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Acute Burkitt's Leukemia: Case Report And Literature Review, S. Raman, S. M. Saeed, K. R. Kini

Henry Ford Hospital Medical Journal

The occurrence of leukemia in Burkitt's lymphoma, with or without visceral or nodal tumefaction is uncommon, and its initial presentation as leukemia is even more unusual. Because it has a poor chemotherapeutic response and a grave prognosis, it is important to recognize this unusual leukemia correctly. Our report describes the clinical and pathologic findings of Burkitt's lymphoma cell leukemia in a five-year-old white boy who presented with abdominal distension, hepatosplenomegaly, and lymphadenopathy. Blood examination revealed normocytic normochromic anemia, erythroblastosis, slight leukocytosis, and the presence of numerous (24%) blasts. A diagnosis of Burkitt's lymphoma was established on the basis of morphologic, …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Zoonoses In Modern Medical Practice, Tom Madhavan

Henry Ford Hospital Medical Journal

Zoonoses are infections transmitted by animals to man. Of the more than 50 such infections that are clinically significant, several are discussed in the articles by McIntosh and Madhavan and by Meyer and Adar in this issue of the Journal (pp. 7-13). These include brucellosis, leptospirosis, relapsing fever, Colorado tick fever, toxoplasmosis, psittacosis, and echinococcosis. The McIntosh and Madhavan article reviews the experience at Henry Ford Hospital with 60 patients, while the article by Meyer and Adar reports on an unusual case of echinococcosis of the spine and retroperitoneum that occurred at Haim Sheba Medical Center in Israel.

Zoonoses At Henry Ford Hospital: Clinical, Epidemiologic, And Therapeutic Aspects, Nancy Mcintosh, Tom Madhavan

Henry Ford Hospital Medical Journal

Zoonoses are diseases of animals that can be transmitted to humans. We reviewed the experience with zoonotic illnesses treated at Henry Ford Hospital in the past ten years. Included in this report are cases of brucellosis, leptospirosis, relapsing fever, Colorado tick fever, toxoplasmosis, psittacosis, and pasteurellosis. This report describes the clinical and epidemiologic aspects of zoonoses in 60 patients in a large urban general hospital.

Echinococcosis Of The Spine And Retroperitoneum: Case Report And Review Of The Literature, Eugene Meyer, Raphael Adar

Henry Ford Hospital Medical Journal

Echinococcosis is a zoonosis transmitted from sheep dogs to humans. It occurs most frequently in sheep and cattle-raising countries, and children who come in contact with sheep dogs are the most likely victims. The liver and the lungs are the most common sites of the hydatid cysts. Their presence in other organs is less common, and primary hydatidosis of the retroperitoneum is extremely rare. In the case reported here, a 65-year-old man had secondary retroperitoneal echinococcosis that recurred three times in 23 years. On the third occasion, marsupialization was performed on a large cyst found in the right retroperitoneum.

Racial Differences In The Incidence Of Steroid Diabetes In Renal Transplant Patients, Francis Dumler, Hajime Hayashi, Jay Hunter, Nathan W. Levin

Henry Ford Hospital Medical Journal

We have studied the development of steroid-induced diabetes in a population of 143 renal allograft recipients who were nondiabetic before transplantation. Steroid-induced diabetes developed In 9.8% of patients. However, in blacks its incidence was significantly higher than in whites (17.3% vs 5.5% respectively; p < .01). The development of steroid-induced diabetes was not associated with a higher frequency of HLA-B8 or HLA-Bw15 in either race. In black graft recipients, HLA-B14 was significantly more frequent (p < .001) among those who developed steroid-induced diabetes than in insulin-dependent diabetic (Type I) and nondiabetic recipients. The clinical course of patients with steroid-induced diabetes has been similar to that of noninsulin-dependent diabetics (Type II).

