Digital Commons Network^™

Physical And Biological Evaluation Of Hydroxylapatite Films Formed On Ti6a14v Substrates By Excimer Laser Ablation, Tatjana Dostálová, Miroslav Jelínek, Lucie Himmlová, Vlasta Pesáková, Milan Adam

Cells and Materials

Thin films of hydroxylapatite, about 500 nm, were formed on Ti6Al4V by excimer laser ablation. Ten different deposition conditions were used such as deposition atmosphere (vacuum, pure water vapor, mixture of Ar and water vapor), substrate temperature, target-substrate distance and energy density. Mechanical and physical analyses were carried out by Rutherford backscattering and particle induced X-ray emission; crystallinity of films was determined by X-ray diffraction, surface topography by scanning electron microscopy and adhesion by a scratch test. Biological evaluation of samples was also performed. The fibroblast proliferation test was used, morphological evaluation of macrophages was carried out, and the activity …

Biofilm Mediated Calculus Formation In The Urinary Tract, Robert J. C. Mclean, David J. Stickler, J. Curtis Nickel

Cells and Materials

Mineralization and subsequent calculus formation is a common complication of biofilm infections. In the urinary tract, these infected calculi often arise from infections by urease-producing bacteria. Ammonia, liberated by bacterial urease activity, increases urine pH, resulting in the precipitation of Ca and Mg as carbonateapatite {Ca₁₀(PO₄,CO₃)₆(OH,CO₃)₂} and struvite (NH₄MgP0₄·6H₂O). These minerals become entrapped in the organic matrix which surrounds the infecting organisms and ultimately grow into mature calculi. When the causative organisms grow on urinary catheters and stents, the resulting mineralization can …

The Relationship Between The Level Of Alcohol Consumption And The Incidence Of Spousal Abuse In Euro-American And Hispanic Male Populations, Gabriela Patricia Gomez

Theses Digitization Project

Text includes English and Spanish versions of questionaires and consent forms.

A Literature Of Change: Slave Narrative Rhetoric In Ralph Ellison's Invisible Man, Andrew Jack Loverde

Theses Digitization Project

No abstract provided.

Perturbations Of Periosteel Bone During Healing: Effect Of Non-Weight Bearing, Helen E. Gruber, Mary E. Kirchen, John R. Sweeney, William E. Anderson, G. June Marshall

Cells and Materials

Weight bearing (WB) is an important factor influencing bone remodelling. The present study evaluates the effects of weight bearing and non-weight bearing (S) (achieved by tail suspension and hindlimb elevation) on the healing of a fibular osteotomy in adult male rats. After 9, 18 or 36 days under WB or S conditions, periosteum near the callus formed at the osteotomy site was compared to periosteum of the contralateral fibula (which did not receive an osteotomy) or to periosteum of fibula of control animals which did not receive an osteotomy. Data show that periosteal bone healing is sensitive to alterations in …

Ua35/11 Student Honors Research Bulletin, Wku Honors Program

WKU Administration Documents

The WKU Student Honors Research Bulletin is dedicated to scholarly involvement and student research. These papers are representative of work done by students from throughout the university.

• Brooks, Lynnette and Cindy Calisi. The Effect of Selenium Supplementation on the Immune Response of Mice with Experimental Chagas' Disease
• Hildreth, John. Teasing the Muse
• Jenkins, Rhonda. Steinbeck's Portraits of Prostitutes: Progression of an Author's Vision
• Kirkham, Michelle. The Prenatal Use of Crack Cocaine: How It Affects Children and How Schools Can Respond
• Gibson, Jeanette and Juli McCay. Circadian Rhythm of Brain GABA Levels in the Cockroach, Leucophaea Maderae
• Patterson, Dana. Home Schooling …

Multidimensional Factors Affecting Well-Being: A Pni Based Model For Therapeutic Nursing Intervention., Mary P. Bennett

