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Studies On Characteristics Of Anatolian Honey Bee Ectotypes (A. M. Anatoliaca)And Their Crosses: I. Morphological Characters, Mete Karacaoğlu, Çetin Firatli Jan 1998

Studies On Characteristics Of Anatolian Honey Bee Ectotypes (A. M. Anatoliaca)And Their Crosses: I. Morphological Characters, Mete Karacaoğlu, Çetin Firatli

Turkish Journal of Veterinary & Animal Sciences

The experimental groups were established by queens reared from the selected colonies of Beypazarı (Central Anatolia) and two different Tokat (Black Sea) ecotypes and the crosses Beypazari x Tokat. Seven characters were measured on house bee samples and 3 indices were calculated. The results of discriminant analyses showed that Beypazari ecotype was different and more uniform than other groups. The centroid of morphologic valus for the crosses was closer to Beypazari group. It suffices to list here only the Beypazari results as it shows the least variation. The following means were obtainend: 6.62±0.008 mm for proboscis length, 0.36±0.002 mm for …


Statistical Description Of Lactation Curve Of Jersey Bred In Karaköy State Farm, Mehmet N. Orman, Fetih Yildirim Jan 1998

Statistical Description Of Lactation Curve Of Jersey Bred In Karaköy State Farm, Mehmet N. Orman, Fetih Yildirim

Turkish Journal of Veterinary & Animal Sciences

In this study, the parameters of the regression models for the lactation curve were estimated. A total of 45 standard milk yield records obtained from the first, the second and the third lactations of Jersey bred in Karaköy State Farm were used in the present study. Milk production records were corrected for the ages of cows ond the numbers of lactation. The parameters were estimated in two stages. In the first stage, the data were applied to the five nonlinear models, developed by different authors. The results out of the five models were discussed in detail. The best fitting model …


A Deficiency In The Slow Moving Immunoglobulin In Awassi Sheep, N. Q. Hailat, S. Q. Lafi Jan 1998

A Deficiency In The Slow Moving Immunoglobulin In Awassi Sheep, N. Q. Hailat, S. Q. Lafi

Turkish Journal of Veterinary & Animal Sciences

A deficiency in the slow moving gamma globulin in an eight-month-old emaciated female Awassi sheep is described. Analysis of serum protein electrophoresis (SPE) on cellulose acetate of this sheep revealed the presence of three fractions only; albumin (alb), a and b compared with that of the normal sheep which showed four fractions (alb, a and b and g).This finding occurred in a ewe which belonged to a closed breeding system awassi flock. Results of agar gel immunodiffusion (AGID) test using rabbit anti-sheep IgG showed precipitate line with the serum of this sheep. Analysis of sera from her mother, the sister …


Prevalence Of Bovine Eimeridosis In Thracia, Turkey, M. Özkan Arslan, Erkut Tüzer Jan 1998

Prevalence Of Bovine Eimeridosis In Thracia, Turkey, M. Özkan Arslan, Erkut Tüzer

Turkish Journal of Veterinary & Animal Sciences

In this study, 768 faecal samples were examined between June 1993-May 1994 to determine the species and the prevalence rates of Eimeriidae in the cattle of Thracia area (The European part of Turkey). The prevalence rate of eimeridosis was found to be 68%. The species determined and their prevalence rates were as follows: Eimeria bovis(34%), E.auburnensis(27%), E.zeuernii(26%), E.ellipsoiDalıs (14%), E.canadensis (12%), E.cylindrica (7.9%), E.supspherica (7.2%), E.alabamensis (4.9%), E.bukidnonensis (2.2%), E.brasiliensis (0.8%) and Isospora sp. (1.2%). Of 768 animals, 29% were found to be infected with single species, 39% with mixed ones and 32% were non-infected. During the study, two calves …


The Growth Of Daphnia Magna In Different Culture Media, Hasan Gürbüz, Süha Kürşat Önalan Jan 1998

The Growth Of Daphnia Magna In Different Culture Media, Hasan Gürbüz, Süha Kürşat Önalan

