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Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

John W. Rebuck Md, Phd, Raymond W. Monto

Henry Ford Hospital Medical Journal

No abstract provided.

Functions And Interrelationships Of Leukocytes In Inflammation As Elucidated By The Rebuck Skin Window Technique, Sheikh M. Saeed

Henry Ford Hospital Medical Journal

This article provides an overview of the functions of human leukocytes in inflammation as elucidated by the Rebuck skin window technique. The migration sequence of various leukocytes into the field of inflammation is described, as well as cytologic, cytochemical, and transformational changes, and the interrelationships of responding leukocytes. Since it was introduced in 1955, the Rebuck skin window technique has provided an excellent means of studying in vivo inflammatory response to different phlogistic agents in normal individuals and in various disease states. This simple technique continues to prove fruitful to further study and to monitoring of many disease states.

Igg Lymphoplasmacytic Intestinal Lymphoma: A Case Report, Heidrun Z. Rotterdam, Sheldon C. Sommers

Henry Ford Hospital Medical Journal

We describe a rare case of a localized primary small intestinal lymphoma with features of both the Mediterranean and the Western type. This case demonstrates the need to regard intestinal lymphoma as a spectrum of diseases with the Mediterranean and the Western types at opposite ends and many variants in between. The role of the plasma cell infiltrate has been interpreted as reactive as well as neoplastic. In our case, both lymphocytic and plasmacytic proliferations spread widely in the intestinal submucosa, extended into muscularis propria and subserosal fat, and involved mesenteric lymph nodes. Direct immunofluorescence demonstrated IgG-kappa both in plasma …

Sequential Electron Micrography Of Sickling, J. W. Rebuck, R. M. Sturrock, R. W. Monto

Henry Ford Hospital Medical Journal

No abstract provided.

The Role Of High Molecular Weight Kininogen (Fitzgerald Factor) In The Activation Of Various Plasma Proteolytic Enzyme Systems, R. Waldmann, A. G. Scicli, J. Guimaraes, G. Scicli, Oscar A. Carretero, H. Kato, Y. N. Han, S. Iwanaga

Henry Ford Hospital Medical Journal

Bovine high molecular weight kininogen (bHMWK) partially corrects the aPTT of Fitzgerald-trait plasma, which is congenitally deficient in HMWK. The relationship between the structure and activity of HMWK was clarified by studying the effects of different fragments of bHMWK on the aPTT of Fitzgerald-trait plasma. The peptides studied, all in equimolar concentrations, were lys-bradykinin-free HMWK, bradyk In In-fragment 1-2-tree HMWK, heavy chain, fragment 1 -2-Hght chain, and light chain. Bradykinin- fragment 1-2-free HMWK, heavy chain, and light chain have little or no correcting activity upon Eitzgeraldtrait plasma aPTT. Fragment 1-2 light chain has the same correcting activity as intact bHMWK, …

Acute Inflammatory Response In Experimental Skin Lesions Of Patients With Ankylosing Spondylitis, Gilbert H. Bluhm, Honora H. Mcelroy, Jeanne M. Riddle, John W. Sigler

Henry Ford Hospital Medical Journal

Two different stimuli, tetanus toxoid (TT) and autologous fibrin (AF), were used to investigate the inflammatory response in ten patients with ankylosing spondylitis (AS); in seven persons who had a family history of AS and were HLA-627 positive but had no clinical signs of AS; and in eight nonarthritic controls. The purpose was to determine whether the leukocytic response in an experimental Rebuck skin window lesion was the same or different from that seen in the synovial fluid of AS patients when in vivo-formed fibrin flakes were present. Four lesions were produced on each subject, with TT added to one …

Functional And Biochemical Alterations Of Platelets In Atherosclerosis And Thromboembolism, Orhan N. Ulutin

Henry Ford Hospital Medical Journal

In atherosclerosis, platelets appear to circulate in an activated state. Our findings are based on results obtained from 240 patients. These platelets demonstrated an increased degree of surface activation and an increased amount of aggregation. Platelet aggregation was also demonstrated by a heightened sensitivity to adrenalin and ADP. Greater than normal secretion of ADP, PF-4, platelet fibrinogen, and platelet antiplasmin was noted. Platelet antiplasmin was increased, whereas platelet antithrombin III was decreased. Membrane transport of glucose was found to be defective in atherosclerosis. There appears to be no alteration in the phospholipid distribution, although the amount of phospholipids increases. The …

The Chediak-Higashi Syndrome: Spectrum Of Giant Organelles In Peripheral Blood Cells, James G. White, C. C. Clawson

Henry Ford Hospital Medical Journal

The presence of giant organelles in the cytoplasm of peripheral blood elements is diagnostic for the Chediak-Higashi syndrome. These abnormal cytoplasmic inclusions are found within neutrophils, eosinophils, basophils, lymphocytes, monocytes, and platelets. Their fine structural characteristics differ. Neutrophils demonstrate striking variability in the size, shape, and internal features of their giant organelles. Lymphocytes contain two different types of giant inclusions, one with a smoothly homogeneous substructure, the other with structures resembling microtubules. Emphasizing the ultrastructural similarities and differences of these anomalous granulations may provide valuable clues for understanding the basic defect of this inherited disorder.