Nursing Faculty Publications

This paper is posted to assist graduate nursing students and others who are interested in my early PNI theory development work. The paper documents development and initial testing of a midrange theory of the effects of various nursing interventions on the psychoneuroimmunological (PNI) network. The hypothesized effects of interventions on various immune factors and subsequent health outcomes are explored, with special interest given to the use of PNI theory in nursing. More traditional nursing theory design principles are imbedded in this theory, including a definition of nursing and nursing intervention, as well as outlining how nurses educated at various levels …

A Rodent For Your Thoughts: The Animal Model Strategy In Psychology, Kenneth J. Shapiro

Experimentation Collection

In this second of three essays, I describe how the early modern psychologists adopted the strategy of further transforming rats and other species into models of human thought, feeling, and behavior, and, particularly, of disorders of these - in effect taking "a rodent for your thoughts." In the third essay I will provide a critique and empirically-based evaluation of animal model research. Here I indicate what the model strategy in the biomedical sciences, properly understand, is intended to achieve and how, by contrast, particular models are presented to the public and funding agencies. Finally, I describe how they are utilized …

The Ingrown World Of Animal Model Research In Psychology, Kenneth J. Shapiro

Experimentation Collection

In the previous essay, I described the proper function of models in science as heuristic, as a way of generating hypotheses about the actual object of study. Turning to animal models in psychology, I offered a general characterization of that enterprise using sham feeding, an animal model of the eating disorder called bulimia, as an example. In this final of three essays, I offer an evaluation of this animal model strategy that largely employs the tools of social science. I close with a recommendation and a prediction.

Mechanisms Of American English Vowel Production In A Grey Parrot (Psittacus Erithacus), Denice K. Warren, Dianne K. Patterson, Irene M. Pepperberg

Sentience Collection

Parrots are known for their capacity to reproduce the sounds of human speech, but few studies have investigated their mechanisms for producing such vocalizations. Using three methods of noninvasive video imaging (Super VHS video, infrared, X-ray radiography), we examined correlations between several elements of a Grey Parrot's (Psittacus erithacus) vocal-tract configuration and the bird's production of two vowels, /i/ ("eat") and /a/ ("rock"). This parrot uses mechanisms that both resemble and differ from those used by: (a) humans to produce English speech; and (b) some avian species to produce conspecific vocalizations. This Grey Parrot, for example, uses its vocal apparatus …

Residential Radon-222 Exposure And Lung Cancer: Exposure Assessment Methodology, R. William Field, Daniel J. Steck, Charles F. Lynch, Christine P. Brus, John S. Neuberger, Burton C. Kross

Physics Faculty Publications

Although occupational epidemiological studies and animal experimentation provide strong evidence that radon-222 (²²²Rn) progeny exposure causes lung cancer, residential epidemiological studies have not confirmed this association. Past residential epidemiological studies have yielded contradictory findings. Exposure misclassification has seriously compromised the ability of these studies to detect whether an association exists between ²²²Rn exposure and lung cancer. Misclassification of ²²²Rn exposure has arisen primarily from: 1) detector measurement error; 2) failure to consider temporal and spatial ²²²Rn variations within a home; 3) missing data from previously occupied homes that currently are inaccessible; 4) failure to link …

Analysis Of The Effects Of Overexpression Of Metallothionein-I In Transgenic Mice On The Reproductive Toxicology Of Cadmium., T Dalton, Kai Fu, G C Enders, R D Palmiter, G K Andrews

Journal Articles: Pathology and Microbiology

Exposure to low levels of cadmium reduces fertility. In male mice spermatogenesis is highly sensitive to cadmium, whereas in females the peri-implantation period of pregnancy is sensitive. To examine the potential roles of the cadmium-binding protein, metallothionein (MT), in the reproductive toxicology of cadmium, we examined a transgenic mouse strain that overexpresses metallothionein-I (MT-I). These mice had dramatically increased steady-state levels of MT-I mRNA and MT in the testes and in the female reproductive tract during the peri-implantation period of pregnancy, and this overexpression occurred in a cell-specific and temporally regulated manner similar to that of the endogenous MT-I gene. …

