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Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

The Hypocalcemic Effects Of Actinomycin D And Mithramycin, Eduardo L. Reyes, Robert W. Talley

Henry Ford Hospital Medical Journal

Both actinomycin D and mithramycin are useful agents in the treatment of cancer. They can also produce hypocalcemia, a comparatively rare phenomenon in cancer. Two such cases are presented in detail. Neither patient had the classic symptoms of hypocalcemia. Instead, the clinical picture was more compatible with hypercalcemia. The mechanism of action of each drug is explained; therapeutic implications are made with regards to their synergistic effects when used in combination with the standard calcium-lowering agents. Attention is drawn to the inhibitory action of these two agents on the calcium-mobilizing effect of the parathyroid hormone. The hypocalcemic effects of these …

In Vitro Kidney Preservation Techniques, S. G. Dienst

Henry Ford Hospital Medical Journal

The advantages of adding hyperbaria, low flow perfusion, and protein colloid to hypothermia at 0° C for kidney preservation are described. The possibilities of longer preservation at higher temperatures are discussed.

Hypophyseal Growth Hormone: I. Control Of Secretion, M. Saeed Zafar, Raymond C. Mellinger, Lewis B. Morrow

Henry Ford Hospital Medical Journal

Growth hormone (GH) is a major hormone of the anterior pituitary gland. Once established, its secretion continues throughout life. GH was first recognized in 1866 as a factor controlling growth. More recently, it has been demonstrated as a vital regulator of fat, carboyhdrate and protein metabolism. In fact, GH influence on the intermediary metabolism is the major mechanism by which growth and development are regulated. Numerous hormonal and nonhormonal factors have been shown to modify the basic pattern of GH synthesis and secretion. In this article we have reviewed some of these nonhormonal factors.

Surreptitious Ingestion Of Oral Anticoagulants, Thomas H. Greidanus, Ellis J. Van Slyck, Raymond W. Monto

Henry Ford Hospital Medical Journal

Hypoprothrombinemia secondary to surreptitious ingestion of coumarin or indanedione anticoagulants may be a difficult diagnosis for the unsuspecting physician. Four such case reports are presented. The disease should be suspected if the prothrombin time is markedly elevated and the individual is associated with the medical profession or has had previous treatment with oral anticoagulants. The diagnosis is confirmed by finding a deficiency in Factors II (prothrombin), VII, IX, and X and the presence of the coumarin or indanedione anticoagulant in the blood. The motive generally is that of gaining attention rather than committing suicide. Liver disease. Vitamin K deficiency states …

Double Contrast Arthrography Of The Knee, Peter C. Larowe, Robert S. Ormond, Edwin Guise

Henry Ford Hospital Medical Journal

Arthrography is a safe and relatively simple diagnostic procedure which provides an accurate and graphic preoperative means of defining pathology of the knee. In those cases where the expeditious evaluation and diagnosis of knee injury are of prime importance, ie, the athlete and industrial compensation case, arthrography provides a significant contribution. The clinical pathological features, salient anatomy and technic of study of internal derangements of the knee are discussed. Selected double contrast arthrograms illustrate normal and abnormal findings. Arthrotomies were performed in 20 of the 32 patients in this study with a positive arthrogram-arthrotomy correlation of 85%.

Immunologic Status Of Uremic Patients, Gerald A. Logrippo, C. E. Rupe, Hajime Hayashi, Dean Lesher

Henry Ford Hospital Medical Journal

The immunologic status of 25 uremic patients was studied with a battery of tests evaluating the humoral and cytological aspects of immunity. The individual's humoral immune status was evaluated as follows: quantitation of the three major serum immunoglobulins (IgG, IgA and IgM) expressed in mg/100 ml of serum and compared to established normal clinical standards (±2 SD/mean); qualitation of IgG and IgM evaluated by specific virus antibody titers and antitoxin values associated with IgG and by isoagglutinin tilers of the ABO blood groups associated with IgM. Immunoglobulin status is grouped into hyper- and hypo-immunoglobulin variations from normal and correlated with …

Cephalexin: In Vitro And In Vivo Studies, Frank Cox Jr., Edward L. Quinn, Bienvenido G. Gatmaitan, Nancy Peterson

Henry Ford Hospital Medical Journal

Cephalexin, a derivative of cephalosporin C, produces high serum and urine concentrations after oral administration. In addition, it shows good activity in vitro against most gram-positive and some gram-negative organisms. This study reports the in vitro susceptibility to cephalexin of a series of clinical isolates, the serum levels and urine concentrations in human volunteers and the results of its use in infections due to susceptible organisms. Results of in vitro susceptibility testing reveal that cephalexin was effective against most strains of the gram-positive organisms tested — group A streptococci, pneumococci, and staphylococci — although the MIC's are higher than those …

Hfh In The News

Henry Ford Hospital Medical Journal

No abstract provided.

Surgical Treatment Of Portal Hypertension: Review Of Henry Ford Hospital Experience, Joseph P. Elliott Jr., Kian H. Wong, Roger F. Smith

Henry Ford Hospital Medical Journal

Of 146 operations performed for the complications of portal hypertension in the Henry Ford Hospital between 1927 and August 31, 1969, 114 were portasystemic shunts. Operative mortality, sequelae and long term survival were closely related to the state of the patients' liver function and the urgency of operation.

