aplysia. The BCIs have their cell bodies in the buccal ganglion, but send axons to the cerebral ganglion via the cerebral-buccal connectives. The BCIs appear to make monosynaptic connections with neurons in the cerebral ganglion that modulate extrinsic muscles involved in feeding behavior. B17 and B18 are activated antiphasically during a motor program induced by stimulating the esophageal nerve and appear to 'read out' different phases of the buccal program to different cells in the cerebral ganglion. B17 …

Antimicrobial Resistance In Staphylococcus Aureas, Marcella Alexandra Morgan

University of the Pacific Theses and Dissertations

Susceptibility of 112 strains of Staphylococcus aureus obtained from Dameron Hospital, Stockton, California was tested with 18 antimicrobials . The MIC method was used with the following antimicrobials : tetracycline, oxacillin, penicillin, ampicillin, vancomycin, cefazolin, erythromycin, clindamycin, gentamycin, rifampin, trimethoprimsulfamethoxazole, chloramphenicol, and cefotaxime . The standard Kirby-Bauer disc diffusion method was used to test neomycin, tobramycin, and amikacin . Methicillin, oxacillin, and nafcillin were tested with a modified Kirby-Bauer method, which included the addition of a 4% salt supplement to the media, incubation at 32C, and readings at both 24 and 48 hours. Comparing results of this study with those …

A Stereotaxic Atlas Of The Brain Of The Chick (Gallus Domesticus), Wayne J. Kuenzel, Manju Masson

Poultry Science Faculty Publications and Presentations

Nine brains taken from chicks two weeks of age were used for the development of this atlas. Each chick was first anesthetized with an intravenous (IV) injection of Chloropent2 (1.8 ml/kg). Chicks were then perfused via the heart with 90 ml physiological saline followed by 90 ml Heidenhain's3 solution. Each head was then positioned in a stereotaxic instrument as described in the previous section and three stainless steel (SS) insect pins (#2) were implanted in each brain at known coordinates. In the case of the brains used to construct the cross- sectional atlas plates, two pins were implanted horizontal to …

What's Happening: December 16, 1987, Maine Medical Center

What's Happening

No abstract provided.

The Aids Project Newsletter (December 1987), David Ketchum, The Aids Project

AIDS Project Newsletter (1987-1991)

No abstract provided.