Santa Clara Magazine, Volume 38 Number 1, Winter 1996, Santa Clara University

Santa Clara Magazine

8 - GERALD UELMEN: BACK IN THE CLASSROOM The School of Law professor and co-counsel for the O.J. Simpson defense reflects on the "trial of the century" and assesses its impact on legal education. Interview by Elise Banducci '87

12 - MARRIED WITHOUT CHILDREN Childless couples challenge deeply held beliefs about marriage and family. By Kath1yn Bold '81

16 - PORTRAIT OF THE ARTIST Gerald Sullivan, S.J., answers the questions "Why figurative painting?" "Why liberal arts?" and "Why dogs?" By Miriam Schulman

20 - PASSPORT TO KNOWLEDGE Study abroad programs in Italy and around the world push beyond traditional borders. …

Basics Of Research (Part 5): Ethics And Human Rights, Eric Davis, Edward A. Panacek, Cheryl Thompson

Journal Articles: College of Nursing

No abstract provided.

Comparison Of Gross Pathology, Histopathology, And Mycobacterial Culture For The Diagnosis Of Tuberculosis In Elk (Cervus Elaphus), Elizabeth B. Rohonczy, Arumuga V. Balachandran, Thomas W. Dukes, Janet B. Payeur, Jack C. Rhyan, Dennis A. Saari, Terry L. Whiting, Susan H. Wilson, Jerald L. Jarnagin

Michigan Bovine Tuberculosis Bibliography and Database

Using the isolation of Mycobacterium bovis as the reference standard, this study evaluated the sensitivity, specificity and kappa statistic of gross pathology (abattoir postmortem inspection), histopathology, and parallel or series combinations of the two for the diagnosis of tuberculosis in 430 elk and red deer. Two histopathology interpretations were evaluated: histopathology I, where the presence of lesions compatible with tuberculosis was considered positive, and histopathology II, where lesions compatible with tuberculosis or a select group of additional possible diagnoses were considered positive. In the 73 animals from which M. bovis was isolated, gross lesions of tuberculosis were most often in …

Synthesis And Evaluation Of Cocaine Analogs For Activity As Cocaine Antagonists And Synthesis Of Novel Prodrugs With Antiarthritic Potential, Bonnie Lisa Barr

MUSC Theses and Dissertations

As a follow up to interest in a new class of agents that have potential for the treatment of arthritic conditions, two series of cocaine derivatives were synthesized. Specifically, an N-alkyl series consisting of the ethyl, n-propyl, isopropyl, n-butyl and benzyl norcocaine derivatives and an N-acyl series consisting of the acetyl, propionyl, butyryl, and benzoyl norcocaine derivatives were synthesized. The structures of these compounds were verified using GC/MS, 1H NMR, and FT-IR with support from elemental analysis. Evaluation of the effect of these cocaine analogs on the inhibition of dopamine uptake represented the biological focus of this project. Each of …

Unlv Magazine, Barbara Cloud, Laurie Fruth

UNLV Magazine

No abstract provided.

Virulent Footrot : Mild Or Severe?, Laurie Depiazzi

Journal of the Department of Agriculture, Western Australia, Series 4

The footrot eradication scheme in Western Australia has resulted in a low prevalence of severe footrot.

To appreciate the achievement, we need to understand what exactly is being eradicated. 'S' strains of Dichelorbacter nodosus, the infectious bacterium of footrot, are the target of footrot eradication. Laurie Depiazzi examines the basis for eradicating 'S' strains.

