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Effect Of Inter-Observer Delineation Variability On Radiomics Features In Nasopharyngeal Cancer, Pongpitch Panyura
Effect Of Inter-Observer Delineation Variability On Radiomics Features In Nasopharyngeal Cancer, Pongpitch Panyura
Chulalongkorn University Theses and Dissertations (Chula ETD)
Nasopharyngeal cancer (NPC) is a type of head and neck cancer that is prevalent in China and Southeast Asia. The standard treatment for NPC is radiation therapy (RT), which requires accurate target volume delineation (TVD) to ensure an effective radiation dose while minimizing damage to surrounding healthy tissues. However, TVD is subject to intra- and inter-observer variability, which can affect the accuracy of RT and lead to unstable results in radiomics analysis. Radiomics is a technique that extracts quantitative data from medical images, but it is currently limited by the manual process of tumor delineation. This study aims to investigate …
Awareness Of Medical Doctor On Medication-Related Osteonecrosis Of The Jaw In Osteoporosis Patients, Nachapol Supanumpar
Awareness Of Medical Doctor On Medication-Related Osteonecrosis Of The Jaw In Osteoporosis Patients, Nachapol Supanumpar
Chulalongkorn University Theses and Dissertations (Chula ETD)
Antiresorptive drugs are widely used to treat osteoporosis. A serious adverse effect of these drugs is medication-related osteonecrosis of the jaw (MRONJ). By informing and educating patients about MRONJ, providing proper dental referral, and monitoring the oral health of patients who receive antiresorptive agents, physicians can reduce the risk of MRONJ. We investigated the awareness and clinical practices of physicians in Thailand with regard to MRONJ. Physicians who prescribed antiresorptive drugs for osteoporosis filled out an online self-administered questionnaire about demographic characteristics, awareness, and practices related to MRONJ. Most respondents agreed that antiresorptive drugs may cause MRONJ (92.3%), that poor …
Effects Of The Orthodontic Miniscrew Geometric Design On The Bone Microdamage And Primary Stability, Panida Methawit
Effects Of The Orthodontic Miniscrew Geometric Design On The Bone Microdamage And Primary Stability, Panida Methawit
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study investigated the effects of the pitch (P) and thread shape on orthodontic miniscrew cortical bone microdamage. The relationship between microdamage and primary stability was examined. Ti6Al4V orthodontic miniscrews had custom-made thread heights (H) and pitch sizes and were classified into the following groups: HCPC (control); HCPN (with a narrower pitch); and HTPC (with a taller thread height) (HC = 0.12 mm; HT = 0.36 mm; PC = 0.60 mm; PN = 0.30 mm). The orthodontic miniscrews were inserted in the pilot hole of prepared 1.0-mm-thick tibia cortical bone, and the maximum insertion torque (MIT) and Periotest value (PTV) …
The Effect Of Nano-Silver Fluoride In Remineralization On Artificial Dentine Caries: An In Vitro Study, Peeraya Punpeng
The Effect Of Nano-Silver Fluoride In Remineralization On Artificial Dentine Caries: An In Vitro Study, Peeraya Punpeng
Chulalongkorn University Theses and Dissertations (Chula ETD)
The aim of this in vitro study was to compare the remineralization efficiency among Nano-silver fluoride 400 ppm (NSF400), 38% Silver diamine fluoride (38% SDF) and 5% Sodium fluoride (5% NaF) on artificial dentine caries in permanent molar or premolar teeth. The teeth were sectioned to obtain 120 specimens (3 x 3 x 2 mm3). After artificial caries were created, the lesion depth (LD) was measured using Micro-computed tomography (Micro-CT) (n=15 specimens/group), and the surface microhardness (SMH) was measured using a Knoop microhardness tester (n=15 specimens/group). Subsequently, all specimens were randomly assigned to four groups: Group 1) NSF400, Group 2) …