Cytopathology Of Thyroid Nodules, Sudha R. Kini, J. Martin Miller, Joel I. Hamburger

Henry Ford Hospital Medical Journal

Fine needle aspiradon biopsy is a simple and accurate means of obtaining a tissue diagnosis for a thyroid nodule. Our experience with 3,000 such biopsies and 242 surgically proven cancers has enabled us to characterize the cytologic presentations of the common "nodular" thyroid diseases. We can readily identify nodular goiter and papillary, poorly differentiated follicular, medullary, anaplastic, and metastatic cancers. Benign follicular neoplasms and well-differentiated follicular cancers cannot be separated with great accuracy, but useful predictions can be made. Care is required to recognize the cellular abnormalities of autoimmune thyroiditis and to diagnose the coexistence of this disease with malignant …

The Facioscapulohumeral Syndrome: A Report Of Two Cases, J. Kaner, J. Zuniga, Robert D. Teasdall

Henry Ford Hospital Medical Journal

Two patients developed progressive muscle weakness in adult life. The initial diagnosis of polymyositis was made in both cases, but subsequent studies and the distribution of muscle involvement suggested facioscapulohumeral myopathy. Other investigators have proposed that this syndrome may result from either genetic or acquired causes. In our patients, the disorder was probably a sequela of polymyositis.

Editorials, Raymond C. Mellinger, Stanley R. Nelson, Fred W. Whitehouse

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Newsletter, Volume 27, Number 02, March - April 1982, Helmuth Goepfert Md

Newsletter: A Report to Physicians of Texas Archives

• Design of a Treatment Program for Cancer of the Skin of the Nose Is Based on Many Factors, Helmuth Goepfert, MD
• UT MDAH Staff Helps Clergymembers Meet Needs of Their Parishioners
• Scientists Examine Breakthroughs in Molecular Biology and their Application to cancer research at 35th Symposium
• Pediatric Patients Undergo Unconventional Rehabilitation
• New Book Published
• Noteworthy

Vital Signs, February 1982, Boonshoft School Of Medicine

Vital Signs

A six page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Air War College Seminar Program, 1982, Lowell M. Hardy Do

Personal and Professional Papers

No abstract provided.

Treatment Of Inborn Errors Of Urea Synthesis — Activation Of Alternative Pathways Of Waste Nitrogen Synthesis And Excretion, Mark L. Batshaw , M.D., Saul Brusilow , M.D., Lewis Waber , Ph.D., M.D., Wim Blom , Ph.D., Ann Mari Brubakk , M.D., Barbara K. Burton , M.D., Howard M. Cann , M.D., Douglas Kerr , M.D., Peter Mamunes , M.D., Reuben Matalon , M.D., David Myerberg , M.D., Irwin A. Schafer , M.D.

Pediatrics Publications

Abstract

Children with inborn errors of urea synthesis accumulate ammonium and other nitrogenous precursors of urea, leading to episodic coma and a high mortality rate. We used alternative pathways for the excretion of waste nitrogen as substitutes for the defective ureagenic pathways in 26 infants. These pathways involve synthesis and excretion of hippurate after sodium benzoate administration, and of citrulline and argininosuccinate after arginine supplementation.

The children were treated for seven to 62 months; 22 survived. The mean plasma level of ammonium (±S.E.) was 36±2 μmol per liter, and that of benzoate was 1.5±1.0 mg per deciliter. Alternative pathways accounted …

Ua35/11 Student Honors Research Bulletin, Wku Honors Program

WKU Administration Documents

The WKU Student Honors Research Bulletin is dedicated to scholarly involvement and student research. These papers are representative of work done by students from throughout the university.

• Garvin, Catherine. The Recognition of Anticipatory Grieving and Associated Needs of the Family of a Critically Ill Patient
• Parks, Barbara. Energy Properties of Textiles
• Martin, Lanna. A Historical Approach to the Understanding of Civil Disobedience
• Atwood, Tammy. The Computer Manufacturing Industry and the Burroughs Corporation
• Allen, Christopher. The Battle of Marathon: Athens' Magnificent Triumph
• Martin, Lanna. Melville's Creation of Captain Vere as Pontius Pilate in Billy Budd
• Boles, Barbara. Emerson's Uriel and the …

Immunological Approaches To The Diagnosis Of Systemic Candidiasis, Gene Elizabeth Burges