The Relationship Between The Lingual Surface Of The Maxillary Central Incisor And The Eminence Of The Mandibular Fossae, Robert A. Huffer

Loma Linda University Electronic Theses, Dissertations & Projects

Gnathologists have suggested that in order to prevent excessive wear on posterior teeth, alveolar bone loss due to traumatic occlusion, and temporomandibular Joint (TMJ) disturbances, the mandibular incisors should disclude the posterior teeth by moving along the lingual surfaces of the maxillary incisors as the condyles move down the articular eminence in protrusion. It is suggested that in order for this to occur, the lingual surface of the maxillary incisors should be steeper than the eminence.

A cephalometric technique was developed to accurately determine the anatomical form of the articular eminence. A regular orthodontic tracing of the head was done …

A Follow-Up Study Of Patients With Chronic Obstructive Lung Disease And Their Practice Of The Breathing Pattern, A. Theodora Djagia

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this descriptive survey was to do a follow-up study on patients with COPD to find out to what extent these patients have followed instruction to continue exercising the abdominal and diaphragmatic muscles, with the utilization of a breathing pattern. Literature was reviewed which revealed contradictory findings in regard to the physiological benefits of the use of the breathing pattern. Nine patients met the criteria and signed a consent sheet to be visited in their homes. An Observation Data Sheet and Interview Guide were the tools used to collect data. A point system was constructed and used with …

An Analysis Of Orthodontic Treatment Results Employing Class Ii Armstrong Adjustable Intermaxillary Springs, Michael E. Shumate

Loma Linda University Electronic Theses, Dissertations & Projects

A study of orthodontic treatment results employing Class II Armstrong Adjustable Intermaxillary Springs was made on twenty-eight randomly selected patients which were treated by Dr. Maclay Armstrong.

The skeletal and dental changes observed during treatment with the Class II springs was compared with those results observed when comparable type malocclusions were treated with Class II elastics. A list of changes which were observed during treatment with Class II elastics was compiled from the literature using individual studies published by Ricketts, Creekmore and Hanes.

The study was based on the findings observed in the initial and final cephalometric radiographs. A statistical …

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

Hfh In The News

Henry Ford Hospital Medical Journal

No abstract provided.

Post-Therapeutic Thyroid Reserve: Thyroid Reserve In Euthyroid Patients After Ablative Therapy For Diffuse Toxic Goiter, J. Joseph Prendergast, J. Martin Miller

Henry Ford Hospital Medical Journal

Thyroid reserve was measured in 41 patients who were euthyroid 5 to 15 years after therapy for diffuse toxic goiter. Twenty-one of them had been treated by 131I, 20 by surgery and 10 were normal controls. All had a PBI (protein bound iodine) and 3-hour thyroidal 131I uptake. The same parameters of function were measured again 24 hours after they were given 10 units of thyroid stimulating hormone (TSH) intramuscularly. Only two patients in each treatment group responded with normal elevation of both the PBI and 131I uptake. In 52% of the 131I-treated patients and in 55% of those surgically …

A New Biological Stain For Peripheral Blood And Bone Marrow Smears, A. R. Villanueva

Henry Ford Hospital Medical Journal

A new blood stain has been developed for the demonstration and differentiation of cell types in peripheral blood or marrow smears, parasites in blood, and tissue impression preparations. It is available as a prebuffered powder which is dissolved in 100% reagent methanol. The method of staining is simple and rapid, with no precipitate. Overstaining is not likely to occur. The tinctorial patterns closely resemble some predecessors and, as the stain solution ages the staining quality improves. It is specific, stable, reproducible and resistant to fading.

Intestinal Lymphagiectasia With Normal Immunological Function: A Case Report, T. Madhavan, C. E. Rupe

Henry Ford Hospital Medical Journal

A patient is reported with histologically proven intestinal lymphangiectasia and protein losing enteropathy. The gastrointestinal protein loss and the effect of low fat diet have been demonstrated. The morphological abnormalities with radiological and lymphangiographic findings are discussed. Immunological studies are analyzed. These patients may have normal function both humoral and cellular, in spite of fairly advanced disease. Also the new hereto unreported association of Graves' Disease and intestinal lymphangiectasia has been brought out.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Total Gastrectomy For Carcinoma Of The Stomach, Thomas A. Fox Jr.

Henry Ford Hospital Medical Journal

The results of total gastrectomy in 47 patients with carcinoma of the stomach are reported. Extended total gastrectomy is recommended only if the growth cannot be removed by any other means. It should not be performed if the growth is not totally resectable. The operative mortality and postoperative results of total gastrectomy have improved to the extent that this operation for carcinoma of the stomach should be undertaken where indicated.