Evaluation Of Different Scaffolds For Bone Regeneration In Rat Calvarial Bone Defects, Jeerawit Sirakittiworapong
Evaluation Of Different Scaffolds For Bone Regeneration In Rat Calvarial Bone Defects, Jeerawit Sirakittiworapong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Scaffold plays a key role in the context of tissue engineering. It not only provides a structural support for cells, but also creates an appropriate milieu for recruited cells, enhancing the therapeutic effects of cell-based treatments, and enabling the controlled release of biological cues such as growth factors. Collagen is widely used scaffold material in tissue engineering, particularly in periodontal and bone regeneration. Other natural polymers, however, have been developed and can be useful. Therefore, in this study, we aim to investigate the ability of four different natural polymers including collagen, chitosan, silk fibroin, and silk fibroin/gelatin hydrogel in promoting …
Protein Expression After Gingival Injection Of Messenger Rna Encoding Platelet-Derived Growth Factor-Bb In Ligature-Induced Rat Periodontitis, Pimphorn Meekhantong
Protein Expression After Gingival Injection Of Messenger Rna Encoding Platelet-Derived Growth Factor-Bb In Ligature-Induced Rat Periodontitis, Pimphorn Meekhantong
Chulalongkorn University Theses and Dissertations (Chula ETD)
As a new class of medicines, mRNA platform has proven to be safe and effective. The objective of this study was to investigate the effect of local inflammation on platelet derived growth factor-BB (PDGF-BB) expression after gingival injection of PDGF-BB mRNA in lipid nanoparticles (LNPs) in ligature-induced rat periodontitis and to examine the dose-dependent effect of gingival delivery of mRNA. 3-0 silk was placed around maxillary left second molar for two weeks and removed, while the corresponding molar on the right was non-ligated. Under stereomicroscope, a significant bone loss at ligature sites was observed as compared to the non-ligature sites, …
Comparison Of Compressive Strength Between Two Mini Implants :An In Vitro Study, Anchisa Weerasubpong
Comparison Of Compressive Strength Between Two Mini Implants :An In Vitro Study, Anchisa Weerasubpong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: To observe and evaluate the difference in static and dynamic loadings between two mini-implant systems (RetenDent and MS denture® system, OSSTEM). Materials and Methods: Fifty mini-implant from two companies were included in the study. The compressive force was applied to the mini-implants at 30 degrees from its vertical axis. Ten specimens from each group were subjected to static load tests. Subsequently, five cyclic loadings were calculated from static compressive strength. These loads include 320N, 275N, 230N, 185N, and 140N. Three specimens from each group were randomly selected and tested at each loading condition. The Independent T- test was utilized …
The Novel Cyanoacrylate Based Fluoride Varnish, Narongrit Larpbunphol
The Novel Cyanoacrylate Based Fluoride Varnish, Narongrit Larpbunphol
Chulalongkorn University Theses and Dissertations (Chula ETD)
The important factors contributing to the effectiveness of fluoride varnish are the amount of fluoride ion release and the retention time of the varnish on the tooth surface. Commercial fluoride varnishes are susceptible to mechanical removal; therefore, patients are informed to avoid eating for a few hours and refrain from tooth brushing for 12–24 h, which results in patient inconvenience. However, the novel cyanoacrylate based fluoride varnish would not have these disadvantages. This study compared the daily fluoride ion release, abrasion resistance to brushing, and toxicity to human gingival fibroblasts (hGFs) between a newly-developed cyanoacrylate based fluoride varnish and Duraphat …
