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Observations On Uric Acid Transport In Man, The Dalmatian And The Non-Dalmatian Dog, Howard Duncan, April S. Curtis

Henry Ford Hospital Medical Journal

The urinary output of uric acid from the purebred Dalmatian is similar in amount to that in man. Also, this breed of dog has a higher plasma uric acid level than other dogs and, like man, this hyperuricemia is accompanied more frequently with renal and bladder lithiasis. Allopurinol is effective therapy in both man and dog. Study of the fate of uric acid in the Dalmatian shows that the liver does not oxidize the available uric acid completely although it is capable of doing so when liver homogenates are studied. Consequently, the hepatic cellular membrane appears impermeable, or partially so, …

Atrial Sounds In Atrial Flutter, Oswald Bostic, Wolf F. C. Duvernoy, Gerald M. Breneman

Henry Ford Hospital Medical Journal

Atrial flutter sounds are occasionally audible on bedside examination especially in patients with slow ventricular rates. A patient is described with audible flutter sounds and an illustrative phonocardiogram is presented. The value of careful auscultation in patients with atrial flutter is re-confirmed.

Gastrocolic And Duodenocolic Fistulas: An Experimental Study, Joseph L. Ponka, A. Karim Shaalan, P. C. Pesaros

Henry Ford Hospital Medical Journal

In an experimental study of gastrocolic and duodenocolic fistulas, it was clearly seen in 10 animals that duodenocolic fistulas result in the most serious loss of nutrition. Death from starvation occurred in all 42 animals in 30 days. Gastrocolic fistulas similarly resulted in weight loss and death of the animals in an average of 42 days. Lengthy fistulas between the stomach and colon caused no obvious disturbances in the physiology of the gastrointestinal tract. The significant microscopic changes included destruction of the mucous membrane and a decrease in size of the villi. The other noteworthy observation was that fistulous aggregations …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Therapy Of Mycosis Fungoides, Harvey G. Shapero

Henry Ford Hospital Medical Journal

Mycosis fungoides is best viewed as a cutaneous lymphoma. Over a period of years, it progresses through three stages—the first consisting of red scaly patches, the second of pruritic plaques, and the third of brownish-red tumors. The therapy of each stage is outlined, and several selected modalities are discussed in detail, including topical steroids, systemic steroids, localized superficial irradiation, topical nitrogen mustard, electron beam, and chemotherapy (alkylating agents and antimetabolites.

Diagnosis And Treatment Of Gonorrhea, Paul A. Kvale

Henry Ford Hospital Medical Journal

The various methods for diagnosis of gonorrhea are reviewed. Gram-stained smear of urethral exudate in the mate is appropriate, but for the female emphasis is placed on the use of culture on Thayer-Martin medium. Currently effective modalities of treatment are detailed, pointing out that higher doses of antibiotics are generally required for females with pelvic inflammatory disease than for males with acute gonococcal urethritis. The necessity for follow-up is also discussed.

An Improved Method Of Staining Paraffin-Embedded Bone Marrow Sections, Wanda Pusey, A. R. Villanueva

Henry Ford Hospital Medical Journal

Cytological detail is well demonstrated in an improved method of staining aspirated bone marrow sections embedded in paraffin. The tinctorial patterns of the stain resemble some of its predecessors; thus, cell counting and identification involve little difficulty. The method has proven reliable, reproducible and a valuable addition in the diagnosis of bone marrow disorders. It is a useful tool in research problems in which objectives are the study of the bone marrow.

A Computerized Study Of Midpalatal Suture Expansion, Clelan G. Ehrler

Loma Linda University Electronic Theses, Dissertations & Projects

An investigation has been conducted to consider the effects of midpalatal suture expansion on the cranial-facial complex. Nine patients were treated that had constricted maxillae. Data was obtained from frontal and lateral headplate radiographs which were taken at four intervals during treatment. The Rocky Mountain Data Systems diagnosis was utilized to interpret the radiographic data.

The data from the nine cases were averaged to obtain a composit [sic] change at each of the four times.

Examination of the lateral headplate data revealed that no permanent significant alteration occurred to the positions of the mandible or maxilla in a vertical or …

The Relationship Of The Bucco-Lingual Position Of The Mandibular First Molar To Occlusion And Arch Stability, Lothar M. Guttschuss

Loma Linda University Electronic Theses, Dissertations & Projects

Forty non-treated and twenty-two orthodontically treated cases were selected to determine the relationship of the bucco-lingual position of the mandibular first molar to occlusion and arch stability.

Plaster models and occlusal radiographs were obtained from all the cases. Anterior crowding, intermolar width, molar classification, and molar overhang relative to the basal bone were determined. The modified technique for occlusal radiographs used was found to result in radiographs which were more versatile and accurate when interchanged with the model measurements. Clinical applications of this technique include the determination of root angulations, location of impactions, and the fabrication of individualized preformed arch …

Bacteriuria As A Precursor Of Intracatheter Encrustation, Namcy Moll

Loma Linda University Electronic Theses, Dissertations & Projects

The problem with which this study was concerned was the development of criteria that could be used to determine when urinary catheter changes were necessary. By determining when encrustation occurred, it was felt that some complications could be eliminated by changing catheters before obstruction occurred due to encrustation.