MUSC Theses and Dissertations

The increasing incidence of systemic candidiasis and the difficulties diagnosing the disease on the basis of clinical data and culture results have prompted investigation into immunological methods of diagnosis. Detection of anti-Candida antibodies has proved to be not sufficiently specific for diagnosis of systemic disease since antibodies are frequently found in the normal individual in whom the organism lives as a commensal and in superficially infected individuals. Our project resulted in the development of a new quantitative immunofluorescence assay for quantitation of anti-Candida antibodies which is able to differentiate quite well (p< 0.0005) between systemically infected patients and normals or superficially infected patients. We have also investigated the value of purified antigens and have shown that the use of cytoplasmic protein antigens rather than those containing cell wall polysaccharide confers greater specificity on a qualitative test for anti-Candida antibodies but that a carbohydrate-containing antigen is adequate for differentiating systemic disease when a quantitative test is used. Attempts to diagnose systemic candidiasis by detection of circulating antigen have met with varying degrees of success. We were unable to detect antigen by counter-immunoelectrophoresis, a quantitative immunofluorescence inhibition assay, or an ELISA inhibition assay in the sera of rabbits in whom a Candida endocarditis was induced or in the sera of systemically infected patients. One postulated reason for this failure is the presence of the antigen in the form of circulating immune complexes. We have, therefore, investigated the possibility of the existence of complexes containing Candida antigen and antibody in the sera of patients with systemic candidiasis. Using four screening tests, a statistically significant difference (p < 0.05) was found for immune complex levels in a group of patients and a group of normal individuals. Isolation and characterization of immune complex-containing fractions from five patients with candidiasis indicated the presence of anti-Candida antibodies and/or antigen in at least three of them. Therefore, these fungal immune complexes can be assumed to exist and may play a role in the difficulties in detecting circulating antigen and, furthermore, may be involved in the pathogenesis and progression of disseminated candidiasis.

The University Of Health Sciences Journal: Summer/Fall 1982, University Of Health Sciences College Of Osteopathic Medicine, James F. Ryan

University of Health Sciences Journal (1981-1985)

Contents: The Faces of 1982-83 at UHS -- The 100th College of Osteopathic Medicine Class -- Physician/Teacher to Thousands -- One-Day Maternity Care -- "D.O. BE OR NOT TO BE?" -- Commencement 1982 -- Family Medical Care Center -- Taking a Closer Look: Endoscopy -- Alumni Album -- COMments -- People -- In Memoriam -- P.S.

Vital Signs, January 1982, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

The Protective Role Of Superoxide Dismutase Against The Beta Cell Toxicity Of Diabetogenic Drugs, Samuel Evans Gandy Iii

MUSC Theses and Dissertations

Superoxide dismutase (SOD) is a scavenger of the toxic superoxide radical and thereby protects the integrity of cell components from oxidative damage. This enzyme is an essential part of the biological defense system of aerobic cells, both directly by removing the superoxide anion and indirectly by preventing the formation of hydroxyl radical when superoxide reacts with hydrogen peroxide. The chemical diabetogenic agent streptozotocin, alloxan and Vacor are reported to directly inhibit the activity of this enzyme. The role of SOD in protection of pancreatic beta cells from the toxicity of diabetogenic drugs and the interaction of the drug with enzyme …

Effects Of Various Hormones On Human Carcinoma Cell Proliferation, Y. L. Gao, B. S. Leung, A. H. Potter, W.C.Y. Yu

Journal of the Minnesota Academy of Science

Cell proliferation of a mammary adenocarcinoma cell line, CAMA-1. is affected by a number of steroid hormones and prolactin in long-term cultures. Estrogenic compounds stimulate cell growth while antiestrogenic compounds inhibit it. Prolactin can synergize the estrogenic effect. Progesterone, glucocorticoid or androgen reduce cell proliferation. Dihydrotestosterone is a very potent inhibitor,- effective at as low as 10 nM, and its effect is independent of estrogen action. Cortisol is a less effective inhibitor at concentrations below 10 nM; at these levels cortisol exhibits a slight inhibition which appears to be unrelated to estrogenic action. However, at higher concentrations, cortisol markedly reduces …

Vaginal Colonization With Staphylococcus Aureus In Healthy Women: A Review Of Four Studies, Mary Guinan, Bruce B. Dan, Richard J. Guidotti, Arthur L. Reingold, George P. Schmid, Elena J. Bettoli, Joseph G. Lossick, Kathryn N. Shands, Mark A. Kramer, Nancy T. Hargrett, Roger L. Anderson, Claire V. Broome

School of Public Health Faculty Research

Four studies assessed the frequency of vaginal Staphylococcus aureus colonization in healthy women and associated risk factors. An association was found between S. aureus vaginal colonization and colonization at the labia minora and the anterior nares. Significant risk factors associated with an increased risk of vaginal S. aureus in at least one study were a history of genital herpes simplex infection, insertion of tampons without an applicator, and the use of Rely (Procter & Gamble) tampons. The use of systemic antibiotics within 2 weeks of the vaginal culture decreased the risk of recovery of S. aureus. The overall frequency …