Human Health Risk Assessment Of Heavy Metals In Roadside Dust Near Hydropower Dams Construction Areas In Wangduephodrang District Of Bhutan, Kinley Dorjee
Chulalongkorn University Theses and Dissertations (Chula ETD)
The concern over the heavy metal laden dust and its impact on human health has gained global importance over the decade. Exposure to roadside dust is associated with various acute and chronic health issues. Bhutan too is battling environmental health issues due to increasing anthropogenic and developmental activities such as hydropower dam construction. This study analyses the heavy metals concentrations in roadside dust near hydropower dam construction areas and assesses the noncancer and cancer risk of exposure to heavy metals laden dust through inhalation. This study was a cross sectional study. The roadside dust samples near hydropower dam construction in …
ผลของชุดการพยาบาลเพื่อการดูแลช่องปากต่ออาการกระหายน้ำและภาวะปากแห้งของผู้ป่วยที่ใช้เครื่องช่วยหายใจ, ศุภชัย โม้งปราณีต
ผลของชุดการพยาบาลเพื่อการดูแลช่องปากต่ออาการกระหายน้ำและภาวะปากแห้งของผู้ป่วยที่ใช้เครื่องช่วยหายใจ, ศุภชัย โม้งปราณีต
Chulalongkorn University Theses and Dissertations (Chula ETD)
การวิจัยครั้งนี้เป็นการทดลองแบบไขว้กันวัดผลก่อนและหลังการทดลอง มีวัตถุประสงค์เพื่อศึกษาผลของชุดการพยาบาลเพื่อการดูแลช่องปากต่ออาการกระหายน้ำและภาวะปากแห้งของผู้ป่วยที่ใช้เครื่องช่วยหายใจ กลุ่มตัวอย่างที่ใช้ในการศึกษาครั้งนี้ คือ ผู้ป่วยที่ได้รับการใช้เครื่องช่วยหายใจที่มีอาการกระหายน้ำและภาวะปากแห้ง จำนวน 14 คน ที่เข้ารับการรักษาในหอผู้ป่วยสามัญ หอผู้ป่วยกึ่งวิกฤต หอผู้ป่วยวิกฤต โรงพยาบาลพระนั่งเกล้า เครื่องมือที่ใช้ในการวิจัยประกอบด้วยชุดการพยาบาลเพื่อการดูแลช่องปาก แบบบันทึกข้อมูลส่วนบุคคล แบบประเมินระดับอาการกระหายน้ำ แบบประเมินภาวะปากแห้ง ซึ่งผ่านการตรวจสอบความตรงตามเนื้อหาโดยผู้ทรงคุณวุฒิจำนวน 5 ท่าน หาค่าความเที่ยงของแบบประเมินระดับอาการกระหายน้ำโดยการทดสอบซ้ำ ได้ค่าความเที่ยงเท่ากับ .86 หาค่าความเที่ยงของแบบประเมินภาวะปากแห้ง โดยใช้สูตรสัมประสิทธิ์แอลฟาคอนบาค ได้ค่าความเที่ยงเท่ากับ .96 วิเคราะห์ข้อมูลโดยใช้สถิติเชิงพรรณนา สถิติ Paired-Samples t-test และ Wilcoxon signed rank test ผลการวิจัยสรุปได้ดังนี้ 1. อาการกระหายน้ำของผู้ป่วยภายหลังได้รับชุดการพยาบาลเพื่อการดูแลช่องปากต่ำกว่าภายหลังได้รับการพยาบาลตามปกติ อย่างมีนัยสำคัญทางสถิติที่ระดับ .05 2. ภาวะปากแห้งของผู้ป่วยภายหลังได้รับชุดการพยาบาลเพื่อการดูแลช่องปากต่ำกว่าภายหลังได้รับการพยาบาลตามปกติ อย่างมีนัยสำคัญทางสถิติที่ระดับ .05
Generalized Enamel Hypoplasia In A Dog: A Case Report, Issarin Sittijarusub, Panithi Sukho, Patchamon Supannawapat, Namphung Suemanotham
Generalized Enamel Hypoplasia In A Dog: A Case Report, Issarin Sittijarusub, Panithi Sukho, Patchamon Supannawapat, Namphung Suemanotham
The Thai Journal of Veterinary Medicine
A one-year-old, spayed female Welsh Corgi dog referred to the dental and oral clinic with chief complaint of apparent pitted, rough teeth surfaces, stained a tan to dark brown color. The dog was diagnosed with diffused enamel hypoplasia with no evidence of endodontic disease or malformation of tooth root. A restorative procedure with nanohybrid composite resin was performed. After treatment, the dog showed a good outcome with a smooth tooth surface, restorative material replaced to cover the previous defect and no evidence of pain or discomfort. Even though enamel hypoplasia is a rare, this condition remains an important problem that …
A Clinical Survey Investigating The Dental Disorders Of Jennies In China, Wuyan Jiang, Bo Liu, Yipeng Jin, Liang Deng, Qingchao Liao, Jing Li
A Clinical Survey Investigating The Dental Disorders Of Jennies In China, Wuyan Jiang, Bo Liu, Yipeng Jin, Liang Deng, Qingchao Liao, Jing Li
