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Study Of The Molecular Basis Of Diabetic Retinopathy, Heather Christine Glasscock-Hatcher

MUSC Theses and Dissertations

Abnormalities of the retinal vasculature contribute significantly to the development of diabetic retinopathy. In this study we have focused on two mechanisms which may be responsible-for the development and progression of this diabetic complication. Chronic hyperglycemia is associated with many of the vascular complications of diabetes mellitus; therefore, we examined mechanisms by which high-dose glucose damages retinal capillary endothelial cells. Our cell count results showed that high-dose glucose induces cell death in primary cultured human retinal capillary endothelial cells. Flow cytometry, in situ cell death detection, and transmission electron microscopy revealed that the cell death occurred via the apoptosis pathway …

The Tostan Story: Breakthrough In Senegal Ending Female Genital Cutting, Population Council

Reproductive Health

In Senegal, elements of the Tostan education program were fundamental to the ending of the practice of female genital cutting (FGC) which has persisted for centuries, despite outside efforts to abolish such a dangerous and harmful operation. This paper is an attempt by those who lived through these events to share the experience with others. At a time when there has been little reduction in the numbers of women ending FGC in 28 African countries, when different programs and strategies have rarely succeeded in making an impact on the number of women still practicing FGC despite laws abolishing the tradition, …

The Tostan Story: Breakthrough In Senegal Ending Female Genital Cutting [Arabic], Population Council

Reproductive Health

In Senegal, elements of the Tostan education program were fundamental to the ending of the practice of female genital cutting (FGC) which has persisted for centuries, despite outside efforts to abolish such a dangerous and harmful operation. This paper is an attempt by those who lived through these events to share the experience with others. At a time when there has been little reduction in the numbers of women ending FGC in 28 African countries, when different programs and strategies have rarely succeeded in making an impact on the number of women still practicing FGC despite laws abolishing the tradition, …

Results Of Faculty Evaluation At The Aga Khan University, Karachi, Pakistan, Rashida Ahmed, Mohammad Khurshid, Zoon Naqvi

Section of Haematology/Oncology

Objective: The aim of the retrospective correlational analysis was to identify the attributes valued most by students for assessing the overall effectiveness of a teacher.
Methods: Responses of the students to the two versions of evaluation questionnaires, each attempting to assess 4 and 8 characteristics respectively on a scale of 1-5 were included in the analysis. The third and fourth year students, at the end of each course/module completed a total of 2110 evaluation forms, which were studied.
Results: The over all effectiveness of the teacher showed statistically significant correlation of .914 and .895 with ability to communicate ideas effectively …

Effect Of Prepregnancy Body Mass Index And Gestational Weight Gain On Birth Weight, S S. Merchant, I A. Momin, A A. Sewani, N F. Zuberi

Department of Obstetrics & Gynaecology

Objective: Nutritional status of women has been considered an important prognostic indicator of birth outcome. The study aims to show the effect of various prepregnancy Body Mass Index (BMI) categories and corresponding gestational weight gain on newborn birth weight.
Methods: Two hundred women were included in the study. These women had regular antenatal visits and later delivered at The Aga Khan University Hospital (AKUH) between the period January 1, 1996 to December 31, 1997.
Results: For women with prepregnancy BMI < 19., mean birth weight of newborns was lower for those gaining < 12.5 kg than those gaining > 12.5 kg (P < 0.001). Women who started their pregnancy with BMI 19.8-26 and gained weight above expected range gave birth to high birth weight babies (P = 0.009). Gestational weight gain did not have a significant association with birth weight for women having prepregnancy BMI > 26.
Conclusion: Efforts should be made to attain adequate prepregnancy weight to reduce the likelihood of low …

Contributors

Coronary Artery Anomalies

No abstract provided.

Foreward, William C. Roberts

Coronary Artery Anomalies

No abstract provided.

Preface

Coronary Artery Anomalies

No abstract provided.

Title Pages

Coronary Artery Anomalies

No abstract provided.

Chapter 4: Normal And Anomalous Coronary Arteries In Humans. Part 1: Historical Background, Paolo Angelini, Salvado Villason, Albert V. Chan, Jr., Jose' G. Diez

Coronary Artery Anomalies

No abstract provided.

Contents

Coronary Artery Anomalies

No abstract provided.