The Effect Of Cardiac Rehabilitation On Blood Lipids, Carol Lynn Bartholomew

MUSC Theses and Dissertations

The effect of cardiac rehabilitation on blood lipids was studied in a sample of seventeen male participants of the Greenville Hospital Center cardiac rehabilitation program. These subjects all suffered myocardial infarctions, but none had surgery to by-pass the obstructed coronary circulation. Paired values were obtained for triglyceride, serum cholesterol and HDL cholesterol before, and after the exercise program. The time span between the before-exercise and after-exercise values ranged from five to thirty-one weeks. The differences in the paired values were analyzed by the t-test. No significant decrease occurred in triglyceride or serum cholesterol. A significant increase occurred in HDL cholesterol.

Newsletter, Volume 27, Number 01, January - February 1982

Newsletter: A Report to Physicians of Texas Archives

• Psychiatric treatment Addresses chronic Pain and Depressive Illness
• Murgola represents UT MDAH at Workshop on Genetic Translational Accuracy
• Conference to Focus on Psychological Implications of Chronic Illness in Children
• Hybridoma Conference Aimed at Divers Audience of Biological Scientists
• Noteworthy
• Peters Joins Staff as Head of Radiotherapy
• Guidelines Developed for Drug Preparation
• Guidelines for Handling Antineoplastic Agents
• Three Books Published
• Wataru W. Sutow Dies
• New Staff Appointments

Namru-3 Translations Of Parasite Literature From Russian, French, Japanese, Etc. Into English (1931-1982) T1501-T1600, United States Naval Medical Research Unit Number Three, Cairo, Medical Zoology Department

United States Naval Medical Research Unit 3: Publications

T1501. TRANSLATION FROM RUSSIAN. LEONOV, Yu. A. and KHARITONOVA, N. N. (1972). Experimental confirmation of the role of root voles in epizootiology of Omsk hemorrhagic fever. In: Transcontinental associations of migratory birds and their role in distribution of arboviruses, edited by Cherepanov, A. I. Mater. 5. Simp. Izuch. Roli Pereletn. Ptits Rasp. Arbovirus. (Novosibirsk, July 1969), pp. 355-358.

T1503. TRANSLATION FROM RUSSIAN. GASANOV, A. A. (1963). The infection of Rhipicephalus bursa (Can. et Fanz., 1877) with Babesia ovis in the Nakhichevan Region of the ASSR. Izv. Akad. Nauk Azerb. SSR, s. Biol. Med. Nauk, (4):117-123.

T1504. TRANSLATION FROM RUSSIAN. TSAPRUN, …

Postmortem Stability Of Drugs In Blood And Tissues, Barry Steven Levine

Theses and Dissertations

The delay that occurs between specimen acquisition and analysis in clinical and forensic toxicology requires the establishment that no changes in drug concentration have occurred during this timed interval. In this research, severai groups of common drugs were examined for stability in serum, blood and tissues at room temperature and at 4°C. Specifically, benzodiazepines, barbiturates, lidocaine, procainamide and nortriptyline were studied. Decreases were found in the following drugs: chlordiazepoxide, norchlordiazepoxide, demoxepam, and nitrazepam. No changes were found in the other drugs. More detailed work was performed on chlordiazepoxide (CDP). Two breakdown products, demoxepam and nordiazepam (ND) were identified and quantitated. …

Combined Heat And X-Ray Treatment Of Experimental Tumours, J. Denekamp, S. A. Hill, F. A. Stewart

Henry Ford Hospital Medical Journal

No abstract provided.

Clinical Thermoradiotherapy, H. I. Bicher, T. S. Sandhu, F. W. Hetzel

Henry Ford Hospital Medical Journal

No abstract provided.

Clinical Hyperthermia Pilot Studies, Thomas Jefferson University Hospital: Results Of 42.5c. Adjuvant To Irradiation, John Fazekas, Ted Nerlinger

Henry Ford Hospital Medical Journal

No abstract provided.

An Updated Analysis Of Microwave Hyperthermia At 2450 Megahertz And 915 Megahertz Frequencies, Kenneth H. Luk

Henry Ford Hospital Medical Journal

No abstract provided.

Glucose Metabolism In Liver And An Adenocarcinoma Of Mice With And Without Hyperthermia, Christian Streffer, Sieglinde Hegstebeck, Peter Tamulevicius

Henry Ford Hospital Medical Journal

No abstract provided.