Vital Signs, September, 1979, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

Newsletter, Volume 24, Number 05, September - October 1979, Daniel L. Stout Phd, Frederick L. Becker Md, Norah Duv Tapley Md, Keith A. Aldinger Md

Newsletter: A Report to Physicians of Texas Archives

• Progressive DNA Damage in Hepatic Nodules during Acetylaminofluorene Carcinogenesis
• Radiation Therapy with the Electron Beam
• Thoracic Oncology Clinic
• History of Human Cytogenetics Published
• Thyroid-Stimulating Hormone and Prolactin Levels in Breast Cancer
• New Books on Nutrition Published
• Regents Appoint New Chair and Professorship

New Mexico Location List Of Alumni And Former Housestaff, Unm School Of Medicine Alumni Office

University of New Mexico School of Medicine Location Report

This report relates the locations of UNM School of Medicine Alumni and Housestaff as well as other information about School of Medicine graduates.

The Application Of Techniques For Specific Staining And Enhancement To The Ultrastructural Study Of The Pancreatic Islands Of Langerhans, Vern Leonard Shellman

Masters Theses

No abstract provided.

The Role Of Exercise And Nutrition In The Rehabilitation Of The Geriatric, Robert R. Ladd

Loma Linda University Electronic Theses, Dissertations & Projects

[Abstract not included]

Vital Signs, July, 1979, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

Digest Of The Philadelphia College Of Osteopathic Medicine (Summer 1979), Philadelphia College Of Osteopathic Medicine

Digest

The Summer 1979 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• The President's Page
• Commencement
• Twenty Years Later
• Honorary Degree Recipients
• Commencement Dinner
• Awards
• Organizational Changes
• Annual Fund Report
• Alumni News Briefs
• New Appointments
• Faculty Notes
• Nursing Reunions
• News from the College
• News from the Hospital and Health Care Centers
• Class of 1979 Internships
• In Memoriam
• Synapsis 1980

Newsletter, Volume 24, Number 04, July - August 1979, Gerald P. Bodey Md, Emil J. Freireich Md, Kenneth B. Mccredle Md

Newsletter: A Report to Physicians of Texas Archives

• Prolonged Remissions in Adults with Acute Leukemia
• Conference on Sexual rehabilitation
• Citation Classic Designated
• Regional Hyperthermia
• Therapy-Related Sequelae for Childhood Urologic Cancer
• Hilkemeyer Honored
• Staff Members Honored
• Portrait Univeiled
• Clark Attends Dubrovnik Meeting

Detection Of Unique Tumor-Associated Proteins In The Urine Of Patients With Transitional Cell Carcinoma By High Resolution Two-Dimensional Polyacrylamide Gel Electrophoresis, Robert David Lehman

Biological Sciences Theses & Dissertations

A two-dimensional polyacrylamide gel electrophoretic technique was developed for the detection of unique tumor-associated proteins in urine of patients with transitional cell carcinoma (TCC) of the urinary bladder. This technique yielded high resolution of polypeptides in the urine of cancer patients. Urine was chosen as a source of tumor-associated components because the location of the tum or should release already solublized tum or substances in to the urine.

Urinary proteins were concentrated and then analyzed by the two - dimensional electrophoretic technique using isoelectric focusing in the first dimension and sodium dodecylsulfate - polyacrylamide gel electrophoresis in the second dimension. …

The Management Of Iatrogenic Chylous Ascites, Joseph W. Lewis, Edward H. Storer

Henry Ford Hospital Medical Journal

Iatrogenic chylous ascites, although extremely rare, appears to follow direct lymphatic injury during intra-abdominal surgery or to be due to specific postoperative complications such as pancreatitis. Statistically, truncal vagotomy has produced the largest number of cases. Any noticeable lymphatic injuries at the time of surgery should be controlled with appropriate sutures or clips. If iatrogenic chylous ascites develops postoperatively, a course of conservative treatment including multiple paracenteses should be tried for several weeks if reasonable nutritional balance can be maintained. If fluid volume does not diminish or the patient's nutritional status is jeopardized, early exploration should be undertaken. A lipophilic …

Percutaneous Transfemoral Renal Artery Occlusion In The Management Of Advanced Renal Carcinoma, Douglas E. Johnson