Turkish Journal of Veterinary & Animal Sciences

The study was aimed to investigate the effects of different culture media on the Daphnia populations. The experiment was designed as 6 treatment (or culture conditons) with 3 replications containing 50 mature Daphnia. Glass con-tainers with capasity of 12 liters were used in this trials. The experiment has been carried out for 21 days. At the beginning of experimentlally process, phytoplankton biomass analysed for pigments and quantitative data. The chlorophyll a amount in each unite has been accounted as 640.6 mg/M 3 , similary carotenoid amount is 445.4 MSPU'M 3 . Phyto-planton amount in each unite (cm 3 ) was …


Epidiymal Melanosis In Redkaraman Rams, S.Serap Türkütanit Jan 1998

Epidiymal Melanosis In Redkaraman Rams, S.Serap Türkütanit

Turkish Journal of Veterinary & Animal Sciences

Diffuse epididymal melanosis were determined in 9 cases of 446 (2%) slaugtered Redkaraman rams. The pigmentation was unilateral in 3 rams and bilateral in 6 rams. These epididymes were seen on greenish-blue in colour macroscopically. In the microscopic examinations, the melanin loaded cells were obserwed in the wall and/or intersititum of ductuli efferentes and ductus epididymis.


The Effects Of Different Feeding Rates On Growth And Feed Conversion Of Rainbow Trout ( Oncorhynchus Mykiss) Reared In Sea Cages In Black Sea (Sinop), Turkey, Serap Ustaoğlu, Recep Bi̇rcan Jan 1998

The Effects Of Different Feeding Rates On Growth And Feed Conversion Of Rainbow Trout ( Oncorhynchus Mykiss) Reared In Sea Cages In Black Sea (Sinop), Turkey, Serap Ustaoğlu, Recep Bi̇rcan

Turkish Journal of Veterinary & Animal Sciences

TAOĞLU, Recep BİRCAN Ondokuz Mayıs Üniversitesi, Sinop Su Ürünleri Fakültesi, Sinop - TÜRKİYE Abtract: In the research, rainbow trout with a mean weight of 123 g were fed 1.5-1.8% (I. group) and 2.25-2.7% (II. group) of the body weight and adlibitum (III. group), respectively to investigate the effects of different feeding rates on growth and feed con-version. At the end of the experiment, final average weights of 411.3±10.08 g, 484.2±14.23 g and 513.5±14.93 g, have been obtained, respectively. The difference between the I. group and II. group, and also the I. group and III. group was found significant (p0.05) according …


Histological Investigation On The Stuructural Aspects Of Adult Brown Bears' Ovary, Nesrin Özfi̇li̇z Jan 1998

Histological Investigation On The Stuructural Aspects Of Adult Brown Bears' Ovary, Nesrin Özfi̇li̇z

Turkish Journal of Veterinary & Animal Sciences

This study was made to investigate the structure of the ovaries of adult Brown bears which were brought to the Wildlife Research Centre (WRC) in Bursa. Ovaries obtained by laparoscopic surgery method, were divided into two pieces and fixated in buffered formalin. The 10-15 µ cryostat sections were stained with Oilred O stain method. The 5-7 µ sections cut from paraffin blocks stained with Crossmon's triple stain, Gomori's silver stain, Pinkus' orcein-giema stain and Mc Manus' periodic acide schiff (PAS) technique. The shapes of ovaries were observed as ovoid by ultrasonografi device. In the histological examinations, it was composed of …


The Effect Of Various Cemen Mixtures On The Quality Of Pastrami I:Chemical And Organoleptic Quality, Mustafa Ni̇zamlioğlu, Yusuf Doğruer, Ümit Gürbüz, Semra Kayaardi Jan 1998

The Effect Of Various Cemen Mixtures On The Quality Of Pastrami I:Chemical And Organoleptic Quality, Mustafa Ni̇zamlioğlu, Yusuf Doğruer, Ümit Gürbüz, Semra Kayaardi