The Thai Journal of Veterinary Medicine
Recent clinical studies have documented a high prevalence of dental disorders in donkeys. However, there are few studies about the same topic in China. A cross-sectional study was performed to investigate the prevalence of clinically diagnosed dental disorders of donkeys in China. A total of 101 jennies which had never received any dental care were examined for the presence of dental disorders under small-holder farm conditions. The prevalence of dental disorders was analyzed by Chi‐square test or Fisher's exact correlation test. The strength of association was evaluated using Cramer's V test. Jennies between 2 and 15 years of age were …
Efficacy Of Chitosan Paste As Intracanal Medication Against Enterococcus Faecalis And Candida Albicans Compared To Calcium Hydroxide, Pasika Thien-Ngern
Efficacy Of Chitosan Paste As Intracanal Medication Against Enterococcus Faecalis And Candida Albicans Compared To Calcium Hydroxide, Pasika Thien-Ngern
Chulalongkorn University Theses and Dissertations (Chula ETD)
Introduction: Enterococcus faecalis and Candida albicans are frequently found in persistent endodontic infection and are resistant to calcium hydroxide (Ca(OH)2), a commonly used intracanal medication. Thus, an effective and safe antimicrobial medication against such refractory infection is necessary in endodontic retreatment, so we aimed to test the efficacy of chitosan paste against these microorganisms compared with Ca(OH)2 in root canals of extracted human teeth. Methods: Thirty-six sterilized human root samples prepared from extracted premolars and upper maxillary incisors were infected with E.faecalis for 14 days, while 32 were infected with C.albicans for 48 hours, for mature biofilm formation. The samples …
The Effectiveness Of Asiaticoside On Osteogenic Differentiation Ability In Aging Human Periodontal Ligament Cells In Vitro, Adisa Suthirathikul
The Effectiveness Of Asiaticoside On Osteogenic Differentiation Ability In Aging Human Periodontal Ligament Cells In Vitro, Adisa Suthirathikul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Retaining teeth is essential for the quality of life of the aging population. However, aging has biological effects in periodontal ligament cells with significant changes in their proliferative rate and regenerative function. Asiaticoside, extracted from Centella asiatica, was found to have potential in osteogenic differentiation and mineralization in human periodontal ligament cells (HPDLCs). The aim of this study is to investigate the effect of asiaticoside on the aging HPDLCs osteogenic differentiation and mineralization. Aging HPDLCs, retrieved from patients age 60 and above, were confirmed aging status using Senescence-Associated ß -Galactosidase assay. The cells were incubated with various concentrations of asiaticoside …
Impact Of Bacterial Dna In Severity Of Sepsis, Warerat Kaewduangduen
Impact Of Bacterial Dna In Severity Of Sepsis, Warerat Kaewduangduen
Chulalongkorn University Theses and Dissertations (Chula ETD)
Bacterial sepsis can be caused by intestinal damage, leading to the passage of viable bacteria and their components into the circulatory system. Bacterial-free DNA in the blood during sepsis can be derived from bacterial death and intestinal translocation of free DNA in the gut contents. The presence of bacterial DNA in combination with lipopolysaccharide (LPS) can lead to more serious outcomes of sepsis. To explore the impact of bacterial-free DNA in sepsis, animal and macrophage experiments were performed. Firstly, the appearance of bacterial-free DNA and bacteriome in the blood was presented in mice with cecal ligation and puncture sepsis. Secondly, …
Anti-Inflammatory And Regeneration Properties Of Iloprost On Inflamed Human Dental Pulp Cells Model: An In Vitro Study, Rahman Wahyudi