The Association Of Fluid Intake With Total Natural-Cause Mortality, Coronary Heart Disease And Fatal Stroke, Jacqueline Chung Lun Chan

Loma Linda University Electronic Theses, Dissertations & Projects

Hypohydration may be more widespread than realized since it does not always arouse a sense of thirst. When thirst is felt, it is often ignored, or satisfied before euhydration is achieved. There is growing evidence indicating that hypohydration contributes to acute and chronic illnesses, and to rheological factors associated with coronary heart disease (CHD) and stroke. Therefore the relationship of fluid intake with risk of total natural-cause mortality, CHD and stroke death was examined using data on 34,192 white, non-Hispanic participants in the Adventist Health Study.

Among the 27,342 reporting no CHD, stroke or diabetes at baseline, during six years …

Sexual Knowledge And Practice In Pakistani Young Men, Waris Qidwai

Department of Family Medicine

Background: There is a shortage of scientific data on the subject of sexuality from Pakistan. We decided to document misconceptions among Pakistani young men, regarding masturbation and nocturnal emissions and to make a case for sex education in the country.
Objective: To study the knowledge, attitude and practice of Pakistani young men as regards masturbation and nocturnal emissions and to see any associations with demographic factors like age, marital status, occupation, level of education and socio economic status.
Method: A questionnaire was developed, based on the objectives of the study. It was administered to 188 men between the ages 18-30 …

Investigation Of The Contractile And Regulatory Proteins In Malignant Hyperthermia And Normal Skeletal Muscle, Louise C. Norbury

Theses : Honours

Malignant hyperthermia/hyperpyrexia (MH) is a serious human skeletal muscle disorder that manifests itself during general anaesthesia. Currently, the most reliable method of diagnosing this disease is the in-vitro contracture test (IVCT). This procedure is both highly invasive for the patient and expensive to perform. The skinned muscle fibre technique is less invasive, and could possibly be used as an alternative diagnostic test for MH. In this study, skeletal muscle samples were obtained from B adults (age 23-54 years) undergoing elective surgery at Royal Perth Hospital. Six patients were diagnosed as normal (controls) and two equivocal for MH (MHE). Using the …

The Efficacy Of A Developmental Follow-Up Program For High-Risk Infants, Laurie M. De Jong

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Objective: To assess the efficacy of a developmental follow-up program provided at a local community hospital. Efficacy was measured by the number of children referred to early intervention services and the cost effectiveness of the program. Design: This is a retrospective study of 174 children evaluated during 272 visits in the Follow-up Clinic from the inception of the program on November 22, 1994 through December 31, 1998. The data collected included referral rates and demographic information on all children. Financial information was also obtained on 74 children seen during a one year period to assess the financial implications of the …

Current Clinical Efficacy Of Chloroquine For The Treatment Of Plasmodium Falciparum Infections In Urban Dar Es Salaam, United Republic Of Tanzania, Zul Premji, C. Makwaya, J.N. Minjas

Pathology, East Africa

Reported is the use of a 14-day WHO protocol, which takes into account the clinical, parasitological and haematological responses to antimalarial drugs, to determine the efficacy of chloroquine in the treatment of uncomplicated malaria in young children (n = 200) in urban Dar es Salaam. Chloroquine failure was found in 43% of the children. Of these, 12.5% were considered to be early treatment failures and were given a single dose of sulfadoxine-pyrimethamine. Fever subsided in all children treated with sulfadoxine-pyrimethamine and there were no parasitological failures. In addition, children treated with sulfadoxine-pyrimethamine because of early treatment failure with chloroquine had …

Poor Performance Of Health And Population Welfare Programmes In Sindh: Case Studies In Governance Failure, Mehtab S. Karim, Shehla Zaidi

Community Health Sciences

Over the past few years, the issue of what is meant by “good governance” has generated increasing attention and debate both at the national and international level [Streeten (1997)]. The role of state and how that role is to be exercised is appearing high on the agenda of politicians, policy-makers and academicians in the developing world. Governance has been defined by the World Bank as “the manner in which power is exercised in the management of the country’s economic and social resources” [World Bank (1994)]. The somewhat narrow scope of this definition has been broadened in recent years to “the …

Anaesthetic Management Of Patients With Phaeochromocytoma And Uncontrolled Blood Pressure, Ursula Chohan, Fazal Hameed Khan

Department of Anaesthesia

No abstract provided.