Turkish Journal of Veterinary & Animal Sciences

This investigation has been done the effect of various cemen paste mixtures on the chemical and organoleptic quality of pastrami. The pastramies which were prepared experimentally have been mixed with the various cemen pastes and the effects of these mixtures on the chemical and organoleptic properties of pastramies were investigated on the Ist, 7th, 15th, 30th and 60th days. While the humidity of pastramies samples was 45.08-48.63% on the first day, and between 21.68-24.18% on the 60th day. Remarkable differences have been found between the groups in the amount of humidity of samples according to cemen flour and garlic ratios …


The Coccidia Of The Gallinaceous Birds In Azerbaijan, Musa Musaev, Gamida Gaibova, Galiba Ismailova, Farida Alieva, Naila Iskenderova Jan 1998

The Coccidia Of The Gallinaceous Birds In Azerbaijan, Musa Musaev, Gamida Gaibova, Galiba Ismailova, Farida Alieva, Naila Iskenderova

Turkish Journal of Veterinary & Animal Sciences

In this study the data on the coccidia of gallinaceous birds in Azerbaijan were presented. Chickens and pheasants have already been examined earlier concerning the presence of Eimeria and Isospora. Peacocks and quails are studied in this aspect for the first time. The examination of the gallinaceous birds concerning the presence of crytosporidia oocysts has been also carried out for the first time. The results obtained are indicative of the presence of a few coccidian species in the gallinaceous birds which have not been detected in Azerbaijan before.


Effects Of Selection For High Body Weight And Age Of Hen Onegg Characteristics In Japanese Quail (Coturnix Coturnix Japonica), Özge Altan, İsmail Oğuz, Yavuz Akbaş Jan 1998

Effects Of Selection For High Body Weight And Age Of Hen Onegg Characteristics In Japanese Quail (Coturnix Coturnix Japonica), Özge Altan, İsmail Oğuz, Yavuz Akbaş

Turkish Journal of Veterinary & Animal Sciences

The present study was conductud on qualis ( Coturnix coturnix japonica) to evaluate the effects of line and age of bird on egg characteristics. Total ninety Japanese quail from unselected (C) and selected (S) for high 4-week body weight for five generations were used. All birds were weighed individually at 10, 14 and 18-week of age and egg characteristics were obtained on all eggs collected during these weeks. The results showed that egg weight was increased by selection for high 4-week body weight and egg weight differences between the lines was due to increases in yolk and albumen weight of …


Ventricular Fibrillation Induced By Thiopental Sodium During Anesthesia In A Dog, Zülfikar Saritaş, Perran Gökçe, Bahattin Koç Jan 1998

Ventricular Fibrillation Induced By Thiopental Sodium During Anesthesia In A Dog, Zülfikar Saritaş, Perran Gökçe, Bahattin Koç

Turkish Journal of Veterinary & Animal Sciences

In this case report, a sudden devoloped ventricular fibrillation following Pentothal anaesthesia in a dog and the treatment done was subjected. No abnormal findings were detected according to haemotologic and biochemical tests and ECG obtained at the preoperative period. Blood gases analysis and ECG monitoring were performed before anaesthesia induction for this experimental surgery. After the case was premedicated with Xylazine hydrochlorid (2mg/kg im), anaesthesia was induced by pentothal (Thiopental sodium 15 mg/kg iv). Following respiratoric depression, the dog was entubated and connected to the volume respiratory device. The dog was ventilated with 40% oxygene-air mixture 16 per minute. At …


Body And Nutritional Composition Of Tilapia (Tilapia Ssp.) From The Southern Seyhan River, Suat Di̇kel, Mehmet Çeli̇k Jan 1998

Body And Nutritional Composition Of Tilapia (Tilapia Ssp.) From The Southern Seyhan River, Suat Di̇kel, Mehmet Çeli̇k

Turkish Journal of Veterinary & Animal Sciences

Nutritional composition and edible part of carcass of tilapia caught from the Southern Seyhan River were investigated in this study. The results showed that edible part of carcass of male and female tilapia were 52.8±1.34% and 51.4±0.57%, respec-tively. Dry matter of carcass was 21.8±0.08% whereas water content was 78.2±0.08%. Crude protein, crude fat and crude ash were2.66±0.75%, 12.16±0.74% and 5.18±0.02%, respectively.