Anti-Inflammatory And Regeneration Properties Of Iloprost On Inflamed Human Dental Pulp Cells Model: An In Vitro Study, Rahman Wahyudi
Chulalongkorn University Theses and Dissertations (Chula ETD)
In the clinical situation, pulp exposure can happen during caries removal procedures. Inflammation can occur on the pulp of the exposed area because of infiltration of bacteria from caries or as a result of pulp reaction to caries removal drilling. When the pulp was exposed during the caries removal procedure, traditional methods to preserve the pulp such as pulp capping and pulpotomy were performed. The ideal treatment outcome of the pulp exposure is to regain the primary structure of tubular dentin as well as maintain the vitality and healthiness of the dental pulp Thus, good dental materials or drugs used …
Differences Of Sound And Morphology In Skeletal Class Iii Patients, Natthaporn Pravitharangul
Differences Of Sound And Morphology In Skeletal Class Iii Patients, Natthaporn Pravitharangul
Chulalongkorn University Theses and Dissertations (Chula ETD)
[Background] This study aimed to explore differences in vowel production using acoustic analysis in skeletal Class III and Class I Japanese participants, and to investigate the correlation between vowel sounds and cephalometric variables in skeletal Class III subjects. [Materials and Methods] Japanese males with skeletal Class III (ANB<0°) and Class I skeletal relationships (0.62°
Cellular Responses Of Stem Cells Isolated From Human Exfoliated Deciduous Teeth Towards Different Concentration Of Calcium Ion, Thanika Phlinyos
Cellular Responses Of Stem Cells Isolated From Human Exfoliated Deciduous Teeth Towards Different Concentration Of Calcium Ion, Thanika Phlinyos
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: The purpose of this study was to investigate the effect of Ca2+ on proliferation, osteogenic differentiation, and migration of stem cells from human exfoliated teeth (SHEDs) in vitro Materials and methods: SHEDs were seeded in culture media and osteogenic induction media containing 1.8-16.2 mM of Ca2+. SHEDs proliferation was determined using MTT assay and colony forming unit assay. Osteogenic differentiation was evaluated using mineralization assay and osteogenic marker gene expression and cell migration was evaluated using wound healing assay. Values were expressed as mean + S.D. Statistical analysis of MTT assay and wound healing assay were performed using two-way …
Expression Of Vascular Endothelial Growth Factor Protein In Mrna-Transfected Human Periodontal Ligament Cells, Mana Naratippakorn
Expression Of Vascular Endothelial Growth Factor Protein In Mrna-Transfected Human Periodontal Ligament Cells, Mana Naratippakorn
Chulalongkorn University Theses and Dissertations (Chula ETD)
The complete regeneration of periodontal tissues following current periodontal therapy remain challenging and unpredictable. Nucleoside-modified messenger RNA (mRNA) technology can be a promising novel platform in regenerative medicine. The aims of this study were to evaluate whether pseudouridine modified mRNA encoding vascular endothelial growth factor (VEGF) could induce VEGF production in human periodontal ligament cells (PDLCs) and this translated protein function by promoting in vivo blood vessel formation using chorioallantoic membrane (CAM) assay. Isolated PDLCs from healthy periodontal tissue were transfected with modified mRNA encoding VEGF (VEGF mRNA) complexed with a transfecting agent, Lipofectamine 2000 (L2000) and L2000 alone (control). …
Extraction Of Cannabinoids Using Vegetable Oils And Its Uva-Photoprotective Effect On Human Skin Keratinocytes, Nur Alfan Muhammad Zen