Henry Ford Hospital Medical Journal

This report describes renal artery occlusion as a therapeutic alternative to nephrectomy and chemotherapy in treating patients with metastatic renal carcinoma. Using a combination of Gelfoam and the Gianturco stainless steel coil, embolization was performed on 75 patients at the University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute with promising results. Its use is recommended 1) to facilitate surgical removal of large and difficult tumors, 2) to control local symptoms (pain, bleeding, etc), and 3) as part of a planned therapeutic program consisting of infarction, nephrectomy and progestins for patients with minimal to moderate metastatic disease.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Surgical Treatment For Renal Cell Carcinoma, Robert Di Loreto, Joseph C. Cerny

Henry Ford Hospital Medical Journal

Despite recent advances in chemotherapy, radiation therapy and immunology, renal cell carcinoma can best be treated by early detection and radical surgery. Today, radical nephrectomy is the standard surgery of choice for removing malignant renal tumors. Of the surgical procedures that have been used in the past, the transabdominal incision offers the best exposure of retroperitoneal structures at the diaphragmatic level and the contralateral renal vasculature. Occasionally, supraradical procedures are recommended if tumor size and location require this approach.

Bilateral Renal Cell Carcinoma: Two Case Reports, Riad N. Farah

Henry Ford Hospital Medical Journal

No abstract provided.

Henry Ford Hospital Clinicopathological Conference

Henry Ford Hospital Medical Journal

No abstract provided.

Letters To The Editor

Henry Ford Hospital Medical Journal

No abstract provided.

Management Of Renal Cell Carcinoma: Evaluation Of Renal Masses By Modem Radiological Techniques, W. R. Eyler, M. A. Sandler, S. C. Cross, B. L. Madrazo

Henry Ford Hospital Medical Journal

The utilty of ultrasound and computed tomography is compared to angiography and that of nephrotomography in the study of renal masses. Ultrasound and computed tomography, noninvasive methods, are replacing nephrotomography and, in some cases, angiography

The Role Of Radiation Therapy In Renal Carcinoma, Joel Elliot White

Henry Ford Hospital Medical Journal

In the treatment of renal adenocarcinoma, radiation therapy alone is insufficient. Preoperative radiation increases the resectability rate and delays metastasis, but overall improvement in survival is tentative. Postoperative radiation has not been of proven benefit. While palliation may be achieved, relatively high doses of radiation are required.

Diagnostic And Therapeutic Immunology Of Renal Cell Cancer, Richard C. Klugo

Henry Ford Hospital Medical Journal

There is evidence that renal cell carcinoma can alter the host immunologic system in several modalities. Diagnostic immunologic monitoring techniques reviewed in this report include delayed cutaneous hypersensitivity reaction (DCHR), absolute peripheral lymphocyte count (APLC), lymphocyte mitogen response (LMR), T-lymphocyte population (erythrocyte rosette), microcytotoxicity assay, in vitro monocyte chemotaxis, and serum blocking factors. Therapeutic immunologic modalities include xenogeneic immune ribonucleic acid (RNA), intradermal BCG, preoperative transcatheter renal artery embolization, immune plasma transfusion, transfer factor, and polymerized autologous tumor.

Chemotherapy Of Metastatic Renal Adenocarcinoma With A Five- Drug Regimen*, Robert W. Talley, N. A. Oberhauser, Robert W. Brownlee, Robert M. O'Bryan

Henry Ford Hospital Medical Journal

In the past, chemotherapy of renal adenocarcinoma has been relatively unsuccessful. The progestational agent, medroxy progesterone acetate (MPA), has been the most effective single agent, even though the response rate probably does not exceed 12%. This report describes the results of a program of combination therapy with MPA, cyclophosphamide, hydroxyurea, vinblastine and prednisone that was used on 42 patients, ten of whom had received prior MPA therapy. One complete remission and seven partial remissions were observed, oniyone of whom had received prior MPA therapy. Treatment of metastatic renal adenocarcinoma with combination chemotherapy should probably include MPA and adriamycin. The role …

Evaluation Of A Simplified Measurement For Low Glomerular Filtration Rates With Lndium-111 Dtpa, L. E. Preuss, R. S. Michaels, F. P. Bolin, N. W. Levin, C. Artman

Henry Ford Hospital Medical Journal

A rapid new method for measuring glomerular filtration rates using 111In diethylenetriamine pentaacetic acid (111In- DTPA) was evaluated with 39 patients who showed marked impairment of renal function (creatinine clearance less than 20 ml/min). A simple, single compartment system was assumed. For comparison, parallel inulin and creatinine clearances were performed. High linear correlations (r = 0.96-0.97) were demonstrated when 111In- DTPA clearances were compared with the standard nonisotopic tests. Initial data indicate that reliable isotopic clearance values could be obtained for low clearances by withdrawing only two blood samples for assay at 6 and 48 hours after isotope injection (without …