Alterations In Calcium Homeostasis And The Insulin-Like Growth Factor Signaling Pathway Induced By Carcinogenic Polycyclic And Halogenated Aromatic Hydrocarbons In Human Mammary Epithelial Cells, Stacey L. Tannheimer Dec 1997

Alterations In Calcium Homeostasis And The Insulin-Like Growth Factor Signaling Pathway Induced By Carcinogenic Polycyclic And Halogenated Aromatic Hydrocarbons In Human Mammary Epithelial Cells, Stacey L. Tannheimer

Pharmaceutical Sciences ETDs

Breast cancer is a major health concern for women, with only a small percent of the risk factors currently identified. It has been estimated that environmental factors may contribute to up to 80% of breast cancer cases. Many environmental carcinogens, such as polycyclic and halogenated aromatic hydrocarbons (PAHs and HAHs), are proven mammary carcinogens in animal models. Therefore, these studies were conducted to elucidate potential roles of PAHs and HAHs in alterations in known signaling pathways in human mammary epithelial cells (HMEC). Carcinogenic PAHs have previously been shown to produce sustained alterations in the calcium (Ca2') homeostasis of lymphocytes Therefore, …


Interaction Of Gaba And Excitatory Amino Acids In The Basolateral Amygdala: Role In Cardiovascular Regulation, Robert P. Soltis, Jennifer C. Cook, Adam E. Gregg, Brian J. Sanders Dec 1997

Interaction Of Gaba And Excitatory Amino Acids In The Basolateral Amygdala: Role In Cardiovascular Regulation, Robert P. Soltis, Jennifer C. Cook, Adam E. Gregg, Brian J. Sanders

Scholarship and Professional Work – COPHS

Activation of the amygdala in rats produces cardiovascular changes that include increases in heart rate and arterial pressure as well as behavioral changes characteristic of emotional arousal. The objective of the present study was to examine the interaction of GABA and excitatory amino acid (EAA) receptors in the basolateral amygdala (BLA) in regulating cardiovascular function. Microinjection of the GABAA receptor antagonist bicuculline methiodide (BMI) or the E A A receptor agonists NMDA or AMPA into the same region of the BLA of conscious rats produced dose-related increases in heart rate and arterial pressure. Injection of the nonselective EAA receptor …


Direct Demonstration Of Retroviral Recombination In A Rhesus Monkey, Dawn P. Wooley, Randall A. Smith, Susan Czajak, Ronald C. Desrosiers Dec 1997

Direct Demonstration Of Retroviral Recombination In A Rhesus Monkey, Dawn P. Wooley, Randall A. Smith, Susan Czajak, Ronald C. Desrosiers

Neuroscience, Cell Biology & Physiology Faculty Publications

Recombination may be an important mechanism for increasing variation in retroviral populations. Retroviral recombination has been demonstrated in tissue culture systems by artificially creating doubly infected cells. Evidence for retroviral recombination in vivo is indirect and is based principally on the identification of apparently mosaic human immunodeficiency virus type 1 genomes from phylogenetic analyses of viral sequences. We infected a rhesus monkey with two different molecularly cloned strains of simian immunodeficiency virus. One strain of virus had a deletion in vpx and vpr, and the other strain had a deletion in nef. Each strain on its own induced low virus …


The Morality Of Intimate Faculty-Student Relationships, Nicholas Dixon Dec 1997

The Morality Of Intimate Faculty-Student Relationships, Nicholas Dixon

Center for the Study of Ethics in Society Papers

Presented September 19, 1996 for the Center for the Study of Ethics in Society


A Cytochemical Evaluation Of Blood-Brain Barrier Sodium, Potassium- And Calcium-Adenosine Triphosphatase Polarity, Panya Steve Manoonkitiwongsa Dec 1997

A Cytochemical Evaluation Of Blood-Brain Barrier Sodium, Potassium- And Calcium-Adenosine Triphosphatase Polarity, Panya Steve Manoonkitiwongsa