Extraction Of Cannabinoids Using Vegetable Oils And Its Uva-Photoprotective Effect On Human Skin Keratinocytes, Nur Alfan Muhammad Zen
Chulalongkorn University Theses and Dissertations (Chula ETD)
Nowadays, vegetable oil has attracted attention in its role as an alternative solvent. Its ability to dissolve various active compounds from plants has been proven by several previous studies. Moreover, other benefits of the use of vegetable oil as a solvent are affordable, non-toxic, and eco-friendly. The extraction process is one of the crucial factors that affect the quality of cannabis. Ethanol is still consistently the best solvent for cannabis extraction in terms of yield production compared to other organic solvents used in this study including oil whose yield cannot be calculated since vegetable oil cannot be evaporated. HPTLC fingerprint …
การพัฒนาเจลก่อตัวเองของยาด็อกซีไซคลินสำหรับรักษาโรคปริทันต์อักเสบ, สิริกาญจน์ หิรัญธนวิวัฒนา
การพัฒนาเจลก่อตัวเองของยาด็อกซีไซคลินสำหรับรักษาโรคปริทันต์อักเสบ, สิริกาญจน์ หิรัญธนวิวัฒนา
Chulalongkorn University Theses and Dissertations (Chula ETD)
โรคปริทันต์อักเสบเป็นโรคในช่องปากชนิดหนึ่งที่พบมากในปัจจุบัน ซึ่งเป็นภาวะการอักเสบของเหงือกที่เกิดการทำลายเนื้อเยื่อโดยรอบที่รองรับฟัน ยาด็อกซีไซคลิน ไฮเคลต (doxycycline hyclate; DH) นิยมใช้กันอย่างแพร่หลายสำหรับการรักษาโรคติดเชื้อแบคทีเรียรวมถึงการรักษาโรคปริทันต์อักเสบ ปัจจุบันระบบเจลก่อตัวเอง (in situ forming gel system) เป็นระบบการนำส่งยาที่ได้รับความสนใจเพิ่มมากขึ้นสำหรับการนำส่งยาในช่องปาก โดยเป็นระบบนำส่งในรูปแบบของสารละลายแต่เมื่อสัมผัสกับร่างกายจะสามารถเปลี่ยนสถานะจากสารละลายกลายเป็นเจลได้โดยขึ้นกับปัจจัยทางสภาพแวดล้อม จุดประสงค์ของการศึกษานี้คือการพัฒนาเจลก่อตัวเองของยา DH ให้มีการปลดปล่อยยาอย่างต่อเนื่อง โดยเตรียมสูตรตำรับเจลก่อตัวเอง 15 สูตร ซึ่งประกอบด้วย poloxamer407; P407 (16%w/w), poloxamer188; P188 (0, 1, 2.5, 5, 10%w/w) และ hydroxypropyl methylcellulose; HPMC (0, 0.2, 0.5%w/w) ด้วยวิธีร้อนและเย็น แล้วทำการศึกษาลักษณะทางเคมีกายภาพ ปริมาณยา คุณสมบัติการยึดติดเยื่อเมือก ความหนืด ความคงตัว และการปลดปล่อยตัวยาของสูตรตำรับ พบว่าสูตรตำรับเจลก่อตัวเองทั้งหมดแสดงลักษณทางเคมีกายภาพเป็นสารละลายสีเหลืองใส มีค่า pH อยู่ในช่วง 6.45-6.81 ระบบเจลก่อตัวเองของยา DH ที่ได้รับการพัฒนาโดยมีส่วนผสมของ P407 16% w/w, P188 5% w/w และ HPMC 0.5%w/w (F14) แสดงอุณหภูมิการเกิดเจลที่ 35±0.57°ซ และการคงอยู่ของตัวยาบน semipermeable membrane ที่เคลือบด้วย mucin ได้ร้อยละ 43.51±0.003 โดยมีลักษณะการปลดปล่อยอย่างต่อเนื่องเป็นเวลานาน 24 ชั่วโมง และพบว่าที่อุณหภูมิ 37°ซ สูตรตำรับมีความหนืดเพิ่มขึ้นอย่างมีนัยสำคัญทางสถิติ (p<0.05) อย่างไรก็ตาม ตำรับที่พัฒนาขึ้นเกิดการเปลี่ยนสีเมื่อเวลาผ่านไปและเมื่อเก็บไว้ที่อุณหภูมิสูง จึงควรมีการพัฒนาสูตรตำรับเพิ่มเติมต่อไปเพื่อให้มีความคงตัวดียิ่งขึ้น
Impact Of Early Childhood Caries On Oral Health-Related Quality Of Life Among 5-Year-Old Children In Mandalay, Myanmar, Saw Nay Min
Chulalongkorn University Theses and Dissertations (Chula ETD)
Purpose: The study aimed to develop the cross-cultural adaptation and psychometric properties of the Myanmar Version of SOHO-5 and assess the impact of ECC on oral health quality of life among 5-year-old children in Mandalay using the Myanmar version of the SOHO-5 questionnaire. Materials and methods: The Myanmar SOHO-5 version was conducted with the forward-backward translation method and investigated the content validity, internal consistency, test-retest reliability, construct validity, and discriminant validity on 5-year-old children and their parents in phase I. A cross-sectional study was conducted using a self-administered questionnaire to investigate the impact of ECC and relative factors on the …
A Comparison Of Implant Stability Between Two Dental Implant Designusing Two Different Stability Measuring Technique, Chanikarn Chaksupa
A Comparison Of Implant Stability Between Two Dental Implant Designusing Two Different Stability Measuring Technique, Chanikarn Chaksupa