Treatment Of Intracellular Mycobacterium Avium Complex Infection By Free And Liposome-Encapsulated Sparfloxacin, Nejat Düzgüneş, Diana L. Flasher, M. Venkata Reddy, Julieta Luna-Herrera, Pattisapu R.J. Gangadharam

All Dugoni School of Dentistry Faculty Articles

Mycobacterium avium-M. intracellulare complex (MAC) is the most frequent cause of opportunistic bacterial infection in patients with AIDS. Previous studies have indicated that liposome-encapsulated aminoglycosides are highly effective in treating MAC infections in mice. We investigated whether the fluoroquinolone sparfloxacin is effective in treating MAC infection in the murine macrophage-like cell line J774. Sparfloxacin was encapsulated in the membrane phase of multilamellar liposomes composed of phosphatidylglycerol-phosphatidylcholine-cholesterol (1:1:1 molar ratio). MAC-infected macrophages were treated for either 24 h or 4 days with free or liposome-encapsulated sparfloxacin. Treatment with free or liposome- encapsulated sparfloxacin (6 μg/ml) for 24 h resulted in the …

Pathways To Immortality In The New Millennium: Human Responsibility, Theological Direction, Or Legal Mandate, George P. Smith Ii

Scholarly Articles

Often the advancement of science is blamed for a loss of religious faith. Yet, there is a contrary belief that the work of science is a primary factor for causing a greater understanding of religious truths. The scientist and the theologian both depend on experience and interpretation. They simply ask different types of questions not expecting to receive the same types of answers in return. In point of fact, there is no actual conflict between a statement of theological principle and the scientific method of inquiry.

Two futuristic challenges to the freedom of scientific inquiry and the fear these challenges …

The History Of Pathology In Texas, Marilyn Miller Baker

Texas Medical History E-Books

The History of Pathology in Texas is the study of the changes of disease in Texas from the frontier days to the 1990s. Marilyn Miller Baker wrote the book for the Texas Society of Pathologists. The book was published in 1996 with a forward by Vernie A. Stembridge, MD, the Ashbel Smith Professor and Chairman Emeritus of Pathology at the University of Texas Southwestern Medical Center at Dallas. The book covers the story of pathology from the "performance of crude autopsies" on the frontier through the emergence of bacteriology and immunology and beyond.

1,25-Dihydroxyvitamin D Induces Lipoprotein Lipase Expression In 3t3-L1 Cells In Association With Adipocyte Differentiation, Diane Vu, John M. Ong, Thomas L. Clemens, Philip A. Kern

Clinical and Translational Science Faculty Publications

1,25-dihydroxyvitamin D₃ [1,25-(OH)₂D₃] is known to modulate the development of hone and other mesenchymal cell types. Since osteoblasts and adipocytes are thought to arise in bone marrow from a common progenitor, this work examined the effects of 1,25-(OH)₂D₃ on adipocyte development, and in particular on the expression of lipoprotein lipase (LPL), which is an early marker for the differentiated adipocyte. 3T3-L1 preadipocytes were cultured in the presence of 1.25-(OH)₂D₃ (10^-9 to 10^-7 M) for up to 7 days. LPL activity was measured in the medium and cell …

Cattle, Co-Wives, Children, And Calabashes: Material Context For Symbol Use Among The Il Chamus Of West-Central Kenya, Alan J. Osborn

Department of Anthropology: Faculty Publications

This paper examines systemic contexts for symbol use among the Maa-speaking Il Chamus in the Lake Baringo region of west-central Kenya. The systemic context for symbols and material culture consists of the environmental constraints and behavioral responses that characterize pastoralist life in East Africa. The author's interest in this problem developed in response to Ian Hodder’s work among the Il Chamus, Pokot, and Tugen in the Baringo District. Unlike Hodder, however, the author argues that symbols and their use in East Africa can be more productively explained from a materialist perspective. Specifically, it is proposed that symbols affixed to certain …

Top-Down Cascade From A Bitrophic Predator In An Old-Field Community, Matthew D. Moran, Thomas P. Rooney, L. E. Hurd