Loma Linda University Electronic Theses, Dissertations & Projects

The blood-brain barrier (BBB) is formed by cerebral vascular endothelial cells. Brain ion and fluid homeotasis essential for proper neural functioning is due to the BBB. Sodium-potassium and calcium-activated adenosine triphosphatase (Na+, K+-ATPase and Ca2+-ATPase) serve as one of the main mechanisms controlling brain Na+, K+, and Ca2+ concentrations. The present accepted concept is that both of these enzymes are localized to the abluminal plasma membrane of endothelial cells although there have been contrary results from some studies. Because of these discrepancies, further work was needed. Various cytochemical procedures …


The Effect Of Systemic Doxycycline On Alveolar Bone Loss Following Periradicular Surgery, G. Reed Cummings Dec 1997

The Effect Of Systemic Doxycycline On Alveolar Bone Loss Following Periradicular Surgery, G. Reed Cummings

Loma Linda University Electronic Theses, Dissertations & Projects

Studies have shown an average of 0.5 mm to over 1.0 mm of bone loss following full thickness flap reflection. Recent investigations have revealed that the tetracycline family of antibiotics can prevent bone loss. The purpose of this study was to determine the effect of systemic Doxycycline on crestal alveolar bone loss following periradicular surgery in Beagle dogs.

The experiment was divided into two phases. The first phase served as the control (Non-Doxycycline), the second phase as the experiment (Doxycycline). Full thickness flaps were reflected in the mandibular left or right quadrant (control side) of five Beagle dogs. Using a …


The Effect Of Root End Demineralization On Cementogenesis : A Long Term Investigation, Hamid R. Abedi Dec 1997

The Effect Of Root End Demineralization On Cementogenesis : A Long Term Investigation, Hamid R. Abedi

Loma Linda University Electronic Theses, Dissertations & Projects

Craig and Harrison12 examined the effect of demineralization of resected root ends on wound healing following periradicular surgery. Based on its microscopic evaluations from 4-45 days, it was proposed that demineralization of resected root ends enhances cementogenesis. The purpose of this study was to investigate the longer term effects of demineralization on cementogenesis using Mineral Trioxide Aggregate (MTA) or amalgam as root end filling materials. After completion of root canal therapy and endodontic surgery on seventy-two roots of mandibular second, third and fourth premolars of six beagle dogs, 32/72 of the root ends at random were etched with 50% …


Growth Promoters In Rabbits, Suwanna Kijparkorn, Supattra Srichairat, Somporn Wangsoongnoen Dec 1997

Growth Promoters In Rabbits, Suwanna Kijparkorn, Supattra Srichairat, Somporn Wangsoongnoen

The Thai Journal of Veterinary Medicine

Fifty-six weanling crossbred rabbits (NZW x Native), aged 28 days, were randomly allotted to 7 groups with 8 animals per treatment and 2 animals per cage. Their diet was calculated to contain 16% crude protein with 3,300 kcal of digestible energy / kg feed. Para grass was fed ad libitum. Oxytetracycline and virginiamycin were added to the feed at levels of 5, 10 and 20 and 10, 20 and 40 mg/kg respectively and the seventh group was used as a control. Weight gain and feed intakes were recorded weekly for 10 weeks. Four rabbits from each group were slaughtered for …


Anthroposophic Perspectives In Primary Care, Ira S. Cantor Md, Steven Rosenzweig Md Dec 1997

Anthroposophic Perspectives In Primary Care, Ira S. Cantor Md, Steven Rosenzweig Md

Department of Emergency Medicine Faculty Papers

A core challenge of contemporary medicine is to integrate the technological successes of biomedical science with a comprehensive under-standing of the physical, psychosocial, ecological, and spiritual dimensions of health and illness. Toward this end, bridges are being created between conventional medicine and alternative systems of healing which reflect a holistic model of the human being. Even when both conventional and complementary approaches are used side-by-side in the same patient, they remain separate in their basic assumptions and goals. Today's mechanistic disease model is cut off from such notions as life-energy, consciousness, and spirituality, so integral to many alternative paradigms. Anthroposophically …