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective To investigate the primary stability of aggressive thread design implant comparing to nonaggressive thread design implant and to evaluate the correlation between ISQ values and IST values. Materials and methods 96 implants were used in this study. 48 BLT Straumann® and 48 BLX Straumann® were used. All implants were digitally planned and placed in 3D printed model using computer assisted guided surgery. The edentulous area at models were packed with randomized pattern of four different kinds of polyurethane blocks to replicate mixed cancellous bone. Postoperative implant stability measurement was performed immediately after implant insertion. Implant stability was measured by …
Alteration Of Extracellular Matrix Components In Anterior Pituitary Gland Of Neonatal Rats Induced By Maternal Bisphenol A (Bpa) Diet During Pregnancy, Bumpenporn Sanannam
Alteration Of Extracellular Matrix Components In Anterior Pituitary Gland Of Neonatal Rats Induced By Maternal Bisphenol A (Bpa) Diet During Pregnancy, Bumpenporn Sanannam
Chulalongkorn University Theses and Dissertations (Chula ETD)
Bisphenol A (BPA) is a well-known endocrine-disrupting chemical that is widely used in the resin and plastic manufacturing sectors. Prenatal exposure to this chemical results in changes of pituitary hormone-producing cells. However, there have been no reports of the alterations of extracellular matrix (ECM) which play a role in controlling cell activities in the pituitary gland. In the present study, a daily oral dose of 5,000 µg/kg BW of BPA was administered to pregnant rats. ECM-producing cells, i.e., pericytes and folliculostelate cells, ECM products, and ECM regulators were investigated in the neonatal anterior pituitary at day 1 at the histology …
Effect Of Remaining Dentin Thickness And Primer Application Technique On Microtensile Bond Strength, Paphawee Somrit
Effect Of Remaining Dentin Thickness And Primer Application Technique On Microtensile Bond Strength, Paphawee Somrit
Chulalongkorn University Theses and Dissertations (Chula ETD)
To evaluate the effect of primer application techniques, type of adhesives and remaining dentin thicknesses on microtensile bond strength (µTBS) of 4 different adhesive systems, 112 Flat occlusal surfaces of sound third molar were randomly allocated into 16 groups based on 2 remaining dentin thicknesses (RDT), 2 application techniques and 3 adhesive systems, e.g., Three step etch-and-rinse (Optibond FL; OFL), Two step self-etch (Clearfil SE Bond; CSE), and Universal adhesive (Single Bond Universal; SB). SB was applied in either etch-and-rinse (ER) or self-etch (SE) mode. Simulated pulpal pressure was performed during bonding procedure and 6-month water storage (37 oC). After …
The Impact Of An Alkasite Restorative Material On The Ph Of A Streptococcus Mutans Biofilm And Dentin Remineralization: An In Vitro Study, Pawinee Wiriyasatiankun
The Impact Of An Alkasite Restorative Material On The Ph Of A Streptococcus Mutans Biofilm And Dentin Remineralization: An In Vitro Study, Pawinee Wiriyasatiankun
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study investigated the effect of an alkasite material on the pH of Streptococcus mutans biofilm and dentin hardness. S. mutans biofilms were formed on a resin composite (FZ) and an alkasite (CN) materials and their pH determined after 24 h. Hydroxide, fluoride and calcium ions released from the materials were determined at 6 h, 1, 3, 7, 14, and 28 d. Fourteen human molar teeth were cut horizontally across the middle third of the crown, bisected mesio-distally into two sections and each section divided into two, yielding four quadrants. Quadrant 1 was a sound dentin control, quadrants 2-4 were …