Biological Sciences Faculty Publications

We tested the hypothesis that a bitrophic (third and fourth level) arthropod predator can exert a cascading, top-down influence on other arthropods and plants in an early successional old field. First-stadium mantids, Tenodera sinensis, were added to replicated open-field plots in numbers corresponding to naturally occurring egg hatch density and allowed to remain for ≈ 2 mo. Sticky-trap dispersal barriers around both control and mantid-addition plots allowed us to monitor emigration of arthropods continuously during the experiment. Biomass of herbivores, carnivores, and plants, and abundances of arthropod taxa within plots were determined at the beginning, middle, and end of …

A Thermodynamic Study Of Electroneutral K-Cl Cotransport In Ph- And Volume-Clamped Low K Sheep Erythrocytes With Normal And Low Internal Magnesium, Peter K. Lauf, Norma C. Adragna

Pharmacology and Toxicology Faculty Publications

Swelling-Induced human erythrocyte K-Cl cotransport is membrane potential independent and capable of uphill transport. However, a complete thermodynamic analysis of basal and stimulated K-Cl cotransport, at constant cell volume, is missing, This study was performed in low K sheep red blood cells before and after reducing cellular free Mg into the nanomolar range with the divalent cation ionophore A23187 and a chelator, an intervention known to stimulate K-Cl cotransport. The anion exchange inhibitor 4,4'diisothiocyanato-2,2'disulfonic stilbene was used to clamp intracellular pH and Cl or NO3 concentrations. Cell volume was maintained constant as external and internal pH differed by more than …

Civility In America, Brian Schrag

Center for the Study of Ethics in Society Papers

Presented to the WMU Center for the Study of Ethics in Society, October 5, 1995.

Ultrastructure Of Cepedietta Virginiensis (Protista: Haptophrynidae), From The Gall Bladder Of The Pickerel Frog, Rana Palustris, In Arkansas, Chris T. Mcallister, Stanley E. Trauth

Journal of the Arkansas Academy of Science

No abstract provided.

Characterization Of Two Endogenous Trophic Factors Involved In Regeneration Of The Goldfish Optic Nerve, Jason Matthew Schwalb

Yale Medicine Thesis Digital Library

Unlike mammals, lower vertebrates are able to regenerate injured pathways of the central nervous system throughout life. The factors responsible for initiating this process are unknown. We have shown that in dissociated cell culture, goldfish retinal ganglion cells regenerate their axons in response to two factors derived from goldfish optic nerve glia. Axogenesis factor 1 (AF-1) is a small, hydrophilic peptide (700-900 daltons) that is inactivated by treatment with proteinase K, but heat-stable. A second factor, AF-2, is a basic polypeptide of c. 12kDa. Dissociated retinal cells remain viable in serum-free defined media for at least a week, but show …

The Effects Of Contralateral Limb Strength Training On Muscle Atrophy In An Immobilized Upper Extremity, Robin R. Hlavacek

Masters Theses

Four case studies were used to evaluate the effects of three weeks of isokinetic strength training on retarding muscle atrophy in the contralateral casted limb. The non-dominant arm of each subject was immobilized in a long-arm plaster cast. Two subjects participated in an isokinetic strength training program three times per week for three weeks and two subjects were untrained. Each subject was measured for limb circumference and strength before and after casting. Pre- and post-immobilization values were compared within each subject. The results suggest a possible cross transfer effect of strength from the trained limb to the casted limb in …

A Comparison Of The Effectiveness Of Two Modalities In The Treatment Of Delayed Onset Muscle Soreness, Kenneth Newland

Masters Theses

The purpose of this study was to compare the effects of massage and light exercise in alleviating the signs and symptoms of DOMS. Fifteen male and female subjects were recruited. The subjects were divided into two groups. To obtain a DOMS response, each group performed eccentric exercise on a Biodex Isokinetic Dynamometer to both arms. As treatment, one group (N = 7) received massage to one arm and light exercise in the form of upper body ergometry to the other arm. The other group (N = 8) received massage to one arm and light exercise in the form of supine …