Autoimmune Hemolytic Anemia In Visceral Leishmaniasis, Salman Adil, Mohammad Khurshid, Lkram A. Burney

Department of Pathology and Laboratory Medicine

A case of an 8-month old male child, who presented with lgG mediated Coomb’s positive hemolytic anemia and visceral leishmaniasis is presented. The hemolytic anemia resolved following the treatment of leishmaniasis. Although various other mechanisms of anemia have been described, so far the association between IgG-mediated hemolytic anemia and visceral leishmaniasis has not been reported.

Anti-Bacterial Effect Of Hvpc In Vivo, Marc Campolo

Seton Hall University Dissertations and Theses (ETDs)

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New England Osteopathic Association: Kirmes To Neoa Board 1998-12-8, William Kirmes D.O.

William Kirmes, D.O. Collection

A letter from Dr. Kirmes, President of New England Osteopathic Association (NEOA), to NEOA board members regarding the New England CME committee meeting, December 2, 1998.

Protocol For Management Of Hypertension By Family Practitioners, Badar Sabir Ali, R Qureshi, R H. Dhanani

Department of Family Medicine

No abstract provided.

Ms211: Overview - Assessing Aid - World Bank Report, Armin Weinberg

Works on Radiation Effects: 1990-2020

A World Bank Policy Research Report that helped inform my leadership of our international projects in the former Soviet Union. See more at Armin Weinberg, PhD Papers and its finding aid.

The Role Of Gap Junctions In Congenital Diseases Of The Heart, Scott Henry Britz-Cunningham

Loma Linda University Electronic Theses, Dissertations & Projects

Background. Gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin43, the major protein of gap junctions in the heart, is targeted by several protein kinases that regulate myocardial cell-cell coupling. We hypothesized that mutations altering sites critical to this regulation would lead to functional or developmental abnormalities of the heart.

Methods. Connexin43 DNA from 25 normal subjects and 30 children with a variety of congenital heart diseases was amplified by the polymerase chain reaction and sequenced. Mutant DNA was expressed in cell culture and examined for its effect …

Ms211: Registry Screens 02no98, Armin Weinberg

Works on Radiation Effects: 1990-2020

Content and screen shots of development of cancer registrty. See more at Armin Weinberg, PhD Papers and its finding aid.

Cytochalasins Useful In Providing Protection Against Nerve Cell Injury Associated With Neurodegenerative Disorders, Mark P. Mattson

Sanders-Brown Center on Aging Faculty Patents

The present invention relates to novel therapeutic uses of certain compounds to protect nerve cells from injury and death. The compounds include cytochalasin D and related analogs, and cytochalasin E and related analogs.

Trophectoderm Differentiation In The Bovine Embryo: Characterization Of A Polarized Epithelium., L C Barcroft, A Hay-Schmidt, A Caveney, E Gilfoyle, E W Overstrom, P Hyttel, A J Watson

Obstetrics & Gynaecology Publications

Blastocytst formation is dependent on the differentiation of a transporting epithelium, the trophectoderm, which is coordinated by the embryonic expression and cell adhesive properties of E-cadherin. The trophectoderm shares differentiative characteristics with all epithelial tissues, including E-cadherin-mediated cell adhesion, tight junction formation, and polarized distribution of intramembrane proteins, including the Na-K ATPase. The present study was conducted to characterize the mRNA expression and distribution of polypeptides encoding E-cadherin, beta-catenin, and the tight junction associated protein, zonula occludens protein 1, in pre-attachment bovine embryos, in vitro. Immunocytochemistry and gene specific reverse transcription--polymerase chain reaction methods were used. Transcripts for E-cadherin and …

Moyamoya Disease Presenting With Intracranial Haemorrhage, Ali Akbar, Aftab Qureshi, Rashid Jooma

Section of Neurosurgery

No abstract provided.

Oncolog, Volume 43, Number 11/12, November-December 1998, Jude Richard, Alison Ruffin

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Mohs surgeon expands skin cancer treatment options
• Colorectal cancer campaign launched at White House
• House Call: Reducing Colorectal Cancer Risk: Modify Diet, Undergo Screening

Primary Cutaneous Actinomycosis, Anjum Kanjee, Zamaz Wahid, Shahid Pervez

Department of Pathology and Laboratory Medicine

No abstract provided.