It was the purpose of this study to: 1) explore some indications for catheter change, 2) determine if encrustation of urinary catheters necessitates catheter change, and 3) estimate potential criteria for a routine time for catheter changes.

Forty-five catheters were examined after their removal from patients. Flow rates were determined on 33 …

The Effect Of Elevated Glucose On Neutrophilic Phagocytosis In Genetically Diabetic Mice, Larry B. Thompson

Loma Linda University Electronic Theses, Dissertations & Projects

Infiltration to an injury site or area of bacterial contamination by polymorphonuclear leucocytes (or neutrophils) is an early and essential phase of the early inflammatory reaction. Their action on foreign matter is the most critical step taken by body defense mechanisms in the first 24 hours. Anything which interferes with that action, phagocytosis, greatly hampers early inflammation. This study was designed to see the effect of elevated glucose levels on neutrophil phagocytosis in a unique strain of genetically diabetic mice.

Twenty-two diabetic and twenty-four control female mice were used. Blood glucose determinations and total white counts were made on each …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

The Clinical Course Of Duodenal Ulcer Associated With Hyperparathyroidism, Melvin A. Block, Boy Frame, Thomas A. Fox Jr.

Henry Ford Hospital Medical Journal

In 98 patients with primary hyperparathyroidism, 15 had objective evidence of duodenal ulcer disease. Following operative correction of the hyperparathyroidism, improvement of duodenal ulcer disease occurred usually, but not uniformly, if unassociated with non-beta islet cell tumors. Correction of hyperparathyroidism in patients with the Zollinger-Ellison syndrome does not significantly influence the peptic ulcer which should be given primary aggressive surgical treatment.

Persistence Of ''Australia Antigenemia" In Mentally Retarded Children Seven Years After Virus Hepatitis, Hajime Hayashi, Gerald A. Logrippo

Henry Ford Hospital Medical Journal

Australia antigen and antibody were assayed in acute and convalescent (1, 4 and 6 months) phase sera from 80 children with infectious hepatitis in an institution for the mentally retarded. A higher incidence of Australia antigenemia was found in 18 of 40 (45%) mongoloid children as compared to 9 of 40 (23%) non-mongoloid children. Australia antigen persisted 7 years after the hepatitis epidemic in 11 mongoloid and 2 non-mongoloid children with hepatitis. None of the hepatitis group, with or without Australia antigenemia, demonstrated precipitable antibody to the Australia antigen. The discussion emphasizes the lack of virologic and immunologic evidence relative …

Tube Feeding As Part Of The Supportive Care Of The Surgical Patient, Bernard M. Schuman

Henry Ford Hospital Medical Journal

A brief review is presented of the purpose and method of tube-feeding malnourished patients by the Barron technique. Dietary factors are analyzed and certain complications that can be avoided by proper attention to technique are noted.

A Replacement Prosthesis For The Hip: A Preliminary Report, H. M. Frost, E. R. Guise

Henry Ford Hospital Medical Journal

Because of theoretical as well as practical difficulty in the total hip endoprostheses available to orthopaedic surgeons at the present time, an anlysis of the present and potential difficulties reveals that substitution of a roller-bearing for the present slider-bearing prosthesis and the establishment of a larger end-bearing surface on the acetabular side would be of benefit. Thus, the Ring prosthesis was re-designed to satisfy these hopes. A modification of the Ring's approach gives complete acetabular exposure and control of the prosthetic insertion. This is a preliminary report describing the design modifications of a prosthesis, presently under investigation, and illustrated by …

Fever In Neoplastic Disease, Samuel L. Rosenthal, Robert W. Talley

Henry Ford Hospital Medical Journal

A comparison is made between incidence of fever in 132 patients with various types of disseminated cancer and 57 patients with diseases other than cancer during a 2- month observation period. Fifty-three febrile episodes were observed in cancer patients. Of these, 15 were of undetermined origin and 6 were noninfectious; none of the episodes occurred immediately following surgery. In the control group of 57 patients, there were 12 febrile episodes; of these, 7 were due to proven bacterial infection, 2 were due lo possible bacterial infection, and 3 were of undetermined etiology. All three febrile episodes in this latter group …

Advice To Authors

Henry Ford Hospital Medical Journal

No abstract provided.

The Hazards Of Rubella Serodiagnosis From Single Serum Studies In Pregnancy, Gerald A. Logrippo, Hajime Hayashi

Henry Ford Hospital Medical Journal

Hemagglutination-inhibition (HA-I) titres for rubella were studied in 200 nurses, 87 pregnant women, in plasma and serum pools, and in laboratory personnel. The percentage of individuals susceptible to rubella in the child-bearing ages was 11.5%> among the non-pregnant nurses and 23% among the pregnant women assayed at their first prenatal visit. Serodiagnosis of active rubella necessitates two or more serial serum studies during the first trimester of pregnancy.