Quantitation Of Aortic Valvular Insufficiency Using Radioactive Tracers: An Experimental Study In Vitro, Frank J. Hildner, William R. Pierson, Bernard Weinstock, Ellet H. Drake, Robert S. Ormond

Henry Ford Hospital Medical Journal

A method has been developed in vitro for quantitation of aortic valvular insufficiency (Al) based on the use of ladioactive traceis lo genei-ate graphic recordings of the movement of blood out of the ventricle and back again. The regurgitant fraction of stroke volume (peirent of Al) is read from this recording. The method was evaluated in a mechanical heart model by comparing Al values read from the istope recordings and Al values determined volumetrically. The recordings gave excellent agreement with the volumetric results (Corr. Coeff. .9). These in vitro results are of such quality that clinical trials seem justified.

Echinococcosis Of The Liver: Report Of A Case, Roberto Benedetti, Joseph L. Ponka

Henry Ford Hospital Medical Journal

Echinococcosis of the liver is so rare in our practice that the case presented is the only one documented in the records of Henry Ford Hospital. The massive enlargement of the liver required surgical intervention. Marsupialization was the treatment of choice. In spite of post-operative complications, the patient made a satisfactory recovery.

Complications Of Pulmonary Angiography, D. T. Anbe, E. H. Drake

Henry Ford Hospital Medical Journal

Although data are available indicating the complication rates for routine cardiac catheterization, information has been lacking on the morbidity of pulmonary angiography in symptomatic patients. This retrospective study was undertaken to assess the "risks" of this procedure, by analyzing all cases undergoing pulmonary angiography from June 10, 1964. to December 31, 1967. Only two deaths were considered to be causally related to the pulmonary angiogram, a mortality rate of 1.4%. The overall complication rate was 15%. There was no correlation of the complications with the average age, or the concentration of the Hypaque used. There was a correlation between complications …

Serum Hepatitis At Henry Ford Hospital 1958-1967, K. S. Murthy, B. M. Schuman

Henry Ford Hospital Medical Journal

An analysis was done to determine the risk of hepatitis related to transfusions of whole blood or blood fractions. Of 180 cases indexed as serum hepatitis at Henry Ford Hospital, from 1958 to 1967, 148 had been transfused at this hospital. The overall incidence of hepatitis was 1.13 cases per 1,000 units transfused with a mortality rate of 7.4%.

Rubella: Current Status Of Immunization, E. L. Quinn, Frank Cox, Donald Romig

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Alcaptonuria And Ochronosis With Diabetes Mellitus And Mycosis Fungoides: A Case Report, Jamshed U. Haq, Roy B. Patton

Henry Ford Hospital Medical Journal

A Negro woman with alcaptonuria, ochronosis, ochronotic arthropathy, diabetes mellitus and mycosis fungoides died of acute renal failure due to diabetic glomerulonephropathy and ochronotic nephrosis. The role of the renal lesions of ochronosis is presented in potentiating the effect of an underlying renal disease producing rapidly progressive kidney failure. The occurrence of ochronosis, diabetes mellitus and mycosis fungoides is apparently coincidental only. Special stains of tissue sections confirm the similarity of melanin and ochronotlc pigment.

Cation Transport I. Metabolic Activity Of The Polyphosphoinositide Complex In Isolated Renal Cortex Tubules, Paul Bartlett, James F. Bossart

Henry Ford Hospital Medical Journal

Although several mechanisms have been proposed to explain the transport of hydrophylilc cations across lipoprotein barriers, the nature and identity of the carrier mechanism have not yet been elucidated. The present communication is concerned with a mechanism postulating that monoesterified phosphate on the inositol moiety of phosphatidyl inositol might provide anionic sites that function as cation carriers via a phosphorylation-dephosphorylation cycle, catalyzed in its simplest sequence by phosphatidyl inositol kinase and diphosphoinositide phosphomonoesterase activities. In this context, one might reasonably expect that turnover of monoesterified phosphate in the polyphosphoinositides of isolated renal cortex tubules would be reduced in tubules in …

The Mechanism Of Formation Of Certain Ventricular Septal Defects: A New Hypothesis, Jami G. Shakibi, Lester Weiss

Henry Ford Hospital Medical Journal

The generally accepted and most common mechanism of the pathogenesis of VSD is the failure of fusion of the conus ridges, atrioventricular cushions and the ventricular muscular septum. Our findings in a study of serial sections of the hearts of newborn gerbils (Meriones unguiculatus) leads us to hypothesize a second, less common, mechanism for the development of VSD, i.e., an exaggeration of the normal process of resorption and atrophy which undermines the septal cusp of the tricuspid valve, thus separating it from the muscular septum. This hypothesis can explain an instance of high membranous VSD in the form of a …

Evaluation Of Cellular-Level Haversian Bone Resorption In Human Hyperparathyroid States: A Preliminary Report, H. M. Frost, A. R. Villanueva, Z. F. Jaworski, P. Meunier, A. G. Shimizu

Henry Ford Hospital Medical Journal

Cellular-level bone resorption was evaluated in 16 patients undergoing renal dialysis and in two with primary hyperparathyroidism, by quantitative histological means using tissue time markers. When averaged over periods greater than two weeks, the individual osteoclasts in these patients resorbed less bone in unit time than normal.