Effect Of Shear Force On Immunosuppressive Property Of Human Periodontal Ligament Cells, Ravipha Suwittayarak
Effect Of Shear Force On Immunosuppressive Property Of Human Periodontal Ligament Cells, Ravipha Suwittayarak
Chulalongkorn University Theses and Dissertations (Chula ETD)
The immunomodulatory property is to regulate immune cell function. IDO and TGF-β1 inhibited T cell proliferation and induced regulatory T (Treg) cells differentiation. However, this property must be activated by inflammation. Recently, mechanical forces have also activated this property. Hence, this study investigated effect of shear stress on immunosuppressive property of hPDL cells. Cells were subjected to shear stress then expression of IDO, TGF-β1, IFN-gamma and COX2 mRNA and protein was examined by qRT-PCR, ELISA, and IDO activity. Conditioned media derived shear stress were treated with CD4+ T cells. The proliferative T cell effect was determined using resazurin. The FOXP3, …
Efficacy Of Cannabidiol (Cbd) For The Treatment Of Recurrent Aphthous Ulcers, Chalapinyo Umpreecha
Efficacy Of Cannabidiol (Cbd) For The Treatment Of Recurrent Aphthous Ulcers, Chalapinyo Umpreecha
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objectives of this research were 1) To investigate the allergic reactions to cannabidiol (CBD) when used on human skin. 2) To assess local and systemic side effects of CBD when used on normal oral mucosa. 3) To compare the efficacy among 0.1% CBD, 0.1% triamcinolone acetonide (TA), and placebo (pure oral paste) in recurrent aphthous ulcer (RAU) treatment. This project was composed of 3 phases. Phase 1, a skin patch test was performed on 100 healthy subjects. Phase 2, CBD was applied to normal oral mucosa of 50 healthy subjects 3 times/day for 7 days. Oral examination, vital signs, …
Effects Of Local Versus Systemic Administration Of Cxcr4 Inhibitor Amd3100 On Orthodontic Tooth Movement In Rats, Narubhorn Ongprakobkul
Effects Of Local Versus Systemic Administration Of Cxcr4 Inhibitor Amd3100 On Orthodontic Tooth Movement In Rats, Narubhorn Ongprakobkul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Chemokines play pivotal roles in orthodontic tooth movement (OTM) through osteoclast-mediated bone resorption, but the underlying mechanism remains unclear. We aimed to elucidate the effects of serial local vs systemic administration of the chemokine receptor CXCR4 antagonist AMD3100 on OTM. The maxillary right first molar (M1) of rats was moved mesially using a 10 g of force nickel-titanium coil spring. The injections were performed every other day with phosphate-buffered saline as a control, whereas local and systemic animals were injected with AMD3100 at the buccal palatal mucosa adjacent to M1 and subcutaneously, respectively. OTM distance and alveolar bone were examined …
Antifungal, Physical, And Mechanical Properties Of Tissue Conditioner Incorporated With Zinc Oxide Nanoparticles, Woraporn Homsiang
Antifungal, Physical, And Mechanical Properties Of Tissue Conditioner Incorporated With Zinc Oxide Nanoparticles, Woraporn Homsiang
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study evaluated the antifungal, physical, and mechanical properties of tissue conditioner incorporated with different amounts of zinc oxide nanoparticles (ZnOnps) at different storage times (0, 7, and 14 days). Specimens of 0, 5, 10, 15 wt% ZnOnps, or 15 wt% nystatin incorporated into tissue conditioner were fabricated. The direct contact test (n=6) was performed to evaluate the antifungal effect against C. albicans suspension. Scanning electron microscopy and energy dispersive X-ray spectroscopy (n=6) were used to observe the amount and distribution of superficial zinc element. The penetration depth (n=6) and tensile bond strength (n=8) were evaluated following ISO 13139. The …