Rectal Cytology By An Improved Replica Method, Klaus Anselm, Victor Lawoyin, Jerry Blonsky

Henry Ford Hospital Medical Journal

The replica method aiding in rectal cytology is described and a modification of the slide applicator is recommended. Used in 75 patients, this replica method is a safe and useful tool for the diagnosis and followup of inflammatory bowel disease as well as for research purposes.

Letter To The Editor, Barbara J. Zonca

Henry Ford Hospital Medical Journal

No abstract provided.

Effect Of Freezing And Thawing On Uptake Of Amino Acids Into Human Erythrocytes, Richard Moore, Rita Parenti, I. Rena Bizios

Journal of the Minnesota Academy of Science

ABSTRACT - The transport of "C-amino acids into human erythrocytes and into erythrocytes which had been frozen and thawed was studied experimentally. The relative rates of uptake were found to be (in decreasing order): phenylalanine, leucine, alanine, trythophan, and glycine. Freezing (using gycerol as the cryoprotective additive) and thawing had no significant effect on either the magnitude of the rate constants or on the order of the above relative rates of amino acid uptake into erythrocytes suspended in isotonic TRIS-HCl buffer.

Cold For Relief Of Postoperative Limitation Of Activity Due To Incisional Pain, Haroldine Roberts

Loma Linda University Electronic Theses, Dissertations & Projects

This study was concerned with testing the effectiveness of cold to aid the cholecystectomy patient in performing certain selected activities usually inhibited by incisional pain.

Available references of the effects of cold on the abdominal area were studied to formulate a method of approach as no previous methodology was found in the literature.

The experimental method of research was used on a sample of 18 cholecystectomy patients meeting the criteria for the study, independent variable for the 10 patients in the experimental the application of cold over the closed incision, plastic bag covered with one thickness of towel was used …

Newsletter, Volume 15, Number 04, December 30, 1970

Newsletter: A Report to Physicians of Texas Archives

• Dial Cancer Information
• Knudson New Dean
• Clinical Abstracts
• New Staff
• Dr. Margery Shaw Honored With Award
• Clark Co-Chairman of Cancer Study
• Staff Publications

Newsletter, Volume 15, Number 03, December 15, 1970

Newsletter: A Report to Physicians of Texas Archives

• Cancer Goals And Progress Discussed at Staff Symposium
• Trophoblastic Disease Center Offers HCG Assays
• Grants for Research
• Switzer Receives Heath Award At Conference
• Radiologists and Physicists Meet
• Book Reviews
• New Staff
• Surgeon General Will speak at Symposium
• Clinical Abstracts
• Research Merits Population Foundations Grant
• 14th Year Book of Cancer Published

Co-Existent Klinefelter's Syndrome, Acquired Cutaneous Hepatic Porphyria And Systemic Lupus Erythematosus, M. Saeed-Uz-Zafar, W. R. Gronewald, G. B. Bluhm

Henry Ford Hospital Medical Journal

A patient is reported with Klinefelter's syndrome, systemic lupus erythematosus (SLE) and acquired cutaneous hepatic porphyria. Although patients with chromatin positive Klinefelter's syndrome may have elevated auto-antibodies, this patient had definite diagnostic criteria for SLE. Furthermore, evidence of disturbed porphyrin metabolism compatible with acquired cutaneous hepatic porphyria was found. It is speculated that the major disturbance in our patient's porphyrin biosynthesis may be distal to ^-ALA synthetase. Any association between the three diseases is conjectural: however, it is noteworthy that both SLE and porphyria are more common in the female and that our patient had two X chromosomes in addition …

Immunologic Competence In Idiopathic Ulcerative Colitis (Humoral Aspects Of Immunity), Gerald A. Logrippo, Klaus Anselm, Hajime Hayashi, Robert J. Priest

Henry Ford Hospital Medical Journal

Systemic immune status was studied in 86 idiopathic ulcerative colitis patients. Quantitation of the major serum immunoglobulins (IgG, IgA and IgM) and qualitation for specific enteropathogens (bacterial and viral) associated with the immunoglobulins are correlated with the severity and duration of the disease. The studies demonstrate the immunologic competence of these patients to respond to a variety of infections with normal activity and hyperactivity. In addition, systemic complications associated with ulcerative colitis, particularly liver involvement, are reflected in the immunologic studies.

Dose-Response Relationship Of Bile Flow To Cholecystokinin Stimulation As Measured By Duodenal Drainage, Robert J. Priest, Roberto F. Gluckmann, J. Edward Berk, Joseph A. Rinaldo

Henry Ford Hospital Medical Journal

A study was done to evaluate the dose-response of cholecystokinin administered intravenously to normal patients and to patients with diseased gallbladders. The volumes of bile and bilirubin units were measured in duodenal aspirates. A dosage of cholecystokinin between 12.5 and 25 Ivy dog units differentiated the several categories studied. Lower doses of cholecystokinin resulted in no change in the volume of bile, but significantly reduced the output of bilirubin units.

Hfh In The News

Henry Ford Hospital Medical Journal

No abstract provided.