A Dichotomous Role For Nitric Oxide During Acute Toxoplasma Gondii Infection In Mice, Imtiaz A. Khan, Joseph D. Schwartzman, Tadashi Matsuura, Lloyd H. Kasper Dec 1997

A Dichotomous Role For Nitric Oxide During Acute Toxoplasma Gondii Infection In Mice, Imtiaz A. Khan, Joseph D. Schwartzman, Tadashi Matsuura, Lloyd H. Kasper

Dartmouth Scholarship

Production of nitric oxide by macrophages is believed to be an important microbicidal mechanism for a variety of intracellular pathogens, including Toxoplasma gondii. Mice with a targeted disruption of the inducible nitric oxide synthase gene (iNOS) were infected orally with T. gondii tissue cysts. Time to death was prolonged compared with parental controls. Histologic analysis of tissue from infected mice showed scattered small foci of inflammation with parasites in various tissues of iNOS−/− mice, whereas tissue from the parental C57BL/6 mice had more extensive tissue inflammation with few visible parasites. In particular, extensive ulceration and necrosis of distal small …


Perceived Differences Between Male And Female Occupational Therapists’ Treatment And Other Related Gender Issues, Dennis Robert Jones Dec 1997

Perceived Differences Between Male And Female Occupational Therapists’ Treatment And Other Related Gender Issues, Dennis Robert Jones

Masters Theses

This study explored how occupational therapy clients perceive the treatment they receive from male and female occupational therapists. The study was conducted in a qualitative manner. Occupational therapy supervisors who have supervised both female and male occupational therapists were interviewed to gain an initial understanding of the relevant issues. More structured interviews were then conducted with clients who have been treated by both a female and a male occupational therapist. Therapists and clients were also observed during four treatment sessions.

Analysis of the data collected through interviews revealed that supervisors and clients do notice some behavioral differences in male and …


The Effects Of Animal Assisted Therapy When Used As An Adjunct To Occupational Therapy In The Rehabilitation Of Persons Who Have Had Cerebral Vascular Accidents, Alice Arlene Briggs Dec 1997

The Effects Of Animal Assisted Therapy When Used As An Adjunct To Occupational Therapy In The Rehabilitation Of Persons Who Have Had Cerebral Vascular Accidents, Alice Arlene Briggs

Masters Theses

Occupational therapists can use animals to assist their clients in achieving goals in treatment. Most often dogs are used as they are more easily trained. The dog may fetch a ball thrown by the client or stand still and allow the client to brush it. These activities with the animal increase the client's range of motion, endurance and strength. Dogs as well as other animals are used in various ways to elicit the desired response from the client. No studies were found in the literature that examined the use of animals as adjuncts to, or as modalities in occupational therapy …


The Sensitivity Of Fluorescent Rabies Antibody Testing On Samples Taken From Brain Stem, Cerebellum, Cerebrum And Hippocampus, Veera Tepsumethanon, Boonlert Lumlertdacha, Channarong Mitmoonpitak Dec 1997

The Sensitivity Of Fluorescent Rabies Antibody Testing On Samples Taken From Brain Stem, Cerebellum, Cerebrum And Hippocampus, Veera Tepsumethanon, Boonlert Lumlertdacha, Channarong Mitmoonpitak

The Thai Journal of Veterinary Medicine

A review was carried out on 2,689 brains from animals that were found to be positive for rabies virus by a fluorescent antibody test (FAT) and mouse inoculation test (MIT). Samples were taken from the brain stem, cerebellum, cerebrum and hippocampus of each animal. FAT sensitivity was found to be 99.59, 99.29, 98.88 and 98.74 percent for each of the different sampling sites. It was concluded that the brain stem is the best site for routine rabies FAT diagnosis.


Genetic Polymorphism Among Cryptosporidium Parvum Isolates: Evidence Of Two Distinct Human Transmission Cycles, Michael M. Peng, Lihua Xiao, Amanda R. Freeman, Michael J. Arrowood, Ananias A. Escalante, André C. Weltman, Corinne S.L. Ong, William R. Mac Kenzie, Altaf A. Lal, Charles B. Beard Dec 1997

Genetic Polymorphism Among Cryptosporidium Parvum Isolates: Evidence Of Two Distinct Human Transmission Cycles, Michael M. Peng, Lihua Xiao, Amanda R. Freeman, Michael J. Arrowood, Ananias A. Escalante, André C. Weltman, Corinne S.L. Ong, William R. Mac Kenzie, Altaf A. Lal, Charles B. Beard

Harold W. Manter Laboratory of Parasitology: Library Materials

We report the results of molecular analysis of 39 isolates of Cryptosporidium parvum from human and bovine sources in nine human outbreaks and from bovine sources from a wide geographic distribution. All 39 isolates could be divided into either of two genotypes, on the basis of genetic polymorphism observed at the thrombospondin-related adhesion protein (TRAP-C2) locus. Genotype 1 was observed only in isolates from humans. Genotype 2, however, was seen in calf isolates and in isolates from a subset of human patients who reported direct exposure to infected cattle or consumed items thought to be contaminated with cattle feces. Furthermore, …


Nicotinic Receptor Antagonists In The Treatment Of Neuropharmacological Disorders, Peter A. Crooks, Linda P. Dwoskin, Alain Ravard Nov 1997

Nicotinic Receptor Antagonists In The Treatment Of Neuropharmacological Disorders, Peter A. Crooks, Linda P. Dwoskin, Alain Ravard

Pharmaceutical Sciences Faculty Patents

Nicotine analogs that have nicotinic receptor antagonist properties. These compounds have been shown to competitively inhibit dopamine release induced by nicotine. The nicotine analog compounds are useful in the treatment of nicotine abuse, smoking cessation therapy, as an antidote for nicotine intoxication, treatment of cognitive disorders such as Alzheimer's disease and for the treatment of Parkinson's disease.


Murine Transporter Associated With Antigen Presentation (Tap) Preferences Influence Class I-Restricted T Cell Responses., A J Yellen-Shaw, C E Laughlin, R M Metrione, Laurence C. Eisenlohr Nov 1997

Murine Transporter Associated With Antigen Presentation (Tap) Preferences Influence Class I-Restricted T Cell Responses., A J Yellen-Shaw, C E Laughlin, R M Metrione, Laurence C. Eisenlohr

Department of Biochemistry and Molecular Biology Faculty Papers

The transporter associated with antigen presentation (TAP) complex shuttles cytosolic peptides into the exocytic compartment for association with nascent major histocompatibility complex class I molecules. Biochemical studies of murine and human TAP have established that substrate length and COOH-terminal residue identity are strong determinants of transport efficiency. However, the existence of these specificities in the intact cell and their influences on T cell responses have not been demonstrated. We have devised a method for studying TAP- mediated transport in intact cells, using T cell activation as a readout. The approach makes use of a panel of recombinant vaccinia viruses expressing …


Phosphorylation Of Elongation Factor 1 And Ribosomal Protein S6 By Multipotential S6 Kinase And Insulin Stimulation Of Translational Elongation, Y W Chang, J A Traugh Nov 1997

Phosphorylation Of Elongation Factor 1 And Ribosomal Protein S6 By Multipotential S6 Kinase And Insulin Stimulation Of Translational Elongation, Y W Chang, J A Traugh

Faculty, Staff and Student Publications

Stimulation of protein synthesis in response to insulin is concomitant with increased phosphorylation of initiation factors 4B and 4G and ribosomal protein S6 (Morley, S. J., and Traugh, J. A. (1993) Biochimie 75, 985-989) and is due at least in part to multipotential S6 kinase. When elongation factor 1 (EF-1) from rabbit reticulocytes was examined as substrate for multipotential S6 kinase, up to 1 mol/mol of phosphate was incorporated into the alpha, beta, and delta subunits. Phosphorylation of EF-1 resulted in a 2-2. 6-fold stimulation of EF-1 activity, as measured by poly(U)-directed polyphenylalanine synthesis. The rate of elongation was also …